Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cbpa.2010.02.015PMID 20188206
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells

  2010cited by this paper
• The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

  2009cited by this paper
• Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisition of thermotolerance.

  2009cited by this paper
• Examination of cadmium-induced expression of the small heat shock protein gene, hsp30, in Xenopus laevis A6 kidney epithelial cells.

  2009cited by this paper
• The ubiquitin proteasome system in neuropathology

  2009cited by this paper
• Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii

  2009cited by this paper
• Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects

  2009cited by this paper
• Adapting Proteostasis for Disease Intervention

  2008cited by this paper
• Development of thermotolerance requires interaction between polymerase‐β and heat shock proteins

  2008cited by this paper
• Comparison of the effect of heat shock factor inhibitor, KNK437, on heat shock- and chemical stress-induced hsp30 gene expression in Xenopus laevis A6 cells.

  2008cited by this paper
• Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis

  2008cited by this paper
• Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.

  2008cited by this paper
• Intracellular localization of the heat shock protein, HSP110, in Xenopus laevis A6 kidney epithelial cells.

  2008cited by this paper
• Chemical and biological approaches synergize to ameliorate protein-folding diseases.

  2008cited by this paper
• Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.

  2008cited by this paper
• Hsp70B′ regulation and function

  2007cited by this paper
• Induction of heat shock proteins in differentiated human and rodent neurons by celastrol

  2007cited by this paper
• Hsp70B′ regulation and function

  2007cited by this paper
• Examination of KNK437- and quercetin-mediated inhibition of heat shock-induced heat shock protein gene expression in Xenopus laevis cultured cells.

  2007cited by this paper
• Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response

  2007cited by this paper
• Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.

  2007cited by this paper
• Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid

  2006cited by this paper
• Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid.

  2006cited by this paper
• Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.

  2006cited by this paper
• Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation*

  2005cited by this paper
• Intracellular localization of Xenopus small heat shock protein; hsp30; in A6 kidney epithelial cells

  2005cited by this paper
• Regulation and function of small heat shock protein genes during amphibian development

  2004cited by this paper
• The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases.

  2004cited by this paper
• Proteasome inhibition alters the transcription of multiple yeast genes.

  2004cited by this paper
• Hydrogen peroxide induces heat shock protein and proto-oncogene mRNA accumulation in Xenopus laevis A6 kidney epithelial cells.

  2004cited by this paper
• Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status

  2004cited by this paper
• Celastrols as Inducers of the Heat Shock Response and Cytoprotection*[boxs]

  2004cited by this paper
• Intracellular trafficking of heat shock factor 2.

  2004cited by this paper
• Expression and function of small heat shock protein genes during Xenopus development.

  2003cited by this paper
• Lowered Temperature Set Point for Activation of the Cellular Stress Response in T-lymphocytes*

  2003cited by this paper
• Phosphorylation-dependent structural alterations in the small hsp30 chaperone are associated with cellular recovery.

  2003cited by this paper
• Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells.

  2002cited by this paper
• Mutation or deletion of the C-terminal tail affects the function and structure of Xenopus laevis small heat shock protein, hsp30.

  2002cited by this paper
• Toxic Proteins in Neurodegenerative Disease

  2002cited by this paper
• Xenopus small heat shock proteins, Hsp30C and Hsp30D, maintain heat- and chemically denatured luciferase in a folding-competent state

  2002cited by this paper
• Inhibition of the ubiquitin-proteasome pathway induces differential heat-shock protein response in cardiomyocytes and renders early cardiac protection.

  2002cited by this paper
• Adjusting the thermostat: the threshold induction temperature for the heat-shock response in intertidal mussels (genus Mytilus) changes as a function of thermal history.

  2001cited by this paper
• NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?

  2001cited by this paper
• NF-κB: pivotal mediator or innocent bystander in atherogenesis?

  2001cited by this paper
• Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones.

