Mechanisms of oestrogen antagonism by nonsteroidal antioestrogens.

No abstract is available for this paper.

• Publication year

  1982

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0303-7207(82)90165-4PMID 7040137
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Binding of [3H] monohydroxytamoxifen in human breast carcinoma cytosols.

  1981cited by this paper
• Interaction of a high affinity anti-estrogen (alpha-[4-pyrrolidinoethoxy]phenyl-4-hydroxy-alpha'-nitrostilbene, CI628M) with uterine estrogen receptors.

  1981cited by this paper
• Differences between oestrogen receptor activation by oestrogen and antioestrogen

  1981cited by this paper
• Modifications in the aminoether side chain of clomiphene influence affinity for a specific antiestrogen binding site in MCF 7 cells cytosol.

  1981cited by this paper
• Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues.

  1981cited by this paper
• Biological potency and uterine estrogen receptor interactions of the metabolites of the antiestrogens CI628 and U23,469.

  1981cited by this paper
• Differential interaction of antiestrogens with cytosol estrogen receptors.

  1981cited by this paper
• Antiestrogen specific, high affinity saturable binding sites in rat uterine cytosol.

  1980cited by this paper
• EVIDENCE FOR THE METABOLIC ACTIVATION OF NON‐STEROIDAL ANTIOESTROGENS: A STUDY OF STRUCTURE‐ACTIVITY RELATIONSHIPS

  1980cited by this paper
• Pharmacology of tamoxifen in laboratory animals.

  1980cited by this paper
• Effect of tamoxifen on oestradiol and progesterone-induced synthesis of ovalbumin and conalbumin in chick oviduct.

  1980cited by this paper
• High-affinity anti-oestrogen binding site distinct from the oestrogen receptor

  1980cited by this paper
• Subcellular effects of monohydroxytamoxifen in the rat uterus: steroid receptors and mitosis.

  1980cited by this paper
• Effect of clomiphene citrate on corticosteroid-binding globulin and serum progesterone levels during ovulation induction.

  1980cited by this paper
• High-affinity binding to the estrogen receptor of [3H]4-hydroxytamoxifen, an active antiestrogen metabolite.

  1980cited by this paper
• Specific binding and biological response of antiestrogens in the fetal uterus of the guinea pig.

  1980cited by this paper
• The binding of tamoxifen to human mammary carcinoma cytosol.

  1980cited by this paper
• Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice.

  1980cited by this paper
• Steroid receptors and effects of oestradiol and progesterone on chick oviduct proteins.

  1980cited by this paper
• Crystal and molecular structure of nafoxidine and stereochemical features of anticancer antiestrogens.

  1980cited by this paper
• The effects of antioestrogens on the oestrogen receptor.

  1979cited by this paper
• Monohydroxytamoxifen: an antioestrogen with high affinity for the chick oviduct oestrogen receptor.

  1979cited by this paper
• Effects of tamoxifen on the binding and metabolism of testosterone by human prostatic tissue and plasma in vitro.

  1979cited by this paper
• Antiestrogens and antiestrogen metabolites: preparation of tritium-labeled (+/-)-cis-3-[p-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthyl)phenoxyl]-1,2-propanediol (U-23469) and characterization and synthesis of a biologically important metabolite.

  1979cited by this paper
• [In vivo occupation of estrogen receptors by hydroxylated metabolites of tamoxifen].

  1979cited by this paper
• Comparison between the action of estradiol and that of the antiestrogen U 11-100 A on the induction in the rat uterus of a specific protein (the induced protein).

  1979cited by this paper
• Effect of oestradiol benzoate, tamoxifen and monohydroxytamoxifen on immature rat uterine progesterone receptor synthesis and endometrial cell division.

  1979cited by this paper
• Chicken oviduct nuclear oestrogen receptors: aspects of steroid hormone action.

  1979cited by this paper
• Estrogen and antiestrogen action in reproductive tissues and tumors.

  1979cited by this paper
• Endocrine consequences of continuous antiestrogen therapy with tamoxifen in premenopausal women.

