The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Cold Spring Harbor Perspectives in Medicine

• Publication date

  2017-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/cshperspect.a026708PMID 28193767PMCID PMC5453381
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Arabidopsis thaliana

  2022cited by this paper
• Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

  2016cited by this paper
• Nucleosome Binding Alters the Substrate Bonding Environment of Histone H3 Lysine 36 Methyltransferase NSD2.

  2016cited by this paper
• Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36

  2016cited by this paper
• A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin*

  2016influential reference
• MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

  2016cited by this paper
• Structural basis for PHDVC5HCHNSD1–C2HRNizp1 interaction: implications for Sotos syndrome

  2016cited by this paper
• Dynamic behavior of the post‐SET loop region of NSD1: Implications for histone binding and drug development

  2016cited by this paper
• NSD3-NUT-expressing midline carcinoma of the lung: first characterization of primary cancer tissue.

  2015cited by this paper
• NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

  2015influential reference
• Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review

  2015cited by this paper
• NUT carcinoma of the thorax: Case report and review of the literature.

  2015cited by this paper
• TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.

  2015cited by this paper
• Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets

  2014cited by this paper
• A Sensitive Luminescent Assay for the Histone Methyltransferase NSD1 and Other SAM-Dependent Enzymes

  2014cited by this paper
• Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1.

  2014cited by this paper
• In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L

  2014influential reference
• Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

  2014influential reference
• Potent co-operation between the NUP98-NSD1 fusion and the FLT3-ITD mutation in acute myeloid leukemia induction

  2014influential reference
• NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

  2014influential reference
• Neural crest specification and migration independently require NSD3-related lysine methyltransferase activity

  2014cited by this paper
• Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

  2014influential reference
• A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro

  2014influential reference
• NUP98‐NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia

  2013cited by this paper
• Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer.

  2013cited by this paper
• Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

  2013cited by this paper
• PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.

  2013influential reference
• The phenotypic spectrum of duplication 5q35.2–q35.3 encompassing NSD1: Is it really a reversed sotos syndrome?

  2013cited by this paper
• Comparison Of Mutational Profiles Of Diagnosis and Relapsed Pediatric B-Acute Lymphoblastic Leukemia: A Report From The COG ALL Target Project

  2013influential reference
• The histone methyltransferase Wolf–Hirschhorn syndrome candidate 1‐like 1 (WHSC1L1) is involved in human carcinogenesis

  2013influential reference
• NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma.

  2013cited by this paper
• Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

  2013cited by this paper
• SET for life: biochemical activities and biological functions of SET domain-containing proteins.

  2013cited by this paper
• A transposon-based analysis of gene mutations related to skin cancer development.

  2013cited by this paper
• Deletions involving genes WHSC1 and LETM1 may be necessary, but are not sufficient to cause Wolf–Hirschhorn Syndrome

  2013cited by this paper
• Further Evidence of Contrasting Phenotypes Caused by Reciprocal Deletions and Duplications: Duplication of NSD1 Causes Growth Retardation and Microcephaly

  2013cited by this paper
• The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition*

  2012cited by this paper
• Mutations in EZH2 cause Weaver syndrome.

  2012cited by this paper
• Generation of the Sotos syndrome deletion in mice

  2012influential reference
• Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

  2012influential reference
• Mining Gene Expression Signature for the Detection of Pre-Malignant Melanocytes and Early Melanomas with Risk for Metastasis

  2012cited by this paper
• The Histone Methyltransferase MMSET/WHSC1 Activates TWIST1 to Promote an Epithelial-Mesenchymal Transition and Invasive Properties of Prostate Cancer

  2012cited by this paper
• Understanding the language of Lys36 methylation at histone H3

  2012cited by this paper
• The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity

  2012cited by this paper
• Inaugural article: Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

  2012cited by this paper
• Targeting MYC dependence in cancer by inhibiting BET bromodomains

  2011cited by this paper
• RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

  2011cited by this paper
• Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

  2011cited by this paper
• NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.

  2011influential reference
• MMSET is highly expressed and associated with aggressiveness in neuroblastoma.

  2011cited by this paper
• The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

  2011cited by this paper
• MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC

  2011cited by this paper
• Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

  2011cited by this paper
• The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors

  2011cited by this paper
• Cancers and the NSD family of histone lysine methyltransferases.

