Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Psychosomatic Research

• Publication date

  2007-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.JPSYCHORES.2006.09.007PMID 17270579
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The stress system in the human brain in depression and neurodegeneration.

  2005cited by this paper
• Effects of adding ribavirin to interferon to treat chronic hepatitis C infection: a systematic review and meta-analysis of randomized trials.

  2005cited by this paper
• Salivary cortisol response to awakening in chronic fatigue syndrome

  2004cited by this paper
• The Awakening Cortisol Response: Methodological Issues and Significance

  2004cited by this paper
• Cytokines and psychopathology: lessons from interferon-alpha.

  2004cited by this paper
• Early increase in vegetative symptoms predicts IFN-α-induced cognitive-depressive changes

  2004cited by this paper
• Differences in cortisol awakening response on work days and weekends in women and men from the Whitehall II cohort.

  2004cited by this paper
• Characteristics and circumstances of homicidal acts committed by offenders with schizophrenia

  2004cited by this paper
• Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change.

  2003cited by this paper
• Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy.

  2003cited by this paper
• Self-Reported Depressive Symptoms and Stress Levels in Healthy Young Men: Associations With the Cortisol Response to Awakening

  2003cited by this paper
• Increase in concentration of waking salivary cortisol in recovered patients with depression.

  2003cited by this paper
• Cytokines: regulation of the hypothalamo-pituitary-adrenocortical axis.

  2003cited by this paper
• A prospective study of neuropsychiatric symptoms associated with interferon-alpha-2b and ribavirin therapy for patients with chronic hepatitis C.

  2003cited by this paper
• Neuroendocrine aspects of the response to stress.

  2002cited by this paper
• Increased Depressive Ratings in Patients With Hepatitis C Receiving Interferon-α–Based Immunotherapy Are Related to Interferon-α–Induced Changes in the Serotonergic System

  2002cited by this paper
• Personality, brain asymmetry, and neuroendocrine reactivity in two immune-mediated disorders: a preliminary report.

  2002cited by this paper
• Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system.

  2002cited by this paper
• Acute effects of low-dose interferon-alpha on serum cortisol and plasma interleukin-6.

  2002cited by this paper
• A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C

  2002cited by this paper
• Acute effects of low-dose interferon-α on serum cortisol and plasma interleukin-6

  2002cited by this paper
• Salivary cortisol levels in children adopted from Romanian orphanages

  2001cited by this paper
• The relationship of depression and stressors to immunological assays: a meta-analytic review.

  2001cited by this paper
• Paroxetine for the prevention of depression induced by high-dose interferon alfa.

  2001cited by this paper
• Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis.

  2001cited by this paper
• Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms.

  2001cited by this paper
• The Corticosteroid Receptor Hypothesis of Depression

  2000cited by this paper
• Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action.

  1999cited by this paper
• The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm.

  1999cited by this paper
• Effects of Cytokines on Glucocorticoid Receptor Expression And Function

  1999cited by this paper
• Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression.

  1999cited by this paper
• The effects of interferon-alpha on the production and action of other cytokines.

  1998cited by this paper
• The effects of interferon-alpha on the production and action of other cytokines.

  1998cited by this paper
• Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: a re-evaluation study.

  1998cited by this paper
• The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses.

  1998cited by this paper
• Increased 24‐hour urinary cortisol excretion in patients with post‐traumatic stress disorder and patients with major depression, but not h patients with fibromyalgia

  1998cited by this paper
• Antidepressants restore hypothalamic-pituitary-adrenal feedback function in aged, cognitively-impaired rats.

  1997cited by this paper
• Indicators of immune activation in major depression.

  1996cited by this paper
• Dexamethasone inhibition of interferon-alpha 2-induced stimulation of cortisol and growth hormone secretion in chronic myeloproliferative syndrome.

  1995cited by this paper
• Evidence for an immune response in major depression: a review and hypothesis.

