Extracellular vesicles in obesity and diabetes mellitus.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Aspects of Medicine

• Publication date

  2017-11-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mam.2017.11.010PMID 29175307
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Classification and Diagnosis of Diabetes.

  2022cited by this paper
• Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise.

  2018cited by this paper
• Human umbilical vein endothelium-derived exosomes play a role in foetoplacental endothelial dysfunction in gestational diabetes mellitus.

  2018cited by this paper
• Exosomes, an Unmasked Culprit in Neurodegenerative Diseases

  2017cited by this paper
• 2. Classification and Diagnosis of Diabetes.

  2017cited by this paper
• Review: Fetal-maternal communication via extracellular vesicles - Implications for complications of pregnancies.

  2017cited by this paper
• Early Pregnancy Biochemical Predictors of Gestational Diabetes Mellitus

  2017cited by this paper
• Perilipins: a diversity of intracellular lipid droplet proteins

  2017cited by this paper
• Liraglutide mitigates TNF‐α induced pro‐atherogenic changes and microvesicle release in HUVEC from diabetic women

  2017cited by this paper
• Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy

  2017cited by this paper
• Molecular implications of adenosine in obesity.

  2017cited by this paper
• Insulin/adenosine axis linked signalling.

  2017cited by this paper
• Maternal insulin therapy does not restore foetoplacental endothelial dysfunction in gestational diabetes mellitus.

  2017cited by this paper
• Vascular and Endothelial Function in Youth with Type 2 Diabetes Mellitus

  2017cited by this paper
• Extracellular Vesicles in Metabolic Syndrome

  2017cited by this paper
• Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease

  2017cited by this paper
• Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy

  2017cited by this paper
• Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus.

  2017cited by this paper
• Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients

  2016cited by this paper
• El ácido acetilsalicílico reduce la liberación de micropartículas eritrocitarias, monocitarias y de células del músculo liso vascular en pacientes diabéticos

  2016cited by this paper
• The potential of endurance exercise-derived exosomes to treat metabolic diseases

  2016cited by this paper
• Targeting adipose tissue in the treatment of obesity-associated diabetes

  2016cited by this paper
• Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients

  2016cited by this paper
• Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress

  2016cited by this paper
• Adiponectin signaling and function in insulin target tissues

  2016cited by this paper
• Urinary exosomal microRNA panel unravels novel biomarkers for diagnosis of type 2 diabetic kidney disease.

  2016cited by this paper
• Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus

  2016cited by this paper
• Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

  2016cited by this paper
• ExoCarta: A Web-Based Compendium of Exosomal Cargo.

  2016cited by this paper
• Dynamics of circulating microparticles in obesity after weight loss

  2016cited by this paper
• MicroRNAs as regulators of beta‐cell function and dysfunction

  2016cited by this paper
• Cell-Derived Microparticles in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis

  2016cited by this paper
• Microparticle Shedding by Erythrocytes, Monocytes and Vascular Smooth Muscular Cells Is Reduced by Aspirin in Diabetic Patients.

  2016cited by this paper
• Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

  2016cited by this paper
• Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease

  2015cited by this paper
• Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical applications

  2015cited by this paper
• Tumour exosome integrins determine organotropic metastasis

  2015cited by this paper
• Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and Related Metabolic Disorders.

  2015cited by this paper
• Microparticles Release by Adipocytes Act as “Find-Me” Signals to Promote Macrophage Migration

  2015cited by this paper
• Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction

  2015cited by this paper
• Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis

  2015cited by this paper
• Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells.

  2015cited by this paper
• Inflamed macrophage microvesicles induce insulin resistance in human adipocytes

  2015cited by this paper
• Insulin therapy and fetoplacental vascular function in gestational diabetes mellitus

  2015cited by this paper
• Platelets microparticles as a link between micro- and macro-angiopathy in young patients with type 1 diabetes

  2015cited by this paper
• Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes‐reduced adenosine transport in human umbilical vein endothelium

  2015cited by this paper
• Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation

  2015cited by this paper
• Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

  2015cited by this paper
• Plasma exosome microRNA profiling unravels a new potential modulator of adiponectin pathway in diabetes: effect of glycemic control.

  2014cited by this paper
• Circulating Extracellular Vesicles with Specific Proteome and Liver MicroRNAs Are Potential Biomarkers for Liver Injury in Experimental Fatty Liver Disease

  2014cited by this paper
• Adipocyte-derived Exosomal miRNAs: A Novel Mechanism for Obesity-Related Disease

  2014cited by this paper
• Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles

  2014cited by this paper
• Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease

  2014cited by this paper
• Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

  2014cited by this paper
• Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages

  2014cited by this paper
• Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes.

