Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Chemico-Biological Interactions

• Publication date

  2016-02-25

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.cbi.2016.01.006PMID 26768587
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Murine models of pulmonary fibrosis.

  2008cited by this paper
• Enhancement of antioxidant defense system by epigallocatechin-3-gallate during bleomycin induced experimental pulmonary fibrosis.

  2008cited by this paper
• Diallyl sulfide attenuates bleomycin-induced pulmonary fibrosis: critical role of iNOS, NF-kappaB, TNF-alpha and IL-1beta.

  2008cited by this paper
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  2007cited by this paper
• Nrf2 Defends the Lung from Oxidative Stress

  2006cited by this paper
• Oxidant and antioxidant balance in the airways and airway diseases.

  2006cited by this paper
• Animal models of pulmonary fibrosis.

  2005cited by this paper
• The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis

  2005cited by this paper
• Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.

  2004cited by this paper
• A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway.

  2004cited by this paper
• Inhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in rats.

  2004cited by this paper
• Regulation of Found in Inflammatory Zone 1 Expression in Bleomycin-Induced Lung Fibrosis: Role of IL-4/IL-13 and Mediation via STAT-61

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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Carbon monoxide provides protection against hyperoxic lung injury.

  1999cited by this paper
• Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis.

  1999cited by this paper
• An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.

  1997cited by this paper
• Generation and disposal of reactive oxygen metabolites in the lung.

  1995cited by this paper
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  1994cited by this paper
• Glutathione, ascorbate, and cellular protection.

  1994cited by this paper
• Mast cells and biogenic amines in radiation-induced pulmonary fibrosis.

  1993cited by this paper
• Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein.

  1992cited by this paper
• Pathobiology of pulmonary fibrosis.

  1990cited by this paper
• Role of free radicals and catalytic metal ions in human disease: an overview.

  1990cited by this paper
• Alterations in pulmonary protective enzymes following systemic bleomycin treatment in mice.

  1988cited by this paper
• Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.

  1987cited by this paper
• The role of intraalveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage.

  1987cited by this paper
• Vitamin E analysis methods for animal tissues.

  1984cited by this paper
• Mast cell heterogeneity and hyperplasia in bleomycin-induced pulmonary fibrosis of rats.

  1984cited by this paper
• Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.

  1980cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids.

  1979cited by this paper
• Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.

  1979cited by this paper
• Ultrastructure of pulmonary mast cells in patients with fibrotic lung disorders.

  1979cited by this paper
• Bleomycin, a review.

  1976cited by this paper
• Bleomycin, a review.

  1976cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper
• Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.

  1974cited by this paper
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  1973cited by this paper
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  1973cited by this paper
• Colorimetric assay of catalase.

  1972cited by this paper
• [259] Fluorometric assay of histamine☆

  1971cited by this paper
• Purification and properties of glutathione reductase of human erythrocytes.

  1969cited by this paper
• SIRIUS RED F3BA AS A STAIN FOR CONNECTIVE TISSUE.

  1964cited by this paper
• The determination of collagen and elastin in tissues.

  1950cited by this paper

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  2017influential citation
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  year unknowninfluential citation