Role of urotensin II in health and disease.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  American Journal of Physiology. Regulatory Integrative and Comparative Physiology

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpregu.00706.2009PMID 20421634
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeted overexpression of the human urotensin receptor transgene in smooth muscle cells: effect of UT antagonism in ApoE knockout mice fed with Western diet.

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• Pharmacokinetics and Pharmacodynamics of the Urotensin‐II Receptor Antagonist Palosuran in Healthy Male Subjects

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• Plasma urotensin II as a marker for severity of rheumatic valve disease.

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• Immunolocalization of urotensin II and its receptor in human adrenal tumors and attached non-neoplastic adrenal tissues.

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• Decreased plasma urotensin II levels inversely correlate with extent and severity of coronary artery disease

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• Photolabelling the urotensin II receptor reveals distinct agonist- and partial-agonist-binding sites.

  2007cited by this paper
• [Urotensin II and atherosclerosis].

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  2006cited by this paper
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  2006cited by this paper
• Urotensin-II and UII-receptor expression and function in the rat adrenal cortex.

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• Characterization of urotensin-II receptor structural domains involved in the recognition of U-II, URP, and urantide.

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• The role of urotensin II in cardiovascular and renal physiology and diseases

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• The Effects of Urotensin‐II on Proliferation of Pheochromocytoma Cells and mRNA Expression of Urotensin‐II and Its Receptor in Pheochromocytoma Tissues

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• Urotensin II and renal function in the rat.

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• Circulating urotensin II levels in moderate to severe congestive heart failure: its relations with myocardial function and well established neurohormonal markers.

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• Pharmacodynamics and pharmacokinetics of the urotensin II receptor antagonist palosuran in macroalbuminuric, diabetic patients

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• Abstract 3000: Increased Human Urotensin II Levels are Correlated With Carotid Atherosclerosis in Essential Hypertension

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• Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation.

  2006cited by this paper
• Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease.

  2006cited by this paper
• Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts.

  2006cited by this paper
• Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance.

  2006cited by this paper
• Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells

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• Urotensin II: Ancient Hormone with New Functions in Vertebrate Body Fluid Regulation

  2005cited by this paper
• Metabolic syndrome.

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• Urotensin II: evidence for cardiac, hepatic and renal production.

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• Role of prostaglandins in urotensin II-induced vasodilatation in the coronary arteries of aged rats.

  2005cited by this paper
• Increased plasma levels of Urotensin-II in preeclampsia-eclampsia: a new mediator in pathogenesis?

  2005cited by this paper
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  2005cited by this paper
• Expression of urotensin-II in human coronary atherosclerosis.

  2005cited by this paper
• Urotensin II Modulates Rapid Eye Movement Sleep through Activation of Brainstem Cholinergic Neurons

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  2005cited by this paper
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  2005cited by this paper
• Cardiac actions of central but not peripheral urotensin II are prevented by beta-adrenoceptor blockade.

  2005cited by this paper
• The metabolic syndrome--a new worldwide definition.

  2005cited by this paper
• The relationship between urotensin II plasma immunoreactivity and left ventricular filling pressures in coronary artery disease.

  2004cited by this paper
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• Urotensin II causes fatal circulatory collapse in anesthesized monkeys in vivo: a "vasoconstrictor" with a unique hemodynamic profile.

  2004cited by this paper
• Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy.

  2004cited by this paper
• Pharmacology of the Urotensin-II Receptor Antagonist Palosuran (ACT-058362; 1-[2-(4-Benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea Sulfate Salt): First Demonstration of a Pathophysiological Role of the Urotensin System

  2004cited by this paper
• Cellular distribution of immunoreactive urotensin-II in human tissues with evidence of increased expression in atherosclerosis and a greater constrictor response of small compared to large coronary arteries.

  2004cited by this paper
• Urotensin-II levels in children with minimal change nephrotic syndrome

  2004cited by this paper
• [Clinical study of plasma urotensin II in patients with coronary heart disease].