  1979cited by this paper
• The binding of tamoxifen to oestrogen receptor proteins under equilibrium and non-equilibrium conditions.

  1979cited by this paper
• [p-(Diméthylamino-2 éthoxy)phényl]-1 trans-diphényl-1,2 butène-1 (tamoxfène) (ICI-46474)

  1979cited by this paper
• Differential binding of antiestrogens by rat uterine and chick oviduct cytosol.

  1979cited by this paper
• Estrogen receptor in hen oviduct chromatin, digested by micrococcal nuclease.

  1978cited by this paper
• High-affinity binding of the antiestrogen [3H]tamoxifen to the 8S estradiol receptor.

  1978cited by this paper
• Tamoxifen in advanced breast cancer.

  1978cited by this paper
• The effects of oestradiol-17beta, Provera and tamoxifen on glucose metabolism in mammary gland, liver and muscle of the rat.

  1978cited by this paper
• Role of estrogen receptor binding and transcriptional activity in the stimulation of hyperestrogenism and nuclear bodies.

  1978cited by this paper
• Regulation of gene expression in the chick oviduct by steroid hormones.

  1978cited by this paper
• Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

  1978cited by this paper
• Effect of non-steroidal anti-oestrogens on the concentration of rat uterine progesterone receptors.

  1978cited by this paper
• Cytoplasmic oestrogen receptor replenishment: oestrogens versus anti-oestrogens.

  1978cited by this paper
• Anti-estrogen interaction with uterine estrogen receptors. Studies with a radiolabeled anti-estrogen (CI-628).

  1978cited by this paper
• Nuclear mechanisms of estrogen action. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing.

  1978cited by this paper
• Dose-related effects of non-steroidal antioestrogens nad oestrogens on the measurement of cytoplasmic oestrogen receptors in the rat and mouse uterus.

  1978cited by this paper
• Nonsteroidal antiestrogens: their biological effects and potential mechanisms of action.

  1978cited by this paper
• Selective blockade of estrogen-induced uterine responses by the antiestrogen nafoxidine.

  1978cited by this paper
• Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen.

  1978cited by this paper
• Retarded administration of an antagonist stops steroid hormone action.

  1977cited by this paper
• Tamoxifen is a potent ‘pure’ anti-oestrogen in chick oviduct

  1977cited by this paper
• The effect of tamoxifen on the in vitro production of prostaglandins F by the guinea pig uterine tissue.

  1977cited by this paper
• Uterine peroxidase as a marker for estrogen action.

  1977cited by this paper
• Progesterone interaction with estrogen and antiestrogen in the rat uterus--receptor effects.

  1977cited by this paper
• PRODUCTION OF PROSTAGLANDINS BY THE PSEUDOPREGNANT RAT UTERUS, in vitro, AND THE EFFECT OF TAMOXIFEN WITH THE IDENTIFICATION OF 6‐KETO‐PROSTAGLANDIN F1α AS A MAJOR PRODUCT

  1977cited by this paper
• Different nuclear binding sites for antiestrogen and estrogen receptor complexes.

  1977cited by this paper
• Inhibition of Tamoxifen of the stimulatory action of FSH on oestradiol-17beta synthesis by rat ovaries in vitro.

  1977cited by this paper
• Fundamental differences in the action of estrogens and antiestrogens on the uterus: comparison between compounds with similar duration of action.

  1977cited by this paper
• A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity.

  1977cited by this paper
• Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat.

  1977cited by this paper
• A comparative study of antiestrogen action: temporal patterns of antagonism of estrogen stimulated uterine growth and effects on estrogen receptor levels.

  1977cited by this paper
• Estrogen receptor translocation and replenishment by the antiestrogen tamoxifen.

  1977cited by this paper
• Binding of [3H]tamoxifen in rat uterine cytosols: a comparison of swinging bucket and vertical tube rotor sucrose density gradient analysis.

  1977cited by this paper
• Estradiol-binding kinetics of the activated and nonactivated estrogen receptor.

