Neuronal Ca(2+) sensor 1. Characterization of the myristoylated protein, its cellular effects in permeabilized adrenal chromaffin cells, Ca(2+)-independent membrane association, and interaction with binding proteins, suggesting a role in rapid Ca(2+) signal transduction.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Biological Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10514519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function

  1999cited by this paper
• Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase

  1999cited by this paper
• Role of carboxyl-terminal charges on S-modulin membrane affinity and inhibition of rhodopsin phosphorylation.

  1999cited by this paper
• Neuronal Ca2+ Sensor 1, the Mammalian Homologue of Frequenin, Is Expressed in Chromaffin and PC12 Cells and Regulates Neurosecretion from Dense-core Granules*

  1998cited by this paper
• Examination of the Role of ADP‐Ribosylation Factor and Phospholipase D Activation in Regulated Exocytosis in Chromaffin and PC12 Cells

  1998cited by this paper
• Molecular mechanics of calcium–myristoyl switches

  1997cited by this paper
• NSF and SNAP are present on adrenal chromaffin granules

  1997cited by this paper
• Calcium Binding, but Not a Calcium-Myristoyl Switch, Controls the Ability of Guanylyl Cyclase-activating Protein GCAP-2 to Regulate Photoreceptor Guanylyl Cyclase*

  1997cited by this paper
• The Neuronal Calcium‐Sensor Protein VILIP Modulates Cyclic AMP Accumulation in Stably Transfected C6 Glioma Cells: Amino‐Terminal Myristoylation Determines Functional Activity

  1997cited by this paper
• The Ca2+ binding protein, frequenin is a nervous system-specific protein in mouse preferentially localized in neurites.

  1997cited by this paper
• Direct modulation of calmodulin targets by the neuronal calcium sensor NCS-1.

  1996cited by this paper
• Drosophila Neurocalcin, a Fatty Acylated, Ca-binding Protein that Associates with Membranes and Inhibits in Vitro Phosphorylation of Bovine Rhodopsin (*)

  1996cited by this paper
• Calcium and membrane binding properties of bovine neurocalcin delta expressed in Escherichia coli.

  1995cited by this paper
• Regulation of rhodopsin phosphorylation by a family of neuronal calcium sensors.

  1995cited by this paper
• Ca-dependent Interaction of Recoverin with Rhodopsin Kinase (*)

  1995cited by this paper
• A role for soluble NSF attachment proteins (SNAPs) in regulated exocytosis in adrenal chromaffin cells.

  1995cited by this paper
• Expression and characterization of calcium-myristoyl switch proteins.

  1995cited by this paper
• Molecular cloning and functional characterization of the Xenopus Ca(2+)-binding protein frequenin.

  1995cited by this paper
• Identification of neuronal calcium sensor (NCS-1) possibly involved in the regulation of receptor phosphorylation.

  1995cited by this paper
• Inhibition of Rhodopsin Kinase by Recoverin

  1995cited by this paper
• Distinct effects of alpha-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis

  1995cited by this paper
• Implication of frequenin in the facilitation of transmitter release in Drosophila.

  1994cited by this paper
• Cation binding and conformational changes in VILIP and NCS-1, two neuron-specific calcium-binding proteins.

  1994cited by this paper
• Modulation of type A K+ current inDrosophila larval muscle by internal Ca2+; effects of the overexpression of frequenin

  1994cited by this paper
• Frequenin--a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system.

  1993cited by this paper
• Identification of Exo2 as the catalytic subunit of protein kinase A reveals a role for cyclic AMP in Ca(2+)‐dependent exocytosis in chromaffin cells.

  1993cited by this paper
• Regulated exocytosis.

  1993cited by this paper
• Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties.

  1993cited by this paper
• Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system.

  1992cited by this paper
• VILIP, a cognate protein of the retinal calcium binding proteins visinin and recoverin, is expressed in the developing chicken brain.

  1992cited by this paper
• Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells.

  1992cited by this paper
• Calcium-myristoyl protein switch.

  1992cited by this paper
• Cloning, expression, and crystallization of recoverin, a calcium sensor in vision.

