Early management of severe sepsis: concepts and controversies.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Chest

• Publication date

  2014-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1378/chest.13-2104PMID 24889440
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Early goal-directed therapy in the treatment of severe sepsis and septic shock.

  2018cited by this paper
• Stress hyperlactataemia: present understanding and controversy.

  2014cited by this paper
• Fluid responsiveness: an evolution of our understanding.

  2014cited by this paper
• Macrolides and Mortality in Critically Ill Patients With Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis*

  2014cited by this paper
• Hyperchloremia After Noncardiac Surgery Is Independently Associated with Increased Morbidity and Mortality: A Propensity-Matched Cohort Study

  2013cited by this paper
• Sepsis definitions: time for change.

  2013cited by this paper
• Fluid balance and cardiac function in septic shock as predictors of hospital mortality

  2013cited by this paper
• Does the Central Venous Pressure Predict Fluid Responsiveness? An Updated Meta-Analysis and a Plea for Some Common Sense*

  2013cited by this paper
• Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.

  2013cited by this paper
• Reappraising Starling: the physiology of the microcirculation

  2013cited by this paper
• Blood Purification and Mortality in Sepsis: A Meta-Analysis of Randomized Trials*

  2013cited by this paper
• If the central venous pressure is [x], call me … maybe.

  2013cited by this paper
• Surviving sepsis campaign : international guidelines for management of severe sepsis and septic shock

  2013cited by this paper
• Mean perfusion pressure deficit during the initial management of shock--an observational cohort study.

  2013cited by this paper
• "Less is more" in critically ill patients: not too intensive.

  2013cited by this paper
• Urgent Ultrasound Guided Hemodynamic Assessments by a Pediatric Medical Emergency Team: A Pilot Study

  2013cited by this paper
• Importance of the Infusion Rate for the Plasma Expanding Effect of 5% Albumin, 6% HES 130/0.4, 4% Gelatin, and 0.9% NaCl in the Septic Rat*

  2013cited by this paper
• Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?

  2013cited by this paper
• Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*

  2013cited by this paper
• Severe sepsis and septic shock

  2013cited by this paper
• Methods of Blood Pressure Measurement in the ICU*

  2013cited by this paper
• Severe sepsis and septic shock.

  2013cited by this paper
• Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial.

  2013cited by this paper
• Severe Sepsis Cohorts Derived From Claims-Based Strategies Appear to be Biased Toward a More Severely Ill Patient Population*

  2013cited by this paper
• Association Between Cell-Free Hemoglobin, Acetaminophen, and Mortality in Patients With Sepsis: An Observational Study*

  2013cited by this paper
• Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

  2013cited by this paper
• The use of bioreactance and carotid Doppler to determine volume responsiveness and blood flow redistribution following passive leg raising in hemodynamically unstable patients.

  2013cited by this paper
• Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe

  2013cited by this paper
• Noninvasive cardiac output monitors: a state-of the-art review.

  2013cited by this paper
• Selective V(1a) agonism attenuates vascular dysfunction and fluid accumulation in ovine severe sepsis.

  2012cited by this paper
• A meta‐analysis of the accuracy and precision of the ultrasonic cardiac output monitor (USCOM)

  2012cited by this paper
• 1023: Decreased Mortality, Morbidity And Emergency Transport In Septic Shock; A New Protocol Based On Advanced Noninvasive Haemodynamics And Early Antibiotics

  2012cited by this paper
• Early initiation of low-dose corticosteroid therapy in the management of septic shock: a retrospective observational study

  2012cited by this paper
• Extravascular lung water is an independent prognostic factor in patients with acute respiratory distress syndrome*

  2012cited by this paper
• Goal directed fluid therapy.

  2012cited by this paper
• Major Complications, Mortality, and Resource Utilization After Open Abdominal Surgery: 0.9% Saline Compared to Plasma-Lyte

  2012cited by this paper
• Prognostic value of B-type natriuretic peptide (BNP) and its potential role in guiding fluid therapy in critically ill septic patients

  2012cited by this paper
• Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis.

  2012cited by this paper
• A critique of fluid bolus resuscitation in severe sepsis

  2012cited by this paper
• Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.

  2012cited by this paper
• The immune response to surgery and trauma: Implications for treatment

  2012cited by this paper
• Norepinephrine or Dopamine for Septic Shock

  2012cited by this paper
• Effects of norepinephrine on mean systemic pressure and venous return in human septic shock*

  2012cited by this paper
• Can changes in arterial pressure be used to detect changes in cardiac index during fluid challenge in patients with septic shock?