  1977cited by this paper
• Quantitative estimates of cytoplasmic and nuclear oestrogen receptors in chick oviduct. Effect of oestrogen on receptor concentration and subcellular distribution.

  1976cited by this paper
• Model systems for the study of estrogen action in tissue culture.

  1976cited by this paper
• Oestrogen synthesis during delayed implantation in the rat.

  1976cited by this paper
• Temporal relationships between hormone receptor binding and biological responses in the uterus: studies with short- and long-acting derivatives of estriol.

  1976cited by this paper
• OESTROGENIC, ANTI‐OESTROGENIC AND FERTILITY EFFECTS OF SOME TRIPHENYLETHANES AND TRIPHENYLETHYLENES RELATED TO ETHAMOXYTRIPHETOL (MER 25)

  1976cited by this paper
• Inhibition of oestradiol binding to oestrogen receptor proteins by a methyl-substituted analogue of tamoxifen.

  1976cited by this paper
• Antiestrogen action: differential nuclear retention and extractability of the estrogen receptor.

  1976cited by this paper
• (E)‐1‐[p‐(Diethylaminoethoxy)phenyl]‐1,2‐diphenyl‐2‐chloroethylene hydrochloride (clomiphene hydrochloride)

  1976cited by this paper
• Nuclear retention of receptor–oestrogen complex and nuclear acceptor sites

  1976cited by this paper
• Synthesis and inducibility of the Uterine estrogen-induced protein, IP, during the rat estrous cycle: clues to uterine estrogen sensitivity.

  1975cited by this paper
• Modulation of uterine morphology and growth by estradiol-17beta and an estrogen antagonist

  1975cited by this paper
• Progesterone-binding components of chick oviduct. VIII. Receptor activation and hormone-dependent binding to purified nuclei.

  1975cited by this paper
• Plasma hormones and pituitary luteinizing hormone in the rat during the early stages of pregnancy and after post-coital treatment with tamoxifen (ICI 46,474).

  1975cited by this paper
• X-ray conformation of some estrogens and their binding to uterine receptors.

  1975cited by this paper
• Endogenous peroxidase: specific marker enzyme for tissues displaying growth dependency on estrogen

  1975cited by this paper
• In vivo effect of anti-estrogens on the localisation and replenishment of estrogen receptor.

  1975cited by this paper
• Dynamics of oestrogen-receptor distribution between the cytosol and nuclear fractions of immature rat uterus after oestradiol administration.

  1975cited by this paper
• Antiestrogen action in the uterus: biological ineffectiveness of nuclear bound estradiol after antiestrogen.

  1975cited by this paper
• Nuclear receptor estradiol complex: a requirement for uterotrophic responses.

  1974cited by this paper
• Female steroid hormones and target cell nuclei.

  1974cited by this paper
• Oestrogen receptors and antagonism of steroid hormone action

  1974cited by this paper
• Female Steroid Hormones and Target Cell Nuclei

  1974cited by this paper
• The molecular mechanism of the in vitro 4 S to 5 S transformation of the uterine estrogen receptor.

  1974cited by this paper
• The effect of antiestrogens on the nuclear binding of the estrogen receptor.

  1974cited by this paper
• The metabolism of tamoxifen (I.C.I. 46,474). I. In laboratory animals.

  1973cited by this paper
• Estrogen receptor-anti-estrogen complex: atypical binding by uterine nuclei and effects on uterine growth.

  1973cited by this paper
• Estrogen-Receptor Interaction

  1973cited by this paper
• Acidophilic activation of steroid hormone receptors.

  1973cited by this paper
• Antiestrogens: studies using an in vitro estrogen-responsive uterine system.

  1973cited by this paper
• Aspects on the mode of action of antiestrogens and antiprogestogens.

  1972cited by this paper
• Effect of some triphenylethylenes on oestradiol binding in vitro to macromolecules from uterus and anterior pituitary.

  1972cited by this paper
• Binding properties of an anti‐estrogen to the estradiol receptor of uterine cytosol

  1972cited by this paper
• Formation of estrogen nuclear receptor in uterus: effect of androgens, estrone and nafoxidine.

