SCIENCE@home

Kleine-Levin syndrome: clues to aetiology

S. AlShareef,Richard M. Smith,Ahmed S. Bahammam

Published 2018 in Sleep and Breathing

ABSTRACT

Kleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1–2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Functional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the development of the abnormalities detected. An autoimmune aetiology is consistent with the available data. In this review, we argue that, in order to further our understanding of KLS, there needs to be a co-ordinated international effort to standardise approaches to functional imaging studies, genetic analyses that specifically address the possibility of an autoimmune aetiology, and clinical trials of immunosuppressive therapies.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-100 of 120 references · Page 1 of 2

12
Next

CITED BY

Showing 1-24 of 24 citing papers · Page 1 of 1