  2012cited by this paper
• Dopamine versus norepinephrine in the treatment of septic shock: A meta-analysis*

  2012cited by this paper
• Initial resuscitation guided by the Surviving Sepsis Campaign recommendations and early echocardiographic assessment of hemodynamics in intensive care unit septic patients: A pilot study*

  2012cited by this paper
• The role of albumin as a resuscitation fluid for patients with sepsis: A systematic review and meta-analysis*

  2011cited by this paper
• Reduced mortality after the implementation of a protocol for the early detection of severe sepsis.

  2011cited by this paper
• Totem and Taboo: Fluids in sepsis

  2011cited by this paper
• Immunosuppression in patients who die of sepsis and multiple organ failure.

  2011cited by this paper
• Early and Adequate Antibiotic Therapy in the Treatment of Severe Sepsis and Septic Shock

  2011cited by this paper
• Glucocorticoids in sepsis: dissecting facts from fiction

  2011cited by this paper
• Is hyperchloremia associated with mortality in critically ill patients? A prospective cohort study.

  2011cited by this paper
• Concomitant arginine-vasopressin and hydrocortisone therapy in severe septic shock: association with mortality

  2011cited by this paper
• Hemodynamic parameters to guide fluid therapy

  2011cited by this paper
• Surviving sepsis: going beyond the guidelines

  2011cited by this paper
• Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality*

  2011cited by this paper
• The pathogenesis of sepsis.

  2011cited by this paper
• Feasibility of cardiac output estimation by ultrasonic cardiac output monitoring in the prehospital setting

  2011cited by this paper
• Release of atrial natriuretic peptide precedes shedding of the endothelial glycocalyx equally in patients undergoing on- and off-pump coronary artery bypass surgery

  2011cited by this paper
• Appropriateness of allogeneic red blood cell transfusion: the international consensus conference on transfusion outcomes.

  2011cited by this paper
• Norepinephrine increases cardiac preload and reduces preload dependency assessed by passive leg raising in septic shock patients*

  2011cited by this paper
• Advances in the management of sepsis and the understanding of key immunologic defects.

  2011cited by this paper
• Broken Barriers: A New Take on Sepsis Pathogenesis

  2011cited by this paper
• Plasma Restoration of Endothelial Glycocalyx in a Rodent Model of Hemorrhagic Shock

  2011cited by this paper
• Mortality after fluid bolus in African children with severe infection.

  2011cited by this paper
• Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

  2010cited by this paper
• Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension

  2010cited by this paper
• Sepsis and endothelial permeability.

  2010cited by this paper
• Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis

  2010cited by this paper
• Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis.

  2010cited by this paper
• Long-term mortality and quality of life in sepsis: A systematic review*

  2010cited by this paper
• Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.

  2010cited by this paper
• Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients

  2010cited by this paper
• Assessment of the clinical utility of an ultrasonic monitor of cardiac output (the USCOM) and agreement with thermodilution measurement.

  2010cited by this paper
• Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.

  2010cited by this paper
• Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia

  2010cited by this paper
• The impact of packed red blood cell transfusion on clinical outcomes in patients with septic shock treated with early goal directed therapy

  2010cited by this paper
• Bundled care for septic shock: An analysis of clinical trials*

  2010cited by this paper
• The end of the line for the Surviving Sepsis Campaign, but not for early goal-directed therapy

  2010cited by this paper
• A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

  2010cited by this paper
• Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department*

  2010cited by this paper
• The Importance of Fluid Management in Acute Lung Injury Secondary to Septic Shock

  2010cited by this paper
• Pilot study of the prevalence, outcomes and detection of occult hypoperfusion in trauma patients

  2010cited by this paper
• HEMODYNAMIC AND PERFUSION END POINTS FOR VOLEMIC RESUSCITATION IN SEPSIS

  2010cited by this paper
• The importance of fluid management in acute lung injury secondary to septic shock.

  2009cited by this paper
• Effect of fluid resuscitation on mortality and organ function in experimental sepsis models

  2009cited by this paper
• Review of A Large Clinical Series: Association of Cumulative Fluid Balance on Outcome in Acute Lung Injury: A Retrospective Review of the ARDSnet Tidal Volume Study Cohort

  2009cited by this paper
• Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study

  2009cited by this paper
• Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: time-dependent effects.

  2009cited by this paper
• The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock*

  2009cited by this paper
• Assessment of the clinical utility of an ultrasonic monitor of cardiac output (the USCOM) and agreement with thermodilution measurement.

  2009cited by this paper
• Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study.

  2009cited by this paper
• Actual incidence of global left ventricular hypokinesia in adult septic shock

  2009cited by this paper
• Albumin Augmentation Improves Condition of Guinea Pig Hearts After 4 hr of Cold Ischemia

  2009cited by this paper
• Influence of surgical treatment timing on mortality from necrotizing soft tissue infections requiring intensive care management

  2009cited by this paper
• Australasian resuscitation of sepsis evaluation (ARISE): A multi-centre, prospective, inception cohort study.

