Neuronal hyperexcitability in the ventral posterior thalamus of neuropathic rats: modality selective effects of pregabalin

Studies on brain mechanisms of neuropathic pain are lacking. This study characterizes the properties of rat ventral posterior thalamic wide dynamic range (WDR) and nociceptive-specific (NS) neurons, the latter of which are uncharacterized in a neuropathic state. We provide evidence of phenotypic changes in neuronal sensitivity that may underlie cold and brush hypersensitivity, and that WDR neurons, and not NS neurons, encode hypersensitivity to low-intensity stimuli. Pregabalin reversed neuronal hyperexcitability in spinal nerve-ligated rats in a modality-selective manner.

• Publication year

  2016

• Venue

  Journal of Neurophysiology

• Publication date

  2016-04-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/jn.00237.2016PMID 27098028PMCID 4961752
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chronic Neuropathic Pain: It's about the Rhythm

  2016cited by this paper
• T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain

  2016cited by this paper
• Mechanisms of the gabapentinoids and α 2 δ‐1 calcium channel subunit in neuropathic pain

  2016cited by this paper
• Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain

  2015cited by this paper
• Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models

  2015cited by this paper
• Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.

  2015cited by this paper
• Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera

  2015cited by this paper
• Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: A comparison with topical menthol

  2014cited by this paper
• Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs

  2014cited by this paper
• Novel TRPM8 Antagonist Attenuates Cold Hypersensitivity after Peripheral Nerve Injury in Rats

  2014cited by this paper
• Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model.

  2014cited by this paper
• Neural coding of nociceptive stimuli—from rat spinal neurones to human perception

  2013cited by this paper
• Pregabalin Rectifies Aberrant Brain Chemistry, Connectivity, and Functional Response in Chronic Pain Patients

  2013cited by this paper
• Pathological Activity in Mediodorsal Thalamus of Rats with Spinal Cord Injury Pain

  2013cited by this paper
• Chronic Pain: Lost Inhibition?

  2013cited by this paper
• Faculty Opinions recommendation of Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold.

  2013cited by this paper
• α2δ-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage

  2013cited by this paper
• Negative reinforcement reveals non-evoked ongoing pain in mice with tissue or nerve injury.

  2012cited by this paper
• Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach.

  2012cited by this paper
• Asymmetric time‐dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation

  2012cited by this paper
• Pregabalin Suppresses Spinal Neuronal Hyperexcitability and Visceral Hypersensitivity in the Absence of Peripheral Pathophysiology

  2011cited by this paper
• Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker

  2010cited by this paper
• Spinal Processing of Noxious and Innocuous Cold Information: Differential Modulation by the Periaqueductal Gray

  2010cited by this paper
• Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

  2010cited by this paper
• Pregabalin for painful HIV neuropathy

  2010cited by this paper
• Pregabalin for painful HIV neuropathy: A randomized, double-blind, placebo-controlled trial

  2010cited by this paper
• The Increased Trafficking of the Calcium Channel Subunit α2δ-1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α2δ Ligand Pregabalin

  2009cited by this paper
• Pregabalin for acute and chronic pain in adults.

  2009cited by this paper
• Thalamic neuron hyperexcitability and enlarged receptive fields in the STZ model of diabetic pain.

  2009cited by this paper
• Sensitization of lamina I spinoparabrachial neurons parallels heat hyperalgesia in the chronic constriction injury model of neuropathic pain

  2009cited by this paper
• Descending facilitation from the brainstem determines behavioural and neuronal hypersensitivity following nerve injury and efficacy of pregabalin

  2008cited by this paper
• Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats

  2008cited by this paper
• Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons

  2007cited by this paper
• Lesions Limited to the Human Thalamic Principal Somatosensory Nucleus (Ventral Caudal) Are Associated with Loss of Cold Sensations and Central Pain

  2007cited by this paper
• Differential pharmacological modulation of the spontaneous stimulus-independent activity in the rat spinal cord following peripheral nerve injury.

  2006cited by this paper
• Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.

