Mild traumatic brain injury induces apoptotic cell death in the cortex that is preceded by decreases in cellular Bcl-2 immunoreactivity.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Neuroscience

• Publication date

  2002-04-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0306-4522(01)00461-4PMID 11934469
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Calpain and caspase: can you tell the difference?

  2000cited by this paper
• Increased Vulnerability of NFH-LacZ Transgenic Mouse to Traumatic Brain Injury-Induced Behavioral Deficits and Cortical Damage

  1999cited by this paper
• Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons.

  1999cited by this paper
• Behavioural and Morphological Outcome of Mild Cortical Contusion Trauma of the Rat Brain: Influence of NMDA-Receptor Blockade

  1999cited by this paper
• Temporal profile of apoptotic-like changes in neurons and astrocytes following controlled cortical impact injury in the rat.

  1999cited by this paper
• Overexpression of Bcl‐2 is neuroprotective after experimental brain injury in transgenic mice

  1999cited by this paper
• Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury.

  1999cited by this paper
• Experimental Brain Injury Induces Regionally Distinct Apoptosis during the Acute and Delayed Post-Traumatic Period

  1998cited by this paper
• Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family

  1998cited by this paper
• Review : Apoptosis and Spinal Cord Injury

  1998cited by this paper
• Functional assessment of mild traumatic brain injury using SPECT and neuropsychological testing.

  1998cited by this paper
• Sustained Sensory/Motor and Cognitive Deficits With Neuronal Apoptosis Following Controlled Cortical Impact Brain Injury in the Mouse

  1998cited by this paper
• Bcl-2 family proteins

  1998cited by this paper
• BCL-2 Overexpression Attenuates Cortical Cell Loss after Traumatic Brain Injury in Transgenic Mice

  1998cited by this paper
• The Neuronal Cytoskeleton Is at Risk After Mild and Moderate Brain Injury

  1998cited by this paper
• Herpes Simplex Viral Vectors Expressing Bcl-2 Are Neuroprotective When Delivered After a Stroke

  1997cited by this paper
• Involvement of Activation of Dopamineraic Neuronal System in Learning and Memory Deficits Associated with Experimental Mild Traumatic Brain Injury

  1997cited by this paper
• A Concussive-Like Brain Injury Model in Mice (II): Selective Neuronal Loss in the Cortex and Hippocampus

  1997cited by this paper
• Involvement of activation of dopaminergic neuronal system in learning and memory deficits associated with experimental mild traumatic brain injury.

  1997cited by this paper
• Metabolic Quantification of Lesion Volume following Experimental Traumatic Brain Injury in the Rat

  1997cited by this paper
• Apoptosis-Suppressor Gene bcl-2 Expression after Traumatic Brain Injury in Rats

  1997cited by this paper
• Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

  1997cited by this paper
• Differential stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor in extensive and poor metabolizers of pantoprazole--a preliminary study.

  1997cited by this paper
• Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury

  1997cited by this paper
• Early Neuropathologic Effects of Mild or Moderate Hypoxemia after Controlled Cortical Impact Injury in Rats

  1997cited by this paper
• Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

  1997cited by this paper
• Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat

  1996cited by this paper
• Hemoglobin Potentiates Excitotoxic Injury in Cortical Cell Culture

  1996cited by this paper
• Changes in microtubule-associated protein 2 and amyloid precursor protein immunoreactivity following traumatic brain injury in rat: influence of MK-801 treatment.

  1996cited by this paper
• Purkinje Cell Vulnerability to Mild Traumatic Brain Injury

  1996cited by this paper
• Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?

  1996cited by this paper
• Prolonged Calpain‐mediated Spectrin Breakdown Occurs Regionally Following Experimental Brain Injury in the Rat

  1996cited by this paper
• Long‐Term Persisting Cognitive Sequelae of Traumatic Brain Injury and the Effect of Age

  1996cited by this paper
• Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

  1996cited by this paper
• Altered Immunoexpression of Microglia and Macrophages after Mild Head Injury

  1995cited by this paper
• Dynamics of cell proliferation and cell death during the emergence of primitive neuroectodermal tumors of the immature central nervous system in transgenic mice.

  1995cited by this paper
• Late neurobehavioural symptoms after mild head injury.

  1995cited by this paper
• Upregulation of bax protein levels in neurons following cerebral ischemia

  1995cited by this paper
• Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia.

  1995cited by this paper
• Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

  1995cited by this paper
• Early Microvascular and Neuronal Consequences of Traumatic Brain Injury: A Light and Electron Microscopic Study in Rats

  1994cited by this paper
• Animate Models of Human Head Injury

  1994cited by this paper
• Lateral Cortical Impact Injury in Rats: Pathologic Effects of Varying Cortical Compression and Impact Velocity

  1994cited by this paper
• Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia.