  2011cited by this paper
• The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

  2011influential reference
• NSD1 PHD domains bind methylated H3K4 and H3K9 using interactions disrupted by point mutations in human sotos syndrome

  2011cited by this paper
• Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

  2011cited by this paper
• MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

  2010cited by this paper
• Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

  2010cited by this paper
• The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation*

  2010influential reference
• Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

  2010cited by this paper
• Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function

  2010cited by this paper
• The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells.

  2010cited by this paper
• Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

  2010cited by this paper
• Transforming properties of 8p11-12 amplified genes in human breast cancer.

  2010influential reference
• Histone H3 Lysine 36 Dimethylation (H3K36me2) Is Sufficient to Recruit the Rpd3s Histone Deacetylase Complex and to Repress Spurious Transcription*

  2009influential reference
• NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes.

  2009cited by this paper
• Processing the H3K36me3 signature

  2009cited by this paper
• Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases

  2009cited by this paper
• Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

  2009cited by this paper
• A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

  2009cited by this paper
• The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate

  2009influential reference
• MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

  2009cited by this paper
• Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65

  2009cited by this paper
• Biased chromatin signatures around polyadenylation sites and exons.

  2009cited by this paper
• Multiple Myeloma-Related WHSC1/MMSET Isoform RE-IIBP Is a Histone Methyltransferase with Transcriptional Repression Activity

  2008cited by this paper
• Differential chromatin marking of introns and expressed exons by H3K36me3

  2008cited by this paper
• The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor.

  2008cited by this paper
• PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

  2008cited by this paper
• The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

  2008cited by this paper
• Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines.

  2008cited by this paper
• NUP98–NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis

  2007influential reference
• A site to remember: H3K36 methylation a mark for histone deacetylation.

  2007cited by this paper
• Drosophila dSet2 functions in H3-K36 methylation and is required for development.

  2007cited by this paper
• Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila

  2007cited by this paper
• High-resolution profiling of histone methylations in the human genome.

  2007cited by this paper
• MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism.

  2007cited by this paper
• SnapShot: Histone-modifying enzymes.

  2007cited by this paper
• Distinctive Signatures of Histone Methylation in Transcribed Coding and Noncoding Human β-Globin Sequences

  2006cited by this paper
• NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique

  2006cited by this paper
• Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.

  2006cited by this paper
• MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line

  2006cited by this paper
• Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity.

  2006influential reference
• NSD1 analysis for Sotos syndrome: Insights and perspectives from the clinical laboratory

  2005influential reference
• Multiple mechanisms are implicated in the generation of 5q35 microdeletions in Sotos syndrome

  2005cited by this paper
• Dimethylation of Histone H3 at Lysine 36 DemarcatesRegulatory and Nonregulatory ChromatinGenome-Wide

  2005cited by this paper
• The SET-domain protein superfamily: protein lysine methyltransferases

  2005cited by this paper
• The etiology of Wolf-Hirschhorn syndrome.

  2005cited by this paper
• High-resolution genomic profiles of human lung cancer.

  2005cited by this paper

• Effects of Spin4 ablation in aging mice: body composition, bone density, and malignancy prevalence

  2026cites this paper
• Many faces of mammalian NSD methyltransferases

  2026cites this paper
• Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition.

  2026cites this paper
• Targeting SETD2 in Cancer therapy: Structure, biological functions, and inhibitor development.

  2026cites this paper
• DNA methylation landscapes in human cells and their chromatin determinants

  2025cites this paper
• Loop Plasticity Drives Paralog-Specific Recognition in BET ET Domains

  2025cites this paper
• NSD Family-Mediated H3K36 Methylation in Human Cancer: Mechanisms and Therapeutic Opportunities

  2025cites this paper
• Synthesis of amide-linked panaxadiol-indolinedione derivatives: A novel NSD2/H3K36me2 epigenetic modulator with significant antitumor efficacy.

  2025cites this paper
• SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

  2025cites this paper
• SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation

  2025cites this paper
• Structural and Molecular Insight into the PWWP1 Domain of NSD2 from the Discovery of Novel Binders Via DNA-Encoded Library Screening.