  2014cited by this paper
• Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells

  2014cited by this paper
• Adiponectin is partially associated with exosomes in mouse serum.

  2014cited by this paper
• Urinary Exosomal MicroRNAs in Incipient Diabetic Nephropathy

  2013cited by this paper
• Microparticle increase in severe obesity: Not related to metabolic syndrome and unchanged after massive weight loss

  2013cited by this paper
• Wilm's Tumor-1 Protein Levels in Urinary Exosomes from Diabetic Patients with or without Proteinuria

  2013cited by this paper
• Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

  2013cited by this paper
• Extracellular vesicles: Exosomes, microvesicles, and friends

  2013cited by this paper
• Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes

  2013cited by this paper
• Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles.

  2013cited by this paper
• Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin

  2012cited by this paper
• AMPK: a nutrient and energy sensor that maintains energy homeostasis

  2012cited by this paper
• Microvesicles/exosomes as potential novel biomarkers of metabolic diseases

  2012cited by this paper
• Adipokines in inflammation and metabolic disease

  2011cited by this paper
• Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes.

  2011cited by this paper
• Insulin Restores Gestational Diabetes Mellitus–Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium

  2011cited by this paper
• Inflammation, Oxidative Stress, and Obesity

  2011cited by this paper
• Macrophage-mediated inflammation in metabolic disease

  2011cited by this paper
• Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.

  2010cited by this paper
• Atorvastatin has antithrombotic effects in patients with type 1 diabetes and dyslipidemia.

  2010cited by this paper
• Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

  2009cited by this paper
• Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals.

  2008cited by this paper
• Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells

  2008cited by this paper
• Obesity, inflammation, and insulin resistance.

  2007cited by this paper
• Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity.

  2007cited by this paper
• Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

  2007cited by this paper
• Type 1 and type 2 diabetic patients display different patterns of cellular microparticles.

  2002cited by this paper
• Binding of activated Factor XII to endothelial cells affects its inactivation by the C1-esterase inhibitor.

  2002cited by this paper
• Redefining Type 2 diabetes: ‘Diabesity’ or ‘Obesity Dependent Diabetes Mellitus’?

  2000cited by this paper
• Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia.

  1996cited by this paper
• Ultrastructure of intracellular and extracellular vesicles, membranes, and myelin figures produced by Ochromonas danica.

  1971cited by this paper

• Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

  2026cites this paper
• Macrophages signal cross-talks under hyperglycemic conditions and their link to cyclophilins

  2026cites this paper
• Adipocyte extracellular vesicles (AdEVs) promote a proinflammatory and profibrotic profile in human renal and endothelial cells in vitro.

  2026cites this paper
• The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity

  2025cites this paper
• The proteome of circulating extracellular vesicles and their functional effect on platelets vary with the isolation method

  2025cites this paper
• Regulation of pancreatic β cells by exosomes from different sources.

  2025cites this paper
• The Proteomic Analysis of Platelet Extracellular Vesicles in Diabetic Patients by nanoLC-MALDI-MS/MS and nanoLC-TIMS-MS/MS

  2025influential citation
• Nanoliter Plasma Sample for Disease Diagnosis by Using a Visualization Platform of Counting Extracellular Vesicle Particles.

  2025cites this paper
• Crosstalk between microRNA and inflammation; critical regulator of diabetes.

  2025cites this paper
• Spectral analysis of blood components in diabetic patients with neuropathic complications: Exploring the diagnostic potential of extracellular vesicles.

  2025cites this paper
• CD4+ T-cell-derived small extracellular vesicles induce the apoptosis of renal tubular epithelial cells in diabetic nephropathy by regulating mitochondrial dynamics.

  2025cites this paper
• Research progress of exosomes in pathogenesis and treatment of preeclampsia

  2024cites this paper
• Promising nanotherapeutics of stem cell extracellular vesicles in liver regeneration

  2024cites this paper
• Shortcomings, limitations and gaps in physiological roles of extracellular vesicles in obesity.

  2024cites this paper
• Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance

  2024cites this paper
• Pathogenic Mechanisms, Diagnostic, and Therapeutic Potential of Microvesicles in Diabetes and Its Complications.

  2024cites this paper
• Biomarkers and diagnostic significance of non-coding RNAs in extracellular vesicles of pathologic pregnancy

  2024cites this paper
• Combination of Evidence from Bibliometrics and Bioinformatics Analysis Identifies miR-21 as a Potential Therapeutical Target for Diabetes

  2024cites this paper
• Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity—A Narrative Review

  2024cites this paper
• Current landscape of exosomal non-coding RNAs in prostate cancer: Modulators and biomarkers

  2024cites this paper
• DBP Exposure Affects Oocyte Fertilization Via Extracellular Vesicles-Derived miR-116-5p in Ovarian Granulosa Cells Through Downregulating FOXO3a Expression

  2024cites this paper
• The emerging role of extracellular vesicle RNAs as mediators of cardiometabolic diseases: from pathophysiology to clinical applications.

