Neferine Enhances the Antitumor Effect of Mitomycin‐C in Hela Cells Through the Activation of p38‐MAPK Pathway

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Cellular Biochemistry

• Publication date

  2017-05-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jcb.26006PMID 28328092
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A

  2016cited by this paper
• Exonuclease-1 interacts with the transcriptional co-repressor KAP1

  2016cited by this paper
• Global cancer statistics, 2012

  2015cited by this paper
• Genome-wide identification of CBX2 targets: insights in the human sex development network.

  2015cited by this paper
• Doxorubicin induced apoptosis was potentiated by neferine in human lung adenocarcima, A549 cells.

  2014influential reference
• Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest.

  2014cited by this paper
• Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

  2014cited by this paper
• Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells.

  2013cited by this paper
• Endoplasmic Reticulum Stress Signaling Is Involved in Mitomycin C(MMC)-Induced Apoptosis in Human Fibroblasts via PERK Pathway

  2013influential reference
• Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer

  2013cited by this paper
• Treatment of metastatic cervical cancer: future directions involving targeted agents.

  2013cited by this paper
• Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization.

  2012influential reference
• Global cancer statistics

  2011cited by this paper
• Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

  2011influential reference
• Curcumin enhanced antiproliferative effect of mitomycin C in human breast cancer MCF-7 cells in vitro and in vivo

  2011cited by this paper
• Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer.

  2011cited by this paper
• ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation.

  2011cited by this paper
• DNA end resection by CtIP and exonuclease 1 prevents genomic instability

  2010cited by this paper
• Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

  2010cited by this paper
• Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells

  2010cited by this paper
• Influence of cyclophosphamide and its metabolic products on the activity of peritoneal macrophages in mice

  2009cited by this paper
• The effect of neferine on foam cell formation by anti-low density lipoprotein oxidation

  2008cited by this paper
• [Effect of neferine on adriamycin-resistance of thermotolerant hepatocarcinoma cell line HepG2/thermotolerance].

  2007cited by this paper
• Multidrug resistance reversal in human gastric carcinoma cells by neferine.

  2004cited by this paper
• Apoptosis of bladder cancer cells induced by short-term and low-dose Mitomycin-C: potential molecular mechanism and clinical implication.

  2003cited by this paper
• Mitochondrial control of cell death

  2000cited by this paper
• The role of glutathione in the regulation of apoptosis

  1999cited by this paper
• Reactive oxygen species regulate activation-induced T cell apoptosis.

  1999cited by this paper
• Glutathione and the regulation of cell death.

  1999cited by this paper
• Involvement of reactive oxygen species and caspase 3 activation in arsenite‐induced apoptosis

  1998cited by this paper
• The effect of neferine on foam cell formation by anti-low density lipoprotein oxidation.

  1998cited by this paper
• Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

  1997cited by this paper
• [Effects of neferine on platelet aggregation in rabbits].

  1997cited by this paper
• Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody*

  1996influential reference
• Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

  1996cited by this paper
• Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress

  1995influential reference
• Effect of brief exposure to mitomycin C on viability and proliferation of cultured human Tenon's capsule fibroblasts.

  1992cited by this paper
• Concurrent Radiation Therapy, cis‐Platinum, and Mitomycin C in Patients with Poor Prognosis Cancer of the Cervix: A Pilot Study

  1989influential reference
• Pharmacokinetics of mitomycin-C in plasma and tumor tissue of cervical cancer patients and in selected tissues of female rats.

  1986cited by this paper
• Bleomycin, vincristine, mitomycin-C, and cisplatin in the management of gynecological squamous cell carcinomas.

  1985cited by this paper
• Concurrent radiation, mitomycin C and 5-fluorouracil in poor prognosis carcinoma of cervix: preliminary results of a phase I-II study.

  1984cited by this paper
• Combination chemotherapy with mitomycin C, adriamycin, and cyclophosphamide (MAC) in stage III and IV ovarian cancer.

  1983cited by this paper
• Mitomycin C and bleomycin in the treatment of far-advanced cervical cancer: a Southwest Oncology Group pilot study.

  1980cited by this paper

• Discovery of a Novel Co-crystal of Chrysin and Oroxylin a with Anticancer Properties from Leaves of Oroxylum indicum.

  2024cites this paper
• Neferine Targeted the NLRC5/NLRP3 Pathway to Inhibit M1-type Polarization and Pyroptosis of Macrophages to Improve Hyperuricemic Nephropathy.

  2024cites this paper
• Anti-inflammatory Activity of Total Alkaloids in Nelumbo nucifera and Simultaneous Determination of Major Bisbenzylisoquinolines

  2023cites this paper
• Cellular Calcium Signals in Cancer Chemoprevention and Chemotherapy by Phytochemicals

  2022cites this paper
• Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells

  2022cites this paper
• Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways

  2022cites this paper
• Neferine, an alkaloid from lotus seed embryo targets HeLa and SiHa cervical cancer cells via pro‐oxidant anticancer mechanism

  2020cites this paper
• Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation.

  2020cites this paper
• Methanol extracts of Teucrium arduini L. and Teucrium flavum L. induce protective effect against mitomycin C in human lymphocytes in vitro

  2020cites this paper
• Small molecules regulating reactive oxygen species homeostasis for cancer therapy

  2020cites this paper
• Antitumor Activity of a Novel Double-Targeted System for Folate Receptor-Mediated Delivery of Mitomycin C

  2020cites this paper
• Neferine induces p38 MAPK/JNK1/2 activation to modulate melanoma proliferation, apoptosis, and oxidative stress

  2020cites this paper
• Neferine in the Lotus Plumule Potentiates the Antitumor Effect of Imatinib in Primary Chronic Myeloid Leukemia Cells In Vitro.

  2019cites this paper
• Genome‐wide analysis of ETV1 targets: Insights into the role of ETV1 in tumor progression

  2019cites this paper
• Neferine and isoliensinine enhance 'intracellular uptake of cisplatin' and induce 'ROS-mediated apoptosis' in colorectal cancer cells - A comparative study.

  2019cites this paper
• The cytoprotective and anti-cancer potential of bisbenzylisoquinoline alkaloids from Nelumbo nucifera.

  2019cites this paper
• The Role of Reactive Oxygen Species in Tumor Treatment and its Impact on Bone Marrow Hematopoiesis.

  2019cites this paper
• Anti-proliferative and Pro-apoptotic Activities of Nelumbo nucifera and Neferine in Human Colorectal HCT116 Cells

  2019cites this paper
• Neferine-induced apoptosis is dependent on the suppression of Bcl-2 expression via downregulation of p65 in renal cancer cells.

  2019cites this paper
• Involvement of Akt in mitomycin C and its analog triggered cytotoxicity in MCF‐7 and K562 cancer cells

  2018cites this paper
• The genotoxic and antigenotoxic potential of the methanolic root extract of Glycyrrhiza glabra L. on human peripheral blood lymphocytes

  2018cites this paper
• Neferine Protects Endothelial Glycocalyx via Mitochondrial ROS in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome

  2018influential citation
• Pharmacological benefits of neferine ‐ A comprehensive review

  2018cites this paper