  1992cited by this paper
• Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus.

  1992cited by this paper
• Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase

  1991cited by this paper
• Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.

  1990cited by this paper
• A role for calpactin in calcium-dependent exocytosis in adrenal chromaffin cells

  1989cited by this paper
• The biology and enzymology of eukaryotic protein acylation.

  1988cited by this paper
• A rapid and sensitive method for detection and quantification of calcineurin and calmodulin-binding proteins using biotinylated calmodulin.

  1985cited by this paper

• Calcium-Associated Proteins in Neuroregeneration

  2024cites this paper
• Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways

  2023influential citation
• The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A

  2023cites this paper
• Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3

  2023cites this paper
• Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder

  2023cites this paper
• Conformational dynamics and target-dependent myristoyl switch of calcineurin B homologous protein 3

  2023cites this paper
• The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A

  2022influential citation
• Membrane Binding of Neuronal Calcium Sensor-1: Highly Specific Interaction with Phosphatidylinositol-3-Phosphate

  2020cites this paper
• Hlutverk innansameinda-óreiðu í Neuronal Calcium Sensor-1

  2020cites this paper
• A Novel Approach to Bacterial Expression and Purification of Myristoylated Forms of Neuronal Calcium Sensor Proteins

  2020cites this paper
• Calcium Sensors in Neuronal Function and Dysfunction.

  2019cites this paper
• The Complex Conformational Dynamics of Neuronal Calcium Sensor-1: A Single Molecule Perspective

  2018cites this paper
• Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators.

  2018cites this paper
• Photoreceptor calcium sensor proteins in detergent-resistant membrane rafts are regulated via binding to caveolin-1.

  2018cites this paper
• Characterisation of the Ca2+ signaling pathway involved in the control of temperature dependent locomotion by Neuronal Calcium Sensor-1 in Caenorhabditis elegans

  2017cites this paper
• Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome

  2017cites this paper
• Identification of critical amino acid residues and functional conservation of the Neurospora crassa and Rattus norvegicus orthologues of neuronal calcium sensor-1

  2016cites this paper
• Integrative Signaling Networks of Membrane Guanylate Cyclases: Biochemistry and Physiology

  2016cites this paper
• Membrane binding of Neuronal Calcium Sensor-1 (NCS1).

  2016cites this paper
• Ca2+ -myristoyl switch in neuronal calcium sensor-1: a role of C-terminal segment.

  2015cites this paper
• Demonstration of Binding of Neuronal Calcium Sensor-1 to the Cav2.1 P/Q-Type Calcium Channel

  2014cites this paper
• Neuronal calcium signaling: function and dysfunction

  2014cites this paper
• Demonstration of Neuronal Calcium Sensor-1 binding to the Cav2.1 P/Q-type calcium channel

  2014cites this paper
• Cinderella story: PI4P goes from precursor to key signaling molecule

  2014cites this paper
• Single-molecule folding mechanism of an EF-hand neuronal calcium sensor.

  2013cites this paper
• The Structure of Neuronal Calcium Sensor-1 in Solution Revealed by Molecular Dynamics Simulations

  2013cites this paper
• Role of neuronal calcium sensor-1 in the cardiovascular system.

  2012influential citation
• Differential effects of swimming training on neuronal calcium sensor-1 expression in rat hippocampus/cortex and in object recognition memory tasks.

  2012cites this paper
• Understanding the physiological roles of the neuronal calcium sensor proteins

  2012cites this paper
• Multiple Roles for Frequenin/NCS-1 in Synaptic Function and Development

  2012cites this paper
• Ca(2+) signaling mechanisms in bovine adrenal chromaffin cells.

  2012cites this paper
• The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺₋ activated state.

