Rabies Virus as a Research Tool and Viral Vaccine Vector

Until recently, single-stranded negative sense RNA viruses (ssNSVs) were one of only a few important human viral pathogens, which could not be created from cDNA. The inability to manipulate their genomes hindered their detailed genetic analysis. A key paper from Conzelmann's laboratory in 1994 changed this with the publication of a method to recover rabies virus (RABV) from cDNA. This discovery not only dramatically changed the broader field of ssNSV biology but also opened a whole new avenue for studying RABV pathogenicity, developing novel RABV vaccines as well a new generation of RABV-based vaccine vectors, and creating research tools important in neuroscience such as neuronal tracing.

• Publication year

  2011

• Venue

  Advances in Virus Research

• Publication date

  2011-05-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-0-12-387040-7.00009-3PMID 21601047PMCID 7150175
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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