Polymorphism in the Interleukin-4 Promoter Affects Acquisition of Human Immunodeficiency Virus Type 1 Syncytium-Inducing Phenotype

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Virology

• Publication date

  2000-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.74.12.5452-5459.2000PMID 10823849PMCID PMC112029
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• THE ASSOCIATION OF ATOPY WITH A GAIN-OF-FUNCTION MUTATION IN THE a SUBUNIT OF THE INTERLEUKIN-4 RECEPTOR

  2000cited by this paper
• The polymorphisms S503P and Q576R in the interleukin‐4 receptor α gene are associated with atopy and influence the signal transduction

  1999cited by this paper
• Evidence for differences in MT2 cell tropism according to genetic subtypes of HIV-1: syncytium-inducing variants seem rare among subtype C HIV-1 viruses.

  1999cited by this paper
• Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.

  1999cited by this paper
• Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression.

  1998influential reference
• Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immunodeficiency virus type 1 infection and in the time to conversion to SI virus variants.

  1998cited by this paper
• A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation

  1998cited by this paper
• Evidence for a role of T‐helper type 2 cytokines in the acquisition of human immunodeficiency virus syncytium‐inducing phenotype

  1998cited by this paper
• Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC)

  1998cited by this paper
• IL‐4 and a glucocorticoid up‐regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV‐1 replication

  1998influential reference
• CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS).

  1998cited by this paper
• Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.

  1998cited by this paper
• Cytokine Regulation of Human Immunodeficiency Virus Type 1 Entry and Replication in Human Monocytes/Macrophages through Modulation of CCR5 Expression

  1998influential reference
• Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus.

  1998cited by this paper
• The role of a stromal cell‐derived factor‐1 chemokine gene variant in the clinical course of HIV‐1 infection

  1998cited by this paper
• Association of asthma and the interleukin‐4 promoter gene in Japanese

  1998influential reference
• Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression

  1998influential reference
• Genetic acceleration of AIDS progression by a promoter variant of CCR5.

  1998influential reference
• CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status.

  1997cited by this paper
• In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression

  1997cited by this paper
• Productive and lytic infection of human CD4+ type 1 helper T cells with macrophage-tropic human immunodeficiency virus type 1

  1997cited by this paper
• The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression

  1997cited by this paper
• Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study.

  1997cited by this paper
• The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.

  1997cited by this paper
• HIV Type 1 V3 Variation Dynamics in Vivo: Long-Term Persistence of Non-Syncytium-Inducing Genotypes and Transient Presence of Syncytium-Inducing Genotypes during the Course of Progressive AIDS

  1997influential reference
• Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.

  1996cited by this paper
• Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy.

  1996cited by this paper
• Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

  1996cited by this paper
• Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

  1996influential reference
• Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy

  1995influential reference
• Biology of human TH1 and TH2 cells

  1995cited by this paper
• Interleukin 4 receptor: signaling mechanisms.

  1994cited by this paper
• Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.

  1994cited by this paper
• The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression.

  1994influential reference
• A TH1-->TH2 switch is a critical step in the etiology of HIV infection.

  1993cited by this paper
• Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals

  1993cited by this paper
• Genotypic and phenotypic characterization of HIV-1 patients with primary infection.

  1993cited by this paper
• Selective decrease of CD26 expression in T cells from HIV-1-infected individuals.

  1992cited by this paper
• Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

  1992cited by this paper
• Interleukin-4: a prototypic immunoregulatory lymphokine.

  1991cited by this paper
• B-cell activation and HIV-1 infection: deeds and misdeeds.

  1990cited by this paper
• Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.

  1990cited by this paper
• Serum IgE and human immunodeficiency virus (HIV) infection.

  1990cited by this paper
• Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality.

  1989cited by this paper
• Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.

  1989cited by this paper
• Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

  1989cited by this paper
• IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

  1988cited by this paper
• Biologic features of HIV-1 that correlate with virulence in the host.

  1988cited by this paper
• Replicative capacity of human immunodeficiency virus from patients with varying severity of HIV infection.

  1986cited by this paper
• Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1

  1985cited by this paper

• Assessment of Metabolic, Inflammatory, and Immunological Disorders Using a New Panel of Plasma Parameters in People Living with HIV Undergoing Antiretroviral Therapy—A Retrospective Study

  2024cites this paper
• Impact of IL-6 and IL-6r variants on HIV-1 susceptibility and progression to AIDS: a case-control study in a Moroccan population

  2024cites this paper
• IL-4 gene polymorphisms and their association with nematodes infection in Pakistani population

  2022cites this paper
• Differences in Expression of Selected Interleukins in HIV-Infected Subjects Undergoing Antiretroviral Therapy

  2022cites this paper
• Redo Percutaneous Mitral Valvuloplasty (Redo PMV) in Patients with Recurrent Mitral Valve Stenosis

  2020cites this paper
• Cytokine gene polymorphisms among North Indians: Implications for genetic predisposition?