  2012cites this paper
• NCS-1 Protein upregulation Facilitates Chronic Hypoxia-induced Respiratory Adaptation in Lymnaea stagnalis

  2012influential citation
• The presence of membranes or micelles induces structural changes of the myristoylated guanylate-cyclase activating protein-2

  2011cites this paper
• Characterisation of the Interaction of the C-Terminus of the Dopamine D2 Receptor with Neuronal Calcium Sensor-1

  2011cites this paper
• The myristoylation of guanylate cyclase‐activating protein‐2 causes an increase in thermodynamic stability in the presence but not in the absence of Ca2+

  2011cites this paper
• Divalent Cations and Redox Conditions Regulate the Molecular Structure and Function of Visinin-Like Protein-1

  2011cites this paper
• Structural and Functional Deficits in a Neuronal Calcium Sensor-1 Mutant Identified in a Case of Autistic Spectrum Disorder

  2010cites this paper
• Neuronal Calcium Sensor-1 Regulation of Calcium Channels, Secretion, and Neuronal Outgrowth

  2010cites this paper
• Frequenin/NCS-1 and the Ca2+-channel α1-subunit co-regulate synaptic transmission and nerve-terminal growth

  2009cites this paper
• Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking

  2009cites this paper
• Hippocalcin, new Ca2+ sensor of a ROS-GC subfamily member, ONE-GC, membrane guanylate cyclase transduction system

  2009cites this paper
• Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli.

  2008cites this paper
• Neuronal calcium sensor proteins are unable to modulate NFAT activation in mammalian cells

  2008cites this paper
• Characterization of the myristoyl lipid modification of membrane-bound GCAP-2 by 2H solid-state NMR spectroscopy.

  2007cites this paper
• AT4 receptor activation increases intracellular calcium influx and induces a non-N-methyl-D-aspartate dependent form of long-term potentiation.

  2006cites this paper
• Identification of transcriptional regulators of neuropeptide FF gene expression.

  2006cites this paper
• Analysis of the interacting partners of the neuronal calcium‐binding proteins L‐CaBP1, hippocalcin, NCS‐1 and neurocalcin δ

  2006cites this paper
• Novel frequenin-modulated Ca2+-signaling membrane guanylate cyclase (ROS-GC) transduction pathway in bovine hippocampus

  2006influential citation
• The Interaction between Calcium- and Integrin-binding Protein 1 and the αIIb Integrin Cytoplasmic Domain Involves a Novel C-terminal Displacement Mechanism*

  2006cites this paper
• Functional Implication of Neuronal Calcium Sensor-1 and Phosphoinositol 4-Kinase-β Interaction in Regulated Exocytosis of PC12 Cells*

  2006cites this paper
• A Flagellum-specific Calcium Sensor*

  2005cites this paper
• Neuronal calcium sensor‐1 facilitates neuronal exocytosis through phosphatidylinositol 4‐kinase

  2005cites this paper
• X-linked mental retardation

  2005cites this paper
• Localization of neuronal calcium sensor‐1 at the adult and developing rat neuromuscular junction

  2005cites this paper
• High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate.

  2005cites this paper
• Functional study of neuronal calcium sensor-1 (NCS-1) in yeast and mice : a role for NCS-1 in learning and memory

  2005cites this paper
• Agonist-induced inhibition of the m-current : involvement of the phosphoinositide cycle.

  2004cites this paper
• Calcium-binding Protein 1 Is an Inhibitor of Agonist-evoked, Inositol 1,4,5-Trisphosphate-mediated Calcium Signaling*

  2004cites this paper
• Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function.

  2004cites this paper
• N-terminal Myristoylation Regulates Calcium-induced Conformational Changes in Neuronal Calcium Sensor-1*

  2004cites this paper
• Identification of Residues That Determine the Absence of a Ca2+/Myristoyl Switch in Neuronal Calcium Sensor-1*

  2004cites this paper
• Activity-dependent regulation of the subcellular localization of neuronal calcium sensor-1 in the avian cochlear nucleus.

  2003cites this paper
• Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1

  2003cites this paper
• Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity?

  2003cites this paper
• Targeted Gene Disruption of the Neuronal Calcium Sensor 1 Homologue in Rice Blast Fungus, Magnaporthe grisea

  2003cites this paper
• Residues within the myristoylation motif determine intracellular targeting of the neuronal Ca2+ sensor protein KChIP1 to post-ER transport vesicles and traffic of Kv4 K+ channels

  2003cites this paper
• Down-regulation of Voltage-gated Ca2+ Channels by Neuronal Calcium Sensor-1 Is β Subunit-specific*

  2003cites this paper
• Identification and Subcellular Localization of Neuronal Calcium Sensor-1 (NCS-1) in Human Neutrophils and HL-60 Cells

  2003cites this paper
• The EF-hand Ca2+-binding protein p22 plays a role in microtubule and endoplasmic reticulum organization and dynamics with distinct Ca2+-binding requirements.

