Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Science

• Publication date

  2010-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/science.1187945PMID 20595612PMCID PMC3863715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

  2010cited by this paper
• DNA demethylation by DNA repair.

  2009cited by this paper
• A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

  2009cited by this paper
• Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

  2009cited by this paper
• The role of poly(ADP-ribosyl)ation in epigenetic events.

  2009cited by this paper
• The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

  2009cited by this paper
• Chromatin dynamics during epigenetic reprogramming in the mouse germ line

  2008cited by this paper
• Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.

  2008cited by this paper
• DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

  2008cited by this paper
• Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

  2008cited by this paper
• Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

  2008cited by this paper
• Cyclical DNA methylation of a transcriptionally active promoter

  2008cited by this paper
• Genetic and epigenetic regulators of pluripotency.

  2007cited by this paper
• Global single-cell cDNA amplification to provide a template for representative high-density oligonucleotide microarray analysis

  2007cited by this paper
• PGC7/Stella protects against DNA demethylation in early embryogenesis

  2007cited by this paper
• Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length

  2007cited by this paper
• XRCC1 interactions with base excision repair DNA intermediates.

  2007cited by this paper
• DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation.

  2006cited by this paper
• Isolation of a small molecule inhibitor of DNA base excision repair

  2005cited by this paper
• Chromatin Loosening by Poly(ADP)-Ribose Polymerase (PARP) at Drosophila Puff Loci

  2003cited by this paper
• Stella is a maternal effect gene required for normal early development in mice.

  2003cited by this paper
• Dynamic reprogramming of DNA methylation in the early mouse embryo.

  2002cited by this paper
• Mbd4 inactivation increases C→T transition mutations and promotes gastrointestinal tumor formation

  2002cited by this paper
• ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase.

  2002cited by this paper
• DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis.

  2002cited by this paper
• Epigenetic reprogramming in mouse primordial germ cells.

  2002cited by this paper
• Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation.

  2002cited by this paper
• Active demethylation of the paternal genome in the mouse zygote.

  2000cited by this paper
• Demethylation of the zygotic paternal genome.

  2000cited by this paper
• Embryogenesis: Demethylation of the zygotic paternal genome

  2000cited by this paper
• Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.

  1999cited by this paper
• Reduced extractability of the XPA DNA repair protein in ultraviolet light‐irradiated mammalian cells

  1999cited by this paper
• A modified and improved method for bisulphite based cytosine methylation analysis.

  1996cited by this paper
• The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin. A role of poly(ADP-ribosyl)ation on core nucleosome structure.

  1989cited by this paper
• The effect of inhibiting DNA replication in the one-cell mouse embryo

  1986cited by this paper
• Turnover of basic chromosomal proteins in fertilized eggs: a cytoimmunochemical study of events in vivo

  1981cited by this paper
• Novel inhibitors of poly(ADP-ribose) synthetase.

  1980cited by this paper
• A cytoskeletal structure with associated polyribosomes obtained from HeLa cells.

  1977cited by this paper

• Epigenetic consequences of DNA damage.

  2026cites this paper
• Epigenetic remodeling during early embryonic development.

  2026cites this paper
• Cross-Kingdom DNA Methylation Dynamics: Comparative Mechanisms of 5mC/6mA Regulation and Their Implications in Epigenetic Disorders

  2025cites this paper
• PARP1 regulates establishment of the ovarian reserve and age at natural menopause

  2025influential citation
• Silencing by the HUSH Epigenetic Transcriptional Repressor Complex.

  2025cites this paper
• Epigenetic dynamics in gastric cancer precancerous lesions: From molecular mechanisms to precision risk stratification

  2025cites this paper
• Mechanisms underlying low mutation rates in mammalian oocytes and preimplantation embryos

  2025cites this paper
• STEMIN transcription factor drives selective chromatin remodeling for gene activation within a relaxed chromatin during reprogramming in the moss Physcomitrium patens

  2025cites this paper
• Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health

  2025cites this paper
• DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1

  2024cites this paper
• 5-Hydroxymethylcytosine: the many faces of the sixth base of mammalian DNA.

