Deficiency in the Multicopy Sycp3-Like X-Linked Genes Slx and Slxl1 Causes Major Defects in Spermatid Differentiation

Slx and Slxl1 are genes present in multiple copies on the mouse X chromosome. Using transgenically-delivered small interfering RNAs to disrupt their function, we show that Slx and Slxl1 are important for normal sperm differentiation and male fertility.

• Publication year

  2010

• Venue

  Molecular Biology of the Cell

• Publication date

  2010-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E10-07-0601PMID 20739462PMCID 2954115
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Copy number changes of CNV regions in intersubspecific crosses of the house mouse.

  2010cited by this paper
• Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity.

  2010cited by this paper
• Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage

  2010cited by this paper
• From meiosis to postmeiotic events: The secrets of histone disappearance

  2010cited by this paper
• Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility

  2009cited by this paper
• The Multicopy Gene Sly Represses the Sex Chromosomes in the Male Mouse Germline after Meiosis

  2009cited by this paper
• AATF mediates anti-apoptotic effect of the unfolded protein response through transcriptional regulation of AKT1

  2009cited by this paper
• Male infertility and the involvement of the X chromosome.

  2009cited by this paper
• Functional Roles of Human Kallikrein-related Peptidases*

  2009cited by this paper
• Faculty Opinions recommendation of The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression.

  2008cited by this paper
• The mouse X chromosome is enriched for multi-copy testis genes exhibiting post-meiotic expression

  2008cited by this paper
• BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells

  2008cited by this paper
• THE ROLES OF MOUSE Y CHROMOSOME GENES IN SPERMATOGENESIS

  2007cited by this paper
• AKT/PKB signaling: navigating downstream.

  2007cited by this paper
• Expression Analysis of the Mouse Multi-Copy X-Linked Gene Xlr-Related, Meiosis-Regulated (Xmr), Reveals That Xmr Encodes a Spermatid-Expressed Cytoplasmic Protein, SLX/XMR1

  2007cited by this paper
• Spermatogenesis and sex chromosome gene content: An evolutionary perspective

  2006cited by this paper
• FNDC3A is required for adhesion between spermatids and Sertoli cells.

  2006cited by this paper
• Cancer/testis antigens, gametogenesis and cancer

  2005cited by this paper
• RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.

  2005cited by this paper
• Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids.

  2005cited by this paper
• A mouse gene encoding a novel member of the WD family of proteins is highly conserved and predominantly expressed in the testis (Wdr13)

  2005cited by this paper
• Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm

  2005cited by this paper
• A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty expression, abnormal sperm development and sterility.

  2004cited by this paper
• Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium.

  2003cited by this paper
• A highly conserved human gene encoding a novel member of WD-repeat family of proteins (WDR13).

  2003cited by this paper
• The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes

  2003cited by this paper
• Expression of serologically identified tumor antigens in acute leukemias.

  2003cited by this paper
• Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

  2002cited by this paper
• Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.

  2001cited by this paper
• Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone deacetylases.

  2000cited by this paper
• Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility

  2000cited by this paper
• Sex and conflict.

  1998cited by this paper
• PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase

  1997cited by this paper
• A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

  1993cited by this paper
• Histological and Histopathological Evaluation of the Testis

  1990cited by this paper
• Separation of spermatogenic cells and nuclei from rodent testes.

  1977cited by this paper

• Non-Mendelian transmission of X chromosomes: mechanisms and impact on sex ratios and population dynamics in different breeding systems

  2024cites this paper
• A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier.

  2023cites this paper
• Bypassing Mendel’s First Law: Transmission Ratio Distortion in Mammals

  2023cites this paper
• Two acquired mouse Y chromosome-linked genes, Prssly and Teyorf1, are dispensable for male fertility

  2022cites this paper
• Protein profiling of testicular tissue from boars with different levels of hyperactive sperm motility

  2022cites this paper
• Meiotic drive in house mice: mechanisms, consequences, and insights for human biology

  2022cites this paper
• A gene deriving from the ancestral sex chromosomes was lost from the X and retained on the Y chromosome in eutherian mammals

  2022cites this paper
• Deletion in the Y chromosome of B10.BR-Ydel mice alters transcription from MSYq genes and has moderate effect on DNA methylation.

