The Brain Prolactin System: Involvement in Stress Response Adaptations in Lactation

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Stress

• Publication date

  2002-01-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1080/1025389021000048638PMID 12475729
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunoreactive material resembling ovine prolactin in perikarya and nerve terminals of the rat hypothalamus

  2004cited by this paper
• The organization of prolactin-like-immunoreactive neurons in the rat central nervous system

  2004cited by this paper
• Endogenous opioid regulation of stress-induced oxytocin release within the hypothalamic paraventricular nucleus is reversed in late pregnancy: a microdialysis study.

  2002cited by this paper
• Prolactin: the new biology of an old hormone.

  2002cited by this paper
• Increased hypothalamic expression of prolactin in lactation: involvement in behavioural and neuroendocrine stress responses

  2002cited by this paper
• Central infusions of the recombinant human prolactin receptor antagonist, S179D-PRL, delay the onset of maternal behavior in steroid-primed, nulliparous female rats.

  2001cited by this paper
• Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women.

  2001cited by this paper
• Prolactin receptors in the brain during pregnancy and lactation: implications for behavior.

  2001cited by this paper
• Lactogenic hormone regulation of maternal behavior.

  2001cited by this paper
• Mechanisms for suckling-induced changes in expression of prolactin receptor in the hypothalamus of the lactating rat.

  2001cited by this paper
• Anxiolytic and Anti-Stress Effects of Brain Prolactin: Improved Efficacy of Antisense Targeting of the Prolactin Receptor by Molecular Modeling

  2001cited by this paper
• Alterations in behavioral and neuroendocrine stress coping strategies in pregnant, parturient and lactating rats.

  2001cited by this paper
• Maternal defence as an emotional stressor in female rats: correlation of neuroendocrine and behavioural parameters and involvement of brain oxytocin

  2001cited by this paper
• The "low-dose" concept and the paradoxical effects of prolactin on grooming and sexual behavior.

  2000cited by this paper
• Prolactin: structure, function, and regulation of secretion.

  2000cited by this paper
• Attenuation of Hypothalamic‐Pituitary‐Adrenal Axis Stress Responses in Late Pregnancy: Changes in Feedforward and Feedback Mechanisms

  2000cited by this paper
• Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats.

  1999cited by this paper
• Lactation-induced reduction in rats' acoustic startle is associated with changes in noradrenergic neurotransmission.

  1999cited by this paper
• Increased expression of both short and long forms of prolactin receptor mRNA in hypothalamic nuclei of lactating rats.

  1999cited by this paper
• Hyper‐Reactive Hypothalamo‐Pituitary‐Adrenocortical Axis in Rats Bred for High Anxiety‐Related Behaviour

  1999cited by this paper
• Increased Prolactin Receptor Immunoreactivity in the Hypothalamus of Lactating Rats

  1999cited by this paper
• Changes in the expression of neurohypophyseal prolactins during the estrous cycle and after estrogen treatment.

  1999cited by this paper
• Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes

  1998cited by this paper
• Review : The Neurobiological Basis of Anxiety and Fear: Circuits, Mechanisms, and Neurochemical Interactions (Part I

  1998cited by this paper
• The role of endogenous opioids in neurohypophysial and hypothalamo-pituitary-adrenal axis hormone secretory responses to stress in pregnant rats.

  1998cited by this paper
• Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.

  1998cited by this paper
• Differential expression of the two forms of prolactin receptor mRNA within microdissected hypothalamic nuclei of the rat.

  1998cited by this paper
• Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene

  1997cited by this paper
• Psychological distress in patients with hyperprolactinaemia

  1997cited by this paper
• Research report Anxiolytic actions of diazepam, but not of buspirone, are influenced by gender and the endocrine stage

  1997cited by this paper
• Immunoreactive prolactin forms colocalize with vasopressin in neurons of the hypothalamic paraventricular and supraoptic nuclei.

  1997cited by this paper
• Dominant negative and cooperative effects of mutant forms of prolactin receptor.

  1997cited by this paper
• Endocrine and Behavioural Responses to Noise Stress:Comparison of Virgin and Lactating Female Ratsduring Non‐Disrupted Maternal Activity

  1997cited by this paper
• Atlas of the neurons that express mRNA for the long form of the prolactin receptor in the forebrain of the female rat.

  1997influential reference
• Restraint stress enhances the gene expression of prolactin receptor long form at the choroid plexus(拘束ストレスは脈絡叢におけるプロラクチン受容体長型の遺伝子発現を高める)

  1996cited by this paper
• Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.

  1996cited by this paper
• Interaction between prolactin and catecholamines on hypothalamic GnRH release in vitro.