  2019cites this paper
• Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis

  2018cites this paper
• Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis

  2018cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Insights from host genomics into HIV infection and disease: Identification of host targets for drug development.

  2013cites this paper
• Polymorphisms in major cytokine genes: a study among human immunodeficiency Virus-1 serodiscordant couples in Mumbai, India.

  2013cites this paper
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  2013cites this paper
• Monitoring HAART in HIV-infected patients in Thailand : Comparison of two strategies to monitor ARV treatment, based on CD4 cell count or viral load, to ensure optimal immunological and clinical outcome and preserve future treatment options in AIDS patients

  2012cites this paper
• Genome-wide association studies on HIV susceptibility, pathogenesis and pharmacogenomics

  2012cites this paper
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  2012cites this paper
• HIV-1 control in battlegrounds: important host genetic variations for HIV-1 mother-to-child transmission and progression to clinical pediatric AIDS

  2012cites this paper
• Frequencies of IL10 SNP genotypes by multiplex PCR-SSP and their association with viral load and CD4 counts in HIV-1-infected Thais.

  2011cites this paper
• Identification of Three Immunologic Correlates for HIV Type 1 Pathogenesis in Youth

  2011cites this paper
• Host genetic polymorphisms associated with innate immune factors and HIV-1.

  2011cites this paper
• The relationship between polymorphisms of interleukin-4 gene and silicosis.

  2011cites this paper
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  2011cites this paper
• Polimorfismos de nucleotídeo simples (SNPs) em genes codificadores de citocinas e suas correlações com parâmetros clínicos e laboratoriais de pacientes portadores do Vírus da Imunodeficiência Humana

  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2007cites this paper
• Adaptative Immune Responses in HIV-1 Infection

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
• Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection

  2006cites this paper
• Dengue and dengue haemorrhagic fever: implications of host genetics.

  2006cites this paper
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  2006cites this paper
• Host polymorphism in steps of the HIV-1 lifecycle after entry and other genetic variants influencing HIV-1 pathogenesis

  2006cites this paper
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  2006cites this paper
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  2006cites this paper
• Protective Effects of IL4-589T and RANTES-28G on HIV-1 disease progression in infected Thai females

  2006cites this paper
• Genetic aspects of HIV-1 risk in an African setting

  2006influential citation
• Host genetics of HIV-1 susceptibility

  2006cites this paper
• Factores inmunogenéticos relacionados con la resistencia/susceptibilidad a la infección por el VIH-1 y su progresión hacia SIDA

  2006cites this paper
• Effect of cytokine genotypes on the hepatitis B virus‐hepatocellular carcinoma association

  2005cites this paper
• An investigation into the role of collectins in tuberculosis infection

  2005cites this paper
• Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study

  2005cites this paper
• Genetic and Environmental Factors in the Immunopathogenesis of Atopy: Interaction of Helicobacter pylori Infection and IL4 Genetics

  2005cites this paper
• Polymorphisms in the interleukin-4 receptor α chain gene influence susceptibility to HIV-1 infection and its progression to AIDS

  2005cites this paper
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  2005cites this paper
• Allelic polymorphisms in the repeat and promoter regions of the interleukin‐4 gene and malaria severity in Ghanaian children

  2004cites this paper
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  2004influential citation
• HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination

  2004cites this paper
• Genetics of infectious diseases.

  2004cites this paper
• Cytokine and Chemokine Gene Polymorphisms Among Ethnically Diverse North Americans With HIV-1 Infection

  2004cites this paper
• The role of polymorphisms in chemokines and chemokine receptors in the clinical course of HIV-1 infection

  2004cites this paper
• Does AID aid AIDS?

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• Genetic Analysis of Cytokine Promoters in Nonhuman Primates: Implications for Th1/Th2 Profile Characteristics and SIV Disease Pathogenesis

  2004cites this paper
• Positive selection on a human-specific transcription factor binding site regulating IL4 expression.

  2003cites this paper
• The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy.

  2003cites this paper
• Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma.

  2003cites this paper
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  2003cites this paper
• Association between an interleukin-4 promoter polymorphism and the acquisition of CXCR4 using HIV-1 variants

  2003cites this paper
• IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai

  2003cites this paper
• Haplotype diversity in the interleukin-4 gene is not associated with HIV-1 transmission and AIDS progression

  2003influential citation
• The impact of human allelic variation on HIV-1 disease.

  2003cites this paper
• Polymorphisms in the IL-4 and IL-4R [α] Genes and Allergic Asthma

  2003cites this paper
• Chapter 12 – The Role of Host Genetic Variation in HIV Infection and its Manifestations

  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
• Genetic control of HIV disease.

  2003cites this paper
• Protective effect of interleukin-4 -589T polymorphism on human immunodeficiency virus type 1 disease progression: relationship with virus load.

  2002cites this paper
• Host Genetic Factors in the Clinical Course of HIV-1 Infection: Chemokines and Chemokine Receptors

  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper