Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles.

Liquid-liquid phase separation of charge- and/or aromatic-enriched intrinsically disordered proteins (IDPs) is critical in the biological function of membraneless organelles. Much of the physics of this recent discovery remains to be elucidated. Here, we present a theory in the random phase approximation to account for electrostatic effects in polyampholyte phase separations, yielding predictions consistent with recent experiments on the IDP Ddx4. The theory is applicable to any charge pattern and thus provides a general analytical framework for studying sequence dependence of IDP phase separation.

• Publication year

  2016

• Venue

  Physical Review Letters

• Publication date

  2016-05-29

• Fields of study

  Biology, Medicine, Physics, Chemistry

• Identifiers
  DOI 10.1103/PhysRevLett.117.178101arXiv 1605.09019PMID 27824447
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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