Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Hypertension

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1097/HJH.0b013e32833ca68cPMID 20616756
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Leptin Stimulated C-Reactive Protein Production by Human Coronary Artery Endothelial Cells

  2009cited by this paper
• Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure

  2009cited by this paper
• Micronutrient prenatal supplementation prevents the development of hypertension and vascular endothelial damage induced by intrauterine malnutrition.

  2009cited by this paper
• Nuclear Factor-&kgr;B Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

  2009cited by this paper
• Activation of NF-&kgr;B by Palmitate in Endothelial Cells: A Key Role for NADPH Oxidase-Derived Superoxide in Response to TLR4 Activation

  2009cited by this paper
• Role of NF- (cid:1) B and PI 3-kinase/Akt in TNF- (cid:2) -induced cytotoxicity in microvascular endothelial cells

  2008cited by this paper
• Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

  2008cited by this paper
• Relations of Inflammatory Biomarkers and Common Genetic Variants With Arterial Stiffness and Wave Reflection

  2008cited by this paper
• Secretory products from human adipocytes impair endothelial function via nuclear factor κB

  2008cited by this paper
• Endothelial and vascular dysfunctions and insulin resistance in rats fed a high-fat, high-sucrose diet.

  2008cited by this paper
• Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats

  2008cited by this paper
• Effects of isoproterenol treatment for 7 days on inflammatory mediators in the rat aorta.

  2008cited by this paper
• Secretory products from human adipocytes impair endothelial function via nuclear factor kappaB.

  2008cited by this paper
• Role of NF-kappaB and PI 3-kinase/Akt in TNF-alpha-induced cytotoxicity in microvascular endothelial cells.

  2008cited by this paper
• Tumor necrosis factor-α reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells

  2007cited by this paper
• Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

  2007cited by this paper
• Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: implications for diet-induced obesity.

  2007cited by this paper
• Overweight and Obese Humans Demonstrate Increased Vascular Endothelial NAD(P)H Oxidase-p47phox Expression and Evidence of Endothelial Oxidative Stress

  2007cited by this paper
• Local adipose tissue depots as cardiovascular risk factors.

  2007cited by this paper
• Defective Insulin and Acetylcholine Induction of Endothelial Cell–Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats

  2007cited by this paper
• Peroxynitrite is Involved in the Dysfunction of Vasorelaxation in SHR/NDmcr-cp Rats, Spontaneously Hypertensive Obese Rats

  2007cited by this paper
• Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells.

  2007cited by this paper
• Regulation of NADPH oxidase subunit p22phox by NF-kB in human aortic smooth muscle cells

  2007cited by this paper
• Type 2 diabetes and cardiovascular disease: getting to the fat of the matter.

  2007cited by this paper
• Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles.

  2006cited by this paper
• Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases

  2006cited by this paper
• Correction of Endothelial Dysfunction in Diabetic Female Rats by Tetrahydrobiopterin and Chronic Insulin

  2006cited by this paper
• High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion.

  2006cited by this paper
• NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox.

  2006cited by this paper
• Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome.

  2006cited by this paper
• NF-κB Regulates Phagocytic NADPH Oxidase by Inducing the Expression of gp91phox*

  2006cited by this paper
• Short-term inhibition of peroxisome proliferator-activated receptor-γ coactivator-1α expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice

  2005cited by this paper
• Mechanisms of endothelial dysfunction in obesity.

  2005cited by this paper
• A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression.

  2005cited by this paper
• Adipose tissue, inflammation, and cardiovascular disease.

  2005cited by this paper
• Cytokines and vascular reactivity in resistance arteries.

  2005cited by this paper
• Arterial Stiffness Is Related to Systemic Inflammation in Essential Hypertension

  2005cited by this paper
• Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice.

  2005cited by this paper
• Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity.

  2005cited by this paper
• Neointimal Smooth Muscle Cells Display a Proinflammatory Phenotype Resulting in Increased Leukocyte Recruitment Mediated by P-Selectin and Chemokines

  2004cited by this paper
• Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells.

  2004cited by this paper
• Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo.

  2004cited by this paper
• CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the clinical practice discussion group.

  2004cited by this paper
• Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice.

  2003cited by this paper
• Effect of tumour necrosis factor-alpha and interleukin 1beta on endothelium-dependent relaxation in rat mesenteric resistance arteries in vitro.

  2003cited by this paper
• Control of COX-2 and iNOS gene expressions by aspirin and salicylate.

  2003cited by this paper
• Effect of tumour necrosis factor‐α and interleukin 1β on endothelium‐dependent relaxation in rat mesenteric resistance arteries in vitro

  2003cited by this paper
• Prevalence and trends in obesity among US adults, 1999-2000.

