Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Pain

• Publication date

  2017-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/j.pain.0000000000001040PMID 28832395PMCID PMC5681862
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development

  2016cited by this paper
• Neuronal hyperexcitability in the ventral posterior thalamus of neuropathic rats: modality selective effects of pregabalin

  2016cited by this paper
• Mechanisms of the gabapentinoids and α 2 δ‐1 calcium channel subunit in neuropathic pain

  2016cited by this paper
• Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model

  2016cited by this paper
• Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain

  2015cited by this paper
• Gabapentin alleviates affective pain after traumatic nerve injury

  2015cited by this paper
• Reward and motivation in pain and pain relief

  2014cited by this paper
• Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy

  2014influential reference
• Gabapentin for chronic neuropathic pain and fibromyalgia in adults.

  2014cited by this paper
• Gabapentin‐induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain

  2014cited by this paper
• Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain

  2014cited by this paper
• Persistent Hyperalgesia in the Cisplatin-Treated Mouse as Defined by Threshold Measures, the Conditioned Place Preference Paradigm, and Changes in Dorsal Root Ganglia Activated Transcription Factor 3: The Effects of Gabapentin, Ketorolac, and Etanercept

  2013cited by this paper
• Pregabalin Rectifies Aberrant Brain Chemistry, Connectivity, and Functional Response in Chronic Pain Patients

  2013cited by this paper
• α2δ-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage

  2013cited by this paper
• Cognitive and emotional control of pain and its disruption in chronic pain

  2013cited by this paper
• Intrathecal Gabapentin to Treat Chronic Intractable Noncancer Pain

  2013cited by this paper
• Descending facilitation maintains long-term spontaneous neuropathic pain.

  2013cited by this paper
• Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry

  2012cited by this paper
• Gabapentin for chronic neuropathic pain and fibromyalgia in adults.

  2011cited by this paper
• Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy

  2011cited by this paper
• Single dose oral gabapentin for established acute postoperative pain in adults.

  2010cited by this paper
• Mood Influences Supraspinal Pain Processing Separately from Attention

  2009cited by this paper
• Treatment of neuropathic pain: an overview of recent guidelines.

  2009cited by this paper
• The Increased Trafficking of the Calcium Channel Subunit α2δ-1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α2δ Ligand Pregabalin

  2009cited by this paper
• Faculty Opinions recommendation of The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.

  2009cited by this paper
• Unmasking the tonic-aversive state in neuropathic pain

  2009cited by this paper
• Activation of the opioidergic descending pain control system underlies placebo analgesia.

  2009cited by this paper
• Determination of dopamine, serotonin, and their metabolites in pediatric cerebrospinal fluid by isocratic high performance liquid chromatography coupled with electrochemical detection.

  2009cited by this paper
• Injury discharges regulate calcium channel alpha‐2‐delta‐1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain

  2008cited by this paper
• Prevalence of chronic pain with neuropathic characteristics in the general population

  2008cited by this paper
• Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin

  2008cited by this paper
• Immunostaining of rat brain, spinal cord, sensory neurons and skeletal muscle for calcium channel alpha2-delta (alpha2-delta) type 1 protein.

  2008cited by this paper
• Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury

  2008influential reference
• Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study

  2008cited by this paper
• Pharmacologic management of neuropathic pain: Evidence‐based recommendations

  2007cited by this paper
• Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.

  2006cited by this paper
• Differential distribution of voltage-gated calcium channel alpha-2 delta (alpha2delta) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia.

  2005cited by this paper
• Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans.

  2005influential reference
• Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat.

  2005cited by this paper
• Mechanisms of neuropathic pain and their implications for the design of clinical trials

  2005cited by this paper
• Gabapentin for acute and chronic pain.

  2005cited by this paper
• Differential distribution of voltage‐gated calcium channel alpha‐2 delta (α2δ) subunit mRNA‐containing cells in the rat central nervous system and the dorsal root ganglia

  2005cited by this paper
• Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal

  2004cited by this paper
• Gabapentin in the treatment of neuropathic pain

  2004cited by this paper
• Neuropathic pain symptoms relative to overall pain rating.