  1994cited by this paper
• Selective cognitive impairment following traumatic brain injury in rats.

  1993cited by this paper
• bcl-2 inhibits death of central neural cells induced by multiple agents.

  1993cited by this paper
• Concussive brain injury is associated with a prolonged accumulation of calcium: a 45Ca autoradiographic study.

  1993cited by this paper
• Unilateral Cortical Contusion Injury in the Rat: Vascular Disruption and Temporal Development of Cortical Necrosis

  1993cited by this paper
• Mild Experimental Brain Injury in the Rat Induces Cognitive Deficits Associated with Regional Neuronal Loss in the Hippocampus

  1993cited by this paper
• Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

  1993cited by this paper
• Pathobiology of traumatically induced axonal injury in animals and man.

  1993cited by this paper
• Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation

  1993cited by this paper
• Long-term consequences of minimal brain injury: loss of consciousness does not predict memory impairment.

  1992cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus

  1992cited by this paper
• Minor head injury: impact on general health after 1 year. A prospective follow‐up study

  1992cited by this paper
• Breakdown of the Blood–Brain Barrier after Fluid Percussive Brain Injury in the Rat. Part 1: Distribution and Time Course of Protein Extravasation

  1992cited by this paper
• Dynamic changes in local cerebral glucose utilization following cerebral conclusion in rats: evidence of a hyper- and subsequent hypometabolic state.

  1991cited by this paper
• Mild head injury classification.

  1990cited by this paper
• Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury.

  1990cited by this paper
• Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model.

  1989cited by this paper
• The epidemiology of mild, uncomplicated brain injury.

  1988cited by this paper
• CNS trauma: head injuries.

  1984cited by this paper
• The morphopathologic substrates of concussion?

  1979cited by this paper

• Tauroursodeoxycholic acid reduces brain lesion volume and cortical edema in a rat model of Traumatic brain injury.

  2025cites this paper
• Traumatic brain injury and neurodegenerative diseases: the role of axonal injury and amyloid-β.

  2025cites this paper
• Role of Thyroid Hormone in Neurodegenerative Disorders of Older People

  2025cites this paper
• Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside

  2024cites this paper
• Temporal expression of brainstem neurotrophic proteins following mild traumatic brain injury.

  2024cites this paper
• Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles inhibit neuronal death after spinal cord injury by regulating the SIRT1/Nrf2/HO-1 pathway

  2024cites this paper
• Potential chemopreventive effects of Broccoli extract supplementation against 7, 12 dimethyl Benz(a)anthracene (DMBA) -induced toxicity in female rats

  2023cites this paper
• A multiscale tissue assessment in a rat model of mild traumatic brain injury

  2022cites this paper
• Concussion in the UK: a contemporary narrative review

  2022cites this paper
• Lupeol Treatment Attenuates Activation of Glial Cells and Oxidative-Stress-Mediated Neuropathology in Mouse Model of Traumatic Brain Injury

  2022cites this paper
• Sports concussion and epigenetics

  2021cites this paper
• Effect of Centella asiatica L. Extract on Apoptosis and Bcl-2 Immunoexpression of Pyramidal Cells in Traumatic Brain Injury Rat Model

  2021cites this paper
• Design and Evaluation of an In Vitro Mild Traumatic Brain Injury Modeling System Using 3D Printed Mini Impact Device on the 3D Cultured Human iPSC Derived Neural Progenitor Cells

  2021cites this paper
• The Cellular and Physiological Basis of Behavioral Health After Mild Traumatic Brain Injury

  2020cites this paper
• Mental Health in the Athlete: Modern Perspectives and Novel Challenges for the Sports Medicine Provider

  2020cites this paper
• What Happens to Concussed Animals?

  2019cites this paper
• High Serum Caspase-Cleaved Cytokeratin-18 Levels and Mortality of Traumatic Brain Injury Patients

  2019cites this paper
• Concussion Pathophysiology and Injury Biomechanics

  2019cites this paper
• Axons Embedded in a Tissue CAN Withstand Larger Deformations Than Isolated Axons Before Mechanoporation Occurs.

  2019cites this paper
• Large animal models of stroke and traumatic brain injury as translational tools.

  2018cites this paper
• Studies on molecular imaging in traumatic brain injury with neurobehavioral disability

  2018cites this paper
• Thyroid hormone and the brain: Mechanisms of action in development and role in protection and promotion of recovery after brain injury

  2018cites this paper
• The Effects of a Combination of Ion Channel Inhibitors in Female Rats Following Repeated Mild Traumatic Brain Injury

  2018cites this paper
• Inflammatory and apoptotic signalling pathways and concussion severity: a genetic association study

  2018cites this paper
• Factors promoting vulnerability to dysregulated stress reactivity and stress‐related disease

  2018cites this paper
• Mesencephalic Astrocyte-Derived Neurotrophic Factor Prevents Traumatic Brain Injury in Rats by Inhibiting Inflammatory Activation and Protecting the Blood-Brain Barrier.