  2009cited by this paper
• Influence of surgical treatment timing on mortality from necrotizing soft tissue infections requiring intensive care management

  2009cited by this paper
• Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock*

  2009cited by this paper
• Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review.

  2009cited by this paper

• Immunomodulatory Effects of Gold Nanoparticles: Impacts on Immune Cells and Mechanisms of Action

  2025cites this paper
• Jinhong decoction ameliorates injury in septic mice without disrupting the equilibrium of gut microbiota.

  2024cites this paper
• Rethinking Fluid Responsiveness during Septic Shock: Ameliorate Accuracy of Noninvasive Cardiac Output Measurements through Evaluation of Arterial Biomechanical Properties

  2024cites this paper
• Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements

  2023cites this paper
• Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen

  2023cites this paper
• Electroacupuncture at ST36 (Zusanli) Prevents T-Cell Lymphopenia and Improves Survival in Septic Mice

  2022cites this paper
• Vasoplegic Syndrome after Cardiopulmonary Bypass in Cardiovascular Surgery: Pathophysiology and Management in Critical Care

  2022cites this paper
• Effect of a tailored sepsis treatment protocol on patient outcomes in the Tikur Anbessa Specialized Hospital, Ethiopia: results of an interrupted time series analysis

  2022cites this paper
• Effect of Pulse Indicator Continuous Cardiac Output Monitoring on Septic Shock Patients: A Meta-Analysis

  2022cites this paper
• Progranulin (PGRN) is serves as an inflammation-response biomarker and promotes lung damage in burn-induced Sepsis via the SIRT1 Pathways by ROS

  2021influential citation
• Mortality benefit of crystalloids administered in 1–6 hours in septic adults in the ED: systematic review with narrative synthesis

  2021cites this paper
• Assessment the Risk Factors of Patients with Septic Shock in the Intensive Care Unit

  2020cites this paper
• The role of early intravenous crystalloid bolus in adult sepsis resuscitation in the emergency department

  2020cites this paper
• Effects of impaired microvascular flow regulation on metabolism‐perfusion matching and organ function

  2020cites this paper
• Performance of a 25% Inferior Vena Cava Collapsibility in Detecting Fluid Responsiveness When Assessed by Novice Versus Expert Physician Sonologists

  2020cites this paper
• The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS): A Randomized Pilot Study.

  2019cites this paper
• Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation.

  2019cites this paper
• Components of Fluid Balance and Monitoring

  2019cites this paper
• A Portable Colorimetric Reader for Early and Rapid Diagnosis of Sepsis

  2019cites this paper
• A nomogram for predicting the risk of sepsis in patients with acute cholangitis

  2019cites this paper
• Optimizing fluid therapy in shock

  2019cites this paper
• Sepsis Management: Non-antibiotic Treatment of Sepsis and Septic Shock

  2018cites this paper
• Noninvasive Blood Pressure Monitoring and Prediction of Fluid Responsiveness to Passive Leg Raising

  2018cites this paper
• miR-23a downregulation modulates the inflammatory response by targeting ATG12-mediated autophagy

  2018cites this paper
• A Flowthrough Assay for Rapid Bedside Stratification of Bloodstream Bacterial Infection in Critically Ill Patients: a Pilot Study

  2018cites this paper
• Early Administration of Intravenous Fluids in Sepsis: Pros and Cons.

  2018cites this paper
• The impact of timing of antibiotics on in-hospital outcomes after major emergency abdominal surgery

  2018cites this paper
• Heatstroke: Clinical Experience from an Italian ICU and Review of the Literature

  2018cites this paper
• ATYPICAL COURSE OF ACUTE SEPSIS AFTER MINOR SURGERY WITH MANIFESTATION IN THE FORM OF SECONDARY PURULENT-INFLAMMATORY GYNECOLOGICAL PATHOLOGY

  2018cites this paper
• Efficacy of norepinephrine , dopamine or vasopressor in the management of septic shock and severe sepsis : a meta-analysis

  2018cites this paper
• Sepsis in pregnancy and the puerperium.

  2018cites this paper
• Personalized hemodynamic management

  2017cites this paper
• Central Venous Oxygen Saturation above 75% on Day Three of Septic Shock is Associated with Tripled Mortality

  2017cites this paper
• Fluid administration in severe sepsis and septic shock, patterns and outcomes: an analysis of a large national database

  2017cites this paper
• Impact of Dobutamine in Patients With Septic Shock: A Meta-Regression Analysis

  2017cites this paper
• Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before‐After Study

  2017cites this paper
• Sepsis: Current Definition, Pathophysiology, Diagnosis, and Management

  2017cites this paper
• Fluid resuscitation-associated increased mortality and inflammatory cytokine expression in murine polymicrobial sepsis

  2017cites this paper
• Inferior vena cava collapsibility detects fluid responsiveness among spontaneously breathing critically‐ill patients

  2017cites this paper
• Stroke volume guided resuscitation in severe sepsis and septic shock improves outcomes

  2017cites this paper
• Management of septic shock in intermediate care unit.