  1995cited by this paper
• Increase in serum interleukin-6, plasma ACTH and serum cortisol levels after systemic interferon-alpha administration.

  1995cited by this paper
• Interferon-alpha stimulates the hypothalamic-pituitary-adrenal axis in vivo and in vitro.

  1993cited by this paper
• Interferon-α Stimulates the Hypothalamic- Pituitary-Adrenal Axis in vivo and in vitro

  1993cited by this paper
• Interferon-alpha-2-induced stimulation of ACTH and cortisol secretion in man.

  1991cited by this paper
• Human corticotropin-releasing hormone in depression--correlation with thyrotropin secretion following thyrotropin-releasing hormone.

  1986cited by this paper
• Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease. Pathophysiologic and diagnostic implications.

  1986cited by this paper
• Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.

  1984cited by this paper
• A New Depression Scale Designed to be Sensitive to Change

  1979cited by this paper
• Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction.

  1976cited by this paper
• Development of a rating scale for primary depressive illness.

  1967cited by this paper

• Minocycline accelerates recovery of sickness behavior score in septic rats

  2026cites this paper
• Inflammatory models of depression in rodents and humans

  2026cites this paper
• Maternal separation alters peripheral immune responses associated with IFN-γ and OT in mice.

  2024cites this paper
• Interferon therapy and its association with depressive disorders – A review

  2023cites this paper
• Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

  2023cites this paper
• Effects of Interferon-α on Depressive-Like Behavior and Brain Neurochemistry in Rats Housed in Standard and Overcrowding Conditions

  2023cites this paper
• Lower Levels of GABAergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the sgACC of Human Subjects With Depression

  2022cites this paper
• A chicken and egg scenario in psychoneuroimmunology: Bidirectional mechanisms linking cytokines and depression

  2021cites this paper
• [Importance of cognitive disorders in internal medicine: Pathophysiology, diagnosis, management. The example of systemic lupus erythematosus].

  2021cites this paper
• Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases

  2020influential citation
• An Overview of the Heterogeneity of Major Depressive Disorder: Current Knowledge and Future Prospective

  2020cites this paper
• Intranasal interferon beta improves memory and modulates inflammatory responses in a mutant APP-overexpressing rat model of Alzheimer's disease.

  2019cites this paper
• Beyond a neurotransmitter: The role of serotonin in inflammation and immunity.

  2019cites this paper
• Individual differences in inflammatory and oxidative mechanisms of stress-related mood disorders.

  2019cites this paper
• Effects of Motivation-Based Academic Group Psychotherapy on Psychological and Physiological Academic Stress Responses among Korean Middle School Students

  2019cites this paper
• N-methyl-D-aspartate receptor antagonists decrease interferon-alpha induced depressive behavior in mice model of despair

  2019influential citation
• A longitudinal study assessing depression in hepatitis C: Does gender play a role in the new-onset depression during interferon-alpha treatment?

  2018cites this paper
• L’immunopsychiatrie existe-t-elle ?

  2018cites this paper
• Behavioral Symptoms of Anxiety and Depression and Brain Monoamine Contents in Rats after Chronic Intranasal Administration of Interferon-α

  2018cites this paper
• Within-subject associations between inflammation and features of depression: Using the flu vaccine as a mild inflammatory stimulus.

  2018cites this paper
• What does plasma CRP tell us about peripheral and central inflammation in depression?

  2018cites this paper
• The neurobiology of depression: An integrated view.

  2017cites this paper
• Suppression of pro‐inflammatory cytokine expression and lack of anti‐depressant‐like effect of fluoxetine in lipopolysaccharide‐treated old female mice

  2017cites this paper
• Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?

  2017cites this paper
• Fatigue and inflammation : a psychoneuroimmunological approach o chronic fatigue

  2017cites this paper
• Somatization disorder: Are we moving towards an over-generalized and over-inclusive diagnosis in DSM-V?