  2024cites this paper
• TNFα Induces DNA and Histone Hypomethylation and Pulmonary Artery Smooth Muscle Cell Proliferation Partly via Excessive Superoxide Formation

  2024cites this paper
• Ten-eleven translocation 1 mediating DNA demethylation regulates the proliferation of chicken primordial germ cells through the activation of Wnt4/β-catenin signaling pathway

  2024cites this paper
• Loss of DNA Polymerase β Delays Atherosclerosis in ApoE−/− Mice Due to Inhibition of Vascular Smooth Muscle Cell Migration

  2024cites this paper
• AP endonuclease 1: Biological updates and advances in activity analysis.

  2024cites this paper
• TET enzyme driven epigenetic reprogramming in early embryos and its implication on long-term health

  2024cites this paper
• Primordial germ cell DNA demethylation and development require DNA translesion synthesis

  2023cites this paper
• Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1

  2023cites this paper
• Cancer and meiotic gene expression: Two sides of the same coin?

  2023cites this paper
• Epigenetic Reprogramming in Mice and Humans: From Fertilization to Primordial Germ Cell Development

  2023cites this paper
• Characterizing inhibitors of human AP endonuclease 1

  2023cites this paper
• A change in biophysical properties accompanies heterochromatin formation in mouse embryos

  2023cites this paper
• Epigenetic Regulation in Uterine Fibroids—The Role of Ten-Eleven Translocation Enzymes and Their Potential Therapeutic Application

  2022cites this paper
• Journal of Reproduction and Development

  2022cites this paper
• Parental competition for the regulators of chromatin dynamics in mouse zygotes

  2022cites this paper
• Involvement of the Linker Histone H1Foo in the Regulation of Oogenesis.

  2022cites this paper
• Gadd45 in DNA Demethylation and DNA Repair.

  2022cites this paper
• Pathways of DNA Demethylation.

  2022cites this paper
• Genomic imprinting in haemopoietic stem cells and leukemia

  2022cites this paper
• Mechanisms that regulate the activities of TET proteins

  2022cites this paper
• The Beginning of Meiosis in Mammalian Female Germ Cells: A Never-Ending Story of Intrinsic and Extrinsic Factors

  2022cites this paper
• Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs.

  2022cites this paper
• A unique glimpse into the crosstalk between different epigenetic mechanisms in porcine embryonic development

  2022cites this paper
• A comprehensive approach for genome-wide efficiency profiling of DNA modifying enzymes

  2022cites this paper
• TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

  2022cites this paper
• Epigenetics and Early Development

  2022cites this paper
• Nutritional Status Impacts Epigenetic Regulation in Early Embryo Development: A Scoping Review.

  2021influential citation
• Base excision repair and nucleotide excision repair

  2021cites this paper
• The PARP Way to Epigenetic Changes

  2021cites this paper
• Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus

  2021cites this paper
• Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage

  2021influential citation
• Genome diversity and instability in human germ cells and preimplantation embryos

  2021cites this paper
• Asymmetrical deposition and modification of histone H3 variants are essential for zygote development

  2021cites this paper
• What is Tet2 and function in DNA methylation?-How did Tet2 alter SRY gene expression and sex determination?-What role does DNA methylation and histone modification have in sex determination?

  2021influential citation
• Genome-wide DNA methylation dynamics during epigenetic reprogramming in the porcine germline

  2021cites this paper
• XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair

  2021cites this paper
• GwEEP - A comprehensive approach for genome-wide efficiency profiling of DNA modifying enzymes

  2021cites this paper
• Molecular mechanisms of reprogramming of differentiated cells into stem cells in the moss Physcomitrium patens.

  2021cites this paper
• The evolutionary acquisition and mode of functions of promoter-associated non-coding RNAs (pancRNAs) for mammalian development.