  2018cites this paper
• Neuroprotection of hyperbaric oxygen treatment for traumatic brain injury involving autophagy pathway in rats

  2017cites this paper
• Biomarkers Associated with the Outcome of Traumatic Brain Injury Patients

  2017cites this paper
• Progress of Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury

  2017cites this paper
• Repeated Mild Traumatic Brain Injury

  2017cites this paper
• Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury

  2017cites this paper
• Effect of docosahexaenoic acid on traumatic brain injury in rats.

  2017cites this paper
• I-123 iomazenil single photon emission computed tomography for detecting loss of neuronal integrity in patients with traumatic brain injury

  2017cites this paper
• White matter damage after traumatic brain injury: A role for damage associated molecular patterns.

  2017cites this paper
• Expression of BDNF and Nogo-A after singular and repetitive mild traumatic brain injury in rats

  2017cites this paper
• Heme Oxygenase 1 expression after traumatic brain injury and effect of pharmacological manipulation on functional recovery.

  2017influential citation
• Mechanical stress models of Alzheimer's disease pathology

  2016cites this paper
• Neuronal loss as evidenced by automated quantification of neuronal density following moderate and severe traumatic brain injury in rats

  2016influential citation
• Review Article Mechanical stress models of Alzheimer's disease pathology

  2016cites this paper
• Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist

  2016cites this paper
• Advanced neuroimaging to quantify myelin in vivo: Application to mild TBI

  2016cites this paper
• Application of Tauroursodeoxycholic Acid for Treatment of Neurological and Non-neurological Diseases: Is There a Potential for Treating Traumatic Brain Injury?

  2016cites this paper
• Moderate Hypothermia Significantly Decreases Hippocampal Cell Death Involving Autophagy Pathway after Moderate Traumatic Brain Injury

  2015cites this paper
• New Prognostic Biomarkers in Patients With Traumatic Brain Injury

  2015cites this paper
• Mechanical Stress as the Common Denominator between Chronic Inflammation, Cancer, and Alzheimer’s Disease

  2015cites this paper
• Serum Levels of Caspase-Cleaved Cytokeratin-18 in Patients with Severe Traumatic Brain Injury Are Associated with Mortality: A Pilot Study

  2015cites this paper
• Neuro-chemical analysis of cortical spreading depolarizations after severe traumatic brain injury : a continuum from a physiologic response to a metabolic crisis?

  2015cites this paper
• Attenuation of Cell Death in Injured Cortex After Post-Traumatic Brain Injury Moderate Hypothermia: Possible Involvement of Autophagy Pathway.

  2015cites this paper
• 1 Mechanical Stress Models of Alzheimer ’ s disease Pathology

  2015cites this paper
• Models of Mild Traumatic Brain Injury: Translation of Physiological and Anatomic Injury.

  2014cites this paper
• Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat.

  2014cites this paper
• Repeated Blast Exposures Cause Brain DNA Fragmentation in Mice

  2014cites this paper
• A rapid lateral fluid percussion injury rodent model of traumatic brain injury and post-traumatic epilepsy

  2014cites this paper
• Possible nitric oxide modulation in the protective effects of rutin against experimental head trauma-induced cognitive deficits: behavioral, biochemical, and molecular correlates.

  2014cites this paper
• Newly identified precipitating factors in mechanical ventilation-induced brain damage: implications for treating ICU delirium

  2014cites this paper
• Models of mild traumatic brain injury: translation of physiological and anatomic injury.

  2014cites this paper
• Terapìa intralesional con células madre mesenquimales alógenicas para la prevención de las secuelas motoras y sensoriales en el modelo animal pediátrico de traumatismo craneoencefálico grave

  2014cites this paper
• Neuroprotective Efficacy of a Proneurogenic Compound after Traumatic Brain Injury

  2014cites this paper
• Effect of normabaric hyperoxia treatment on neuronal damage following fluid percussion injury in the striatum of mice: A morphological approach

  2013cites this paper
• Osteopontin Expression During the Acute Immune Response Mediates Reactive Synaptogenesis and Adaptive Outcome

  2013cites this paper
• Brain injury, neuroinflammation and Alzheimer's disease

  2013cites this paper
• Challenges in the Development of Rodent Models of Mild Traumatic Brain Injury

  2013cites this paper
• Do β-Defensins and Other Antimicrobial Peptides Play a Role in Neuroimmune Function and Neurodegeneration?