  2002cited by this paper
• Essential Role of the NADPH Oxidase Subunit p47phox in Endothelial Cell Superoxide Production in Response to Phorbol Ester and Tumor Necrosis Factor-&agr;

  2002cited by this paper
• Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide.

  2001cited by this paper
• Diet-induced endothelial dysfunction in the rat is independent of the degree of increase in total body weight.

  2001cited by this paper
• NAD(P)H oxidase: role in cardiovascular biology and disease.

  2000cited by this paper
• The transcription factor NF-kappa B and the regulation of vascular cell function.

  2000cited by this paper
• The Transcription Factor NF-κB and the Regulation of Vascular Cell Function

  2000cited by this paper
• Inhibition of Vascular Smooth Muscle Cell Proliferation by Sodium Salicylate Mediated by Upregulation of p21Waf1 and p27Kip1

  2000cited by this paper
• Transient device modeling using the Lei‐Ting hydrodynamic balance equations

  1996cited by this paper
• Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance.

  1996cited by this paper
• Effects of tumor necrosis factor and interleukin-1 on the constriction induced by angiotensin II in rat aorta.

  1996cited by this paper
• IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

  1996cited by this paper
• Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration.

  1996cited by this paper
• Interleukin-6 stimulates hepatic triglyceride secretion in rats.

  1995cited by this paper
• Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

  1995cited by this paper
• NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation

  1994cited by this paper
• The inducible transcription factor NF-kappa B: structure-function relationship of its protein subunits.

  1993cited by this paper
• Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines

  1990cited by this paper
• Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

  1990cited by this paper
• 0021-972X/04/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 89(6):2583–2589 Printed in U.S.A. Copyright © 2004 by The Endocrine Society doi: 10.1210/jc.2004-0535 Medical Consequences of Obesity

  year unknowncited by this paper

• Molecular Hybridization Strategy for Developing Lipid‐Lowering Compounds: Design and Synthesis of Vanillin‐Based Fibrate Derivatives

  2026cites this paper
• Induction of hyperlipidemic pancreatitis by different fatty acids: A narrative review

  2025cites this paper
• Time-restricted feeding reduces cardiovascular disease risk in obese mice

  2025influential citation
• Sex‐specific characterization of aortic function and inflammation in a new diet‐induced mouse model of metabolic syndrome

  2025cites this paper
• Effects of a Western Diet on Colonic Dysbiosis, Bile Acid Dysmetabolism and Intestinal Inflammation in Clinically Healthy Dogs

  2025cites this paper
• Green Tea Intake Reduces High-Fat Diet-Induced Sensory Neuropathy in Mice by Upregulating the Antioxidant Defense System in the Spinal Cord

  2025cites this paper
• Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye

  2025influential citation
• Beneficial Effects of Molasses Extract in Treatment of Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Rats through Regulation of Lipid Metabolism, Bile Acid, and Oxidative Stress.

  2025cites this paper
• The Intersection of Genetic Factors, Aberrant Nutrient Metabolism and Oxidative Stress in the Progression of Cardiometabolic Disease

  2024cites this paper
• The mitigating role of lysophospholipids in hepatic lipid metabolism and intestinal immunity in juvenile black seabream (Acanthopagrus schlegelii) fed a high-fat diet

  2024cites this paper
• The place of beta-adrenergic receptor blockers in the treatment of arterial hypertension: from bench-to-bedside.

  2024cites this paper
• Gastric Cancer, Immunotherapy, and Nutrition: The Role of Microbiota

  2024cites this paper
• Silymarin prevents endothelial dysfunction by upregulating Erk-5 in oxidized LDL exposed endothelial cells.

  2024cites this paper
• miRNA-22 is involved in the aortic reactivity in physiological conditions and mediates obesity-induced perivascular adipose tissue dysfunction.

  2023cites this paper
• PECULIARITIES OF PRENATAL INFLUENCE OF A NUTRITIONAL FACTOR ON THE STRUCTURAL AND FUNCTIONAL STATE OF THE LIVER OF NEWBORN RATS

  2022cites this paper
• Rutin ameliorates the promotion effect of fine particulate matter on vascular calcification in calcifying vascular cells and ApoE-/- mice.

  2022cites this paper
• Repeated glucose spikes and insulin resistance synergistically deteriorate endothelial function and bardoxolone methyl ameliorates endothelial dysfunction

  2022cites this paper
• Anti-obesity effect of fermented lemon peel on high-fat diet-induced obese mice by modulating the inflammatory response.

  2022cites this paper
• Etanercept Prevents Endothelial Dysfunction in Cafeteria Diet-Fed Rats

  2022cites this paper
• Pyridoxamine and Caloric Restriction Improve Metabolic and Microcirculatory Abnormalities in Rats with Non-Alcoholic Fatty Liver Disease

  2021cites this paper
• Microsomal prostaglandin E synthase‐1 is involved in the metabolic and cardiovascular alterations associated with obesity

  2021cites this paper
• High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review

  2021cites this paper
• MRI-based in vivo detection of coronary microvascular dysfunction before alterations in cardiac function induced by short-term high-fat diet in mice

  2021cites this paper
• Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity.