  2004cited by this paper
• Gabapentin Is a First Line Drug for the Treatment of Neuropathic Pain in Spinal Cord Injury

  2004cited by this paper
• Reduction by gabapentin of K+‐evoked release of [3H]‐glutamate from the caudal trigeminal nucleus of the streptozotocin‐treated rat

  2004cited by this paper
• The use of gabapentin for the treatment of postherpetic neuralgia.

  2003cited by this paper
• Hemodynamic effects of gabapentin in rats.

  2003cited by this paper
• In vivo single unit extracellular recordings from spinal cord neurones of rats.

  2003cited by this paper
• Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C

  2003cited by this paper
• Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury.

  2002cited by this paper
• Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases.

  2002cited by this paper
• The effect of intrathecal gabapentin on mechanical and thermal hyperalgesia in neuropathic rats induced by spinal nerve ligation.

  2002cited by this paper
• Time-Dependent Descending Facilitation from the Rostral Ventromedial Medulla Maintains, But Does Not Initiate, Neuropathic Pain

  2002cited by this paper
• Pharmacological characterisation of the spared nerve injury model of neuropathic pain

  2002cited by this paper
• The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

  2001cited by this paper
• Upregulation of Dorsal Root Ganglion α2δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats

  2001cited by this paper
• Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.

  2001cited by this paper
• Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord

  2000cited by this paper
• Synergistic Effect between Intrathecal Non-NMDA Antagonist and Gabapentin on Allodynia Induced by Spinal Nerve Ligation in Rats

  2000cited by this paper
• Journal of pain : official journal of the American Pain Society.

  2000cited by this paper
• Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat.

  1999cited by this paper
• Effects of Gabapentin on the Different Components of Peripheral and Central Neuropathic Pain Syndromes: A Pilot Study

  1998cited by this paper
• The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.

  1997cited by this paper
• The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the Subunit of a Calcium Channel (*)

  1996cited by this paper
• Effect of Subarachnoid Gabapentin on Tactile-Evoked Allodynia in a Surgically Induced Neuropathic Pain Model in the Rat

  1996cited by this paper
• Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate.

  1993cited by this paper
• Selected CSF biochemistry and gabapentin concentrations in the CSF and plasma in patients with partial seizures after a single oral dose of gabapentin.

  1992cited by this paper
• An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

  1992cited by this paper
• Pharmacokinetics and metabolism of gabapentin in rat, dog and man.

  1986cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms.

  1980cited by this paper
• Efficient analysis of experimental observations.

  1980cited by this paper

• Functional Magnetic Resonance Imaging in Prurigo Nodularis: A Systematic Review.

  2025cites this paper
• The Increased Activity of CaV3.2 Channels Contributes to Nociceptors’ Hyperexcitability and Chronic Neuropathic Pain Following Spinal Cord Injury in Mice

  2025cites this paper
• Assessments of Evoked and Spontaneous Pain Following Administration of Gabapentin and the Cannabinoid CB2 agonist LY2828360 in a Rat Model of Spared Nerve Injury

  2025cites this paper
• Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect.

  2025cites this paper
• 3D-printed Gabapentin-loaded Implants for Sustained Release: Leveraging 3D Printing and Hot Melt Extrusion (HME) for Customizable Drug Delivery

  2025cites this paper
• Enhancing clinical translation of analgesics for neuropathic pain: a systematic review and meta-analysis on the role of non-evoked pain assessment in preclinical trials

  2025cites this paper
• Keratinocyte–TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch

  2025cites this paper
• Effects of Sumatriptan, Baclofen and Gabapentin on Acute and Chronic Neuropathic Pain in a Rat Model of Sciatic Nerve Ligation

  2025cites this paper
• Pathology of pain and its implications for therapeutic interventions

  2024cites this paper
• A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice

  2024cites this paper
• It all began in Issaquah 50 years ago.