  1972cited by this paper
• Mechanism of action of the female sex hormones.

  1972cited by this paper
• Antiestrogenic and antifertility compounds. 4. 1,1,2-Triarylalkan-1-ols and 1,1,2-Triarylalk-1-enes containing basic ether groups.

  1971cited by this paper
• Inhibition of DMBA-induced mammary carcinogenesis in the rat by 2-br- -ergocryptine (CB 154), an inhibitor of prolactin secretion, and by nafoxidine (U-11, 100 A), an estrogen antagonist.

  1971cited by this paper
• Structure-activity relationships of anti-oestrogens with regard to interaction with 17-beta-oestradiol in the mouse uterus and vagina.

  1971cited by this paper

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  2007cites this paper
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  2007cites this paper
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  2005cites this paper
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  2005cites this paper
• Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance

  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2002cites this paper
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  1999cites this paper
• Tamoxifen inhibits colorectal cancer metastases in the liver: A study in a murine model

  1998cites this paper
• Binding characteristics of novel nonsteroidal antiestrogens to the rat uterine estrogen receptors.

  1998cites this paper
• Estrogen modulation: tiered testing for human hazard evaluation. American Industrial Health Council, Reproductive and Developmental Effects Subcommittee.

  1997cites this paper
• An estrogen receptor binding site within the human galanin gene.

  1997cites this paper
• Investigation into the possible role of androgens in the induction of hepatic vitellogenesis in the European eel:in vivo andin vitro studies

  1997cites this paper
• Synthesis and biological activities of thioether derivatives related to the antiestrogens tamoxifen and ICI 164384.

  1995cites this paper
• Synthesis and antiestrogenic activity of diaryl thioether derivatives.

  1994cites this paper
• N-butyl, N-methyl, 11-[3′,17′ β-(dihydroxy)-1′,3′,5′(10′)- estratrien-16′ α-yl]-9(R/S)-bromo undecanamide: synthesis and 17β-HSD inhibiting, estrogenic and antiestrogenic activities

  1994cites this paper
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  1994cites this paper
• Vitellogenin synthesis in cultured hepatocytes; an in vitro test for the estrogenic potency of chemicals.

  1993cites this paper
• Effects of nonsteroidal antiestrogens in the in vitro rat uterus.

  1992cites this paper
• Regulation of gene expression by steroid hormones.

  1992cites this paper
• Antiestrogens prevent the stimulatory effects of L-triiodothyronine on cell proliferation.

  1992cites this paper
• Inhibition of decidual induction in rats by clomiphene and tamoxifen.

  1992cites this paper
• Studies on the activation of the oestrogen receptor bound to the anti-oestrogens 4-hydroxytamoxifen and ICI 164,384 by using three monoclonal antibodies.

  1991cites this paper
• Involvement of oestrogens in sexual differentiation of gonads as a function of temperature in turtles

  1991cites this paper
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  1991cites this paper
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  1990cites this paper
• Endocrine pharmacology of antiestrogens as antitumor agents.

  1990cites this paper
• Enclomiphene induces luteolysis in the nonpregnant guinea pig.

  1989cites this paper
• Effects of triiodothyronine and tamoxifen on cell transformation induced by an activated c-Ha-ras oncogene.

  1989cites this paper
• Regulation of transforming growth factor alpha and transforming growth factor beta messenger ribonucleic acid abundance in T-47D, human breast cancer cells.

  1989cites this paper
• Points of action of estrogen antagonists and a calmodulin antagonist within the MCF-7 human breast cancer cell cycle.

  1989cites this paper
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  1989cites this paper
• Ovarian hormones, antiestrogen and pregnancy effects on the expression of class II histocompatibility antigens by N-nitroso-N-methylurea-induced rat mammary carcinomas.

  1989cites this paper
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  1989cites this paper
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  1989cites this paper
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  1989cites this paper
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  1989cites this paper
• Variant estrogen receptor mRNA species detected in human breast cancer biopsy samples.