  2025cites this paper
• REIIBP methylates nucleolar proteins and regulates pre-rRNA processing

  2025cites this paper
• NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers

  2025influential citation
• Sotos Syndrome With NSD1 Mutations in a Chinese Cohort: Identification of Two Novel Mutations and Literature Review

  2025cites this paper
• NSD proteins in anti-tumor immunity and their therapeutic targeting by protein degraders

  2025cites this paper
• Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma

  2025cites this paper
• Integrated Network Pharmacology, Molecular Modeling, LC–MS Profiling, and Semisynthetic Approach for the Roots of Rubia tinctorum L. Metabolites in Cancer Treatment

  2025cites this paper
• NSD3: A Promising Target for Cancer Therapy

  2025cites this paper
• H3K36me2 methyltransferase NSD2/WHSC1 promotes triple-negative breast cancer metastasis via activation of ULK1-dependent autophagy

  2025cites this paper
• The sotos syndrome gene Nsd1 safeguards developmental gene enhancers poised for transcription by maintaining the precise deposition of histone methylation

  2025cites this paper
• H3K36 Methylation as a Guardian of Epigenome Integrity

  2025cites this paper
• Targeting nuclear receptor-binding SET domain protein 2 (NSD2) for cancer therapy: Challenges and emerging strategies.

  2025cites this paper
• NSD2 targeting reverses plasticity and drug resistance in prostate cancer

  2025cites this paper
• Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader

  2024cites this paper
• NSD3 protein methylation and stabilization transforms human ES cells into variant state

  2024cites this paper
• The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma

  2024cites this paper
• The oncogenic role of the NSD histone methyltransferases in head and neck and cervical cancers

  2024cites this paper
• Identification of potential methyltransferase NSD2 enzymatic inhibitors through a multi-step structure-based drug design

  2024cites this paper
• Therapeutic targeting potential of the protein lysine and arginine methyltransferases to reverse cancer chemoresistance

  2024cites this paper
• Covalent inhibitors meet epigenetics: New opportunities.

  2024cites this paper
• Context-specific targeting of the androgen receptor in prostate cancer

  2024cites this paper
• NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

  2024cites this paper
• Histone H3 mutations and their impact on genome stability maintenance.

  2024cites this paper
• Unveiling the potential of phytochemicals to inhibit nuclear receptor binding SET domain protein 2 for cancer: Pharmacophore screening, molecular docking, ADME properties, and molecular dynamics simulation investigations

  2024cites this paper
• Epigenetic modulators provide a path to understanding disease and therapeutic opportunity

  2024cites this paper
• Discovery of NSD2 non-histone substrates and design of a super-substrate

  2024cites this paper
• Recent advances in targeting histone H3 lysine 36 methyltransferases for cancer therapy.

  2024cites this paper
• Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.

  2024cites this paper
• DNA Repair in Nucleosomes: Insights from Histone Modifications and Mutants

  2024cites this paper
• Targeted therapy for multiple myeloma: an overview on CD138-based strategies

  2024cites this paper
• Approaching the catalytic mechanism of protein lysine methyltransferases by biochemical and simulation techniques

  2024cites this paper
• NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

  2024cites this paper
• CRISPRing KRAS: A Winding Road with a Bright Future in Basic and Translational Cancer Research

  2024cites this paper
• NSD2 Modulates Drp1-mediated Mitochondrial Fission in Chronic Renal Allograft Interstitial Fibrosis by methylating STAT1.

  2024cites this paper
• Characterizing crosstalk in epigenetic signaling to understand disease physiology.

  2023cites this paper
• Small molecules targeting selected histone methyltransferases (HMTs) for cancer treatment: Current progress and novel strategies.

  2023cites this paper
• Dose-dependent effects of histone methyltransferase NSD2 on site-specific double-strand break repair

  2023cites this paper
• Multilevel Regulation of NF‐κB Signaling by NSD2 Suppresses Kras‐Driven Pancreatic Tumorigenesis

  2023cites this paper
• Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).

  2023cites this paper
• Target validation and structure-based virtual screening to Discover potential lead molecules against the oncogenic NSD1 histone methyltransferase

  2023cites this paper
• A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins

  2023cites this paper
• NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

  2023cites this paper
• Epigenetic causes of overgrowth syndromes.

