Evidence for Redox Regulation of Cytochrome c Release during Programmed Neuronal Death: Antioxidant Effects of Protein Synthesis and Caspase Inhibition

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Neuroscience

• Publication date

  2001-03-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1523/JNEUROSCI.21-06-01949.2001PMID 11245680PMCID PMC6762616
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.

  2000cited by this paper
• The Release of Cytochrome c from Mitochondria during Apoptosis of NGF-deprived Sympathetic Neurons Is a Reversible Event

  1999cited by this paper
• Free Radicals in Biology and Medicine. Third Edition: Barry Halliwell and John M.C. Gutteridge, Oxford University Press. ISBN 1-29-850044-0/45-0. H/B £75.00, P/B £34.95

  1999influential reference
• BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases

  1999cited by this paper
• Presence of a pre‐apoptotic complex of pro‐caspase‐3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

  1999cited by this paper
• Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.

  1999cited by this paper
• Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

  1999cited by this paper
• Activation of Membrane-associated Procaspase-3 Is Regulated by Bcl-2

  1999cited by this paper
• Blocking Cytochrome c Activity within Intact Neurons Inhibits Apoptosis

  1998influential reference
• Prevention of PC12 Cell Death by N-Acetylcysteine Requires Activation of the Ras Pathway

  1998cited by this paper
• Control of Neuronal Size Homeostasis by Trophic Factor–mediated Coupling of Protein Degradation to Protein Synthesis

  1998cited by this paper
• Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c.

  1998cited by this paper
• The Regulation of Reactive Oxygen Species Production during Programmed Cell Death

  1998influential reference
• Mitochondria and Free Radicals in Neurodegenerative Diseases

  1998cited by this paper
• Mitochondria and Free Radicals in Neurodegenerative Diseases

  1998cited by this paper
• Superoxide in Apoptosis

  1998cited by this paper
• The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

  1998cited by this paper
• Superoxide Production by the Mitochondrial Respiratory Chain

  1997cited by this paper
• A model for p53-induced apoptosis

  1997cited by this paper
• Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function

  1997cited by this paper
• Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

  1997cited by this paper
• Analysis of the Mechanism of Loss of Trophic Factor Dependence Associated with Neuronal Maturation: A Phenotype Indistinguishable fromBax Deletion

  1997cited by this paper
• Cytochrome c: can't live with it--can't live without it.

  1997cited by this paper
• Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway.

  1997cited by this paper
• Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

  1996influential reference
• BAX is required for neuronal death after trophic factor deprivation and during development.

  1996cited by this paper
• Human ICE/CED-3 protease nomenclature.

  1996influential reference
• Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B

  1995cited by this paper
• N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells

  1995cited by this paper
• Programmed cell death and Bcl-2 protection in very low oxygen

  1995cited by this paper
• Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death.

  1995cited by this paper
• Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

  1995cited by this paper
• Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

  1995influential reference
• Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

  1994influential reference
• Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

  1994cited by this paper
• Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

  1994cited by this paper
• Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.

  1993cited by this paper
• Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

  1993cited by this paper
• Bcl-2 functions in an antioxidant pathway to prevent apoptosis.

  1993cited by this paper
• Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells.

  1993cited by this paper
• Neuronal death after trophic factor deprivation.

  1992cited by this paper
• Cell death during development of the nervous system.

  1991cited by this paper
• The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A.

  1991cited by this paper
• Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo.

  1991cited by this paper
• Nitric oxide (NO): a versatile second messenger in brain.

  1991cited by this paper
• Dicarboxy-dichlorofluorescein: a new fluorescent probe for measuring acidic intracellular pH.

  1990cited by this paper
• The use of monochlorobimane to determine hepatic GSH levels and synthesis.

  1990cited by this paper
• Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

  1988influential reference
• Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.

  1987influential reference
• Techniques in the tissue culture of rat sympathetic neurons.

  1983cited by this paper
• [20] Techniques in the tissue culture of rat sympathetic neurons

  1983cited by this paper
• Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

  1979cited by this paper
• Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of mitochondria.