  2004cited by this paper
• Urotensin-II activates L-arginine/nitric oxide pathway in isolated rat aortic adventitia.

  2004cited by this paper
• Differential Effect of Urotensin II on Vascular Tone in Normal Subjects and Patients With Chronic Heart Failure

  2004cited by this paper
• Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy.

  2004cited by this paper
• Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta.

  2004influential reference
• Elevated plasma human urotensin-II-like immunoreactivity in ischemic cardiomyopathy.

  2004cited by this paper
• Human Urotensin II Modulates Collagen Synthesis and the Expression of MMP-1 in Human Endothelial Cells

  2004cited by this paper
• Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor.

  2004influential reference
• Identification and pharmacological characterization of native, functional human urotensin‐II receptors in rhabdomyosarcoma cell lines

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• Vasoconstrictive effects of endothelin-1, endothelin-3, and urotensin II in isolated perfused human lungs and isolated human pulmonary arteries

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• Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas.

  2004cited by this paper
• Plasma concentration of urotensin II is raised in hypertension

  2004cited by this paper
• Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention.

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• The metabolic syndrome.

  2003cited by this paper
• Structure–Activity Relationships of Human Urotensin II and Related Analogues on Rat Aortic Ring Contraction

  2003influential reference

• Urotensin II system contributes to ischemic acute kidney injury in neonatal pigs

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• Targeting urotensin II with silymarin: potential therapeutic strategies for diabetes and associated cardiovascular complications

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• Characterization of human Urotensin II peptide adsorbed on silver electrode by surface-enhanced Raman scattering spectroscopy.

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• Expanding Structure-Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal Region for Novel Urotensin II Receptor Modulators.

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• The effects of the urotensin-II receptor antagonist palosuran treatment on the corpora cavernosa of streptozotocin-induced diabetic rats

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• Urotensin II Enhances Advanced Aortic Atherosclerosis Formation and Delays Plaque Regression in Hyperlipidemic Rabbits

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• Urotensin II Receptor Modulation with 1,3,4-Benzotriazepin-2-one Tetrapeptide Mimics.

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• Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea

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• EXPLORATION OF THE UROCONTRIN A SCAFFOLD YIELDS NEW UROTENSINERGIC SYSTEM ALLOSTERIC MODULATOR AND COMPETITIVE ANTAGONISTS.

  2023cites this paper
• The Association of Passive Smoking and Serum Urotensin-II Levels in Children.

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• Urotensin-II Prevents Cartilage Degeneration in a Monosodium Iodoacetate-Induced Rat Model of Osteoarthritis

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• The Role of Urotensin-II in Obesity and Metabolic Syndrome in Pediatric Population

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• The importance of urotensin II level in the diagnosis of acute mesenteric ischemia

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• Urotensin II level is elevated in inflammatory bowel disease patients

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• Identifying Circulating Urotensin II and Urotensin II-Related Peptide-Generating Enzymes in the Human Plasma Fraction Cohn IV-4.

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• Urantide prevents CCl4-induced acute liver injury in rats by regulating the MAPK signalling pathway

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• Urotensin receptor antagonist urantide improves atherosclerosis-related kidney injury by inhibiting JAK2/STAT3 signaling pathway in rats.

  2020cites this paper
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  2020cites this paper
• Insights into the Molecular Determinants Involved in Urocontrin and Urocontrin A Action.

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• Dynamic Changes in Plasma Urotensin II and Its Correlation With Plaque Stability

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• An Integral Approach for Understanding the Bioactive Small Molecules in Cardiovascular Diseases

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• Urotensin II: an inflammatory cytokine.

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• [Changes in serum chromogranin A and urotensin II levels in children with chronic heart failure].

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• Renal Urotensin II System Plays Roles in the Regulation of Blood Pressure in Dahl Salt-Resistant Rat

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