Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Cell Stem Cell

• Publication date

  2016-05-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.stem.2016.01.024PMID 26996597
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CRISPR Display: A modular method for locus-specific targeting of long noncoding RNAs and synthetic RNA devices in vivo

  2015cited by this paper
• Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation.

  2015cited by this paper
• Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development

  2014cited by this paper
• A long non-coding RNA protects the heart from pathological hypertrophy

  2014cited by this paper
• Noncoding transcription by alternative RNA polymerases dynamically regulates an auxin-driven chromatin loop.

  2014cited by this paper
• CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53

  2014cited by this paper
• The rise of regulatory RNA

  2014cited by this paper
• Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

  2014cited by this paper
• Deep sequencing reveals a novel class of bidirectional promoters associated with neuronal genes

  2014cited by this paper
• Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.

  2014cited by this paper
• Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes.

  2014cited by this paper
• A versatile framework for microbial engineering using synthetic non-coding RNAs

  2014cited by this paper
• Divergent transcription is associated with promoters of transcriptional regulators

  2013cited by this paper
• Divergent transcription: a driving force for new gene origination?

  2013cited by this paper
• Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo.

  2013cited by this paper
• Long noncoding RNAs: cellular address codes in development and disease.

  2013cited by this paper
• Multiple knockout mouse models reveal lincRNAs are required for life and brain development

  2013cited by this paper
• Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

  2013cited by this paper
• The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse.

  2013cited by this paper
• Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells

  2013cited by this paper
• Targeting nuclear RNA for in vivo correction of myotonic dystrophy

  2012cited by this paper
• Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions.

  2012cited by this paper
• The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

  2012cited by this paper
• EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression.

  2012cited by this paper
• Airn Transcriptional Overlap, But Not Its lncRNA Products, Induces Imprinted Igf2r Silencing

  2012cited by this paper
• Antisense expression increases gene expression variability and locus interdependency

  2011cited by this paper
• Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses.

  2011cited by this paper
• Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions.

  2011cited by this paper
• Characterization of the RNA content of chromatin.

  2010cited by this paper
• Chromosomal Redistribution of Male-Biased Genes in Mammalian Evolution with Two Bursts of Gene Gain on the X Chromosome

  2010cited by this paper
• The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

  2010cited by this paper
• RNA-Seq analysis to capture the transcriptome landscape of a single cell

  2010cited by this paper
• Long noncoding RNAs with enhancer-like function in human cells.

  2010cited by this paper
• A Bacterial Ras-Like Small GTP-Binding Protein and Its Cognate GAP Establish a Dynamic Spatial Polarity Axis to Control Directed Motility

  2010cited by this paper
• Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.

  2009cited by this paper
• Genomic and Transcriptional Co-Localization of Protein-Coding and Long Non-Coding RNA Pairs in the Developing Brain

  2009cited by this paper
• Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

  2009cited by this paper
• Specific expression of long noncoding RNAs in the mouse brain

  2008cited by this paper
• Ripples from neighbouring transcription

  2008cited by this paper
• Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation.

  2008cited by this paper
• Gene function in mouse embryogenesis: get set for gastrulation

  2007cited by this paper
• The relationship between non-protein-coding DNA and eukaryotic complexity.

  2007cited by this paper
• Embryonic stem cell differentiation: emergence of a new era in biology and medicine.

  2005cited by this paper
• Drawing lines in the sand: even skipped et al. and parasegment boundaries.

  2004cited by this paper
• Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development

  2004cited by this paper
• Nuclear run-on assay using biotin labeling, magnetic bead capture and analysis by fluorescence-based RT-PCR.

  2000cited by this paper
• Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression.

  1995cited by this paper
• Transcriptional Repression by the Human Homeobox Protein EVX1 in Transfected Mammalian Cells (*)

  1995cited by this paper
• Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak.

  1992cited by this paper
• Concentration-dependent activities of the even-skipped protein in Drosophila embryos.

  1992cited by this paper

• Decoding the modulatory role of long non-coding RNAs in embryogenesis: a comprehensive review

  2026cites this paper
• An Emphasis on the Role of Long Non-Coding RNAs in Viral Gene Expression, Pathogenesis, and Innate Immunity in Viral Chicken Diseases

  2025cites this paper
• Profiling and functional characterization of long noncoding RNAs during human tooth development

  2025cites this paper
• The role of lnc‑MAPKAPK5‑AS1 in immune cell infiltration in hepatocellular carcinoma: Bioinformatics analysis and validation

  2025cites this paper
• A combination of transcriptomics and epigenomics identifies genes and regulatory elements involved in embryonic tail development in the mouse

  2025influential citation
• Prognostic modeling of disulfidptosis gene-associated lncRNAs aids in identifying the tumor microenvironment and guiding the selection of therapy

  2025cites this paper
• GWAS and Replication Analysis of Apparent Treatment-Resistant Hypertension.

