Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Heat Shock Proteins

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-3-030-23158-3_20
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation

  2018cited by this paper
• Celastrol pretreatment attenuates rat myocardial ischemia/ reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway.

  2018cited by this paper
• Targeting Hodgkin and Reed–Sternberg Cells with an Inhibitor of Heat-Shock Protein 90: Molecular Pathways of Response and Potential Mechanisms of Resistance

  2018cited by this paper
• Celastrol reverses palmitic acid (PA)‐caused TLR4‐MD2 activation‐dependent insulin resistance via disrupting MD2‐related cellular binding to PA

  2018cited by this paper
• Effect and mechanisms of celastrol on the apoptosis of HOS osteosarcoma cells.

  2018cited by this paper
• Celastrol aggravates LPS-induced inflammation and injuries of liver and kidney in mice.

  2018cited by this paper
• The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response

  2018cited by this paper
• Effect of celastrol on toll-like receptor 4-mediated inflammatory response in free fatty acid-induced HepG2 cells

  2018cited by this paper
• Celastrol inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways.

  2018cited by this paper
• Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury

  2018cited by this paper
• Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1

  2018cited by this paper
• Molecular targets of celastrol in cancer: Recent trends and advancements.

  2018cited by this paper
• Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance

  2018cited by this paper
• Celastrol as a pentacyclic triterpenoid with chemopreventive properties.

  2018cited by this paper
• Celastrol attenuates pain and cartilage damage via SDF‐1/CXCR4 signalling pathway in osteoarthritis rats

  2018cited by this paper
• Celastrol ameliorates acetaminophen-induced oxidative stress and cytotoxicity in HepG2 cells

  2018cited by this paper
• Protective effects of celastrol against γ irradiation-induced oxidative stress in human umbilical vein endothelial cells

  2018cited by this paper
• Celastrol attenuates incision‐induced inflammation and pain associated with inhibition of the NF‐&kgr;B signalling pathway via SARM

  2018cited by this paper
• Celastrol attenuates symptoms of preeclampsia in rats by inhibiting matrix metalloproteinase‐9

  2018cited by this paper
• The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression

  2018cited by this paper
• A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

  2018cited by this paper
• Histone deacetylase inhibitor SAHA-induced epithelial–mesenchymal transition by upregulating Slug in lung cancer cells

  2018cited by this paper
• Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization

  2018cited by this paper
• Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.

  2017cited by this paper
• Celastrol improves self-renewal and differentiation of human tendon-derived stem cells by suppressing Smad7 through hypoxia

  2017cited by this paper
• Protective effect of celastrol on myocardial ischemia–reperfusion injury

  2017cited by this paper
• TLR4 knockout attenuated high fat diet-induced cardiac dysfunction via NF-κB/JNK-dependent activation of autophagy.

  2017cited by this paper
• Autophagy induction by celastrol augments protection against bleomycin-induced experimental pulmonary fibrosis in rats: Role of adaptor protein p62/ SQSTM1.

  2017cited by this paper
• Effect of celastrol on bone structure and mechanics in arthritic rats

  2017cited by this paper
• Celastrol attenuates impairments associated with lipopolysaccharide-induced acute respiratory distress syndrome (ARDS) in rats

  2017cited by this paper
• Improvement of mitochondrial function by celastrol in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway.

  2017cited by this paper
• Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol

  2017cited by this paper
• Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes

  2017cited by this paper
• Celastrol Attenuates Multiple Sclerosis and Optic Neuritis in an Experimental Autoimmune Encephalomyelitis Model

  2017cited by this paper
• Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways

  2017cited by this paper
• A new mechanism of inhibition of IL‐1&bgr; secretion by celastrol through the NLRP3 inflammasome pathway

  2017cited by this paper
• Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells

  2017cited by this paper
• Celastrol Attenuates Cadmium‐Induced Neuronal Apoptosis via Inhibiting Ca2+‐CaMKII‐Dependent Akt/mTOR Pathway

  2017cited by this paper
• Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation

  2017cited by this paper
• Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

  2017cited by this paper
• Celastrol induces apoptosis in hepatocellular carcinoma cells via targeting ER-stress/UPR

  2017cited by this paper
• Celastrol modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: Secretory phospholipase A2 group IIA, 5-lipoxygenase and cyclooxygenase-2.

  2016cited by this paper
• Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats

  2016cited by this paper
• Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.

  2016cited by this paper
• Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics.

