Longitudinal tau PET in ageing and Alzheimer’s disease

C. Jack,H. Wiste,C. Schwarz,V. Lowe,M. Senjem,P. Vemuri,S. Weigand,T. Therneau,D. Knopman,J. Gunter,David T. Jones,J. Graff‐Radford,K. Kantarci,R. Roberts,M. Mielke,M. Machulda,R. Petersen

Published 2018 in Brain : a journal of neurology

ABSTRACT

See Hansson and Mormino (doi:10.1093/brain/awy065) for a scientific commentary on this article. Where should measurements be taken to best capture tau accumulation in ageing and Alzheimer’s disease? Jack et al. report that in clinically symptomatic stages of Alzheimer’s disease, tau accumulation occurs throughout the brain, rather than only in specific areas. Rate measurements from simple meta-regions of interest may be sufficient to capture progressive within-person tau accumulation.

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