  2025cites this paper
• Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal interaction with Cubn to ensure proper stem cell differentiation in vitro and in vivo

  2025cites this paper
• BDNF-DT and BDNF-AS-DT: Novel Genes in the BDNF locus

  2025cites this paper
• A novel lncRNA enhances autophagy to suppress extracellular matrix via modulating TP53INP1 in human trabecular meshwork cells under oxidative stress

  2025cites this paper
• The Role of Long Non-Coding RNAs in Human Endoderm Differentiation

  2025cites this paper
• HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement

  2025cites this paper
• A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA

  2025cites this paper
• NRIR promotes immune escape in hepatocellular cancer by regulating IFNγ-induced PD-L1 expression

  2025influential citation
• Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives

  2025influential citation
• A symphony of signals: the intricate role of lncRNAs in dermatological disorders

  2025cites this paper
• Differentially Expressed Genes Identify FIGO Stage II Cervical Cancer Patients with a Higher Risk of Relapse in a Small Cohort

  2025cites this paper
• Decoding BRCA1 promoter hypermethylation: a new frontier in understanding sporadic breast cancer

  2025cites this paper
• The role of wheat long intergenic non-coding RNAs in drought stress

  2025cites this paper
• Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease

  2025cites this paper
• Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling

  2024cites this paper
• Screening lncRNAs essential for cardiomyocyte proliferation by integrative profiling of lncRNAs and mRNAs associated with heart development.

  2024cites this paper
• Rare germline disorders implicate long non-coding RNAs disrupted by chromosomal structural rearrangements

  2024cites this paper
• Expression profile of long noncoding RNAs and comprehensive analysis of lncRNA-cisTF-DGE regulation in condyloma acuminatum

  2024influential citation
• Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling

  2024cites this paper
• Unraveling the Regulatory Role of HuR/microRNA Axis in Colorectal Cancer Tumorigenesis

  2024cites this paper
• Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: HTRA1/lncRNA BX842242.1 dominates, with no evidence for Complement Cascade involvement

  2024cites this paper
• Small and long non-coding RNAs: Past, present, and future.

  2024cites this paper
• Expression Profiling of Coding and Noncoding RNAs in the Endometrium of Patients with Endometriosis

  2024cites this paper
• Nuclear RNA: a transcription-dependent regulator of chromatin structure

  2024cites this paper
• Exploring the noncoding genome with chromosomal structural rearrangements.

  2024cites this paper
• LncRNAs and asymmetric cell division: The epigenetic mechanisms

  2024cites this paper
• The Role of lncRNAs in the Protective Action of Tamoxifen on the Ovaries of Tumor-Bearing Rats Receiving Cyclophosphamide

  2024cites this paper
• Comprehensive analysis identifies long non-coding RNA RNASEH1-AS1 as a potential prognostic biomarker and oncogenic target in hepatocellular carcinoma.

  2024cites this paper
• Chromosomal structural rearrangements implicate long non-coding RNAs in rare germline disorders

  2024cites this paper
• A Bidirectional Non-Coding RNA Promoter Mediates Long-Range Gene Expression Regulation

  2024cites this paper
• Dysregulated lncRNAs regulate human umbilical cord mesenchymal stem cell differentiation into insulin-producing cells by forming a regulatory network with mRNAs

  2024cites this paper
• Interaction between long noncoding RNA and microRNA in lung inflammatory diseases

  2024cites this paper
• RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation

  2024cites this paper
• Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence.

  2024cites this paper
• Genetic and Epigenetic Interactions Involved in Senescence of Stem Cells

  2024cites this paper
• LncRNA Functional Screening in Organismal Development

  2023cites this paper
• Functional identification of cis-regulatory long noncoding RNAs at controlled false discovery rates

  2023cites this paper
• Potential role of lncRNA in impairing cellular properties of human neural progenitor cells following exposure to Zika virus E protein.

  2023cites this paper
• Identification of Long Intergenic Noncoding RNAs in Rhizoctonia cerealis following Inoculation of Wheat

  2023cites this paper
• BRCA1 Hypermethylation In Sporadic Breast Cancers: Discovering A Novel Pathway To Tumorigenesis Via Coordinate NBR2 Deregulation And TNBC Transformation

  2023cites this paper
• Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks

  2023cites this paper
• A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA

  2023cites this paper
• Species-specific regulation of XIST by the JPX/FTX orthologs

  2023cites this paper
• Interferon-τ -induced ISG15-AS regulates endometrial receptivity during early goat pregnancy.