  2017cites this paper
• Transfusion of red blood cells in patients with traumatic brain injuries admitted to Canadian trauma health centres: a multicentre cohort study

  2017cites this paper
• The haemodynamic dilemma in emergency care: Is fluid responsiveness the answer? A systematic review

  2017cites this paper
• Sepsis in Solid-Organ Transplant Patients

  2017influential citation
• Practical Considerations in Sepsis Resuscitation.

  2017influential citation
• Vasoplegia After Cardiovascular Procedures-Pathophysiology and Targeted Therapy.

  2017cites this paper
• Accountability for Sepsis Treatment: The SEP-1 Core Measure.

  2017cites this paper
• Glycocalyx in Sepsis Resuscitation

  2016cites this paper
• Utilidad de la termodilución transpulmonar en la categorización y pronóstico de pacientes con choque refractario. Estudio de cohorte prospectivo

  2016cites this paper
• Utilización del índice de shock en el manejo de pacientes con sepsis severa y choque séptico: una revisión sistemática

  2016cites this paper
• Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice.

  2016cites this paper
• The Fab Fragment of a Human Anti-Siglec-9 Monoclonal Antibody Suppresses LPS-Induced Inflammatory Responses in Human Macrophages

  2016cites this paper
• Epidemiología, diagnóstico y tratamiento de la sepsis severa en Uruguay: un estudio multicéntrico prospectivo

  2016influential citation
• Multidrug-Resistant Gram-Negative Bacterial Infections in the Hospital Setting: Overview, Implications for Clinical Practice, and Emerging Treatment Options

  2016cites this paper
• Predictors of Acute Hemodynamic Decompensation in Early Sepsis: An Observational Study

  2016cites this paper
• Sepsis in Patients With Cirrhosis

  2016cites this paper
• Advanced Hemodynamic Management in Patients with Septic Shock

  2016cites this paper
• Association of Fluid Accumulation with Clinical Outcomes in Critically Ill Children with Severe Sepsis

  2016cites this paper
• Don't Go Chasing Waterfalls: Excessive Fluid Resuscitation in Severe Sepsis and Septic Shock

  2016cites this paper
• Management of Sepsis and Septic Shock for the Obstetrician-Gynecologist.

  2016cites this paper
• Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis

  2016cites this paper
• A rational approach to fluid therapy in sepsis.

  2016cites this paper
• Predictors of in-hospital mortality for sepsis patients in intensive care units

  2016influential citation
• Fluid Resuscitation in Animal Models of Sepsis : A Comprehensive Review of the Current State of Knowledge

  2016cites this paper
• Early goal-directed resuscitation of patients with septic shock: current evidence and future directions

  2015cites this paper
• Cytokines as Diagnostic Biomarkers in Canine Pyometra and Sepsis

  2015cites this paper
• Passive Leg Raising Maneuver and Prediction of Fluid Responsiveness: Noninvasive Monitoring of Pulse Pressure and Systolic Blood Pressure

  2015cites this paper
• “Less Is More”: The New Paradigm in Critical Care

  2015cites this paper
• Activated Complement Factors as Disease Markers for Sepsis

  2015cites this paper
• The effect of vasopressor dosing strategy on microcirculatory perfusion in preclinical models of sepsis: a systematic review

  2015cites this paper
• Early Management of Severe Sepsis: Concepts and Controversies

  2015cites this paper
• Antibiotic resistance pattern and clinical outcomes in acute cholecystitis: 567 consecutive worldwide patients in a prospective cohort study.

  2015cites this paper
• Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

  2015cites this paper
• Effects of omega-3 fatty acid nutrition on mortality in septic patients: a meta-analysis of randomized controlled trials

  2015cites this paper
• Surviving Sepsis in the Critical Care Environment

  2015cites this paper
• Thyroid function status and its impact on clinical outcome in patients admitted to critical care

  2015cites this paper
• The demise of early goal‐directed therapy for severe sepsis and septic shock

  2015cites this paper
• Fluid and electrolyte overload in critically ill patients: An overview.

  2015cites this paper
• Systemic vascular resistance should be banned.

  2014cites this paper
• Angiotensin II: a new approach for refractory shock management?

  2014cites this paper
• The Physiology of Volume Resuscitation

  2014cites this paper
• Current controversies in the support of sepsis

  2014cites this paper
• Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice.

  2014cites this paper