  2003cites this paper
• A Novel Ca2+-induced Ca2+ Release Mechanism in A7r5 Cells Regulated by Calmodulin-like Proteins*

  2003cites this paper
• Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3.

  2003cites this paper
• Neuronal calcium sensor-1: a multifunctional regulator of secretion.

  2003cites this paper
• IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis.

  2003cites this paper
• Differential Use of Myristoyl Groups on Neuronal Calcium Sensor Proteins as a Determinant of Spatio-temporal Aspects of Ca2+ Signal Transduction*

  2002cites this paper
• Neuronal calcium sensor-1 binds to regulated secretory organelles and functions in basal and stimulated exocytosis in PC12 cells.

  2002influential citation
• Mechanisms Underlying the Neuronal Calcium Sensor-1-evoked Enhancement of Exocytosis in PC12 Cells*

  2002cites this paper
• Modulation of Kv4-encoded K+ Currents in the Mammalian Myocardium by Neuronal Calcium Sensor-1*

  2002cites this paper
• Biochemical and immunocytochemical characterization of calsenilin in mouse brain.

  2002cites this paper
• Reversible Translocation and Activity-Dependent Localization of the Calcium–Myristoyl Switch Protein VILIP-1 to Different Membrane Compartments in Living Hippocampal Neurons

  2002cites this paper
• Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase β interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis

  2002cites this paper
• Interaction with Neuronal Calcium Sensor NCS-1 Mediates Desensitization of the D2 Dopamine Receptor

  2002cites this paper
• Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin.

  2002cites this paper
• A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents

  2001cites this paper
• Calsenilin Is a Substrate for Caspase-3 That Preferentially Interacts with the Familial Alzheimer's Disease-associated C-terminal Fragment of Presenilin 2*

  2001cites this paper
• Over-expression of NCS-1 in AtT-20 cells affects ACTH secretion and storage.

  2001cites this paper
• Immunocytochemical Localization and Crystal Structure of Human Frequenin (Neuronal Calcium Sensor 1)*

  2001cites this paper
• Phosphorylation of Cysteine String Protein by Protein Kinase A

  2001cites this paper
• The distribution of neuronal calcium sensor-1 protein in the developing and adult rat retina

  2001cites this paper
• Overexpression of rat neuronal calcium sensor‐1 in rodent NG108‐15 cells enhances synapse formation and transmission

  2001cites this paper
• Regulated expression of the neuronal calcium sensor-1 gene during long-term potentiation in the dentate gyrus in vivo.

  2001cites this paper
• Immunochemical assessment of neural visinin-like calcium-binding protein 3 expression in rat brain.

  2001cites this paper
• Interaction of Neuronal Calcium Sensor-1 (NCS-1) with Phosphatidylinositol 4-Kinase β Stimulates Lipid Kinase Activity and Affects Membrane Trafficking in COS-7 Cells*

  2001cites this paper
• Voltage-independent Inhibition of P/Q-type Ca2+Channels in Adrenal Chromaffin Cells via a Neuronal Ca2+Sensor-1-dependent Pathway Involves Src Family Tyrosine Kinase*

  2001cites this paper
• Synaptic vesicle endocytosis

  2000cites this paper
• Purification of myristoylated and nonmyristoylated neuronal calcium sensor-1 using single-step hydrophobic interaction chromatography.

  2000cites this paper
• The neuronal calcium sensor family of Ca2+-binding proteins.

  2000cites this paper
• PtdIns 4‐kinaseβ and neuronal calcium sensor‐1 co‐localize but may not directly associate in mammalian neurons

  2000cites this paper
• Expression of the neuronal calcium sensor protein family in the rat brain.

  2000cites this paper
• Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1).

  2000cites this paper