  1996cited by this paper
• Noradrenergic facilitation of the adrenocorticotropin response to stress is absent during lactation in the rat.

  1996cited by this paper
• Region-specific reduction in stress-induced c-fos mRNA expression during pregnancy and lactation.

  1996cited by this paper
• Restraint stress enhances the gene expression of prolactin receptor long form at the choroid plexus.

  1995cited by this paper
• Inhibitory effects of anti-prolactin receptor antibodies on prolactin binding in brain and prolactin-induced feeding behavior in ring doves.

  1995cited by this paper
• A 14-kilodalton prolactin-like fragment is secreted by the hypothalamo-neurohypophyseal system of the rat.

  1995cited by this paper
• Central endogenous opioid inhibition of supraoptic oxytocin neurons in pregnant rats

  1995cited by this paper
• Mood and hormonal changes during late pregnancy and puerperium.

  1995cited by this paper
• Role of prolactin and gonadal steroids in regulation of oxytocin mRNA during lactation.

  1995cited by this paper
• Prolactin modulates oxytocin mRNA during lactation by its action on the hypothalamo-neurohypophyseal axis.

  1995cited by this paper
• Osmotic responsiveness and cross talk involving oxytocin, but not vasopressin or amino acids, between the supraoptic nuclei in virgin and lactating rats

  1995cited by this paper
• Dissociation Between Behavioral and Hormonal Responses to the Forced Swim Stress in Lactating Rats

  1995cited by this paper
• Prolactin Receptor mRNA Localization in the Hypothalamus by in situ Hybridization

  1994cited by this paper
• Stimulation of oxytocin release within the supraoptic nucleus and into blood by CCK-8.

  1994cited by this paper
• Hypothalamic injection of prolactin or its antibody alters the rat sleep-wake cycle.

  1994cited by this paper
• Preferential expression of long form prolactin receptor mRNA in the rat brain during the oestrous cycle, pregnancy and lactation: hormones involved in its gene expression.

  1994influential reference
• The prolactin gene is expressed in the hypothalamic-neurohypophyseal system and the protein is processed into a 14-kDa fragment with activity like 16-kDa prolactin.

  1994cited by this paper
• Anatomical distribution of prolactin-like immunoreactivity in the rat brain.

  1993cited by this paper
• Oxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: a microdialysis study.

  1993cited by this paper
• Effect of chronic bromocriptine treatment on psychological profile of patients with PRL-secreting pituitary adenomas.

  1993cited by this paper
• Effects of systemic and central prolactin injections on food intake, weight gain, and estrous cyclicity in female rats.

  1993cited by this paper
• Prolactin receptors in the rat hypothalamus: autoradiographic localization and characterization.

  1993cited by this paper
• Estradiol increases prolactin synthesis and prolactin messenger ribonucleic acid in selected brain regions in the hypophysectomized female rat.

  1992cited by this paper
• The rat prolactin gene is expressed in brain tissue: detection of normal and alternatively spliced prolactin messenger RNA.

  1992cited by this paper
• Prolactin enhancement of its own uptake at the choroid plexus.

  1992cited by this paper
• The prolactin/growth hormone receptor family.

  1991cited by this paper
• Central effects of oxytocin.

  1991cited by this paper
• Stimulation of hypothalamic prolactin release by veratridine and angiotensin II in the female rat: effect of ovariectomy and estradiol administration.

  1991cited by this paper
• Central prolactin infusions stimulate maternal behavior in steroid-treated, nulliparous female rats.

  1990influential reference
• Evidence for the involvement of corticotropin-releasing factor in the inhibition of gonadotropin release induced by hyperprolactinemia.

  1990cited by this paper
• The actions of diazepam and serotonergic anxiolytics vary according to the gender and the estrous cycle phase.

  1990cited by this paper
• Effects of TRH and prolactin in the behavioral despair (swim) model of depression in rats.

  1990cited by this paper
• Lactation inhibits stress-mediated secretion of corticosterone and oxytocin and hypothalamic accumulation of corticotropin-releasing factor and enkephalin messenger ribonucleic acids.

  1989cited by this paper
• Distribution and partial characterization of immunoreactive prolactin in the rat brain.

  1989cited by this paper
• Effects of maternal hormones on 'timidity' and attraction to pup-related odors in female rats.

  1989cited by this paper
• Distribution of immunoreactive prolactin in the male and female rat brain: effects of hypophysectomy and intraventricular administration of colchicine.

  1988cited by this paper
• Psychologic stress increases plasma levels of prolactin, cortisol, and POMC‐derived peptides in man.

