Reperfusion-Induced Oxidative/Nitrative Injury to Neurovascular Unit After Focal Cerebral Ischemia

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Stroke

• Publication date

  2004-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.STR.0000126044.83777.f4PMID 15073398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide.

  2003cited by this paper
• Neurodegeneration in Striatum Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Role of Matrix Metalloproteinase-9 in Early Blood-Brain Barrier Disruption?

  2003cited by this paper
• S-Nitrosylation of Matrix Metalloproteinases: Signaling Pathway to Neuronal Cell Death

  2002cited by this paper
• Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration.

  2002cited by this paper
• Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice: Implications for the Production and Role of Superoxide Radicals

  2002cited by this paper
• Oxygen radicals in cerebral ischemia: the 2001 Willis lecture.

  2001cited by this paper
• Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

  2001cited by this paper
• Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain

  2001cited by this paper
• Nitric Oxide: A Critical Determinant in Ischemia-Reperfusion

  2000cited by this paper
• Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia.

  2000cited by this paper
• Reduction of Tissue Plasminogen Activator-Induced Hemorrhage and Brain Injury by Free Radical Spin Trapping after Embolic Focal Cerebral Ischemia in Rats

  2000cited by this paper
• Using gene-targeted mice to investigate the pathophysiology of myocardial reperfusion injury

  2000cited by this paper
• Cellular distribution of superoxide dismutases in the rat CNS

  2000cited by this paper
• Nitric oxide : biology and pathobiology

  2000cited by this paper
• Thrombolysis in acute ischemic stroke: controlled trials and clinical experience.

  1999cited by this paper
• Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia.

  1999cited by this paper
• CACNA1A mutations

  1999cited by this paper
• Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo

  1998cited by this paper
• Modulation of basal and postischemic leukocyte-endothelial adherence by nitric oxide.

  1998cited by this paper
• Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke

  1998cited by this paper
• Mechanisms of NO neurotoxicity.

  1998cited by this paper
• Increased Formation of Reactive Oxygen Species after Permanent and Reversible Middle Cerebral Artery Occlusion in the Rat

  1998cited by this paper
• Xanthine oxidase-derived superoxide causes reoxygenation injury of ischemic cerebral endothelial cells.

  1998cited by this paper
• Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

  1998cited by this paper
• Chapter 16 Mechanisms of NO neurotoxicity

  1998cited by this paper
• Protection against blood-brain barrier disruption in focal cerebral ischemia by the type IV phosphodiesterase inhibitor BBB022: a quantitative study.

  1998cited by this paper
• Dose‐ and time‐dependence of l‐NAME neuroprotection in transient focal cerebral ischaemia in rats

  1997cited by this paper
• Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat

  1997cited by this paper
• PEROXYNITRITE: A MEDIATOR OF INCREASED MICROVASCULAR PERMEABILITY?

  1997cited by this paper
• Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase gene knockout mutant mice.

  1997cited by this paper
• Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.

  1997cited by this paper
• Nitric oxide- and superoxide-mediated toxicity in cerebral endothelial cells.

  1997cited by this paper
• Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

  1996cited by this paper
• Effects of Nitric Oxide Synthase Inhibition on Brain Infarction in SOD-1-Transgenic Mice following Transient Focal Cerebral Ischemia

  1996cited by this paper
• Generation of nitric oxide and superoxide during reperfusion after focal cerebral ischemia in rats.

  1996cited by this paper
• Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion.

  1995cited by this paper
• Human Copper‐Zinc Superoxide Dismutase Transgenic Mice Are Highly Resistant to Reperfusion Injury After Focal Cerebral Ischemia

  1994cited by this paper
• Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.

  1994cited by this paper
• The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

  1991cited by this paper
• The large apparent work capability of the blood‐brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat

  1977cited by this paper

• Therapeutic potential of nitric oxide and its donors in hemorrhagic and ischemic stroke: a systematic review.

  2026cites this paper
• Association of triglyceride-glucose index with all-cause mortality in critically ill non-diabetic ischemic stroke: a retrospective cohort study based on the MIMIC-IV database

  2026cites this paper
• Expression and purification of C14orf119 and generation of its polyclonal antibody.

  2025cites this paper
• Decoding ischemic stroke: Perspectives on the endoplasmic reticulum, mitochondria, and their crosstalk

  2025cites this paper
• Using human genomics to validate drug targets for acute ischemic stroke.

  2025cites this paper
• Significance of Neurotransmitters in Cerebral Ischemia: Understanding the Role of Serotonin, Dopamine, Glutamate, and GABA in Stroke Recovery and Treatment.

  2024cites this paper
• The role of oxidative stress in blood-brain barrier disruption during ischemic stroke: Antioxidants in clinical trials.

