5,10-Methylenetetrahydrofolate Reductase Polymorphisms and the Risk of Pancreatic Cancer

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cancer Epidemiology, Biomarkers and Prevention

• Publication date

  2005-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/1055-9965.EPI-04-0894PMID 15941958
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo.

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• Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.

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• The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.

  2004influential reference
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  2004influential reference
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• Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness.

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• Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma.

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• Association of Methylenetetrahydrofolate Reductase Gene Polymorphism With Carotid Atherosclerosis Depending on Smoking Status in a Japanese General Population

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• Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene.

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• Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia.

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  1999influential reference
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• The 677C-->T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease.

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• Genetic Predisposition to Hyperhomocysteinemia: Deficiency of Methylenetetrahydrofolate Reductase (MTHFR)

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  1995influential reference
• Epidemiology of and risk factors for pancreatic cancer.

  1995influential reference
• Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.

  1994cited by this paper
• Local and systemic effects of cigarette smoking on folate and vitamin B-12.

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