  1988cited by this paper
• Oxytocin responses to stress in lactating and hyperprolactinaemic rats.

  1987influential reference
• A receptor-mediated mechanism for the transport of prolactin from blood to cerebrospinal fluid.

  1987cited by this paper
• Depression in hyperprolactinemia.

  1986cited by this paper
• Comparison of plasma profiles of oxytocin and prolactin following suckling in the rat.

  1986cited by this paper
• Reduced fearfulness in the lactating rat.

  1985cited by this paper
• Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.

  1985cited by this paper
• Prolactin inhibits the development of stress-induced ulcers in the rat.

  1985cited by this paper
• Prolactin stimulation of maternal behavior in female rats.

  1985cited by this paper
• Effects of hyperprolactinaemia on core temperature of the rat.

  1984cited by this paper
• Prolactin-enhanced grooming behavior: interaction with ACTH.

  1983cited by this paper
• Termination of prolactin surges with development of placental lactogen secretion in the pregnant rat.

  1983cited by this paper
• Immunocytochemical localization of corticotropin-releasing factor (CRF) in the rat brain.

  1982cited by this paper
• Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin.

  1979cited by this paper
• Intraspecific fighting during late pregnancy and lactation in rats and effects of litter removal.

  1978cited by this paper
• Comparative Endocrinology of Prolactin

  1977cited by this paper
• Prolactin-like immunoreactivity: localization in nerve terminals of rat hypothalamus.

  1977cited by this paper
• Stress response patterns of plasma corticosterone, prolactin, and growth hormone in the rat, following handling or exposure to novel environment.

  1975cited by this paper
• The role of prolactin in the depressed or 'buffered' adrenocorticosteroid response of the rat.

  1974cited by this paper
• Pituitary-adrenal responsiveness during lactation in rats.

  1973cited by this paper
• Enhancement of maternal behavior and nest building following systemic and diencephalic administration of prolactin and progesterone in the mouse.

  1973cited by this paper
• Human prolactin and growth hormone release during surgery and other conditions of stress.

  1972cited by this paper
• Effect of "stress" on serum prolactin and luteinizing hormone levels during the estrous cycle of the rat.

  1970cited by this paper
• Nonhormonal Basis of Maternal Behavior in the Rat

  1967cited by this paper
• Printed in U.S.A. Copyright © 1998 by The Endocrine Society Null Mutation of the Prolactin Receptor Gene Produces a Defect in Maternal Behavior

  year unknowncited by this paper

• Interactions Between Prolactin, Intracellular Signaling, and Possible Implications in the Contractility and Pathophysiology of Asthma

  2025cites this paper
• Multimodal insights into adult neurogenesis: An integrative review of multi-omics approaches

  2025cites this paper
• Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner

  2025cites this paper
• Few effects of sow lactational stress on maternal behavior, but altered physiology with implications for piglet early life stress coping

  2025cites this paper
• Loss of transient receptor potential channel 5 causes obesity and postpartum depression

  2024cites this paper
• Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress.

  2024cites this paper
• Wheel Running During Pregnancy Alleviates Anxiety-and Depression-Like Behaviors During the Postpartum Period in Mice: The Roles of NLRP3 Neuroinflammasome Activation, Prolactin, and the Prolactin Receptor in the Hippocampus

  2024cites this paper
• Does the brain make prolactin?

  2024cites this paper
• Hypothalamic GnRH expression and pulsatility depends on a balance of prolactin receptors in the plains vizcacha, Lagostomus maximus

  2023cites this paper
• Role of Hormones and the Potential Impact of Multiple Stresses on Infertility

  2023cites this paper
• Postpartum depression in rats causes poor maternal care and neurochemical alterations on dams and long-lasting impairment in sociability on the offspring.

  2022cites this paper
• Prolactin and glucocorticoid receptors in the prefrontal cortex are associated with anxiety‐like behavior in prenatally stressed adolescent offspring rats

  2022cites this paper
• Prolactin as an adrenocorticotropic hormone: Prolactin signalling is a conserved key regulator of sexually dimorphic adrenal gland function in health and disease

  2022cites this paper
• Prior parental experience attenuates hormonal stress responses and alters hippocampal glucocorticoid receptors in both sexes of the biparental rock dove

  2022cites this paper
• Stressful life events in pregnancy: A risk factor for exclusive breastfeeding among high-income mothers.

  2022cites this paper
• Light and electron microscopic studies on the influence of stress on prolactin‐immunoreactivity in rat anterior pituitary lobe

  2022cites this paper
• Effects of fluoxetine on fish: What do we know and where should we focus our efforts in the future?

  2022cites this paper
• Neurobiology of peripartum mental illness.

