The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Channels

• Publication date

  2010-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4161/chan.4.5.13327PMID 20855978PMCID PMC3051875
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional Consequences of the Interactions among the Neural Cell Adhesion Molecule NCAM, the Receptor Tyrosine Kinase TrkB, and the Inwardly Rectifying K+ Channel KIR3.3*

  2010cited by this paper
• Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

  2010cited by this paper
• Cellular modelling: experiments and simulation to develop a physiological model of G-protein control of muscarinic K+ channels in mammalian atrial cells

  2010cited by this paper
• Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?*

  2010cited by this paper
• Inwardly rectifying potassium channels: their structure, function, and physiological roles.

  2010cited by this paper
• Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

  2010cited by this paper
• Supramolecular assemblies and localized regulation of voltage-gated ion channels.

  2009influential reference
• Subcellular compartment‐specific molecular diversity of pre‐ and post‐synaptic GABAB‐activated GIRK channels in Purkinje cells

  2009cited by this paper
• Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GαiGDP and Gβγ

  2009cited by this paper
• Direct Interaction of GABAB Receptors with M2 Muscarinic Receptors Enhances Muscarinic Signaling

  2009cited by this paper
• The Role of G βγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes

  2009cited by this paper
• Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels

  2009cited by this paper
• The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.

  2009cited by this paper
• Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes.

  2009cited by this paper
• Behavioral characterization of mice lacking GIRK/Kir3 channel subunits

  2008cited by this paper
• Cell type‐specific subunit composition of G protein‐gated potassium channels in the cerebellum

  2008cited by this paper
• Pre‐ and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK‐knockout mice

  2008cited by this paper
• GPCR-Kir channel signaling complexes: defining rules of engagement.

  2008cited by this paper
• Predisposition to late-onset obesity in GIRK4 knockout mice

  2008cited by this paper
• Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.

  2008cited by this paper
• Dissociation of Heterotrimeric G Proteins in Cells

  2008cited by this paper
• Absence and Rescue of Morphine Withdrawal in GIRK/Kir3 Knock-out Mice

  2008cited by this paper
• Dynamic integration of alpha-adrenergic and cholinergic signals in the atria: role of G protein-regulated inwardly rectifying K+ channels.

  2007cited by this paper
• PIP2--the master key.

  2007cited by this paper
• Identification and Characterization of a New Class of Trafficking Motifs for Controlling Clathrin-independent Internalization and Recycling*

  2007cited by this paper
• Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes.

  2007cited by this paper
• Mechanism of PLC-Mediated Kir3 Current Inhibition

  2007cited by this paper
• Crystal structure of a Kir3.1‐prokaryotic Kir channel chimera

  2007influential reference
• Interaction of Gαq and Kir3, G Protein-Coupled Inwardly Rectifying Potassium Channels

  2007cited by this paper
• RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area

  2007cited by this paper
• Specificity of Gβγ Signaling to Kir3 Channels Depends on the Helical Domain of Pertussis Toxin-sensitive Gα Subunits*

  2007cited by this paper
• Subunit-Specific Regulation of Kir3 Channels by Sorting nexin 27

  2007cited by this paper
• Evidence for association of GABAB receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins

  2007cited by this paper
• A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction

  2007cited by this paper
• Gαi3 primes the G protein‐activated K+ channels for activation by coexpressed Gβγ in intact Xenopus oocytes

  2007cited by this paper
• Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding

  2007cited by this paper
• Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation.

  2006cited by this paper
• Rapid Activation of Inwardly Rectifying Potassium Channels by Immobile G-Protein-Coupled Receptors

  2006cited by this paper
• Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells

  2006cited by this paper
• Mammalian RGS proteins: multifunctional regulators of cellular signalling.

  2006cited by this paper
• Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels.

  2006cited by this paper
• GIRK channel activation involves a local rearrangement of a preformed G protein channel complex.

  2006cited by this paper
• Seven Transmembrane Receptor Core Signaling Complexes Are Assembled Prior to Plasma Membrane Trafficking*

  2006cited by this paper
• Biosynthesis and trafficking of seven transmembrane receptor signalling complexes.