  2016cited by this paper
• Plant-derived triterpene celastrol ameliorates oxygen glucose deprivation-induced disruption of endothelial barrier assembly via inducing tight junction proteins.

  2016cited by this paper
• Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties.

  2016cited by this paper
• Proteasome inhibitors, including curcumin, improve pancreatic β-cell function and insulin sensitivity in diabetic mice

  2016cited by this paper
• Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.

  2016cited by this paper
• Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway

  2016cited by this paper
• Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells

  2016cited by this paper
• Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms.

  2016cited by this paper
• Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis.

  2016cited by this paper
• Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro

  2016cited by this paper
• Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

  2016cited by this paper
• Mutations Y493G and K546D in human HSP90 disrupt binding of celastrol and reduce interaction with Cdc37

  2016cited by this paper
• Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition

  2016cited by this paper
• Celastrol attenuates bone erosion in collagen-Induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW264.7.

  2015cited by this paper
• Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids

  2015cited by this paper
• Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways.

  2015cited by this paper
• Celastrol Ameliorates EAE Induction by Suppressing Pathogenic T Cell Responses in the Peripheral and Central Nervous Systems

  2015cited by this paper
• Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ

  2015cited by this paper
• Treatment of obesity with celastrol.

  2015cited by this paper
• Celastrol prevents circulatory failure via induction of heme oxygenase-1 and heat shock protein 70 in endotoxemic rats.

  2015cited by this paper
• Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study

  2015cited by this paper
• Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.

  2015cited by this paper
• Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner.

  2015cited by this paper
• Celastrol supports survival of retinal ganglion cells injured by optic nerve crush.

  2015cited by this paper
• Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I

  2015cited by this paper
• Celastrol induces unfolded protein response-dependent cell death in head and neck cancer.

  2015cited by this paper
• Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death

  2014cited by this paper
• Celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells.

  2014cited by this paper
• Celastrol protects ischaemic myocardium through a heat shock response with up‐regulation of haeme oxygenase‐1

  2014cited by this paper
• Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.

  2014cited by this paper
• Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.

  2014cited by this paper
• Celastrol Inhibits Lung Infiltration in Differential Syndrome Animal Models by Reducing TNF-α and ICAM-1 Levels while Preserving Differentiation in ATRA-Induced Acute Promyelocytic Leukemia Cells

  2014cited by this paper
• The Systemic Amyloid Precursor Transthyretin (TTR) Behaves as a Neuronal Stress Protein Regulated by HSF1 in SH-SY5Y Human Neuroblastoma Cells and APP23 Alzheimer's Disease Model Mice

  2014cited by this paper
• Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy

  2014cited by this paper
• Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing-remitting model of multiple sclerosis in rats.

  2014cited by this paper
• Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis.

  2014cited by this paper
• Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism.

  2014cited by this paper
• Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2

  2014cited by this paper
• Celastrol protects kidney against ischemia-reperfusion-induced injury in rats.

  2014cited by this paper
• Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury

  2014cited by this paper
• Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells

  2014cited by this paper
• Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes.

  2014cited by this paper
• The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90kDa heat shock protein Hsp90α, a chaperone implicated in the stabilization of the tumor phenotype.

  2014cited by this paper
• A New Multicolor Bioluminescence Imaging Platform to Investigate NF-κB Activity and Apoptosis in Human Breast Cancer Cells

  2014cited by this paper
• Celastrol Inhibits Lipopolysaccharide-Stimulated Rheumatoid Fibroblast-Like Synoviocyte Invasion through Suppression of TLR4/NF-κB-Mediated Matrix Metalloproteinase-9 Expression

  2013cited by this paper
• Genera Plantarum Ad Exemplaria Imprimis in Herbariis Kewensibus Servata Definita

  2013cited by this paper
• Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice

  2013cited by this paper
• Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy.

  2013cited by this paper
• Celastrol Prevents Atherosclerosis via Inhibiting LOX-1 and Oxidative Stress

  2013cited by this paper
• Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90.

  2013cited by this paper
• Anti-invasive effects of celastrol in hypoxia-induced fibroblast-like synoviocyte through suppressing of HIF-1α/CXCR4 signaling pathway.

  2013cited by this paper
• Non-Specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense

  2013cited by this paper
• Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer

  2013cited by this paper
• Proteasome inhibition protects human peripheral blood mononuclear cells from radiation-induced oxidative stress

  2013cited by this paper
• ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network

  2013cited by this paper
• Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines.

  2012cited by this paper

• Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β

  2023cites this paper
• Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue

  2022cites this paper