  2001cited by this paper
• Structure and function of small heat shock/α-crystallin proteins: established concepts and emerging ideas

  2000cited by this paper
• Functional characterization of Xenopus small heat shock protein, Hsp30C: the carboxyl end is required for stability and chaperone activity

  2000cited by this paper
• Stress-induced, tissue-specific enrichment of hsp70 mRNA accumulation in Xenopus laevis embryos

  2000cited by this paper
• Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.

  2000cited by this paper
• Characterization and Dynamics of Aggresome Formation by a Cytosolic Gfp-Chimera✪

  1999cited by this paper
• Spatial pattern of constitutive and heat shock-induced expression of the small heat shock protein gene family, Hsp30, in Xenopus laevis tailbud embryos.

  1999cited by this paper
• Proteasome Inhibitors Cause Induction of Heat Shock Proteins and Trehalose, Which Together Confer Thermotolerance inSaccharomyces cerevisiae

  1998cited by this paper
• Stress–inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

  1998cited by this paper
• Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death.

  1998cited by this paper
• Proteasome inhibitors: valuable new tools for cell biologists.

  1998cited by this paper
• Heat-shock-induced assembly of Hsp30 family members into high molecular weight aggregates in Xenopus laevis cultured cells.

  1998cited by this paper
• Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.

  1998cited by this paper
• Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance*

  1997cited by this paper
• Heat shock protein gene expression during Xenopus development

  1997cited by this paper
• Effect of herbimycin A on hsp30 and hsp70 heat shock protein gene expression in Xenopus cultured cells.

  1997cited by this paper
• Preferential activation of HSF-binding activity and hsp70 gene expression in Xenopus heart after mild hyperthermia.

  1997cited by this paper
• Structure of 20S proteasome from yeast at 2.4Å resolution

  1997cited by this paper
• Stress-Inducible Cellular Responses

  1996cited by this paper
• Male Germ Cell-specific Alteration in Temperature Set Point of the Cellular Stress Response (*)

  1995cited by this paper
• Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

  1995cited by this paper
• Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.

  1995cited by this paper
• Effects of anti-nuclear factor κB reagents in blocking adhesion of human cancer cells to vascular endothelial cells.

  1995cited by this paper
• Effects of anti-nuclear factor kappa B reagents in blocking adhesion of human cancer cells to vascular endothelial cells.

  1995cited by this paper
• Arachidonate is a potent modulator of human heat shock gene transcription.

  1994cited by this paper
• Comparison of regulatory and structural regions of the Xenopus laevis small heat-shock protein-encoding gene family.

  1992cited by this paper
• DNA sequence-specific binding activity of the heat-shock transcription factor is heat-inducible before the midblastula transition of early Xenopus development.

  1990cited by this paper
• Heat and sodium arsenite act synergistically on the induction of heat shock gene expression in Xenopus laevis A6 cells.

  1987cited by this paper
• Identification and Characterization of a Drosophila Proteasome Regulatory Network†

  year unknowncited by this paper

• Heat shock protein 70 in Cynops orientalis: bidirectional thermal regulation and metabolic optimization in amphibian climatic adaptation

  2026cites this paper
• Phytocompounds as modulators of HSF1 in Neurodegenerative disease: Special emphasis on Alzheimer's disease.

  2025cites this paper
• Development of Proteasome Inhibitors for Cancer Therapy

  2024cites this paper
• Alterations in the gut microbiome and metabolic profile in rats acclimated to high environmental temperature

  2021cites this paper
• Traditional Chinese medicine, “Celastrol” and its nanotechnology for cancers: a narrative review

  2021cites this paper
• Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family

  2019cites this paper
• Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells

  2018cites this paper
• Celastrol as a pentacyclic triterpenoid with chemopreventive properties.

  2018cites this paper
• Effect of isothiocyanates, BITC and PEITC, on stress protein accumulation, protein aggregation and aggresome-like structure formation in Xenopus A6 kidney epithelial cells.