  2023cites this paper
• Long noncoding RNA GATA2-AS1 augments endothelial hypoxia inducible factor 1-α induction and regulates hypoxic signaling

  2023cites this paper
• Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression

  2023influential citation
• Techniques for investigating lncRNA transcript functions in neurodevelopment

  2023cites this paper
• Transcriptional repression of lncRNA and miRNA subsets mediated by LRF during erythropoiesis

  2023cites this paper
• A model for cis-regulation of transcriptional condensates and gene expression by proximal lncRNAs

  2023influential citation
• Regulatory Potential of Non-Coding RNAs Colocalized with Cardiomyopathy-Related Genes

  2023cites this paper
• Approaches for Modes of Action Study of Long Non-Coding RNAs: From Single Verification to Genome-Wide Determination

  2023cites this paper
• Noncoding RNA-chromatin association: Functions and mechanisms

  2023influential citation
• Lens epithelium cell ferroptosis mediated by m6A-lncRNA and GPX4 expression in lens tissue of age-related cataract

  2023cites this paper
• Enhancers are genes that express organizational RNAs

  2023cites this paper
• Estrogen‐Induced LncRNA, LINC02568, Promotes Estrogen Receptor‐Positive Breast Cancer Development and Drug Resistance Through Both In Trans and In Cis Mechanisms

  2023cites this paper
• Genome-wide transcriptome analysis reveals the diversity and function of long non-coding RNAs in dinoflagellates

  2023cites this paper
• Long non-coding RNAs: controversial roles in drug resistance of solid tumors mediated by autophagy

  2023cites this paper
• Inferring cell developmental stage-specific lncRNA regulation in the developing human neocortex with CDSlncR

  2023cites this paper
• Long non-coding RNA LHX1-DT regulates cardiomyocyte differentiation through H2A.Z-mediated LHX1 transcriptional activation

  2023cites this paper
• Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression

  2023cites this paper
• Enriched atlas of lncRNA and protein-coding genes for the GRCg7b chicken assembly and its functional annotation across 47 tissues

  2023cites this paper
• Characterization of SOD1-DT, a Divergent Long Non-Coding RNA in the Locus of the SOD1 Human Gene

  2023cites this paper
• Genome-wide differential expression profiling of long non-coding RNAs in FOXA2 knockout iPSC-derived pancreatic cells

  2023cites this paper
• Regulatory Potential of Noncoding RNAs Co-Located with Cardiomyopathy Related Genes

  2023cites this paper
• N6-methyladenosine–mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling

  2023cites this paper
• Genome-wide identification of long intergenic non-coding RNAs of responsive to powdery mildew stress in wheat (Triticum aestivum)

  2023cites this paper
• LncRNAs: the good, the bad, and the unknown.

  2023cites this paper
• RNA–Chromatin Interactome: What? Where? When?

  2022cites this paper
• Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

  2022influential citation
• LINC01535 Attenuates ccRCC Progression through Regulation of the miR-146b-5p/TRIM2 Axis and Inactivation of the PI3K/Akt Pathway

  2022cites this paper
• Characterization of immunomodulatory lncRNAs in the head kidney of yellow catfish (Pelteobagrus fulvidraco) infected by Aeromonas hydrophila

  2022cites this paper
• Cotton long non-coding RNAs regulate cell wall defense genes and strengthen resistance to Verticillium wilt.

  2022cites this paper
• Epigenetic regulation of human non-coding RNA gene transcription.

  2022cites this paper
• The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis

  2022cites this paper
• Trophectoderm non-coding RNAs reflect the higher metabolic and more invasive properties of young maternal age blastocysts

  2022cites this paper
• Identification of lncRNA-related protein-coding genes using multi-omics data based on deep learning and matrix completion

  2022cites this paper
• ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters

  2022cites this paper
• Amino acid restriction induces a long non‐coding RNA UBA6‐AS1 to regulate GCN2‐mediated integrated stress response in breast cancer

  2022cites this paper
• Dynamic Transcriptome Profiling Reveals LncRNA-Centred Regulatory Networks in the Modulation of Pluripotency

  2022cites this paper
• Contingent Synergistic Interactions between Non-Coding RNAs and DNA-Modifying Enzymes in Myelodysplastic Syndromes

  2022cites this paper
• Identification of long non-coding RNAs in response to downy mildew stress in grape

  2022cites this paper
• The long and short: Non-coding RNAs in the mammalian inner ear.

  2022cites this paper
• PLIC11 drives lung cancer progression through regulating the YY1/PIWIL4 axis

  2022cites this paper
• Inferring cell-specific lncRNA regulation with single-cell RNA-sequencing data in the developing human neocortex

  2022cites this paper
• Functional evolutionary convergence of long noncoding RNAs involved in embryonic development

  2022cites this paper
• LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex

  2022cites this paper
• Linc-RAM is a metabolic regulator maintaining whole-body energy homeostasis in mice

  2022cites this paper
• annotate_my_genomes: an easy-to-use pipeline to improve genome annotation and uncover neglected genes by hybrid RNA sequencing

  2022cites this paper
• Enhancer RNA (eRNA) in Human Diseases

  2022cites this paper
• A Green Light to Switch on Genes: Revisiting Trithorax on Plants

  2022cites this paper
• SNHG20 promotes the development of laryngeal squamous cell carcinoma via miR-342-3p/MTDH axis

  2022cites this paper
• Long noncoding RNA Lx8-SINE B2 interacts with Eno1 to regulate self-renewal and metabolism of embryonic stem cells.

  2022cites this paper
• RSC and GRFs confer promoter directionality by restricting divergent noncoding transcription

  2022cites this paper
• LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis

  2022cites this paper