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Bordetella pertussis infection

M. P. Barros Pinto

Published 2024 in Pediatric Pulmonology

ABSTRACT

IN common with many other mucous membranes, the nasopharynx is covered by a film of mucus kept in continuous motion by the cilia arising from its epithelium. To avoid exclusion and removal from the nasopharyngeal surface, organisms like Bordetella pertussis must therefore be able to anchor themselves to some fixed structure there. It has been shown that in whooping cough in children Bord. pertussis has a marked tendency to attach itself to the cilia of the nasopharynx (Rich, 1932), and in intracerebral infection in mice to the cilia of the ventricular ependyma (Berenbaum, Ungar and Stevens, 1960; Iida et al., 1962). In neither of these situations is experimental examination of the local circumstances at all easy, so it is necessary to consider a parallel case and devise a comparable system free from this defect.

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