  2006cited by this paper
• The selective interactions and functions of regulators of G-protein signalling.

  2006cited by this paper
• Neuronal Kir3.1/Kir3.2a channels coupled to serotonin 1A and muscarinic m2 receptors are differentially modulated by the "short" RGS3 isoform.

  2005cited by this paper
• G-Protein-Gated Potassium (GIRK) Channels Containing the GIRK2 Subunit Are Control Hubs for Pharmacologically Induced Hypothermic Responses

  2005cited by this paper
• Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification

  2005cited by this paper
• Tyrosine Phosphorylation of Kir3.1 in Spinal Cord Is Induced by Acute Inflammation, Chronic Neuropathic Pain, and Behavioral Stress*

  2005cited by this paper
• Sorting Nexins – Unifying Trends and New Perspectives

  2005cited by this paper
• Master Key

  2005cited by this paper
• Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein

  2005cited by this paper
• Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.

  2005influential reference
• Coordination of Membrane Excitability through a GIRK1 Signaling Complex in the Atria*

  2004cited by this paper
• Cell signal control of the G protein‐gated potassium channel and its subcellular localization

  2004cited by this paper
• Characteristic Interactions with Phosphatidylinositol 4,5-Bisphosphate Determine Regulation of Kir Channels by Diverse Modulators*

  2004cited by this paper
• βL–βM loop in the C‐terminal domain of G protein‐activated inwardly rectifying K+ channels is important for Gβγ subunit activation

  2004cited by this paper
• Gαi1 and Gαi3 Differentially Interact with, and Regulate, the G Protein-activated K+ Channel*

  2004cited by this paper
• Spinal G-Protein-Gated K+ Channels Formed by GIRK1 and GIRK2 Subunits Modulate Thermal Nociception and Contribute to Morphine Analgesia

  2004cited by this paper
• Regulation of the inward rectifying properties of G-protein-activated inwardly rectifying K+ (GIRK) channels by Gbeta gamma subunits.

  2003cited by this paper
• Regulation of the Inward Rectifying Properties of G-protein-activated Inwardly Rectifying K+ (GIRK) Channels by Gβγ Subunits*

  2003cited by this paper
• Gβγ and KACh: Old Story, New Insights

  2003cited by this paper
• Merging functional studies with structures of inward-rectifier K+ channels

  2003cited by this paper
• Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity.

  2003cited by this paper
• G beta gamma and KACh: old story, new insights.

  2003cited by this paper
• Interaction of G Protein β Subunit with Inward Rectifier K+ Channel Kir3

  2003cited by this paper
• Interaction of G protein beta subunit with inward rectifier K(+) channel Kir3.

  2003cited by this paper
• Crystal Structure of the Potassium Channel KirBac1.1 in the Closed State

  2003cited by this paper
• Insights into G protein structure, function, and regulation.

  2003cited by this paper
• Decreased Cocaine Self-Administration in Kir3 Potassium Channel Subunit Knockout Mice

  2003cited by this paper
• Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel.

  2003cited by this paper
• Critical Determinants of the G Protein γ Subunits in the Gβγ Stimulation of G Protein-activated Inwardly Rectifying Potassium (GIRK) Channel Activity*

  2003cited by this paper
• Mapping the Gβγ-binding Sites in GIRK1 and GIRK2 Subunits of the G Protein-activated K+ Channel*

  2003cited by this paper
• Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart.

  2002cited by this paper
• Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.

  2002cited by this paper
• Distinct Sites on G Protein βγ Subunits Regulate Different Effector Functions*

  2002cited by this paper
• G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase*

  2002cited by this paper
• Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels.

  2002cited by this paper
• Identification of Critical Residues Controlling G Protein-gated Inwardly Rectifying K+ Channel Activity through Interactions with the βγ Subunits of G Proteins*

  2002cited by this paper
• Gβ Residues That Do Not Interact with Gα Underlie Agonist-independent Activity of K+ Channels*

  2002cited by this paper
• Graded contribution of the Gβγ binding domains to GIRK channel activation

  2002cited by this paper
• Contribution of the Kir3.1 Subunit to the Muscarinic-gated Atrial Potassium Channel IKACh *

  2002cited by this paper
• Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice

  2002cited by this paper
• The Neural Cell Adhesion Molecule Regulates Cell-Surface Delivery of G-Protein-Activated Inwardly Rectifying Potassium Channels Via Lipid Rafts

  2002cited by this paper
• GIRK channel trafficking: different paths for different family members.