  2024cites this paper
• Spinal Cord Stimulation Paradigms and Alleviation of Neuropathic Pain Behavior in Experimental Painful Diabetic Polyneuropathy.

  2024cites this paper
• Looking for a Beam of Light to Heal Chronic Pain

  2024cites this paper
• Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect

  2023cites this paper
• Combination Drug Therapy for the Management of Chronic Neuropathic Pain

  2023cites this paper
• Neuropathic pain; what we know and what we should do about it

  2023cites this paper
• Cucurbita pepo seeds improve peripheral neuropathy in diabetic rats by modulating the inflammation and oxidative stress in rats

  2023cites this paper
• Principles of nociceptive coding in the anterior cingulate cortex

  2023cites this paper
• Advances and challenges in neuropathic pain: a narrative review and future directions.

  2023cites this paper
• Inhibition of T-type calcium channels with TTA-P2 reduces chronic neuropathic pain following spinal cord injury in rats.

  2023cites this paper
• Effects of Gabapentinoids on Heroin-Induced Ventilatory Depression and Reversal by Naloxone.

  2023cites this paper
• MANAGING THE ONCOLOGICAL PAIN IN DOG AND CATS

  2022cites this paper
• Natural Herbal Non-Opioid Topical Pain Relievers—Comparison with Traditional Therapy

  2022cites this paper
• Gabapentin—Friend or foe?

  2022cites this paper
• Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations

  2022cites this paper
• Effect of Sufentanil Combined with Gabapentin on Acute Postoperative Pain in Patients Undergoing Intraspinal Tumor Resection: Study Protocol for a Randomized Controlled Trial

  2022cites this paper
• Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient

  2022cites this paper
• Association of Peripheral Serum MicroRNAs With Persistent Phantom Limb Pain in Individuals With Amputation

  2022cites this paper
• One size doesn't fit all: towards optimising the therapeutic potential of endogenous pain modulatory systems.

  2022cites this paper
• Verbascoside administered intrathecally attenuates hyperalgesia via activating mu‐opioid receptors in a rat chronic constriction injury model

  2022cites this paper
• Chronic facial inflammatory pain-induced anxiety is associated with bilateral deactivation of the rostral anterior cingulate cortex.

  2022cites this paper
• Time-Dependent Changes in Protein Composition of Medial Prefrontal Cortex in Rats with Neuropathic Pain

  2022cites this paper
• Virtual Reality Environments in Pain Management

  2022cites this paper
• Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets

  2021cites this paper
• Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research

  2021cites this paper
• The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation.

  2021cites this paper
• Challenges and opportunities in translational pain research – An opinion paper of the working group on translational pain research of the European pain federation (EFIC)

  2021cites this paper
• Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain—Narrative Review

  2021cites this paper
• On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review.

  2021cites this paper
• PREVALENCE, TREATMENT, AND SURVIVAL OF BURNED WILDLIFE PRESENTING TO REHABILITATION FACILITIES FROM 2015 TO 2018

  2021cites this paper
• Neocortical circuits in pain and pain relief

  2021cites this paper
• Gabapentin Reduces Alcohol Intake in Rats by Regulating NF-κB Signaling Pathway Via PPAR γ.

  2021cites this paper
• Blockade of kappa opioid receptors reduces mechanical hyperalgesia and anxiety-like behavior in a rat model of trigeminal neuropathic pain.

  2021cites this paper
• Neuropharmacological basis for multimodal analgesia in chronic pain

  2021cites this paper
• Analgesic potency of intrathecally administered punicalagin in rat neuropathic and inflammatory pain models

  2021cites this paper
• Pharmacological use of gamma-aminobutyric acid derivatives in osteoarthritis pain management: a systematic review

  2021cites this paper
• Intrathecally administered perampanel alleviates neuropathic and inflammatory pain in rats.

  2020cites this paper
• Neuropathic Pain: Mechanism-Based Therapeutics.