  1989cites this paper
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  1989cites this paper
• The effect of the aromatase inhibitor, 4-(phenylthio)-4-androstene-3,17-dione, on dimethylbenz(A)anthracene-induced rat mammary tumors.

  1989cites this paper
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  1989cites this paper
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  1989cites this paper
• Regulation of Transforming Growth Factor α and Transforming Growth Factor β Messenger Ribonucleic Acid Abundance in T-47D, Human Breast Cancer Cells

  1989cites this paper
• Enclomiphene induces luteolysis in the nonpregnant guinea pig.

  1989cites this paper
• The significance of estrogen receptors in tamoxifen and toremifene therapy.

  1988cites this paper
• Differential induction of progestin-binding sites in uterine cell types by estrogen and antiestrogen.

  1988cites this paper
• Tamoxifen reduces calcium currents in a clonal pituitary cell line.

  1988cites this paper
• A chemical classification of nonsteroidal antagonists of sex-steroid hormone action.

  1988cites this paper
• Differential extraction of estradiol- and tamoxifen-receptor complexes from hypothalamic cell nuclei.

  1988cites this paper
• Chapter 12 Oestrogen actions

  1988cites this paper
• Receptors bound to antiprogestin form abortive complexes with hormone responsive elements

  1988cites this paper
• Binding of estrogen and antiestrogen in uterine cell nuclei: in vivo autoradiographic studies.

  1988cites this paper
• Suppression of Delayed‐Type Hypersensitivity in Mice Pretreated With Diethylstilbesterol: Involvement of Sex Hormones in Immunomodulation

  1988cites this paper
• Role of estrogen receptors and antiestrogen binding sites in an early effect of antiestrogens, the inhibition of cholesterol biosynthesis.

  1988cites this paper
• Analysis of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen levels in cytosol and KCl-nuclear extracts of breast tumours from tamoxifen treated patients by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM).

  1987cites this paper
• Keoxifene (LY 156758) inhibits follicle-stimulating hormone induced differentiation of cultured rat granulosa cells.

  1987cites this paper
• Serum protects HeLa cells from antiestrogen effects in culture.

  1987cites this paper
• Analysis of tamoxifen and 4-hydroxytamoxifen levels in immature rat uterine cytoplasm and KCl-nuclear extracts by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM).

  1987cites this paper
• Posttranscriptional regulation of albumin gene expression in Xenopus liver: evidence for an estrogen receptor-dependent mechanism.

  1987cites this paper
• Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM).

  1987cites this paper
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  1987cites this paper
• Murine antiestrogen-binding protein: characterization, solubilization and modulation by lipids.

  1987cites this paper
• Clomiphene citrate augments follicle-stimulating hormone-induced luteinizing hormone receptor content in cultured rat granulosa cells.

  1987cites this paper
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  1987cites this paper
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  1987cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1986cites this paper
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  1985cites this paper
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  1985cites this paper
• Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver.

  1985cites this paper
• Estrogenic effect of tamoxifen and its derivatives on the proliferation of MCF7 human breast tumor cells.

  1985cites this paper
• Inhibition of intestinal smooth muscle function by tamoxifen and clomiphene.

  1985cites this paper
• CHAPTER 9 – Control of Prolactin Production by Estrogen

  1985cites this paper
• Comparative fates of clomiphene and tamoxifen in the immature female rat.

  1985cites this paper
• Affinity of ligands other than triarylethylenes for liver microsomal antiestrogen binding sites.

  1985cites this paper
• Modulation of lymphokine-induced macrophage activation by estrogen metabolites.

  1985cites this paper
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  1985cites this paper
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  1985cites this paper
• Synthesis and receptor-binding affinity of fluorotamoxifen, a possible estrogen-receptor imaging agent.

  1985cites this paper
• Antioestrogen inhibition of oestradiol-induced alterations in hypothalamic noradrenaline turnover.

  1985cites this paper
• Biochemical pharmacology of antiestrogen action.

  1984cites this paper
• Estrogen immunosuppression is regulated through estrogenic responses in the thymus.

  1984cites this paper
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  1984cites this paper