  2021cites this paper
• Effect Of Parsley On Weight Reduction And Antioxidant Enzymes In Overweight And Obese Women Subjects

  2021cites this paper
• Role of Perivascular Adipose Tissue and Exercise on Arterial Function with Obesity

  2021cites this paper
• Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest

  2021cites this paper
• Oxidative Stress and Vascular Damage in the Context of Obesity : The Hidden

  2021cites this paper
• Nobiletin ameliorates high-fat diet-induced vascular and renal changes by reducing inflammation with modulating AdipoR1 and TGF-β1 expression in rats.

  2020cites this paper
• Castanea sativa Mill. bark extract cardiovascular effects in a rat model of high‐fat diet

  2020cites this paper
• Xyloglucan compounded inulin or arabinoxylan against glycometabolism disorder via different metabolic pathways: Gut microbiota and bile acid receptor effects

  2020cites this paper
• In Vivo Magnetic Resonance Imaging‐Based Detection of Heterogeneous Endothelial Response in Thoracic and Abdominal Aorta to Short‐Term High‐Fat Diet Ascribed to Differences in Perivascular Adipose Tissue in Mice

  2020cites this paper
• Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

  2020cites this paper
• Knockout of vascular smooth muscle EGF receptor in a mouse model prevents obesity-induced vascular dysfunction and renal damage in vivo

  2020cites this paper
• Leptin improves intestinal flora dysfunction in mice with high-fat diet-induced obesity

  2020cites this paper
• Morin attenuates high-fat diet induced-obesity related vascular endothelial dysfunction in Wistar albino rats

  2020cites this paper
• The Vascular Consequences of Metabolic Syndrome: Rodent Models, Endothelial Dysfunction, and Current Therapies

  2020cites this paper
• Deficiency of T-type voltage-gated calcium channels results in attenuated weight gain and improved endothelium-dependent dilatation of resistance vessels induced by a high-fat diet in mice

  2020cites this paper
• Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis

  2019cites this paper
• NADPH oxidase 4 mediates the protective effects of physical activity against obesity-induced vascular dysfunction.

  2019cites this paper
• Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects

  2019cites this paper
• Human myometrial artery function and endothelial cell calcium signalling are reduced by obesity: Can this contribute to poor labour outcomes?

  2019cites this paper
• The metabolic and vascular protective effects of Olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties.

  2019cites this paper
• GQ‐130, a novel analogue of thiazolidinedione, improves obesity‐induced metabolic alterations in rats: Evidence for the involvement of PPARβ/δ pathway

  2019cites this paper
• Biologically Active Lipids in Vascular Biology

  2019cites this paper
• High-fat diet-induced functional and pathological changes in lacrimal gland.

  2019cites this paper
• Metabolic Syndrome Induces Over Expression of the Human AT1R: A Haplotype-Dependent Effect With Implications on Cardio-Renal Function

  2018cites this paper
• Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study.

  2018cites this paper
• Arabinoxylan activates lipid catabolism and alleviates liver damage in rats induced by high-fat diet.

  2018cites this paper
• OKSIDATIVNI STRES KOD GOJAZNE DECE-KAKO GA SPREČITI ILI SMANJITI?

  2018influential citation
• Effect of under‐ and overfeeding on sheep and goat milk and plasma enzymes activities related to oxidation

  2018cites this paper
• Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction.

  2018cites this paper
• MRI assessment of coronary microvascular endothelial nitric oxide synthase function using myocardial T1 mapping

  2018cites this paper
• Relationship between Adiposity, Blood Pressure, Cardiac Autonomic Function and Arterial Stiffness in Young Healthy Individuals

  2018cites this paper
• Endothelial Dysfunction and Inflammation Precedes Elevations in Blood Pressure Induced by a High-Fat Diet

  2018cites this paper
• Evaluation of Mn-superoxide dismutase and catalase gene expression in childhood obesity: its association with insulin resistance

  2018cites this paper
• Association of anthropometric measurements with oxidant-antioxidant status among young Saudi females.