  2006cited by this paper
• Corticofugal Output from the Primary Somatosensory Cortex Selectively Modulates Innocuous and Noxious Inputs in the Rat Spinothalamic System

  2006cited by this paper
• Spinal‐supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin

  2005influential reference
• Gabapentin Normalizes Spinal Neuronal Responses That Correlate with Behavior in a Rat Model of Cancer-induced Bone Pain

  2005cited by this paper
• Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury.

  2005cited by this paper
• Allodynia in patients with post‐stroke central pain (CPSP) studied by statistical quantitative sensory testing within individuals

  2004cited by this paper
• Microstimulation in the region of the human thalamic principal somatic sensory nucleus evokes sensations like those of mechanical stimulation and movement.

  2004cited by this paper
• Nerve injury-induced changes in opioid modulation of wide dynamic range dorsal column nuclei neurones.

  2002cited by this paper
• Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

  2002cited by this paper
• Gabapentin Suppresses Cutaneous Hyperalgesia following Heat-Capsaicin Sensitization

  2002cited by this paper
• Projections from the marginal zone and deep dorsal horn to the ventrobasal nuclei of the primate thalamus

  2001cited by this paper
• Functional plasticity in primate somatosensory thalamus following chronic lesion of the ventral lateral spinal cord.

  2000cited by this paper
• Dorsal column‐thalamic pathway is involved in thalamic hyperexcitability following peripheral nerve injury: a lesion study in rats with experimental mononeuropathy

  2000cited by this paper
• Changes in neuronal activities in the two ventral posterior medial thalamic nuclei in an experimental model of trigeminal pain in the rat by constriction of one infraorbital nerve.

  2000cited by this paper
• Enlargement of the receptive field size to low intensity mechanical stimulation in the rat spinal nerve ligation model of neuropathy.

  2000cited by this paper
• Thalamic relay site for cold perception in humans.

  1999cited by this paper
• Effects of Gabapentin on the Different Components of Peripheral and Central Neuropathic Pain Syndromes: A Pilot Study

  1998cited by this paper
• Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5‐L6

  1998cited by this paper
• Altered receptive fields and sensory modalities of rat VPL thalamic neurons during spinal strychnine-induced allodynia.

  1997influential reference
• Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents

  1997cited by this paper
• The triple cold syndrome. Cold hyperalgesia, cold hypoaesthesia and cold skin in peripheral nerve disease.

  1994cited by this paper
• Squirrel monkey lateral thalamus. I. Somatic nociresponsive neurons and their relation to spinothalamic terminals

  1994cited by this paper
• The thermal grill illusion: unmasking the burn of cold pain.

  1994cited by this paper
• The roles of spatial recruitment and discharge frequency in spinal cord coding of pain: a combined electrophysiological and imaging investigation

  1993cited by this paper
• Thermal and pain sensations evoked by microstimulation in the area of human ventrocaudal nucleus.

  1993cited by this paper
• Nociceptive neurons of the raccoon lateral thalamus.

  1993cited by this paper
• Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy.

  1992cited by this paper
• Neuronal responsiveness in the ventrobasal thalamic complex of rats with an experimental peripheral mononeuropathy.

  1990cited by this paper
• The correlation of monkey medullary dorsal horn neuronal activity and the perceived intensity of noxious heat stimuli.

  1989cited by this paper
• Nociceptive body representation in nucleus ventralis posterolateralis of cat thalamus.

  1988cited by this paper
• Wide-dynamic-range dorsal horn neurons participate in the encoding process by which monkeys perceive the intensity of noxious heat stimuli.

  1986cited by this paper
• Response characteristics of neurons in the ventral posterior lateral nucleus of the monkey thalamus.

  1986cited by this paper
• Ethical guidelines for investigations of experimental pain in conscious animals.

  1983cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983influential reference
• Somatic responses of ventrobasal thalamic neurones in polyarthritic rats.

  1982cited by this paper
• Responses of neurons in primate ventral posterior lateral nucleus to noxious stimuli.

  1980cited by this paper
• Neurones responding to noxious stimulation in VB complex and caudal adjacent regions in the thalamus of the rat

  1980cited by this paper

• Reevaluating thalamic contributions to pain: A translational framework for precision neuromodulation.