  1970cited by this paper
• Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

  1969cited by this paper

• Marine trichodermamide B inhibits prostate cancer progression via catalase inhibition-induced apoptosis.

  2026cites this paper
• The intrinsic apoptotic pathway lies upstream of reactive species production in cortical neurons and age-related oxidative stress in the brain.

  2023cites this paper
• Hyperthermia alters neurobehavior by affecting cell proliferation and neuronal survival in young male rats

  2023cites this paper
• Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy

  2022cites this paper
• Neurotoxic Effect of Doxorubicin Treatment on Cardiac Sympathetic Neurons

  2022cites this paper
• N-Acetylcysteine Induces Apoptotic, Oxidative and Excitotoxic Neuronal Death in Mouse Cortical Cultures

  2022cites this paper
• NAC and Vitamin D Restore CNS Glutathione in Endotoxin-Sensitized Neonatal Hypoxic-Ischemic Rats

  2021cites this paper
• Membrane Depolarization Inhibits BIMEL Upregulation but Prevents Neuronal Apoptosis Primarily by Increasing Cellular GSH Levels

  2021cites this paper
• NGF-Dependent and BDNF-Dependent DRG Sensory Neurons Deploy Distinct Degenerative Signaling Mechanisms

  2020cites this paper
• The intrinsic apoptotic pathway lies upstream of oxidative stress in multiple organs.

  2020cites this paper
• Apoptotic cell death regulation in neurons

  2019cites this paper
• The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice.

  2019cites this paper
• Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration

  2019cites this paper
• AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair

  2019cites this paper
• Protective effects of melatonin on mitochondrial injury and neonatal neuron apoptosis induced by maternal hypothyroidism

  2019cites this paper
• Mitochondrial Metabolism

  2018cites this paper
• Inhibitory effects of mouse bone marrow mesenchymal stem cell soup on staurospurine-induced cell death in MCF-7 and AGS.

  2017cites this paper
• Ischemic brain injury: New insights on the protective role of melatonin.

  2017cites this paper
• The cathepsin B inhibitor z-FA-CMK induces cell death in leukemic T cells via oxidative stress

  2017cites this paper
• (13)C metabolic flux analysis in neurons utilizing a model that accounts for hexose phosphate recycling within the pentose phosphate pathway.

  2016cites this paper
• Ag nanoparticles generated using bio-reduction and -coating cause microbial killing without cell lysis

  2016cites this paper
• Dissociation of JNK Activation from Elevated Levels of Reactive Oxygen Species, Cytochrome c Release, and Cell Death in NGF-Deprived Sympathetic Neurons

  2016cites this paper
• Bax and caspases regulate increased production of mitochondria-derived reactive species in neuronal apoptosis: LACK of A role for depletion of cytochrome c from the mitochondrial electron transport chain

  2015cites this paper
• 3D Printed Hydrogel Micro-Environments And Bioreactor Conditioning To Develop Native Heterogeneity In Tissue Engineered Heart Valves

  2014influential citation
• Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths.

  2014cites this paper
• Caffeic acid phenylethyl ester and MG132, two novel nonconventional chemotherapeutic agents, induce apoptosis of human leukemic cells by disrupting mitochondrial function

  2014cites this paper
• Assessment of DNA damage, cytotoxicity, and apoptosis in human hepatoma (HepG2) cells after flurochloridone herbicide exposure.

  2014cites this paper
• Glycogen Synthase Kinase 3 Regulates Cell Death and Survival Signaling in Tumor Cells under

  2014cites this paper
• Spitz DR. 2006. Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose. Cancer Res. 66:1605-10

  2014cites this paper
• Glycogen Synthase Kinase 3 Regulates Cell Death and Survival Signaling in Tumor Cells under Redox Stress1

  2014cites this paper
• Mitochondrial Reactive Oxygen Species Production Mediated by Romo1 Expression

  2013cites this paper
• Neuroprotective Effects of Paeoniflorin, But Not the Isomer Albiflorin, are Associated with the Suppression of Intracellular Calcium and Calcium/Calmodulin Protein Kinase II in PC12 Cells

  2013cites this paper
• The role of Transforming Growth Factor (TGF) - Beta 1 Activated Kinase 1 (TAK1) in wound repair

  2013cites this paper
•  Role of nitric oxide in liver regeneration.