  2024cites this paper
• Challenges and opportunities in obesity: the role of adipocytes during tissue fibrosis.

  2024cites this paper
• Extracellular vesicles in heart failure.

  2024cites this paper
• Proteomic Profiling of Plasma- and Gut-Derived Extracellular Vesicles in Obesity

  2024cites this paper
• Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease

  2024cites this paper
• Editorial: Organ crosstalk in the pathophysiology and treatment of type-2 diabetes

  2024cites this paper
• Systematic review and bioinformatics analysis of plasma and serum extracellular vesicles proteome in type 2 diabetes

  2024cites this paper
• Contribution of extracellular vesicles to neuroinflammation and cognitive and motor deficits in hyperammonemia and hepatic encephalopathy

  2024cites this paper
• How does exosome cause diabetes?

  2024cites this paper
• Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling

  2024cites this paper
• The role of extracellular vesicles in intercellular communication in human reproduction.

  2023cites this paper
• Waste to Medicine: Evidence from Computational Studies on the Modulatory Role of Corn Silk on the Therapeutic Targets Implicated in Type 2 Diabetes Mellitus

  2023cites this paper
• Polymicrobial Infection Induces Adipose Tissue Dysfunction via Gingival Extracellular Vesicles

  2023cites this paper
• Adipocyte-derived exosomal miR-22-3p modulated by circadian rhythm disruption regulates insulin sensitivity in skeletal muscle cells

  2023cites this paper
• Extracellular vesicles modulate key signalling pathways in refractory wound healing

  2023cites this paper
• Extracellular Vesicles for Drug Delivery in Cancer Treatment

  2023cites this paper
• Downregulation of Exosomal hsa-miR-551b-3p in Obesity and Its Link to Type 2 Diabetes Mellitus

  2023cites this paper
• Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease

  2023cites this paper
• MicroRNA and Protein Cargos of Human Limbal Epithelial Cell-Derived Exosomes and Their Regulatory Roles in Limbal Stromal Cells of Diabetic and Non-Diabetic Corneas

  2023cites this paper
• Obesity Modifies the Proteomic Profile of the Periodontal Ligament

  2023cites this paper
• Placenta‐derived exosomal miR‐135a‐5p promotes gestational diabetes mellitus pathogenesis by activating PI3K/AKT signalling pathway via SIRT1

  2023influential citation
• Biomarkers of aging in frailty and age-associated disorders: state of the art and future perspective.

  2023cites this paper
• Extracellular Vesicles and Obesity.

  2023cites this paper
• Adipocyte-Derived Exosomal NOX4-Mediated Oxidative Damage Induces Premature Placental Senescence in Obese Pregnancy

  2023cites this paper
• Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease

  2023cites this paper
• The effect of obesity on uterine receptivity is mediated by endometrial extracellular vesicles that control human endometrial stromal cell decidualization and trophoblast invasion

  2023cites this paper
• New signaling kid on the block in the endocrine system: the role of extracellular vesicles.

  2023cites this paper
• Serum amyloid A and metabolic disease: evidence for a critical role in chronic inflammatory conditions

  2023cites this paper
• Extracellular vesicle-mediated intercellular and interorgan crosstalk of pancreatic islet in health and diabetes

  2023cites this paper
• Molecular Mechanisms of Western Diet-Induced Obesity and Obesity-Related Carcinogenesis—A Narrative Review

  2023cites this paper
• Extracellular Vesicles and Their Zeta Potential as Future Markers Associated with Nutrition and Molecular Biomarkers in Breast Cancer

  2023cites this paper
• Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk

  2023cites this paper
• Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

  2023cites this paper
• Cryo-electron microscopy of adipose tissue extracellular vesicles in obesity and type 2 diabetes mellitus

  2023influential citation
• Inter-organ crosstalk and the effect on the aging process in obesity.

  2023cites this paper
• Serum small extracellular vesicles in overweight and obese dogs before and after weight loss: preliminary observations

  2023cites this paper
• Multi-Omics Integrative Approach of Extracellular Vesicles: A Future Challenging Milestone

  2022cites this paper
• Resveratrol Enhances Wound Healing in Type 1 Diabetes Mellitus by Promoting the Expression of Extracellular Vesicle-Carried MicroRNA-129 Derived from Mesenchymal Stem Cells.

  2022cites this paper
• The global trend of exosome in diabetes research: A bibliometric approach.