  2012cites this paper
• MRI Characterization of Progressive Brain Alterations After Experimental Traumatic Brain Injury: Region Specific Tissue Damage, Hemodynamic Changes and Axonal Injury

  2012cites this paper
• Genetic Manipulation of Cell Death and Neuroplasticity Pathways in Traumatic Brain Injury

  2012cites this paper
• Biological mechanisms involved in the spread of traumatic brain damage

  2012influential citation
• Quelles potentialités thérapeutiques pour l’érythropoiétine recombinante dans le traitement des traumatismes du système nerveux central ?

  2012cites this paper
• [Biological mechanisms involved in the spread of traumatic brain damage].

  2012cites this paper
• Increased Expression of Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Delta after Rat Traumatic Brain Injury

  2012cites this paper
• Fas and FasL Expression in the Spinal Cord Following Cord Hemisection in the Monkey

  2011cites this paper
• Oligodendrocyte vulnerability following traumatic brain injury in rats.

  2011cites this paper
• Neurochemical Pathomechanisms in Traumatic Brain Injury

  2011cites this paper
• Differential Effects of Injury Severity on Cognition and Cellular Pathology after Contusive Brain Trauma in the Immature Rat

  2011cites this paper
• HIPPOCAMPAL VOLUME IN DIFFERENT NEUROPSYCHIATRIC COHORTS USING A SEMIAUTOMATIC, STEREOLOGICAL AND AUTOMATIC METHOD

  2011cites this paper
• Evidence for cellular injury in the midbrain of rats following chronic constriction injury of the sciatic nerve.

  2011cites this paper
• Cognitive deficits, behavioral changes and gene expression profiling in a mouse model of repeated mild traumatic brain injury

  2011cites this paper
• Stereology and Ultrastructure of Chronic Phase Axonal and Cell Soma Pathology in Stretch-Injured Central Nerve Fibers

  2011cites this paper
• Oligodendrocyte Vulnerability Following Traumatic Brain Injury in Rats: Effect of Moderate Hypothermia

  2011cites this paper
• Changes in the Brain after Intracerebral Implantation of a Lead Pellet in the Rat

  2010cites this paper
• Die Rolle der alternativen Komplementaktivierung im experimentellen Schädel-Hirn-Trauma Modell der Maus

  2010cites this paper
• Cell death mechanisms in the early stages of acute glutamate neurotoxicity.

  2010cites this paper
• Evaluación del polimorfismo Arg72Pro de p53 como factor pronóstico del traumatismo craneoencefálico grave y su participación en la construcción de un modelo predictivo

  2009cites this paper
• Activation of NR2B and Autophagy Signaling Pathways Following Traumatic Brain Injury

  2009cites this paper
• Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat--11 months follow-up.

  2009cites this paper
• [Evaluation of the p53 Arg72Pro polymorphism as a prognostic factor in severe head injury and the inclusion of this indicator in a predictive model].

  2009cites this paper
• Diazepam attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons.

  2008cites this paper
• Magnetic Resonance Imaging of Progressive Changes in Traumatic Brain Injury and Epileptogenesis

  2008cites this paper
• Mild traumatic brain injury to the infant mouse causes robust white matter axonal degeneration which precedes apoptotic death of cortical and thalamic neurons.

  2008cites this paper
• Cerebral Apoptosis in Severe Traumatic Brain Injury Patients: An In Vitro, In Vivo, and Postmortem Study

  2008cites this paper
• Apoptotic and behavioral sequelae of mild brain trauma in mice

  2007cites this paper
• [Neurodegeneration in experimental stroke--involvement of apoptosis-regulating proteins].

  2007cites this paper
• Vaccinia virus complement control protein significantly improves sensorimotor function recovery after severe head trauma.

  2007cites this paper
• Spatio-temporal distribution of apoptosis and the modulators thereof following a cortical microinfarct in rat brain.

  2007cites this paper
• Cellular and subcellular change evoked by diffuse traumatic brain injury: a complex web of change extending far beyond focal damage.

  2007cites this paper
• Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: relationship with neuronal cell death and inflammatory mediators.

  2007cites this paper
• The role of extracellular matrix proteins in traumatic brain injury and cell transplantation

  2006cites this paper
• Loss of neuronal integrity: a cause of hypometabolism in patients with traumatic brain injury without MRI abnormality in the chronic stage

  2006cites this paper
• Genomic clues to secondary injury mechanisms in brain trauma

  2006cites this paper
• Differential Behavioral and Histopathological Responses to Graded Cortical Impact Injury in Mice

  2006cites this paper
• Lateral fluid percussion injury in the developing rat causes an acute, mild behavioral dysfunction in the absence of significant cell death.

  2006cites this paper