Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin αEβ7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. αE −CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, αE-positive subsets (CD25+ and CD25−) displayed an effector/memory phenotype expressing high levels of E/P-selectin–binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, αE-expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.

• Publication year

  2004

• Venue

  Journal of Experimental Medicine

• Publication date

  2004-02-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20031562PMID 14757740PMCID 2211798
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• αE-expressing cells are the most potent suppressors of inflammatory processes in antigen-induced arthritis.

  Confidence 0.93

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• αE-positive regulatory T cells show an effector/memory phenotype marked by E/P-selectin-binding ligands and inflammatory chemokine receptors, supporting migration into inflamed sites.

  Confidence 0.96

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• αE−CD25+ regulatory T cells express L-selectin and CCR7, consistent with recirculation through lymphoid tissues.

  Confidence 0.98

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• Integrin αEβ7 separates murine CD4+ regulatory T cells into αE−CD25+ and αE-positive subsets.

  Confidence 0.94

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review

• antigen-induced arthritis

  disease model

  An inflammatory disease model used to assess suppressive activity in vivo.

  Aliases: AIA

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• ccr7

  chemokine receptor

  A chemokine receptor involved in homing and recirculation within lymphoid tissues.

  Aliases: chemokine receptor 7

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• effector/memory phenotype

  cell phenotype

  A T-cell phenotype associated with an activated or experienced state rather than a naive state.

  Aliases: effector memory phenotype

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• e/p-selectin-binding ligands

  ligand, adhesion molecule

  Cell-surface ligands that bind E-selectin and P-selectin and support leukocyte trafficking.

  Aliases: E-selectin/P-selectin-binding ligands

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• inflammatory chemokine receptors

  chemokine receptor

  Chemokine receptors associated with migration toward inflammatory signals in tissues.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• integrin αeβ7

  molecular marker, integrin

  An integrin heterodimer used here as a marker to distinguish murine CD4+ regulatory T-cell subsets.

  Aliases: alphaEbeta7, integrin alphaEbeta7

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• l-selectin

  adhesion molecule, receptor

  A lymphocyte homing adhesion receptor associated with trafficking through lymphoid tissues.

  Aliases: CD62L

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• αe−cd25+ regulatory t cells

  cell subset

  A subset of murine CD4+ regulatory T cells characterized by lack of αE expression and positivity for CD25.

  Aliases: alphaE-negative CD25+ cells, alphaE−CD25+ cells

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review
• αe-positive regulatory t cells

  cell subset

  Murine CD4+ regulatory T cells that express αE, including both CD25+ and CD25− populations.

  Aliases: alphaE-positive subsets, alphaE+ regulatory T cells

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewB (s683577b42) review

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• Supporting Online Material

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