Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Blood

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1182/blood.v77.1.75.75PMID 1702031
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vitronectin binds to activated human platelets and plays a role in platelet aggregation.

  1990cited by this paper
• Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits.

  1990cited by this paper
• Cloning, primary structure and properties of a novel human integrin beta subunit.

  1990cited by this paper
• Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

  1990cited by this paper
• A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

  1990cited by this paper
• Isolation and characterization of a platelet membrane protein related to the vitronectin receptor.

  1989cited by this paper
• Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins.

  1989cited by this paper
• Immunoblot analysis of platelet glyeoprotein IIb in patients with Glanzmann thrombasthenia in Israel

  1989cited by this paper
• Expression of the alloantigen Zwa (or P1A1) on human vascular smooth muscle cells and foreskin fibroblasts: a study on normal individuals and a patient with Glanzmann's thrombasthenia.

  1989cited by this paper
• An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin.

  1989cited by this paper
• The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor

  1989cited by this paper
• Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells.

  1989cited by this paper
• A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.

  1989cited by this paper
• Novel purification of vitronectin from human plasma by heparin affinity chromatography.

  1988cited by this paper
• Exposure of binding sites for vitronectin on platelets following stimulation.

  1988cited by this paper
• Interaction of Thrombin-Stimulated Platelets with Vitronectin (S-Protein of Complement) Substrate: Inhibition by a Monoclonal Antibody to Glycoprotein IIb-IIIa Complex

  1988cited by this paper
• The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit.

  1988cited by this paper
• Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical beta subunits and distinct alpha subunits.

  1987cited by this paper
• NORMAL SYNTHESIS AND EXPRESSION OF ENDOTHELIAL GP IIb/IIIa IN GLANZMANN'S THROMBASTENIA

  1987cited by this paper
• Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.

  1987cited by this paper
• Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes

  1987cited by this paper
• Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.

  1987cited by this paper
• Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

  1987cited by this paper
• Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix.

  1987cited by this paper
• Type I Glanzmann thrombasthenia patients from the Iraqi-Jewish and Arab populations in Israel can be differentiated by platelet glycoprotein IIIa immunoblot analysis.

  1987cited by this paper
• Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells.

  1986cited by this paper
• Immunologic and biochemical characterization of homozygous and heterozygous Glanzmann thrombasthenia in the Iraqi‐Jewish and Arab populations of Israel: comparison of techniques for carrier detection

  1986cited by this paper
• Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa

  1986cited by this paper
• Immunohistochemical localization of membrane and alpha-granule proteins in human megakaryocytes: application to plastic-embedded bone marrow biopsy specimens.

  1986cited by this paper
• cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors.

  1986cited by this paper
• Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.

  1986cited by this paper
• A monoclonal antibody to human platelet glycoprotein IIIa detects a related protein in cultured human endothelial cells.

  1985cited by this paper
• Human and bovine endothelial cells synthesize membrane proteins similar to human platelet glycoproteins IIb and IIIa.

  1985cited by this paper
• Prenatal diagnosis of Glanzmann's thrombasthenia.

  1985cited by this paper
• Characterization of human S protein, an inhibitor of the membrane attack complex of complement. Demonstration of a free reactive thiol group.

  1985cited by this paper
• A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex.

  1985cited by this paper
• A Glanzmann’s Thrombasthenia Cluster Among Iraqi Jews in Israel

  1984cited by this paper
• A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa.

  1983cited by this paper

• Talin autoinhibition is required for normal hemostasis

  2025cites this paper
• Flow cytometric analysis of platelet surface glycoproteins in the diagnosis of thirty-two Turkish patients with Glanzmann thrombasthenia: a multicenter experience

  2021influential citation
• Mutations in RASGRP2 gene identified in patients misdiagnosed as Glanzmann thrombasthenia patients.

  2021cites this paper
• Glanzmann Thrombasthenia: Perspectives from Clinical Practice on Accurate Diagnosis and Optimal Treatment Strategies

  2021cites this paper
• Qualitative disorders of platelets and vasculature

  2020cites this paper
• Integrin β3 Deficiency Results in Hypertriglyceridemia via Disrupting LPL (Lipoprotein Lipase) Secretion

  2020cites this paper
• Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

  2019cites this paper
• Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex

  2019cites this paper
• Low Concentrations of Recombinant Factor VIIa May Improve the Impaired Thrombin Generation of Glanzmann Thrombasthenia Patients

  2018cites this paper
• RGDfK-functionalized gold nanorods bind only to activated platelets.

  2017cites this paper
• Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins.

  2017cites this paper
• Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?

  2017cites this paper
• Mutations in the I I b and 3 Genes that Cause Glanzmann

  2017cites this paper
• Mechanism Action of Platelets and Crucial Blood Coagulation Pathways in Hemostasis

  2017cites this paper
• The integrin antagonist, cilengitide, is a weak inhibitor of αIIbβ3 mediated platelet activation and inhibits platelet adhesion under flow

  2015cites this paper
• Disulfide Bonds as Regulators of Integrin Function in Thrombosis and Hemostasis

  2014cites this paper
• Disulfide bond exchanges in integrins αIIbβ3 and αvβ3 are required for activation and post-ligation signaling during clot retraction.

