Mitochondrial permeability transition: a common pathway to necrosis and apoptosis.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2003-05-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0006-291X(03)00618-1PMID 12729580
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Heat Shock Suppresses the Permeability Transition in Rat Liver Mitochondria*

  2003cited by this paper
• Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes.

  2003cited by this paper
• Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811.

  2002cited by this paper
• Mitochondrial Targeted Cyclophilin D Protects Cells from Cell Death by Peptidyl Prolyl Isomerization*

  2002cited by this paper
• Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?

  2002cited by this paper
• Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by myocardial ischaemia.

  2001cited by this paper
• Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia

  2001cited by this paper
• Mitochondria: a target for myocardial protection.

  2001cited by this paper
• Mechanism of cell death during warm hepatic ischemia‐reperfusion in rats: Apoptosis or necrosis?

  2001cited by this paper
• Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

  2001cited by this paper
• Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

  2000cited by this paper
• V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis.

  1999cited by this paper
• The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187.

  1999cited by this paper
• Signal presequences increase mitochondrial permeability and open the multiple conductance channel.

  1999cited by this paper
• Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced by tert‐butylhydroperoxide in rat hepatocytes

  1999cited by this paper
• V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis.

  1999cited by this paper
• Molecular characterization of mitochondrial apoptosis-inducing factor

  1999cited by this paper
• Development of porous defects in plasma membranes of adenosine triphosphate-depleted Madin-Darby canine kidney cells and its inhibition by glycine.

  1998cited by this paper
• Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.

  1998cited by this paper
• Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation

  1998cited by this paper
• Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore.

  1998cited by this paper
• Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

  1997cited by this paper
• The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis

  1997cited by this paper
• Apoptosis after intestinal ischemia-reperfusion injury: a morphological study.

  1997cited by this paper
• Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

  1997cited by this paper
• Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes.

  1997cited by this paper
• The Reversible Antiport-Uniport Conversion of the Phosphate Carrier from Yeast Mitochondria Depends on the Presence of a Single Cysteine*

  1997cited by this paper
• The mechanism of action of cyclosporin A and FK506.

  1996cited by this paper
• Mitochondrial control of nuclear apoptosis

  1996cited by this paper
• Mitochondrial ADP/ATP carrier can be reversibly converted into a large channel by Ca2+.

  1996cited by this paper
• Activity of the Mitochondrial Multiple Conductance Channel Is Independent of the Adenine Nucleotide Translocator (*)

  1996cited by this paper
• Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.

  1996cited by this paper
• Control of apoptosis by the cellular ATP level

  1996cited by this paper
• Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

  1996cited by this paper
• The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition (*)

  1995cited by this paper
• Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study

  1995cited by this paper
• Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide.

  1995cited by this paper
• ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition.

  1994cited by this paper
• Physiological pH. Effects on posthypoxic proximal tubular injury.

  1993cited by this paper
• Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin.

  1992cited by this paper
• Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies.

  1992cited by this paper
• Efflux of protons from acidic vesicles contributes to cytosolic acidification of hepatocytes during ATP depletion

  1991cited by this paper
• Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox

  1991cited by this paper
• A pH-dependent phospholipase A2 contributes to loss of plasma membrane integrity during chemical hypoxia in rat hepatocytes.

  1991cited by this paper
• Protection by acidotic pH against anoxia/reoxygenation injury to rat neonatal cardiac myocytes.

  1991cited by this paper
• The cell biology of ischemic renal injury.

  1991cited by this paper
• The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A.

  1991cited by this paper
• Mechanisms by which mitochondria transport calcium.

  1990cited by this paper
• Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase.

  1990cited by this paper
• The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents.

  1990cited by this paper
• Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

  1989cited by this paper
• Relationship between configuration, function, and permeability in calcium-treated mitochondria.

  1976cited by this paper
• Chemical and physical fixation of isolated mitochondria in low-energy and high-energy states.

  1968cited by this paper

• Mitochondria-targeting natural product rhein conjugated with dichloroacetate as the dual inhibitor of glycolysis and oxidative phosphorylation to off energize cancer cells and induce ROS storm

  2025cites this paper
• Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental studies in rats

  2025cites this paper
• Dynamic mechanisms and targeted interventions in cerebral ischemia–reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies

  2025cites this paper
• Effects of ultra-fast nanosecond electric pulses on mitochondria transmembrane potential and oxidation

  2025cites this paper
• In vitro antioxidant and antimicrobial activities and therapeutic effects of Rhizopogon luteolus Fr. extract on cecal ligation and puncture-induced sepsis in rats

  2025cites this paper
• Purinergic P2X receptor 7 (P2X7R) inhibition induced cytotoxicity in glioblastoma

  2025influential citation
• Targeting metalloptosis in tumor therapy: from molecular mechanisms to application of metal nanoparticles

  2025cites this paper
• Explosive cytotoxicity of ‘ruptoblasts’ bridges hormonal surveillance and immune defense

  2025cites this paper
• From Euphoria to Cardiac Stress: Role of Oxidative Stress on the Cardiotoxicity of Methylone and 3,4-DMMC