  2026cites this paper
• Exploring the supraspinal antihyperalgesic effects of levetiracetam in the rat model of chronic constriction injury.

  2025cites this paper
• Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of neuropathic pain

  2025cites this paper
• Uncaria Rhynchophylla and hirsuteine as TRPV1 agonists inducing channel desensitization.

  2024cites this paper
• The Peripheral Nerve Surgeon’s Role in the Management of Neuropathic Pain

  2023cites this paper
• In Vivo Measurements reveal that both low- and high-frequency spinal cord stimulation heterogeneously modulate superficial dorsal horn neurons.

  2023cites this paper
• Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner

  2023cites this paper
• Secondary somatosensory cortex glutamatergic innervation of the thalamus facilitates pain.

  2023cites this paper
• Mapping the neuroethological signatures of pain, analgesia, and recovery in mice.

  2023cites this paper
• Principles of nociceptive coding in the anterior cingulate cortex

  2023cites this paper
• Neuropathic pain

  2022cites this paper
• Maximizing treatment efficacy through patient stratification in neuropathic pain trials

  2022cites this paper
• Pharmacological modulation of brain activation to non-noxious stimulation in a cynomolgus macaque model of peripheral nerve injury

  2021cites this paper
• Neuropharmacological basis for multimodal analgesia in chronic pain

  2021cites this paper
• Challenges and opportunities in translational pain research – An opinion paper of the working group on translational pain research of the European pain federation (EFIC)

  2021cites this paper
• Translational issues in precision medicine in neuropathic pain

  2020cites this paper
• GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents.

  2020cites this paper
• Supraspinal Opioid Circuits Differentially Modulate Spinal Neuronal Responses in Neuropathic Rats

  2020cites this paper
• Association Between Cognitive Impairment and Substance Use Disorder Attributed to Pregabalin in Egypt: A Case-Control Study

  2020cites this paper
• Challenges of neuropathic pain: focus on diabetic neuropathy

  2020cites this paper
• Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States

  2019cites this paper
• Comparison of ex vivo and in vitro actions of gabapentin in superficial dorsal horn and the role of extra-spinal sites of drug action.

  2019cites this paper
• Issues in the future development of new analgesic drugs

  2019cites this paper
• Pain matrix shift in the rat brain following persistent colonic inflammation revealed by voxel-based statistical analysis

  2019cites this paper
• Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone

  2018cites this paper
• Giving priority to preclinical pain measures resistant to existing drugs for developing innovative analgesics

  2018cites this paper
• PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE ( Mus musculus )

  2018cites this paper
• Modality selective roles of pro-nociceptive spinal 5-HT2A and 5-HT3 receptors in normal and neuropathic states

  2018cites this paper
• Etiology and Pharmacology of Neuropathic Pain

  2018cites this paper
• Alterations in the Activity of Spinal and Thalamic Opioid Systems in a Mice Neuropathic Pain Model.

  2018cites this paper
• Neuropathy following spinal nerve injury shares features with the irritable nociceptor phenotype: A back‐translational study of oxcarbazepine

  2018cites this paper
• Sense and sensibility-logical approaches to profiling in animal models.

  2018cites this paper
• Low-threshold mechanoreceptors play a frequency-dependent dual role in subjective ratings of mechanical allodynia.

  2017cites this paper
• Wo der Schmerz in das Bewusstsein tritt: das thalamo-kortikale System bei der Schmerzverarbeitung

  2017cites this paper
• Pain processing in the thalamocortical system

  2017cites this paper
• Sensory processing of deep tissue nociception in the rat spinal cord and thalamic ventrobasal complex

  2017cites this paper
• Acute and Chronic Pain Processing in the Thalamocortical System of Humans and Animal Models.

  2017cites this paper
• Calcium channel modulation as a target in chronic pain control

  2017influential citation
• Acute anti‐allodynic action of gabapentin in dorsal horn and primary somatosensory cortex: Correlation of behavioural and physiological data

  2017cites this paper
• Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain

  2017cites this paper
• Neuropathic Pain: Central vs. Peripheral Mechanisms

  2017cites this paper
• Neuropathic Pain

  2013cites this paper