  2002cited by this paper
• Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution.

  2002cited by this paper
• Distinct sites on G protein beta gamma subunits regulate different effector functions.

  2002cited by this paper
• Overexpression of beta 1 and beta 2 adrenergic receptors in rat atrial myocytes. Differential coupling to G protein-gated inward rectifier K(+) channels via G(s) and G(i)/o.

  2001cited by this paper
• The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs).

  2001cited by this paper
• Rab GTPases: specifying and deciphering organelle identity and function.

  2001cited by this paper
• Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic

  2001cited by this paper
• Interaction Sites of the G Protein β Subunit with Brain G Protein-coupled Inward Rectifier K+ Channel*

  2001cited by this paper
• The Stoichiometry of Gβγ Binding to G-protein-regulated Inwardly Rectifying K+ Channels (GIRKs)*

  2001cited by this paper
• Ion-channel regulation by G proteins.

  2001cited by this paper
• Inhibition of a Gi-activated Potassium Channel (GIRK1/4) by the Gq-coupled m1 Muscarinic Acetylcholine Receptor*

  2001cited by this paper
• Evidence that a protein‐protein interaction ‘hot spot’ on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors

  2001cited by this paper
• Receptor-mediated Inhibition of G Protein-coupled Inwardly Rectifying Potassium Channels Involves Gαq Family Subunits, Phospholipase C, and a Readily Diffusible Messenger*

  2001cited by this paper
• Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells

  2001cited by this paper
• Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors.

  2001cited by this paper
• Neuronal Inwardly Rectifying K+ Channels Differentially Couple to PDZ Proteins of the PSD-95/SAP90 Family

  2000cited by this paper

• De Novo Variant in the KCNJ9 Gene as a Possible Cause of Neonatal Seizures

  2023cites this paper
• Sinus node dysfunction: current understanding and future directions.

  2022cites this paper
• Trace amine-associated receptor 1 (TAAR1): Potential Application in Mood Disorders: A Systematic Review.

  2021cites this paper
• A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors

  2020cites this paper
• Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection

  2018cites this paper
• DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels.

  2018cites this paper
• Opioid analgesia: modulation by drug interactions and glial activation

  2017cites this paper
• Estradiol, Substance P, and the PI3K-Akt-mTOR Pathway in the Dorsal Horn of the Spinal Cord during Inflammatory Pain

  2017cites this paper
• Localization and Targeting of GIRK Channels in Mammalian Central Neurons.

  2015cites this paper
• The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels.

  2015cites this paper
• Anti-incretin, Anti-proliferative Action of Dopamine on β-Cells.

  2015cites this paper
• A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ

  2015cites this paper
• Gβγ-dependent modulation of ion channels

  2014cites this paper
• Recruitment of Gβγ controls the basal activity of G‐protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1

  2014cites this paper
• Kir3 channel ontogeny – the role of Gβγ subunits in channel assembly and trafficking

  2014influential citation
• From Genetic Abnormalities to Pathophysiological Mechanisms

  2014cites this paper
• Differential effects of genetically-encoded Gβγ scavengers on receptor-activated and basal Kir3.1/Kir3.4 channel current in rat atrial myocytes.

  2014cites this paper
• The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels

  2012cites this paper
• Kir3 channel signalling complexes in cardiac arrhythmias

  2012cites this paper
• Ionic conductances regulating the excitability of colonic smooth muscles

  2012cites this paper
• Genetic defects in the hotspot of inwardly rectifying K(+) (Kir) channels and their metabolic consequences: a review.

  2012cites this paper
• Two Distinct Aspects of Coupling between Gαi Protein and G Protein-activated K+ Channel (GIRK) Revealed by Fluorescently Labeled Gαi3 Protein Subunits*

  2011cites this paper
• Organizational complexity of β-adrenergic receptor signaling systems.

  2011cites this paper