  2020cites this paper
• Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation.

  2020cites this paper
• In silico validation and fabrication of matrix diffusion based polymeric transdermal films for repurposing gabapentin hydrochloride in oncogenic neuropathic pain

  2020cites this paper
• Dorsal horn disinhibition and movement-induced behaviour in a rat model of inflammatory arthritis.

  2020cites this paper
• A COVID-19 patient with intense burning pain

  2020cites this paper
• Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth

  2020cites this paper
• Central Nervous System Targets: Supraspinal Mechanisms of Analgesia

  2020cites this paper
• Dorsal Root Ganglion Stimulation Alleviates Pain-related Behaviors in Rats with Nerve Injury and Osteoarthritis

  2020cites this paper
• Antihyperalgesic effects of intrathecal perospirone in a rat model of neuropathic pain.

  2020cites this paper
• Gabapentin to reduce pain in women aged between 18 and 50 years with chronic pelvic pain: the GaPP2 RCT

  2020cites this paper
• The Medial Prefrontal Cortex as a Central Hub for Mental Comorbidities Associated with Chronic Pain

  2020cites this paper
• Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice

  2020cites this paper
• Analgesia with Gabapentin and Pregabalin May Involve N-Methyl-d-Aspartate Receptors, Neurexins, and Thrombospondins

  2020cites this paper
• Translational issues in precision medicine in neuropathic pain

  2020cites this paper
• Amygdala, neuropeptides, and chronic pain-related affective behaviors.

  2020cites this paper
• Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion.

  2019cites this paper
• The gene regulatory network in different brain regions of neuropathic pain mouse models.

  2019cites this paper
• A study of cortical and brainstem mechanisms of diffuse noxious inhibitory controls in anaesthetised normal and neuropathic rats

  2019cites this paper
• Gabapentin Regimens and Their Effects on Opioid Consumption A randomized controlled trial

  2019cites this paper
• GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness

  2019cites this paper
• Sham surgeries for central and peripheral neural injuries persistently enhance pain-avoidance behavior as revealed by an operant conflict test.

  2019cites this paper
• Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement

  2019cites this paper
• Discovery of GlyT2 Inhibitors Using Structure-Based Pharmacophore Screening and Selectivity Studies by FEP+ Calculations.

  2019cites this paper
• Alterations in evoked and spontaneous activity of dorsal horn wide dynamic range neurons in pathological pain: A systematic review and analysis.

  2019cites this paper
• Targeting Neuropathic Pain: Pathobiology, Current Treatment and Peptidomimetics as a New Therapeutic Opportunity.

  2019cites this paper
• Core Outcome Measures in Preclinical Assessment of Candidate Analgesics

  2019cites this paper
• The multiple challenges of neuropathic pain.

  2019cites this paper
• Comparison of ex vivo and in vitro actions of gabapentin in superficial dorsal horn and the role of extra-spinal sites of drug action.

  2019cites this paper
• Modulation of Opioid Transport at the Blood-Brain Barrier by Altered ATP-Binding Cassette (ABC) Transporter Expression and Activity

  2018cites this paper
• Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain

  2018cites this paper
• Pregabalin induces conditioned place preference in the rat during the early, but not late, stage of neuropathic pain.

  2018cites this paper
• Etiology and Pharmacology of Neuropathic Pain

  2018influential citation
• Diffuse noxious inhibitory controls and brain networks are modulated in a testosterone-dependent manner in Sprague Dawley rats

  2018cites this paper
• The influence of pre- and perioperative administration of gabapentin on pain 3–4 years after total knee arthroplasty

  2018cites this paper
• Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review

  2018cites this paper
• Sense and sensibility-logical approaches to profiling in animal models.

  2018cites this paper
• Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain

  2018cites this paper
• Mechanisms Underlying Bone and Joint Pain

  2018cites this paper
• Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls

  2018cites this paper
• Behavioral Insights into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms in Rats

  2018influential citation
• Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model

  2016cites this paper