  2018cites this paper
• Aspalatone Prevents VEGF-Induced Lipid Peroxidation, Migration, Tube Formation, and Dysfunction of Human Aortic Endothelial Cells

  2017cites this paper
• Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy

  2017cites this paper
• An Investigation into Gilbert’s Syndrome: Understanding the Role of Unconjugated Bilirubin in Targeting Platelet and Haemostatic Mechanisms Associated with Thrombotic Risk Factors

  2017cites this paper
• Mechanisms underlying sodium nitroprusside‐induced tolerance in the mouse aorta: Role of ROS and cyclooxygenase‐derived prostanoids

  2017cites this paper
• Test system for evaluation of the influence of the biological activity of substances on the signal system of NF-kB: focus on the derivatives of 3-hydroxypyridine

  2017cites this paper
• Obesity Induces Artery-Specific Alterations: Evaluation of Vascular Function and Inflammatory and Smooth Muscle Phenotypic Markers

  2017cites this paper
• Bifidobacterium pseudocatenulatum CECT 7765 supplementation restores altered vascular function in an experimental model of obese mice

  2017cites this paper
• Angiotensin‐(1‐7) improves non‐alcoholic steatohepatitis through an adiponectin‐independent mechanism

  2017cites this paper
• Sweet potato (Ipomoea batatas) attenuates diet-induced aortic stiffening independent of changes in body composition.

  2017cites this paper
• Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice.

  2017cites this paper
• Propranolol treatment lowers blood pressure, reduces vascular inflammatory markers and improves endothelial function in obese mice

  2017cites this paper
• Down-regulation of vascular PPAR-γ contributes to endothelial dysfunction in high-fat diet-induced obese mice exposed to chronic intermittent hypoxia.

  2017cites this paper
• Autophagy Induced FHL2 Upregulation Promotes IL-6 Production by Activating the NF-κB Pathway in Mouse Aortic Endothelial Cells after Exposure to PM2.5

  2017cites this paper
• The Role of Quercetin on some CardioVascular Parameters in Rats with Insulin Resistance Syndrome

  2017cites this paper
• Dietary fat and cholesterol in the pathogenesis of obesity and non-alcoholic fatty liver disease

  2016cites this paper
• Small Vessels – Big Problems : Novel Insights Into Microvascular Mechanisms of Diseases Hydrogen sulfide depletion contributes to microvascular remodeling in obesity

  2016cites this paper
• Obesity, Inflammation, and Exercise Training: Relative Contribution of iNOS and eNOS in the Modulation of Vascular Function in the Mouse Aorta

  2016cites this paper
• THE ROLE OF THE ACE2/ANG-(1-7)/MASR AXIS IN THE DEVELOPMENT OF OBESITY- HYPERTENSION IN MALE AND FEMALE MICE

  2016cites this paper
• From the Cover: Zinc Deficiency Worsens and Supplementation Prevents High-Fat Diet Induced Vascular Inflammation, Oxidative Stress, and Pathological Remodeling.

  2016cites this paper
• Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats.

  2016cites this paper
• Hydrogen sulfide depletion contributes to microvascular remodeling in obesity.

  2016cites this paper
• Reduced antioxidant capacity and increased subclinical inflammation markers in prepubescent obese children and their relationship with nutritional markers and metabolic parameters

  2016cites this paper
• Pharmacological modulation of dietary lipid-induced cerebral capillary dysfunction: Considerations for reducing risk for Alzheimer’s disease*

  2016cites this paper
• Nanoformulated copper/zinc superoxide dismutase attenuates vascular cell activation and aortic inflammation in obesity.

  2016cites this paper
• Obesity and atherosclerosis: mechanistic insights.

  2015cites this paper
• Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats

  2015cites this paper
• Adipokines, diabetes and atherosclerosis: an inflammatory association

  2015cites this paper
• Olive Leaf Extract Improves the Atherogenic Lipid Profile in Rats Fed a High Cholesterol Diet

  2015cites this paper
• Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms.

  2015cites this paper
• An Evolutionary Perspective of Nutrition and Inflammation as Mechanisms of Cardiovascular Disease

  2015cites this paper
• Effect of 3,4-Dihydroxyacetophenone on Endothelial Dysfunction in Streptozotocin-induced Rats With Type 2 Diabetes

  2015cites this paper
• Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease.

  2015cites this paper
• SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver.

  2015cites this paper
• MRI-based assessment of endothelial function in mice in vivo

  2015cites this paper
• Chronic peroxisome proliferator-activated receptor&bgr;/&dgr; agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity

  2015cites this paper
• EFFECT OF TERMINALIA BELERICA FRUITS ON STREPTOZOTOCIN-INDUCED DIABETES MELLITUS AND ITS

  2015cites this paper
• Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats.

  2015cites this paper
• The effect of weight reduction on antioxidant enzymes and their association with dietary intake of vitamins A, C and E.

  2014cites this paper
• Unconjugated bilirubin inhibits collagen induced platelet activation

  2014cites this paper
• The role of oxidative stress and inflammatory response in high-fat diet induced peripheral neuropathy.

  2014influential citation
• The probiotic Lactobacillus coryniformis CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice.

  2014cites this paper
• The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states

  2014cites this paper
• Short‐term intensive atorvastatin therapy improves endothelial function partly via attenuating perivascular adipose tissue inflammation through 5‐lipoxygenase pathway in hyperlipidemic rabbits

  2014cites this paper