Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Nature Immunology

• Publication date

  2000-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/76932PMID 10881177
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1970cited by this paper

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