  2025cites this paper
• Reactive Oxygen Species Across Death Pathways: Gatekeepers of Apoptosis, Ferroptosis, Pyroptosis, Paraptosis, and Beyond

  2025cites this paper
• The therapeutic role of ginseng in promoting hippocampal neurogenesis and ameliorating cognitive function following whole brain radiotherapy in rats

  2025cites this paper
• Therapeutic Potential of Hydrogen Sulfide in Ischemia and Reperfusion Injury

  2024cites this paper
• Calcium and Non-Penetrating Traumatic Brain Injury: A Proposal for the Implementation of an Early Therapeutic Treatment for Initial Head Insults

  2024cites this paper
• Altered mitochondrial lymphocyte in overweight schizophrenia patients treated with atypical antipsychotics and its association with cognitive function

  2024cites this paper
• Polyethylene Glycol and Caspase Inhibitor Emricasan Alleviates Cold Injury in Primary Rat Hepatocytes.

  2024cites this paper
• The Bordetella effector protein BteA induces host cell death by disruption of calcium homeostasis

  2024cites this paper
• Caspase-3 interactins with calpain and cathepsin L: implications for protein stability and quality in fish fillets during postmortem storage

  2024cites this paper
• Vitrification of Mammalian Oocytes: Recent Studies on Mitochondrial Dysfunction

  2024cites this paper
• Fluorescence lifetime imaging unravels the pathway of glioma cell death upon hypericin-induced photodynamic therapy

  2024cites this paper
• Effect of Cannabidiol and hemp extract on viability and function of hepatocytes derived from human induced pluripotent stem cells.

  2024cites this paper
• Selected Functions and Disorders of Mitochondrial Metabolism under Lead Exposure

  2024cites this paper
• UDCA for Drug-Induced Liver Disease: Clinical and Pathophysiological Basis

  2024cites this paper
• Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo

  2024cites this paper
• A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines

  2024cites this paper
• Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection

  2024cites this paper
• Tissue‐specific differences in Ca2+ sensitivity of the mitochondrial permeability transition pore (PTP). Experiments in male rat liver and heart

  2024cites this paper
• Mitochondrial Pharmacotherapeutics - Advancements and Applications

  2024cites this paper
• Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma

  2023cites this paper
• Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury

  2023cites this paper
• Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer

  2023cites this paper
• The Impact of Neurotransmitters on the Neurobiology of Neurodegenerative Diseases

  2023cites this paper
• Evaluation of in vitro effects of ifosfamide drug on mitochondrial functions using isolated mitochondria obtained from vital organs

  2023cites this paper
• Cyclophilin D Contributes to Airway Epithelial Mitochondrial Damage in Chronic Obstructive Pulmonary Disease

  2023cites this paper
• The potential role of glucose metabolism, lipid metabolism, and amino acid metabolism in the treatment of Parkinson's disease

  2023cites this paper
• Reproductive toxicity of microplastics in female mice and their offspring from induction of oxidative stress.

  2023cites this paper
• Polyethylene Glycol and Caspase Inhibitor Emricasan Alleviates Cold Injury in Primary Rat Hepatocytes

  2023cites this paper
• Chronic exposure to bisphenol A induces behavioural, neurochemical, histological, and ultrastructural alterations in the ganglia tissue of the date mussels Lithophaga lithophaga

  2023cites this paper
• The development of new biomarkers of spermatozoa quality in cattle

  2023cites this paper
• Effects of Vitamin D On Cisplatin Induced Heart and Lung Toxicity in Albino Rat

  2022cites this paper
• Mitochondrial Autophagy in Ischemic Aged Livers

  2022cites this paper
• Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury

  2022cites this paper
• Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers

  2022cites this paper
• Mitochondrial Damage of Lymphocytes in Patients with Acute Relapse of Schizophrenia: A Correlational Study with Efficacy and Clinical Symptoms

  2022cites this paper
• Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury

  2022cites this paper
• Based on network pharmacology and molecular docking to explore the protective effect of Epimedii Folium extract on cisplatin-induced intestinal injury in mice

  2022cites this paper
• Effects of light-emitting diodes on cell biology

  2022cites this paper
• Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury

  2022cites this paper
• Pre-Ischemic Hypothermic Oxygenated Perfusion Alleviates Protective Molecular Markers of Ischemia-Reperfusion Injury in Rat Liver.

  2022cites this paper
• Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.

  2022cites this paper
• Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease

  2022cites this paper
• Clinical use of N-acetyl cysteine during liver transplantation: Implications of oxidative stress and inflammation as therapeutic targets.

  2022cites this paper
• Permeability-Controlled Probe for Directly Visualizing the Opening of Mitochondrial Permeability Transition Pore in Native Status.

  2022cites this paper
• The Molecular Quality and Mitochondrial Activity of Porcine Cumulus–Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation Conditions

  2022cites this paper
• LSTM-MPT Based Quantitative Portfolio Decision Model

  2022cites this paper
• Effects of lysophosphatidic acid (LPA) signaling via LPA receptors on cellular functions associated with ATP reduction in osteosarcoma cells treated with ethidium bromide

  2022cites this paper
• Integrative pharmacology reveals the mechanisms of Erzhi Pill, a traditional Chinese formulation, against diabetic cardiomyopathy.