  2018cites this paper
• Celastrol enhances Atoh1 expression in inner ear stem cells and promotes their differentiation into functional auditory neuronal-like cells

  2018cites this paper
• Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular Function

  2017cites this paper
• The expression and function of hsp30-like small heat shock protein genes in amphibians, birds, fish, and reptiles.

  2017cites this paper
• The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

  2016cites this paper
• The 26S proteasome is a multifaceted target for anti-cancer therapies

  2015cites this paper
• Short Time Tripterine Treatment Enhances Endothelial Progenitor Cell Function via Heat Shock Protein 32

  2015cites this paper
• Chalcones from Angelica keiskei: Evaluation of Their Heat Shock Protein Inducing Activities.

  2015cites this paper
• Celastrol overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation.

  2015cites this paper
• Application of a Heat Shock Protein Inducer to Remedy for an Atrophied Muscle Cell: A Basic Research for ISS/JEM Onboard Experiment

  2014cites this paper
• Analysis of heat shock protein 30 gene expression and function in Xenopus laevis A6 kidney epithelial cells

  2014influential citation
• Stress-induced accumulation of heme oxygenase-1 in Xenopus laevis A6 kidney epithelial cells

  2014influential citation
• Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells

  2014cites this paper
• Accumulation of heme oxygenase-1 (HSP32) in Xenopus laevis A6 kidney epithelial cells treated with sodium arsenite, cadmium chloride or proteasomal inhibitors.

  2014cites this paper
• The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol.

  2014cites this paper
• Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells

  2014cites this paper
• Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis

  2014cites this paper
• Lack of Neuroprotective Effect of Celastrol Under Conditions of Proteasome Inhibition by Lactacystin in In Vitro and In Vivo Studies: Implications for Parkinson’s Disease

  2014influential citation
• Synthese und Pharmakologie von Proteasom‐Inhibitoren

  2013cites this paper
• Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones

  2013cites this paper
• Synthesis and pharmacology of proteasome inhibitors.

  2013cites this paper
• Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways.

  2013cites this paper
• Effect of combined sodium arsenite and cadmium chloride treatment on heat shock protein gene expression in Xenopus laevis A6 kidney epithelial cells

  2013cites this paper
• Heat Shock Factor 1 Inducers from the Bark of Eucommia ulmoides as Cytoprotective Agents

  2013cites this paper
• The Extent of Neurodegeneration and Neuroprotection in Two Chemical In Vitro Models Related to Parkinson’s Disease is Critically Dependent on Cell Culture Conditions

  2013cites this paper
• The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis.

  2012cites this paper
• Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

  2012cites this paper
• Sodium arsenite and cadmium chloride induction of proteasomal inhibition and HSP accumulation in Xenopus laevis A6 kidney epithelial cells.

  2012cites this paper
• Synthesis and proteasome inhibition of lithocholic acid derivatives.

  2011cites this paper
• Examination of sodium arsenite- and cadmium chloride-induced HSP accumulation and inhibition of proteasome activity in Xenopus laevis A6 kidney epithelial cells

  2011influential citation
• Attenuation of Muscle Atrophy by Triterpentene Celastrol

  2011cites this paper
• Inhibitory action of Celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1α pathway.

  2011cites this paper
• Diarylheptanoids from the seeds of Alpinia katsumadai as heat shock factor 1 inducers.

  2011cites this paper
• Soluble proteome analysis of male Ericerus pela Chavannes cuticle at the stage of the second instar larva

  2011cites this paper
• Curcumin-induced inhibition of proteasomal activity, enhanced HSP accumulation and the acquisition of thermotolerance in Xenopus laevis A6 cells.

  2011cites this paper
• Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.

  2011cites this paper
• The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine

  2011cites this paper
• Examination of curcumin-induced heat shock protein gene expression in Xenopus laevis A6 kidney epithelial cells

  2010influential citation
• Examination of the effect of the natural plant extract, withaferin A, on heat shock protein gene expression in Xenopus laevis A6 cells

  2010cites this paper