  2022cites this paper
• Stage-specific disruption of X chromosome expression during spermatogenesis in sterile house mouse hybrids

  2021cites this paper
• Y chromosome functions in mammalian spermatogenesis

  2021cites this paper
• Testicular germ cell–specific lncRNA, Teshl, is required for complete expression of Y chromosome genes and a normal offspring sex ratio

  2021cites this paper
• Patterns and Mechanisms of Sex Ratio Distortion in the Collaborative Cross Mouse Mapping Population

  2021cites this paper
• Battle of the Sex Chromosomes: Competition between X and Y Chromosome-Encoded Proteins for Partner Interaction and Chromatin Occupancy Drives Multicopy Gene Expression and Evolution in Muroid Rodents

  2020cites this paper
• Genomic Structure, Evolutionary Origins, and Reproductive Function of a Large Amplified Intrinsically Disordered Protein-Coding Gene on the X Chromosome (Laidx) in Mice

  2020cites this paper
• Genomic structure, evolutionary origins, and reproductive function of a large amplified intrinsically disordered protein gene on the X chromosome (Laidx) in mice

  2020cites this paper
• X-Chromosome Regulation and Sex Differences in Brain Anatomy.

  2020cites this paper
• The aryl hydrocarbon receptor mediates sex ratio distortion in the embryos sired by TCDD-exposed male mice.

  2020influential citation
• Meiotic drive mechanisms: lessons from Drosophila

  2019cites this paper
• The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy

  2019cites this paper
• Differential Sperm Motility Mediates the Sex Ratio Drive Shaping Mouse Sex Chromosome Evolution

  2019cites this paper
• Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines

  2019cites this paper
• A Neofunctionalized X-Linked Ampliconic Gene Family Is Essential for Male Fertility and Equal Sex Ratio in Mice.

  2019influential citation
• SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice

  2018cites this paper
• Transcriptional and developmental consequences of aneuploidy during male meiosis

  2018cites this paper
• Sex chromosome repeats tip the balance towards speciation

  2018cites this paper
• Mammalian X Chromosome Dosage Compensation: Perspectives From the Germ Line

  2018cites this paper
• Spermatogenesis and the Evolution of Mammalian Sex Chromosomes.

  2018cites this paper
• DNA demethylation facilitates the specific transcription of the mouse X-linked Tsga8 gene in round spermatids†.

  2018cites this paper
• Explorer SLXL 1 , a novel acrosomal protein , interacts with DKKL 1 and is involved in fertilization in mice

  2017influential citation
• Sequence and structural diversity of mouse Y chromosomes

  2017cites this paper
• Étude de SLY et de la régulation (épi)génétique des chromosomes sexuels pendant la spermiogenèse

  2016cites this paper
• Contrasting Levels of Molecular Evolution on the Mouse X Chromosome

  2016cites this paper
• The Composite Regulatory Basis of the Large X-Effect in Mouse Speciation.

  2016cites this paper
• Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development

  2016cites this paper
• Expression and epigenomic landscape of the sex chromosomes in mouse post-meiotic male germ cells

  2016cites this paper
• Insight into the Function of X-linked Lymphocyte Regulated 3 (XLR3) and the Mechanism Regulating its Imprinted Expression

  2015cites this paper
• Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells

  2015cites this paper
• Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L.

  2015cites this paper
• Functional significance of the sex chromosomes during spermatogenesis.

  2015cites this paper
• Identification and Characterization of Xlr5c as a Novel Nuclear Localization Protein in Mouse Germ Cells

  2015cites this paper
• Meiotic Silencing in Mammals.

  2015cites this paper
• A mutation study of sperm head shape and motility in the mouse: lessons for the clinic

  2015influential citation
• CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo

  2015cites this paper
• Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes.

  2014influential citation
• SSTY proteins co‐localize with the post‐meiotic sex chromatin and interact with regulators of its expression

  2014cites this paper
• A genome-wide association analysis for porcine serum lipid traits reveals the existence of age-specific genetic determinants

  2014cites this paper
• The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility

  2014cites this paper
• A 1.1-Mb Segmental Deletion on the X Chromosome Causes Meiotic Failure in Male Mice1

  2013cites this paper
• The Contribution of the Y Chromosome to Hybrid Male Sterility in House Mice

  2012cites this paper
• The Conflict within and the Escalating War between the Sex Chromosomes

  2012cites this paper
• A Genetic Basis for a Postmeiotic X Versus Y Chromosome Intragenomic Conflict in the Mouse

  2012influential citation
• Notice of Retraction Spermatogenesis-Related Gene Selection by Singular Value Decomposition and Correlation Analysis

  2011cites this paper
• Transcriptional dynamics of the sex chromosomes and the search for offspring sex-specific antigens in sperm.

  2011cites this paper
• Spermiation

  2011cites this paper
• SLXL1, a Novel Acrosomal Protein, Interacts with DKKL1 and Is Involved in Fertilization in Mice

  2011cites this paper
• Notice of RetractionSpermatogenesis-Related Gene Selection by Singular Value Decomposition and Correlation Analysis

  2011cites this paper