  2024cites this paper
• Neuro- and vasoprotective potential of neuropeptide Y2 receptor agonist, NPY13-36, against transient focal cerebral ischemia in spontaneously hypertensive rats.

  2024cites this paper
• Before, during, and after: An Argument for Safety and Improved Outcome of Thrombolysis in Acute Ischemic Stroke with Direct Oral Anticoagulant Treatment

  2024cites this paper
• Pericytes in the brain and heart: functional roles and response to ischaemia and reperfusion

  2024cites this paper
• Dried Blood Spot Metabolome Features of Ischemic–Hypoxic Encephalopathy: A Neonatal Rat Model

  2024cites this paper
• Up-regulation of BMAL1 by epigallocatechin-3-gallate improves neurological damage in SBI rats.

  2024cites this paper
• Effect of prothymosin α on neuroplasticity following cerebral ischemia‑reperfusion injury

  2024cites this paper
• The Role of Stem Cells as Therapeutics for Ischaemic Stroke

  2024cites this paper
• Design of an Anti-HMGB1 Synthetic Antibody for In Vivo Ischemic/Reperfusion Injury Therapy

  2023cites this paper
• Identification of Metabolomic Signatures for Ischemic Hypoxic Encephalopathy Using a Neonatal Rat Model

  2023cites this paper
• Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

  2023cites this paper
• Activation of the Epac/Rap1 signaling pathway alleviates blood-brain barrier disruption and brain damage following cerebral ischemia/reperfusion injury.

  2023cites this paper
• Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke

  2023cites this paper
• Effects of Natural Polyphenols on Oxidative Stress-Mediated Blood-Brain Barrier Dysfunction

  2022cites this paper
• Roles of Nitric Oxide in Brain Ischemia and Reperfusion

  2022cites this paper
• The effect of acupuncture on oxidative stress: A systematic review and meta-analysis of animal models

  2022cites this paper
• Disengaging the COVID-19 Clutch as a Discerning Eye Over the Inflammatory Circuit During SARS-CoV-2 Infection

  2022cites this paper
• Cross-Talk between Amyloid, Tau Protein and Free Radicals in Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy

  2022cites this paper
• Vitamin D3 and Ischemic Stroke: A Narrative Review

  2022cites this paper
• Central Nervous System Pericytes Contribute to Health and Disease

  2022cites this paper
• Effects of Lycopene Attenuating Injuries in Ischemia and Reperfusion

  2022cites this paper
• Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities.

  2022cites this paper
• Single-Nucleotide Polymorphisms in Oxidative Stress-Related Genes and the Risk of a Stroke in a Polish Population—A Preliminary Study

  2021cites this paper
• Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative

  2021cites this paper
• Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation

  2021cites this paper
• Pericytes in Retinal

  2021cites this paper
• Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/β-catenin signaling in mice.

  2021cites this paper
• Changes of Metabolites in Acute Ischemic Stroke and Its Subtypes

  2021cites this paper
• The Role of Natural Antioxidants in the Prevention of Dementia—Where Do We Stand and Future Perspectives

  2021cites this paper
• Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage

  2021cites this paper
• Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation.

  2021cites this paper
• Glutathione peroxidase-1 and neuromodulation: novel potentials of an old enzyme.

  2020cites this paper
• Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke.

  2020cites this paper
• Therapeutic Potentials of Crocin in Medication of Neurological Disorders.

  2020cites this paper
• Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

  2020cites this paper
• Stroke Incidence in Survivors of Carbon Monoxide Poisoning in South Korea: A Population-Based Longitudinal Study

  2020cites this paper
• Circ_002664/miR-182-5p/Herpud1 pathway importantly contributes to OGD/R-induced neuronal cell apoptosis.

  2020cites this paper
• The Role of Oxidative Stress in Early Brain Injury after Subarachnoid Hemorrhage

  2020cites this paper
• Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia- reperfusion in rats

  2020cites this paper
• Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds

  2020cites this paper
• Association Between Carbon Monoxide Intoxication and Incidence of Ischemic Stroke: A Retrospective Nested Case-Control Study in South Korea.

  2020cites this paper
• The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats

  2020cites this paper
• Protective Effects of ShcA Protein Silencing for Photothrombotic Cerebral Infarction

  2020cites this paper
• Oxidative stress in the pathogenesis of Alzheimer's disease and cerebrovascular disease with therapeutic implications.

  2020cites this paper
• Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies.

  2020cites this paper
• Expression of S100B Protein in Ischemia/Reperfusion-Induced Brain Injury After Cyclosporine Therapy: A Biochemical Serum Marker with Prognostic Value?

  2019cites this paper
• Reactive species-induced microvascular dysfunction in ischemia/reperfusion.