  2014cites this paper
• Autoradiography screening of potential positron emission tomography tracers for asymptomatic abdominal aortic aneurysms

  2014cites this paper
• Is there a redundancy of β3 and other platelet receptors in the brain and central nervous system?

  2013cites this paper
• Unique Disulfide Bonds in Epidermal Growth Factor (EGF) Domains of β3 Affect Structure and Function of αIIbβ3 and αvβ3 Integrins in Different Manner

  2012cites this paper
• Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment

  2012cites this paper
• A novel ELISA for diagnosis of Glanzmann’s thrombasthenia and the heterozygote carriers

  2012cites this paper
• Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models.

  2011influential citation
• Are bone defects in rare patients with Glanzmann's thrombasthenia associated with ITGB3 or ITGA2B mutations?

  2011cites this paper
• alternative splicing in the glycoprotein IIb gene Glanzmann's thrombasthenia associated with deletion-insertion and

  2011cites this paper
• Advances in our understanding of the molecular basis of disorders of platelet function

  2011cites this paper
• Classification of Iranian patients with Glanzmann's Thrombasthenia using a flow cytometric method

  2011cites this paper
• Cystine‐knot peptides engineered with specificities for αIIbβ3 or αIIbβ3 and αvβ3 integrins are potent inhibitors of platelet aggregation

  2011cites this paper
• Glanzmann's thrombasthenia: report of a case and review of the literature.

  2010cites this paper
• Novel Mutations in the GPIIb and GPIIIa Genes in Glanzmann Thrombasthenia

  2010cites this paper
• Potential future clinical applications for the GPIIb/IIIa antagonist, abciximab in thrombosis, vascular and oncological indications

  2009cites this paper
• Analysis of adenoviral attachment to human platelets

  2009influential citation
• Endometriosis in two sisters with Glanzmann's thrombasthenia.

  2009cites this paper
• Glanzmann's thrombasthenia in North Indians: Sub classification and carrier detection by flow cytometry

  2009cites this paper
• Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear

  2009cites this paper
• Platelet Adhesion under Flow

  2009cites this paper
• The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.

  2008cites this paper
• The GPIIb/IIIa (integrin (cid:1) IIb (cid:2) 3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

  2008cites this paper
• Carrier detection in Glanzmann thrombasthenia: comparison of flow cytometry and Western blot with respect to DNA mutation.

  2008cites this paper
• Regulation of angiogenesis: apoptotic cues from the ECM

  2008cites this paper
• Immunoglobulin prophylaxis in hematological malignancies and hematopoietic stem cell transplantation.

  2008cites this paper
• Von Willebrand factor: Looking back and looking forward

  2007cites this paper
• Activation of Platelet Function Through G Protein–Coupled Receptors Platelets As Immune Cells: Bridging Inflammation and Cardiovascular Disease In Vivo Thrombus Formation in Murine Models Clinical Aspects of Platelet Inhibitors and Thrombus Formation Adhesion Mechanisms in Platelet Function

  2007cites this paper
• Glanzmann thrombasthenia

  2006cites this paper
• Efficient platelet delta-granule release induced by [Ca2+]i elevation is modulated by GPIIbIIIa.

  2006cites this paper
• A 13‐bp deletion in αIIb gene is a founder mutation that predominates in Palestinian‐Arab patients with Glanzmann thrombasthenia

  2005cites this paper
• Fibrin but Not Adsorbed Fibrinogen Supports Fibronectin Assembly by Spread Platelets

  2005cites this paper
• Inhibition of Tumor Growth by RGD Peptide–Directed Delivery of Truncated Tissue Factor to the Tumor Vasculature

  2005cites this paper
• A novel homozygous mutation (1619delC) in GPIIb gene associated with Glanzmann thrombasthenia, the decay of GPIIb-mRNA and the synthesis of a truncated GPIIb unable to form complex with GPIIIa

  2005cites this paper
• Integrins and angiogenesis.

  2004cites this paper
• Osteopetrosis and Glanzmann's thrombasthenia in a child

  2003cites this paper
• Disruption of the beta3 663-687 disulfide bridge confers constitutive activity to beta3 integrins.

  2003cites this paper
• ATVB In Focus Extracellular Mediators in Atherosclerosis and Thrombosis

  2003cites this paper
• Disruption of the 3 663-687 disulfide bridge confers constitutive activity to 3 integrins

  2003cites this paper
• Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells.

  2003cites this paper
• Type I Glanzmann thrombasthenia: Most common subtypes in North Indians

  2003cites this paper
• Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy.

