Identification of mismatch repair genes and their role in the development of cancer.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Current Opinion in Genetics and Development

• Publication date

  1995-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0959-437X(95)80055-7PMID 7549435
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae.

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• Interspecies gene exchange in bacteria: the role of SOS and mismatch repair systems in evolution of species.

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• The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions.

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• Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.

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• Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

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• Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

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• Purified human MSH2 protein binds to DNA containing mismatched nucleotides.

  1994cited by this paper
• Binding of mismatched microsatellite DNA sequences by the human MSH2 protein.

  1994cited by this paper
• Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

  1994cited by this paper
• Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

  1994cited by this paper
• Genetic instability of microsatellite sequences in many non-small cell lung carcinomas.

  1994cited by this paper
• Instability of short tandem repeats (microsatellites) in human cancers

  1994cited by this paper
• Mutator phenotypes in human colorectal carcinoma cell lines.

  1994cited by this paper
• MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast.

  1994cited by this paper
• Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

  1994cited by this paper
• Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.

  1994cited by this paper
• Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.

  1994cited by this paper
• Mutation of an mutL homologue in a Navajo family with hereditary nonpolyposis colorectal cancer.

  1994cited by this paper
• Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

  1994cited by this paper
• hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.

  1994cited by this paper
• Frequent microsatellite instability in primary small cell lung cancer.

  1994cited by this paper
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  1994cited by this paper
• Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage.

  1994cited by this paper
• Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene

  1994cited by this paper
• Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes.

  1994cited by this paper
• Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.

  1994cited by this paper
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• Colon cancer and DNA repair: have mismatches met their match?

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• Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

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• Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches.

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• Microsatellite instability occurs frequently in human gastric carcinoma.

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• Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development.

  1994cited by this paper
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  1994cited by this paper
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• Microsatellite Instability: Marker of a Mutator Phenotype in Cancer

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  1993cited by this paper
• An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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• Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

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• Genomic instability occurs in colorectal carcinomas but not in adenomas

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• The yeast gene MSH3 defines a new class of eukaryotic MutS homologues

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• Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

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• Microsatellite instability in cancer of the proximal colon.

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• Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.

  1993cited by this paper
• Slippery DNA and diseases

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• Genomic instability and tumor progression: mechanistic considerations.

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• Methyl-directed mismatch repair is bidirectional.

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• The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.

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• Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

  1993cited by this paper
• Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

  1993cited by this paper
• Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

  1993cited by this paper
• Genetic instability of microsatellites in endometrial carcinoma.

  1993cited by this paper
• Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

  1993cited by this paper
• Clues to the pathogenesis of familial colorectal cancer.

  1993cited by this paper
• Hypermutability and mismatch repair deficiency in RER+ tumor cells.

  1993cited by this paper
• Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction.

  1993cited by this paper
• Identification of hereditary nonpolyposis colorectal cancer in the general population. The 6‐year experience of a population‐based registry

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• Initiation of methyl-directed mismatch repair.

  1992cited by this paper
• Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

  1992cited by this paper
• Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

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• Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.

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• Recombination between similar but not identical DNA sequences during yeast transformation occurs within short stretches of identity.

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• Uracil-DNA glycosylase affects mismatch repair efficiency in transformation and bisulfite-induced mutagenesis in Streptococcus pneumoniae.

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  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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• Specificity of mismatch repair following transformation of Saccharomyces cerevisiae with heteroduplex plasmid DNA.

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