  2023cites this paper
• Prospect of targeting lysine methyltransferase NSD3 for tumor therapy.

  2023cites this paper
• Recent advances in developing degraders & inhibitors of lysine methyltransferases.

  2023cites this paper
• Cancer drug resistance can be combated by targeting histone methyltransferases – A novel therapeutic approach: A narrative review

  2023cites this paper
• Chemically induced degradation of epigenetic targets.

  2023cites this paper
• Discovery of cysteine-targeting covalent histone methyltransferase inhibitors.

  2023cites this paper
• NSD3: Advances in cancer therapeutic potential and inhibitors research.

  2023cites this paper
• NSD3, a member of nuclear receptor‐binding SET domain family, is a potential prognostic biomarker for pancreatic cancer

  2023cites this paper
• From classic medicinal chemistry to state‐of‐the‐art interdisciplinary medicine: Recent advances in proteolysis‐targeting chimeras technology

  2023cites this paper
• Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.

  2023cites this paper
• The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation

  2023cites this paper
• Rhabdomyosarcoma With Epithelioid Features And NSD3::FOXO1 Fusion: Evidence For Reconsideration Of Previously Reported FOXO1::FGFR1 Fusion

  2022cites this paper
• Adult Wilms Tumor

  2022cites this paper
• NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

  2022cites this paper
• Set2 histone methyltransferase regulates transcription coupled-nucleotide excision repair in yeast

  2022cites this paper
• Morpholino-driven blockade of Dkk-1 in osteosarcoma inhibits bone damage and tumour expansion by multiple mechanisms

  2022cites this paper
• NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics

  2022cites this paper
• The H3.3 G34W oncohistone mutation increases K36 methylation by the protein lysine methyltransferase NSD1.

  2022cites this paper
• Exploring Methods of Targeting Histone Methyltransferases and Their Applications in Cancer Therapeutics.

  2022cites this paper
• Posttranslational modification of Aurora A‐NSD2 loop contributes to drug resistance in t(4;14) multiple myeloma

  2022cites this paper
• H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells

  2022cites this paper
• Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian

  2022cites this paper
• The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors

  2022cites this paper
• NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.

  2022cites this paper
• Pancancer Analyses Reveal Genomics and Clinical Characteristics of the SETDB1 in Human Tumors

  2022cites this paper
• Chemical biology and pharmacology of histone lysine methylation inhibitors.

  2022cites this paper
• Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.

  2022cites this paper
• The Immunotherapy and Immunosuppressive Signaling in Therapy-Resistant Prostate Cancer

  2022cites this paper
• Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos.

  2022cites this paper
• The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications

  2022cites this paper
• Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis

  2022cites this paper
• NSD2 as a Promising Target in Hematological Disorders

  2022cites this paper
• Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?

  2022cites this paper
• Nizp1 is a specific NUP98‐NSD1 functional interactor that regulates NUP98‐NSD1‐dependent oncogenic programs

  2022cites this paper
• The Role of Epigenetics in the Development and Progression of Multiple Myeloma

  2022cites this paper
• Understanding the Roles of the NSD Protein Methyltransferases in Head and Neck Squamous Cell Carcinoma

  2022cites this paper
• Morpholino-driven transcriptional blockade of Dkk-1 in experimental osteosarcoma inhibits bone damage and tumor expansion by multiple mechanisms.

  2021cites this paper
• Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis

  2021cites this paper
• The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression

  2021cites this paper
• SETDB1 in cancer: overexpression and its therapeutic implications.

  2021cites this paper
• The language of chromatin modification in human cancers

  2021cites this paper
• Transcription factor ZmPLATZ2 positively regulate the starch synthesis in maize

  2021cites this paper
• Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis

  2021cites this paper
• Molecular Landscapes and Models of Acute Erythroleukemia

  2021cites this paper
• A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells.

  2021cites this paper
• ‘Enhancing’ red cell fate through epigenetic mechanisms

  2021cites this paper
• Profiling NSD3-dependent neural crest gene expression reveals known and novel candidate regulatory factors.

  2021cites this paper
• Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

  2021cites this paper