  2003cites this paper
• Concurrent signaling from Gαq‐ and Gαi‐coupled pathways is essential for agonist‐induced αvβ3 activation on human platelets

  2003cites this paper
• Upregulation of osteoclast α2β1 integrin compensates for lack of αvβ3 vitronectin receptor in Iraqi‐Jewish‐type Glanzmann thrombasthenia

  2003cites this paper
• Update on GPIIb/IIIa antagonists

  2003cites this paper
• Apoptotic cues from the extracellular matrix: regulators of angiogenesis

  2003cites this paper
• Quantitative analysis of platelet alpha v beta 3 binding to osteopontin using laser tweezers.

  2003cites this paper
• Association of thrombospondin-1 with the actin cytoskeleton of human thrombin-activated platelets through an alphaIIbbeta3- or CD36-independent mechanism.

  2002cites this paper
• Role for beta3 integrins in human melanoma growth and survival.

  2002cites this paper
• Bone marrow does not contribute substantially to endothelial-cell replacement in transplant arteriosclerosis

  2002cites this paper
• Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment.

  2002cites this paper
• Comparative studies of a humanized anti-glycoprotein IIb/IIIa monoclonal antibody, YM337, and abciximab on in vitro antiplatelet effect and binding properties.

  2002cites this paper
• Integrin-mediated death: An explanation of the integrin-knockout phenotype?

  2002cites this paper
• Missense mutations in the beta(3) subunit have a different impact on the expression and function between alpha(IIb)beta(3) and alpha(v)beta(3).

  2002cites this paper
• ECM Remodeling Regulates Angiogenesis: Endothelial Integrins Look for New Ligands

  2002cites this paper
• Role for β3 integrins in human melanoma growth and survival

  2002cites this paper
• Missense mutations in the (cid:1) 3 subunit have a different impact on the expression and function between (cid:2) IIb (cid:1) 3 and (cid:2) v (cid:1) 3

  2002cites this paper
• Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

  2001cites this paper
• Molecular and genetic basis for thrombasthenic thrombopathia in otterhounds.

  2001cites this paper
• Clinical, Biochemical, and Molecular Aspects of Glanzmann's Thrombasthenia in Humans and Dogs

  2001cites this paper
• Anti-αvβ3 Antibodies in Chronic Immune Thrombocytopenic Purpura

  2001cites this paper
• Pharmacological control of platelet function.

  2001cites this paper
• Are patients with Glanzmann thrombasthenia and the Bernard-Soulier syndrome protected against atherosclerosis?

  2001cites this paper
• &bgr;3-Integrin–Deficient Mice but Not P-Selectin–Deficient Mice Develop Intimal Hyperplasia After Vascular Injury: Correlation With Leukocyte Recruitment to Adherent Platelets 1 Hour After Injury

  2001cites this paper
• Greater inhibition of platelet procoagulant activity by antibody‐derived glycoprotein IIb–IIIa inhibitors than by peptide and peptidomimetic inhibitors

  2001cites this paper
• A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3.

  2000cites this paper
• GPIIb-IIIa Antagonist-induced Reduction in Platelet Surface Factor V/Va Binding and Phosphatidylserine Expression in Whole Blood

  2000cites this paper
• Expression of Antisense to Integrin Subunit β3Inhibits Microvascular Endothelial Cell Capillary Tube Formation in Fibrin*

  2000cites this paper
• Effects of abciximab and tirofiban on vitronectin receptors in human endothelial and smooth muscle cells.

  2000cites this paper
• Glanzmann thrombasthenia: integrin alpha IIb beta 3 deficiency.

  2000cites this paper
• Effects of abciximab, ticlopidine, and combined Abciximab/Ticlopidine therapy on platelet and leukocyte function in patients undergoing coronary angioplasty.

  2000cites this paper
• Homozygous Cys542→Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann's thrombasthenia

  1999cites this paper
• Binding of Abciximab to αVβ3 and Activated αMβ2 Receptors: With a Review of Platelet-Leukocyte Interactions

  1999cites this paper
• Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand.

  1999cites this paper
• Potential non-glycoprotein IIb/IIIa effects of abciximab.

  1999cites this paper
• Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand factor.

  1999cites this paper
• A naturally occurring mutation near the amino terminus of a IIb defines a new region involved in ligand binding to a IIb b 3

  1999cites this paper
• Inherited Abnormalities of Platelets

  1999cites this paper
• Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).

  1999cites this paper
• Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

  1999cites this paper
• Binding of abciximab to alpha V beta 3 and activated alpha M beta 2 receptors: with a review of platelet-leukocyte interactions.

  1999cites this paper
• Role of Integrin αvβ3 in Vascular Biology

  1998cites this paper
• Mutations in the αIIb and β3 Genes that Cause Glanzmann Thrombasthenia Can Be Distinguished by a Simple Procedure Using Transformed B-Lymphocytes

  1998cites this paper
• Role of alphaII(b)beta3 integrin in prostate cancer metastasis.

  1998cites this paper
• Glanzmann thrombasthenia in two Iraqi-Jewish siblings is caused by a novel splice junction mutation in the glycoprotein IIb.

  1998cites this paper