  2019cites this paper
• Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

  2019cites this paper
• Neuroprotective effect of Crocus sativus against cerebral ischemia in rats

  2019cites this paper
• MiR-34b Protects Against Focal Cerebral Ischemia-Reperfusion (I/R) Injury in Rat by Targeting Keap1.

  2019cites this paper
• Study on the cellular and molecular responses to a shock wave in the rat brain

  2019cites this paper
• Pericytes in Ischemic Stroke.

  2019cites this paper
• The Role of Antioxidant Treatment in Acute Ischemic Stroke: Past, Present and Future

  2019cites this paper
• Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling

  2019cites this paper
• Identification and functional analysis of microRNAs in rats following focal cerebral ischemia injury

  2019cites this paper
• Hispidulin Protects Against Focal Cerebral Ischemia Reperfusion Injury in Rats

  2018cites this paper
• Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia/reperfusion injury in diabetic rats

  2018cites this paper
• Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

  2018cites this paper
• Systematic studies on the in vivo substance basis and the pharmacological mechanism of Acanthopanax Senticosus Harms leaves by UPLC-Q-TOF-MS coupled with a target-network method.

  2018cites this paper
• Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

  2018cites this paper
• Regulation of Hypertension for Secondary Prevention of Stroke: The Possible ‘Bridging Function' of Acupuncture

  2018cites this paper
• Effet protecteur des HDL en phase aiguë d’AVC ischémique en condition d’hyperglycémie

  2018cites this paper
• Synergistic Interaction Between Zinc and Reactive Oxygen Species Amplifies Ischemic Brain Injury in Rats

  2018cites this paper
• Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption

  2018cites this paper
• In Vivo Photoacoustic Detection and Imaging of Peroxynitrite.

  2018cites this paper
• The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway

  2018cites this paper
• Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke

  2018cites this paper
• Gp91phox (NOX2) in Activated Microglia Exacerbates Neuronal Damage Induced by Oxygen Glucose Deprivation and Hyperglycemia in an in Vitro Model

  2018cites this paper
• A comprehensive review on regulatory effects of crocin on ischemia/reperfusion injury in multiple organs.

  2018cites this paper
• Potential molecular targets of peroxynitrite in mediating blood–brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment

  2018cites this paper
• Therapeutic Strategies Harnessing Oxidative Stress to Treat Stroke

  2017cites this paper
• The vascular basement membrane in the healthy and pathological brain

  2017cites this paper
• The Role of Pericytes in Neurovascular Unit: Emphasis on Stroke.

  2017cites this paper
• Blood-brain barrier dysfunction and recovery after ischemic stroke.

  2017cites this paper
• Nitric Oxide Donors in Brain Inflammation

  2017cites this paper
• Systematic in vitro assessment of responses of roGFP2‐based probes to physiologically relevant oxidant species

  2017cites this paper
• Neuroprotective effects of adjunctive treatments for acute stroke thrombolysis: a review of clinical evidence

  2017cites this paper
• Increased circulating leukocyte-derived microparticles in ischemic cerebrovascular disease.

  2017cites this paper
• The role of nitric oxide in stroke

  2017cites this paper
• Role of Carbon Monoxide in Neurovascular Repair Processing

  2017cites this paper
• Anatomy and Physiology of the Blood–Brain Barrier

  2017cites this paper
• Pharmacological Management Options to Prevent and Reduce Ischemic Hemorrhagic Transformation.

  2017cites this paper
• Chapter 14 – Stroke

  2017cites this paper
• Preserved Collateral Blood Flow in the Endovascular M2CAO Model Allows for Clinically Relevant Profiling of Injury Progression in Acute Ischemic Stroke

  2017cites this paper
• Reperfusion therapy-What's with the obstructed, leaky and broken capillaries?

  2017cites this paper
• Platelet glycoprotein receptor Ib blockade ameliorates experimental cerebral ischemia-reperfusion injury by strengthening the blood-brain barrier function and anti-thrombo-inflammatory property.

  2017influential citation
• Neuroprotective Mechanisms of Melatonin in Hemorrhagic Stroke

  2017cites this paper
• Targeting ONOO-/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment

  2016cites this paper
• Neuroprotection Following Stroke in the Gyrencephalic Non-Human Primate Brain

  2016cites this paper
• Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats

  2016cites this paper
• Proteomic Profiling in the Spinal Cord and Sciatic Nerve in a Global Cerebral Ischemia-Induced Mechanical Allodynia Mouse Model.

  2016cites this paper
• Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis.

  2016cites this paper
• NADPH Oxidase: A Potential Target for Treatment of Stroke

  2016cites this paper
• Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke.

  2016cites this paper