  2012cites this paper
• Reactive oxygen species inactivate neuronal nicotinic acetylcholine receptors through a highly conserved cysteine near the intracellular mouth of the channel: implications for diseases that involve oxidative stress

  2012cites this paper
• ROS Mediated the Effects of Extracellular Calcium on Staurosporine-induced Cell Death in PC12 Cells

  2012cites this paper
• Wound Repair Studies Reveal New Insights to Psoriasis

  2012cites this paper
• Influence of delphinidin-3-glucoside on oxidized low-density lipoprotein-induced oxidative stress and apoptosis in cultured endothelial cells.

  2012cites this paper
• Release of Mitochondrial Apoptogenic Factors and Cell Death are Mediated by CK2 and NADPH Oxidase

  2012cites this paper
• Impact of Cyanidin-3-Glucoside on Glycated LDL-Induced NADPH Oxidase Activation, Mitochondrial Dysfunction and Cell Viability in Cultured Vascular Endothelial Cells

  2012cites this paper
• Spontaneous generation of reactive oxygen species and effect on motility and fertilizability of sea urchin spermatozoa

  2012cites this paper
• Glutathione Efflux and Cell Death

  2012cites this paper
• Redox Regulation of the Intrinsic Pathway in Neuronal Apoptosis

  2011influential citation
• Apoptosis-induced changes in mitochondrial lipids.

  2011cites this paper
• In Vitro and in Vivo Aggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production*

  2011cites this paper
• The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

  2011cites this paper
• Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death

  2011cites this paper
• A combination of 2-deoxy-d-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction

  2011cites this paper
• Regulation of reactive oxygen species generation in cell signaling

  2011influential citation
• Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

  2011cites this paper
• Reactive Oxygen Species and the Regulation of Hyperproliferation in a Colonial Hydroid

  2011cites this paper
• Novel Nitroxide Resuscitation Strategies in Experimental Traumatic Brain Injury

  2010cites this paper
• Neuroprotection and axonal regeneration after peripheral nerve injury

  2010cites this paper
• Impact of diabetes-associated lipoproteins on oxygen consumption and mitochondrial enzymes in porcine aortic endothelial cells.

  2010cites this paper
• A Saccharomyces cerevisiae strain unable to store neutral lipids is tolerant to oxidative stress induced by α-synuclein.

  2010cites this paper
• Bax Regulates Production of Superoxide in Both Apoptotic and Nonapoptotic Neurons: Role of Caspases

  2010cites this paper
• Effect of hypoxia on susceptibility of RGC-5 cells to nitric oxide.

  2010cites this paper
• Effet de la biosynthèse de lipides sur la toxicité de l'α-synucléine, protéine impliquée dans la maladie de Parkinson, chez Saccharomyces cerevisiae

  2010cites this paper
• A rare polymorphism of the COX7B2 gene in a cantonese family with nasopharyngeal carcinoma

  2010cites this paper
• Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT.

  2010cites this paper
• Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment

  2009cites this paper
• Adjuvanticity and protective immunity of Plasmodium yoelii nigeriensis blood-stage soluble antigens encapsulated in fusogenic liposome.

  2009cites this paper
• Flow Dilation in Rat Small Mesenteric Arteries is Mediated by Hydrogen Peroxide Generated from CYP Epoxygenases and Xanthine Oxidase

  2009cites this paper
• Prolyl Hydroxylase Inhibitors Depend on Extracellular Glucose and Hypoxia-Inducible Factor (HIF)-2α to Inhibit Cell Death Caused by Nerve Growth Factor (NGF) Deprivation: Evidence that HIF-2α Has a Role in NGF-Promoted Survival of Sympathetic Neurons

  2009cites this paper
• Apoptosis and glutathione: beyond an antioxidant

  2009cites this paper
• Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion.