  2022cites this paper
• Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway

  2022cites this paper
• Neurohormonal Connections with Mitochondria in Cardiomyopathy and Other Diseases.

  2022cites this paper
• Proteomic analysis suggests that monoterpenes in lemongrass disrupt Ca2+ homeostasis in Haemaphysalis longicornis leading to mitochondrial depolarization and cytotoxicity

  2022cites this paper
• E-prostanoid 3 receptor deficiency on myeloid cells protects against ischemic acute kidney injury via breaking the auto-amplification loop of necroinflammation.

  2022cites this paper
• Rotenone induces hepatotoxicity in rats by activating the mitochondrial pathway of apoptosis

  2022cites this paper
• The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy

  2022cites this paper
• Amelioration of myocardial ischemia/reperfusion injury in diabetes: A narrative review of the mechanisms and clinical applications of dexmedetomidine

  2022cites this paper
• POTENTIAL ROLE OF VITAMIN D RECEPTOR AGONIST IN ACETAMINOPHEN-INDUCED HEPATIC INJURY: ROLE OF CASPASE-1

  2021cites this paper
• Transcriptome profile of Haemaphysalis longicornis (Acari: Ixodidae) exposed to Cymbopogon citratus essential oil and citronellal suggest a cytotoxic mode of action involving mitochondrial Ca2+ overload and depolarization.

  2021cites this paper
• New Insights into the Mechanism of Action of the Cyclopalladated Complex (CP2) in Leishmania: Calcium Dysregulation, Mitochondrial Dysfunction, and Cell Death

  2021cites this paper
• Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action

  2021cites this paper
• The Role of Mitochondria in Acute Kidney Injury and Chronic Kidney Disease and Its Therapeutic Potential

  2021cites this paper
• A Novel Oxygen Carrier (M101) Attenuates Ischemia-Reperfusion Injuries during Static Cold Storage in Steatotic Livers

  2021cites this paper
• Coupling/Uncoupling Reversibility in Isolated Mitochondria from Saccharomyces cerevisiae

  2021cites this paper
• Dynamic Regulation of Cysteine Oxidation and Phosphorylation in Myocardial Ischemia–Reperfusion Injury

  2021cites this paper
• Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis

  2021cites this paper
• Protective effects of pretreatment with Fe2+, Cu2+, and Rb+ on phoxim poisoning in silkworm, Bombyx mori.

  2021cites this paper
• Mitochondrial Targeting Therapy Role in Liver Transplant Preservation Lines: Mechanism and Therapeutic Strategies

  2021cites this paper
• MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1α/SIRT3 Signaling Pathway

  2021cites this paper
• Flavonoids and cellular stress: a complex interplay affecting human health

  2021cites this paper
• The Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Do Not Know

  2021cites this paper
• Tumor necrosis: A synergistic consequence of metabolic stress and inflammation

  2021influential citation
• Cerebral and myocardial mitochondrial injury differ in a rat model of cardiac arrest and cardiopulmonary resuscitation.

  2021cites this paper
• Cytoprotection of rat hepatocytes by desipramine in a model of simulated ischemia/reperfusion

  2021cites this paper
• Mitochondria Content and Activity Are Crucial Parameters for Bull Sperm Quality Evaluation

  2021cites this paper
• Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease

  2021influential citation
• The Macrophage Response to Mycobacterium tuberculosis and Opportunities for Autophagy Inducing Nanomedicines for Tuberculosis Therapy

  2021cites this paper
• Regulated cell death in cisplatin-induced AKI: Relevance of myo-inositol metabolism.

  2021cites this paper
• The Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Don’t Know

  2021cites this paper
• Drug-Induced Vanishing Bile Duct Syndrome: From Pathogenesis to Diagnosis and Therapeutics

  2021cites this paper
• BAP31: Physiological functions and roles in disease.

  2021cites this paper
• Mitochondrial Dysfunction and Oxidative Stress Caused by Cryopreservation in Reproductive Cells

  2021cites this paper
• Mitochondrial osmoregulation in evolution, cation transport and metabolism.

  2021cites this paper
• Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers

  2021cites this paper
• Molecular mechanisms and consequences of mitochondrial permeability transition

  2021cites this paper
• The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice

  2021cites this paper
• Paraganglioma and Pheochromocytoma

  2021cites this paper
• Procoagulant Platelets

  2020cites this paper
• Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease.

  2020cites this paper
• Mitochondria-Targeted Polyamidoamine Dendrimer-Curcumin Construct for Hepatocellular Cancer Treatment.

  2020cites this paper
• Mechanical View on the Mitochondria

  2020cites this paper
• Recent Advances in Peptide-Based Approaches for Cancer Treatment.

  2020cites this paper
• Liver Transplantation and NAFLD/NASH

  2020cites this paper
• Efeito da infusão da solução M&G na proteção do tecido renal de ratos Wistar submetidos a isquemia e reperfusão programada

  2020cites this paper