  2021cites this paper
• Hormones regulating energy homeostasis in breastfeeding versus formula feeding mothers.

  2021cites this paper
• Shared pathological mechanisms of systemic lupus erythematosus and affective disorders

  2021cites this paper
• Reproduction-Associated Hormones and Adult Hippocampal Neurogenesis

  2021cites this paper
• Lactation is not required for maintaining maternal care and active coping responses in chronically stressed postpartum rats: Interactions between nursing demand and chronic variable stress.

  2021cites this paper
• POSTPARTUM DEPRESSION IN MOTHERS AND FATHERS – AN UNDERESTIMATED DIAGNOSIS

  2021cites this paper
• Motherhood‐induced gene expression in the mouse medial amygdala: Changes induced by pregnancy and lactation but not by pup stimuli

  2021cites this paper
• Brief communication: Plasma cortisol concentration is affected by lactation, but not intra-nasal oxytocin treatment, in beef cows

  2021cites this paper
• Prolactin and Its Altered Action in Alzheimer’s Disease and Parkinson’s Disease

  2021cites this paper
• Postpartum Depression: Current Status and Possible Identification Using Biomarkers

  2021cites this paper
• Daily and seasonal rhythmic secretary pattern of endocrinological profiles in mithun bull.

  2021cites this paper
• Prolactin attenuates global cerebral ischemic injury in rat model by conferring neuroprotection

  2020cites this paper
• How stress can influence brain adaptations to motherhood

  2020cites this paper
• Reproductive status impact on tau phosphorylation induced by chronic stress

  2020cites this paper
• Working Smarter Not Harder: Oxytocin Increases Domestic Dogs’ (Canis familiaris) Accuracy, but Not Attempts, on an Object Choice Task

  2019cites this paper
• Opioids and reproduction.

  2019cites this paper
• Patterns of prolactin secretion.

  2019cites this paper
• Adaptive Modifications of Maternal Hypothalamic-Pituitary-Adrenal Axis Activity during Lactation and Salsolinol as a New Player in this Phenomenon

  2018cites this paper
• Influence of Stress on the GnRH Neuronal Network

  2018cites this paper
• Effect of adrenalectomy on prolactin secretion in primiparous and multiparous lactating rats

  2018cites this paper
• Endogenous opioid signalling in the brain during pregnancy and lactation

  2018cites this paper
• Glial cells as mediators of protective actions of prolactin (PRL) in the CNS.

  2018cites this paper
• Involvement of prolactin in newborn infant irritability following maternal perinatal anxiety symptoms.

  2018cites this paper
• Tau Phosphorylation in Female Neurodegeneration: Role of Estrogens, Progesterone, and Prolactin

  2018cites this paper
• Physiologic Function of Oxytocin After Birth: Influence on Postpartum Blood Loss and Lactation

  2018cites this paper
• Involvement of miR-106b in tumorigenic actions of both prolactin and estradiol

  2017cites this paper
• Hormonal systems, human social bonding, and affiliation

  2017cites this paper
• Linking Stress and Infertility: A Novel Role for Ghrelin.

  2017cites this paper
• Association of testosterone levels and heroin usage characteristics in male heroin users.

  2017cites this paper
• Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation

  2017cites this paper
• Determinants of uncertainty in wildlife responses to human disturbance

  2017cites this paper
• Prolactin and Somatostatin Responses to Antidepressant Therapy

  2016cites this paper
• The role of the prolactin/vasoinhibin axis in rheumatoid arthritis: an integrative overview

  2016cites this paper
• Postnatal Stress Induced by Injection with Valproate Leads to Developing Emotional Disorders Along with Molecular and Cellular Changes in the Hippocampus and Amygdala

  2016cites this paper
• The birth of new neurons in the maternal brain: Hormonal regulation and functional implications.

  2016cites this paper
• Reproductive Health Assessment of Female Elephants in North American Zoos and Association of Husbandry Practices with Reproductive Dysfunction in African Elephants (Loxodonta africana)

  2016cites this paper
• A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone

  2016cites this paper
• Neues von Prolaktin

  2016influential citation
• Exploring a novel mechanism instructing maternal care and influencing offspring outcomes

  2016cites this paper
• Interaction between a tannin-containing legume and endophyte-infected tall fescue seed on lambs' feeding behavior and physiology.

  2016cites this paper
• Breastfeeding and Postnatal Depression

  2016cites this paper
• Mood, Food, and Fertility: Adaptations of the Maternal Brain.