  2017cites this paper
• Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances

  2016influential citation
• DEPRESSIVE EPISODE INCIDENCE IN PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN.

  2016influential citation
• An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment

  2016cites this paper
• Stress-Related Immune Markers in Depression: Implications for Treatment

  2016cites this paper
• Functional Polymorphism in the Interleukin 6 (IL6) Gene with Respect to Depression Induced in the Course of Interferon-α and Ribavirin Treatment in Chronic Hepatitis Patients

  2016cites this paper
• Pathogen–Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance

  2016cites this paper
• THE RELATIONSHIP BETWEEN TRAINING LOAD, CORTISOL AWAKENING RESPONSE AND ORTHOSTATIC HEART RATE

  2016cites this paper
• Adult Neurogenesis and Mental Illness

  2015cites this paper
• Incidência de episódio depressivo em pacientes com hepatite C crônica tratados com interferon peguilado e ribavirina

  2015cites this paper
• Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats.

  2015cites this paper
• Lupus brain fog: a biologic perspective on cognitive impairment, depression, and fatigue in systemic lupus erythematosus

  2015cites this paper
• Glia in the cytokine-mediated onset of depression: fine tuning the immune response

  2015cites this paper
• Lupus brain fog: a biologic perspective on cognitive impairment, depression, and fatigue in systemic lupus erythematosus

  2015cites this paper
• Melanoma tumors alter proinflammatory cytokine production and monoamine brain function, and induce depressive-like behavior in male mice.

  2014cites this paper
• Inflamed moods: a review of the interactions between inflammation and mood disorders.

  2014cites this paper
• Insights from interferon-α-related depression for the pathogenesis of depression associated with inflammation.

  2014cites this paper
• The Immune System and Electroconvulsive Therapy for Depression

  2014cites this paper
• Pegylated Interferon Pharmacokinetics and Self-Reported Depressive Symptoms During Antiviral Treatment for Chronic Hepatitis C

  2014cites this paper
• Biological phenotypes underpin the physio‐somatic symptoms of somatization, depression, and chronic fatigue syndrome

  2014cites this paper
• Rapid Regulation of Depression-Associated Genes in a New Mouse Model Mimicking Interferon-α-Related Depression in Hepatitis C Virus Infection

  2014cites this paper
• A Conceptual Model of Psychoneurological Symptom Cluster Variation in Women with Breast Cancer: Bringing Nursing Research to Personalized Medicine.

  2013cites this paper
• Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration.

  2013cites this paper
• Women in recovery from PTSD have similar inflammation and quality of life as non-traumatized controls.

  2013cites this paper
• [Roles of cytokines in stress-induced depression].

  2013cites this paper
• Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations.

  2013cites this paper
• Vitamin D and Multiple Sclerosis : immunological and clinical outcome

  2013cites this paper
• Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review

  2013cites this paper
• Inflammation and depression.

  2013cites this paper
• Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways.

  2013cites this paper
• Antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action.

  2013cites this paper
• Concomitant Interferon Alpha Stimulation and TLR3 Activation Induces Neuronal Expression of Depression-Related Genes That Are Elevated in the Brain of Suicidal Persons

  2013cites this paper
• A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior

  2013cites this paper
• Central administration of murine interferon-α induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: a mini-review and original experiments.

  2013cites this paper
• [HIV, depression and compliance: the mediating role of cytokines. A review of the international literature].

  2013cites this paper
• Cognitive, biological and psychosocial factors predicting interferon-alpha-induced depression

  2013influential citation
• Effects of Antidepressants on Cytokine Alterations in Serum and Depressive-like Behavior After Lipopolysaccharide Administration in Mice

  2013cites this paper
• Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.

  2013cites this paper
• Neuroimaging and Clinical Studies on Brain–Immune Interactions

  2013cites this paper
• A Role for Orexin Neuron Activity in Cytotoxic Chemotherapy-Induced Fatigue

  2013cites this paper
• Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims.