  2022cites this paper
• Integration of Metabolomics and Proteomics in Exploring the Endothelial Dysfunction Mechanism Induced by Serum Exosomes From Diabetic Retinopathy and Diabetic Nephropathy Patients

  2022cites this paper
• Impact of Storage Conditions on EV Integrity/Surface Markers and Cargos

  2022cites this paper
• Obesity affects the proteome profile of periodontal ligament submitted to mechanical forces induced by orthodontic tooth movement in rats.

  2022cites this paper
• The Combined Partial Knockdown of CBS and MPST Genes Induces Inflammation, Impairs Adipocyte Function-Related Gene Expression and Disrupts Protein Persulfidation in Human Adipocytes

  2022cites this paper
• Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dysfunction: a Systematic Review

  2022cites this paper
• Physische Aktivität: genetische Gewebekommunikation Basis präventiver Wirkungen

  2022cites this paper
• Differential Proteomic Profiles of Coronary Serum Exosomes in Acute Myocardial Infarction Patients with or Without Diabetes Mellitus: ANGPTL6 Accelerates Regeneration of Endothelial Cells Treated with Rapamycin via MAPK Pathways

  2022cites this paper
• Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy

  2022cites this paper
• Extracellular RNAs from immune cells under obesity—a narrative review

  2022cites this paper
• Obesity induces extracellular vesicle release from the endothelium as a contributor to brain damage after cerebral ischemia in rats

  2022cites this paper
• The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles

  2022cites this paper
• Research progress on the role of exosomes in obstructive sleep apnea-hypopnea syndrome-related atherosclerosis.

  2022cites this paper
• Brown Adipose Tissue Sheds Extracellular Vesicles That Carry Potential Biomarkers of Metabolic and Thermogenesis Activity Which Are Affected by High Fat Diet Intervention

  2022cites this paper
• Evaluation of circulating extracellular vesicles and miRNA in neutered and obese female dogs

  2022cites this paper
• Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications

  2022cites this paper
• Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview

  2022cites this paper
• Circulating Extracellular Vesicles Impair Mesenchymal Stromal Cell Differentiation Favoring Adipogenic Rather than Osteogenic Differentiation in Adolescents with Obesity

  2022cites this paper
• Deposition of platelet‑derived microparticles in podocytes contributes to diabetic nephropathy

  2022cites this paper
• The emerging roles of extracellular vesicles as intercellular messengers in liver physiology and pathology

  2022cites this paper
• ‘Treasure’ in garbage bags: extracellular vesicles based biomarker for neurological diseases

  2021cites this paper
• The impact of obesity on adipocyte-derived extracellular vesicles

  2021cites this paper
• Organ Crosstalk and the Modulation of Insulin Signaling

  2021cites this paper
• CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis

  2021cites this paper
• Clinical outcomes in 'diabese' burn patients: A systematic review and meta-analysis.

  2021cites this paper
• Dark-Side of Exosomes.

  2021cites this paper
• Synergistic Effects of Milk-Derived Exosomes and Galactose on α-Synuclein Pathology in Parkinson’s Disease and Type 2 Diabetes Mellitus

  2021cites this paper
• Extracellular Vesicles in Comorbidities Associated with Ischaemic Heart Disease: Focus on Sex, an Overlooked Factor

  2021cites this paper
• Exosomes from β-Cells Promote Differentiation of Induced Pluripotent Stem Cells into Insulin-Producing Cells Through microRNA-Dependent Mechanisms

  2021cites this paper
• Immunoregulatory Effects of Mitochondria Transferred by Extracellular Vesicles

  2021cites this paper
• Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets

  2021cites this paper
• FO‐SPR biosensor calibrated with recombinant extracellular vesicles enables specific and sensitive detection directly in complex matrices

  2021influential citation
• Obesity epigenetics and exercise

  2021cites this paper
• Exosomes from β -Cells Promote Differentiation of Induced Pluripotent Stem Cells into Insulin-Producing Cells Through microRNA-Dependent Mechanisms Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

  2021cites this paper
• miR-93-5p promotes insulin resistance to regulate type 2 diabetes progression in HepG2 cells by targeting HGF

  2021cites this paper
• Dietary modulation of large extracellular vesicles: the good and the bad for human health.

  2021cites this paper
• DMSO_A_342647 4767..4782

  2021cites this paper
• Friends and foes: Extracellular vesicles in aging and rejuvenation

  2021cites this paper
• Cancer Cells’ Metabolism Dynamics in Renal Cell Carcinoma Patients’ Outcome: Influence of GLUT-1-Related hsa-miR-144 and hsa-miR-186

  2021cites this paper
• Microparticles: An Alternative Explanation to the Behavior of Vascular Antiphospholipid Syndrome

  2021cites this paper
• Overview and Update on Methods for Cargo Loading into Extracellular Vesicles

  2021cites this paper