  2009cites this paper
• The role of nicotinic receptor function in the development of synapses and in diabetes-induced dysautonomias

  2009cites this paper
• Prolyl hydroxylase inhibitors depend on extracellular glucose and HIF-2α to inhibit cell death caused by NGF deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic neurons

  2009cites this paper
• Glucose Metabolism Inhibits Apoptosis in Neurons and Cancer Cells by Redox Inactivation of Cytochrome c

  2008cites this paper
• Redox-Based Therapies for Neuroprotection

  2008cites this paper
• Persistent mitochondrial dysfunction and oxidative stress hinder neuronal cell recovery from reversible proteasome inhibition

  2008cites this paper
• Gap Junction Mediated Intercellular Metabolite Transfer in the Cochlea Is Compromised in Connexin30 Null Mice

  2008cites this paper
• Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis – there is nothing more practical than a good theory

  2008cites this paper
• Mitochondrial Reactive Oxygen Species Inactivate Neuronal Nicotinic Acetylcholine Receptors and Induce Long-Term Depression of Fast Nicotinic Synaptic Transmission

  2008cites this paper
• Reduction of ascorbate free radical by the plasma membrane of synaptic terminals from rat brain.

  2008cites this paper
• Ca2+‐dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP‐ribose) polymerase‐1 activation during glutamate excitotoxicity

  2007cites this paper
• Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis

  2007cites this paper
• Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates.

  2007cites this paper
• Rapid Activation of Antioxidant Defenses by Nerve Growth Factor Suppresses Reactive Oxygen Species during Neuronal Apoptosis: Evidence for a Role in Cytochrome c Redistribution

  2007cites this paper
• Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis.

  2007cites this paper
• Rate of neurite outgrowth in sympathetic neurons is highly resistant to suppression of protein synthesis: role of protein degradation/synthesis coupling.

  2007cites this paper
• Nerve growth factor prevents the apoptosis-associated increase in acetylcholinesterase activity after hydrogen peroxide treatment by activating Akt.

  2007cites this paper
• Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion.

  2007cites this paper
• Bax affects production of reactive oxygen by the mitochondria of non-apoptotic neurons.

  2007cites this paper
• Generation of reactive oxygen species is an early event in dolichyl phosphate‐induced apoptosis

  2007cites this paper
• Oxidative Stress and Neurodegenerative Disorders

  2007cites this paper
• The central role of glutathione in the pathophysiology of human diseases

  2007cites this paper
• Postmitochondrial regulation of apoptosis in neurons and cancer cells

  2007cites this paper
• Mercury-Induced Externalization of Phosphatidylserine and Caspase 3 Activation in Human Liver Carcinoma (HepG2) Cells

  2006cites this paper
• Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria.

  2006cites this paper
• Hypoxia-targeted bioreductive tyrosine kinase inhibitors with glutathione-depleting function

  2006cites this paper
• Oxidative Stress in Immature Brain after Traumatic Brain Injury

  2006cites this paper
• Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration.

  2006cites this paper
• Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cells.

  2005cites this paper
• Regulation of apoptosis by glutathione redox state in PC12 cells exposed simultaneously to iron and ascorbic acid.

  2005cites this paper
• Protective effect of L‐trans‐pyrrolidine‐2,4‐dicarboxilic acid preload against cell death induced by oxygen/glucose deprivation in differentiated PC12 cells

  2005cites this paper
• Catalase Plays a Critical Role in the CSF-independent Survival of Human Macrophages via Regulation of the Expression of BCL-2 Family*

  2005cites this paper
• Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl) retinamide.

  2005cites this paper
• Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons*

  2005cites this paper
• Zinc deficiency‐induced cell death

  2005cites this paper