  2021cites this paper
• Epigenetic Regulation during Primordial Germ Cell Development and Differentiation

  2021cites this paper
• ACCEPTED MANUSCRIPT: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS) Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds

  2020cites this paper
• L-Ascorbic Acid in the Epigenetic Regulation of Cancer Development and Stem Cell Reprogramming

  2020cites this paper
• Epigenetics modifiers: potential hub for understanding and treating neurodevelopmental disorders from hypoxic injury

  2020cites this paper
• Specification and epigenetic resetting of the pig germline exhibit conservation with the human lineage

  2020cites this paper
• Interplay between Metabolism, Nutrition and Epigenetics in Shaping Brain DNA Methylation, Neural Function and Behavior

  2020cites this paper
• PRMT7 is involved in regulation of germ cell proliferation during embryonic stage.

  2020cites this paper
• Genome wide efficiency profiling reveals modulation of maintenance and de novo methylation by Tets

  2020cites this paper
• MCM complexes are barriers that restrict cohesin-mediated loop extrusion

  2020cites this paper
• Placental DNA methylation in caesarean sections – a pilot study

  2020cites this paper
• Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo

  2020cites this paper
• Zygotic Nuclear F-Actin Safeguards Embryonic Development.

  2020cites this paper
• The round goby genome provides insights into mechanisms that may facilitate biological invasions

  2020cites this paper
• Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo

  2020cites this paper
• Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma.

  2020cites this paper
• A change in culture: Modeling human germ cell development in vitro

  2020cites this paper
• Characterising the role of TET2 in oestrogen receptor positive breast cancer

  2020cites this paper
• DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation

  2020cites this paper
• Human germ cell tumours from a developmental perspective

  2019cites this paper
• DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development

  2019cites this paper
• Evolved for success in novel environments: The round goby genome

  2019cites this paper
• XRCC1 protein; Form and function.

  2019cites this paper
• TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression

  2019cites this paper
• Epigenetic inheritance across multiple generations

  2019cites this paper
• Maternal epigenetic inheritance

  2019cites this paper
• Genetic basis for primordial germ cells specification in mouse and human: Conserved and divergent roles of PRDM and SOX transcription factors.

  2019cites this paper
• Developmental features of DNA methylation in CpG islands of human gametes and preimplantation embryos

  2019cites this paper
• Global impact of somatic structural variation on the DNA methylome of human cancers

  2019cites this paper
• Germline and Transgenerational Impacts of Toxicant Exposures

  2019cites this paper
• Chapter 3 Primordial Germ Cell Reprogramming

  2019cites this paper
• PARP Inhibitor Affects Long-term Heat-stress Response via Changes in DNA Methylation.

  2019cites this paper
• Ovarian Life Cycle

  2019cites this paper
• Consequences of assisted reproductive techniques on the embryonic epigenome in cattle.

  2019cites this paper
• Role of PARP-catalyzed ADP-ribosylation in the crosstalk between DNA strand breaks and epigenetic regulation.

  2019cites this paper
• Epigenetic Mechanisms in Neural Plasticity

  2019cites this paper
• Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus

  2019cites this paper
• Epigenetic reprogramming enables the primordial germ cell-to-gonocyte transition

  2018cites this paper
• Dynamics of the epigenetic landscape during the maternal-to-zygotic transition

  2018cites this paper
• Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics

  2018cites this paper
• Exploring The Role Of Tet1 In Genomic Imprinting

  2018influential citation
• Transcriptional and developmental consequences of aneuploidy during male meiosis

  2018cites this paper
• Non-canonical Bases in the Genome: The Regulatory Information Layer in DNA.

  2018cites this paper
• Epigenetics and testicular germ cell tumors.

  2018cites this paper
• Out of sight, out of mind? Germ cells and the potential impacts of epigenomic drugs

  2018cites this paper
• Impact du stress oxydant sur l'intégrité de l'épigénome spermatique murin

  2018cites this paper
• SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation

  2018cites this paper
• DNA Demethylation by DNMT3A and DNMT3B in vitro and of Methylated Episomal DNA in Transiently Transfected Cells.

  2018cites this paper
• Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspring

  2018cites this paper
• Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development

  2018influential citation
• Single Cell Genetics and Epigenetics in Early Embryo: From Oocyte to Blastocyst.

  2018cites this paper
• Not just heads and tails: The complexity of the sperm epigenome

  2018cites this paper