  2012cites this paper
• Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

  2012cites this paper
• Selective Hyper-responsiveness of the Interferon System in Major Depressive Disorders and Depression Induced by Interferon Therapy

  2012cites this paper
• The Canadian Network for Mood and Anxiety Treatments (Canmat) Task Force Recommendations for the Management of Patients with Mood Disorders and Select Comorbid Medical Conditions

  2012cites this paper
• Pre-treatment waking cortisol response and vulnerability to interferon α induced depression.

  2012cites this paper
• Indoleamine 2,3-Dioxygenase Activation and Depressive Symptoms: Results From the Young Finns Study

  2012cites this paper
• Understanding clinical risk decision making regarding development of depression during interferon-alpha treatment for hepatitis-C: a qualitative interview study.

  2012cites this paper
• The Canadian Network for Mood and Anxiety Treatments (Canmat) Task Force Recommendations for the Management of Patients with Mood Disorders and Comorbid Substance Use Disorders

  2012cites this paper
• A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase

  2011cites this paper
• Association between increased tryptophan degradation and depression in cancer patients

  2011cites this paper
• Suicide risk in hepatitis C and during interferon‐alpha therapy: a review and clinical update

  2011cites this paper
• Is Depression an Inflammatory Disorder?

  2011cites this paper
• Melatonin Kynurenic acid Xanthurenic acid 3-Hydroxy anthranilic acid NAD 3-Hydroxy kynurenine Quinolinic acid Anthranilic acid * ¶

  2011cites this paper
• The Role of Inflammation in the Pathophysiology of Depression: Different Treatments and Their Effects

  2011cites this paper
• Vascular Pathology and Blood-Brain Barrier Disruption in Cognitive and Psychiatric Complications of Type 2 Diabetes Mellitus

  2011cites this paper
• Persistent pro‐inflammatory cytokines following the initiation of pegylated IFN therapy in hepatitis C infection is associated with treatment‐induced depression

  2011cites this paper
• Risk factors for the development of depression in patients with hepatitis C taking interferon-α

  2011cites this paper
• Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression.

  2011cites this paper
• Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?

  2011influential citation
• Blood-Brain Barrier Breakdown and Blood-Brain Communication in Neurological and Psychiatric Diseases

  2011cites this paper
• Treatments and Their Effects The Role of Inflammation in the Pathophysiology of Depression : Different

  2011cites this paper
• Association of a Polymorphism in the Indoleamine-2,3-Dioxygenase Gene and Interferon-α-Induced Depression in Patients with Chronic Hepatitis C

  2011cites this paper
• The liver‐cytokine‐brain circuit in interferon‐based treatment of patients with chronic viral hepatitis

  2011cites this paper
• Immune system to brain signaling: neuropsychopharmacological implications.

  2011cites this paper
• Regulatory T cells increased while IL-1β decreased during antidepressant therapy.

  2010cites this paper
• Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol.

  2010cites this paper
• Labile Anger During Interferon Alfa Treatment is Associated With a Polymorphism in Tumor Necrosis Factor &agr;

  2010cites this paper
• A Review of Sleep Disturbance in Hepatitis C

  2010cites this paper
• Sustained elevation of serum interleukin-6 and relative insensitivity to hydrocortisone differentiates posttraumatic stress disorder with and without depression.

  2010cites this paper
• Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior

  2010cites this paper
• Psychological and biological mechanisms of cytokine induced depression

  2010cites this paper
• Psychobiological differences between depression and somatization.

  2010cites this paper
• A critical review of human endotoxin administration as an experimental paradigm of depression.

  2010cites this paper
• Pegylated interferon and ribavirin-induced depression in chronic hepatitis C: role of personality.

  2009cites this paper
• Changes in immune and endocrine systems in posttraumatic stress disorder – prospective study

  2009cites this paper