  2016cites this paper
• Maternal Brain Adaptations in Pregnancy

  2015cites this paper
• Prolactin and hostility in hospitalised patients and healthy women: A systematic review and meta-analysis

  2015cites this paper
• Reproductive Stage and Modulation of Stress‐Induced Tau Phosphorylation in Female Rats

  2015cites this paper
• 60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis

  2015cites this paper
• Chronic Subordinate Colony Housing Paradigm: A Mouse Model to Characterize the Consequences of Insufficient Glucocorticoid Signaling

  2015cites this paper
• Biological Basis of Motherhood and Effect of Stress on Maternal Psychophysiology

  2015cites this paper
• Maternally responsive neurons in the bed nucleus of the stria terminalis and medial preoptic area: Putative circuits for regulating anxiety and reward.

  2015cites this paper
• Beyond the Stress Concept: Allostatic Load—A Developmental Biological and Cognitive Perspective

  2015cites this paper
• Biological and psychosocial predictors of postpartum depression: systematic review and call for integration.

  2015cites this paper
• Plasma cortisol and prolactin secretion rhythms in cattle under varying external environments and management techniques.

  2014cites this paper
• Both prolactin (PRL) and a molecular mimic of phosphorylated PRL, S179D-PRL, protect the hippocampus of female rats against excitotoxicity.

  2014cites this paper
• In Search of Neural Endophenotypes of Postpartum Psychopathology and Disrupted Maternal Caregiving

  2014cites this paper
• Role of Prolactin and Prolactin Receptor Signaling in Colorectal Tumorigenesis

  2014cites this paper
• Neuroendocrinology of pregnancy and parturition.

  2014cites this paper
• Minireview: Extrapituitary prolactin: an update on the distribution, regulation, and functions.

  2014cites this paper
• Artiele-Physiologicaland behavioral responses to social and transportation in calves isolation

  2014cites this paper
• Does stress elicit depression? Evidence from clinical and preclinical studies.

  2014cites this paper
• Transgenerational effects of social stress on social behavior, corticosterone, oxytocin, and prolactin in rats.

  2014influential citation
• Hormonal influences on neuroimmune responses in the CNS of females

  2014cites this paper
• Emotion and Mood Adaptations in the Peripartum Female: Complementary Contributions of GABA and Oxytocin

  2014cites this paper
• Prolactin-derived vasoinhibins increase anxiety- and depression-related behaviors.

  2014cites this paper
• Arthritis and prolactin: a phylogenetic viewpoint.

  2014cites this paper
• Individual difference in serum oxytocin concentrations of calves and the correlation with those in dams.

  2014cites this paper
• Neuroendocrinology of childbirth and mother-child attachment: the basis of an etiopathogenic model of perinatal neurobiological disorders.

  2014influential citation
• Altered bold fMRI response toward survival-pertinent stimuli in the early postpartum dam

  2013cites this paper
• Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment

  2013cites this paper
• S100B overexpression increases behavioral and neural plasticity in response to the social environment during adolescence.

  2013cites this paper
• New Insight into Onset of Lactation: Mediating the Negative Effect of Multiple Perinatal Biopsychosocial Stress on Breastfeeding Duration

  2013cites this paper
• Effects of early life social stress on endocrinology, maternal behavior, and lactation in rats.

  2013cites this paper
• The role of maternal care in shaping CNS function.

  2013cites this paper
• Lactation deficit in OFA hr/hr rats may be caused by differential sensitivity to stress compared with Wistar and Sprague Dawley rats

  2012cites this paper
• Stress and animal models of inflammatory bowel disease--an update on the role of the hypothalamo-pituitary-adrenal axis.

  2012cites this paper
• The molecular physiology of CRH neurons.

  2012cites this paper
• Extrapituitary production of anterior pituitary hormones: an overview

  2012cites this paper
• Trophic Actions of Prolactin in the Central Nervous System

  2012cites this paper
• and Endocrine Variables Differences Between Exclusive Breastfeeders, Formula-Feeders, and Controls: A Study of Stress, Mood,

  2012cites this paper
• The Hypothalamic–Pituitary–Adrenal Axis and Neuroendocrine Responses to Stress

  2012cites this paper
• Failed Lactation and Perinatal Depression: Common Problems with Shared Neuroendocrine Mechanisms?

  2012cites this paper
• Recent Findings on Neuroprotection Against Excitotoxicity in the Hippocampus of Female Rats

  2011cites this paper
• Mother-offspring dialogue in early pregnancy: impact of adverse environment on pregnancy maintenance and neurobiology.

  2011cites this paper
• Differential Changes in Responses of Hypothalamic and Brainstem Neuronal Populations to Prolactin During Lactation in the Mouse1

  2011cites this paper