Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after wounding.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2008-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpcell.00232.2008PMID 18923057PMCID PMC2603560
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of myosin regulatory light chain and Rac1 in the migration of polyamine-depleted intestinal epithelial cells.

  2007cited by this paper
• Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding.

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• Phospholipase C-gamma1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation.

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• Regulation of calcium signalling by the small GTP-binding proteins Ras and Rac1.

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• Phospholipase Cγ/diacylglycerol‐dependent activation of β2‐chimaerin restricts EGF‐induced Rac signaling

  2006cited by this paper
• TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding.

  2006cited by this paper
• Regulation of Kv Channel Activity and Intercellular Junctions by Polyamines in Intestinal Epithelial Cells

  2006cited by this paper
• Polyamine Depletion Increases Cytoplasmic Levels of RNA-binding Protein HuR Leading to Stabilization of Nucleophosmin and p53 mRNAs*

  2006cited by this paper
• Store-operated calcium channels.

  2005cited by this paper
• Phospholipase Cγ1 controls surface expression of TRPC3 through an intermolecular PH domain

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• Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes.

  2005cited by this paper
• Cdc42–MRCK and Rho–ROCK signalling cooperate in myosin phosphorylation and cell invasion

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• Polyamines and cancer: old molecules, new understanding

  2004cited by this paper
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  2004cited by this paper
• Hyaluronan-CD44 Interaction with Rac1-dependent Protein Kinase N-γ Promotes Phospholipase Cγ1 Activation, Ca2+ Signaling, and Cortactin-Cytoskeleton Function Leading to Keratinocyte Adhesion and Differentiation*

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• The Requirement for Polyamines for Intestinal Epithelial Cell Migration Is Mediated through Rac1*

  2003influential reference
• Modification of phospholipase C-gamma-induced Ca2+ signal generation by 2-aminoethoxydiphenyl borate.

  2003cited by this paper
• Calcium Signaling Regulates Translocation and Activation of Rac*

  2003cited by this paper
• Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution.

  2003cited by this paper
• Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding.

  2002cited by this paper
• Rho GTPases in cell biology

  2002cited by this paper
• Polyamines regulate β-catenin tyrosine phosphorylation via Ca2+ during intestinal epithelial cell migration

  2002cited by this paper
• The cellular and molecular basis of store-operated calcium entry

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• Ca 2+ Signaling in Epithelial Restitution

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• Gastrointestinal mucosal repair and experimental therapeutics

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• JunD stabilization results in inhibition of normal intestinal epithelial cell growth through P21 after polyamine depletion.

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• Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells.

  2002cited by this paper
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• Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migration.

  2002cited by this paper
• Regulation of phosphoinositide-specific phospholipase C.

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• Rac1 Protects Epithelial Cells against Anoikis*

  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  1999influential reference
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Luminal polyamines substitute for tissue polyamines in duodenal mucosal repair after stress in rats.

  1992cited by this paper
• The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments.

  1991cited by this paper
• Polyamines and ornithine decarboxylase during repair of duodenal mucosa after stress in rats.

  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Mechanisms for rapid re-epithelialization of the gastric mucosal surface.

  1985cited by this paper
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  1959cited by this paper

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  2022cites this paper
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