Engineering and physical sciences in oncology: challenges and opportunities

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Nature Reviews. Cancer

• Publication date

  2017-10-13

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1038/nrc.2017.83PMID 29026204PMCID PMC5683724
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

  2017cited by this paper
• DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration.

  2017cited by this paper
• Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.

  2017cited by this paper
• Convergence: The future of health

  2017cited by this paper
• Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma

  2017cited by this paper
• Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis

  2017cited by this paper
• TGF-B1 inhibition with losartan in combination with FOLFIRINOX (F-NOX) in locally advanced pancreatic cancer (LAPC): Preliminary feasibility and R0 resection rates from a prospective phase II study.

  2017cited by this paper
• Next-generation in vivo optical imaging with short-wave infrared quantum dots

  2017cited by this paper
• Delivery technologies for genome editing

  2017cited by this paper
• Emerging Biological Principles of Metastasis.

  2017cited by this paper
• Nuclear constriction segregates mobile nuclear proteins away from chromatin.

  2016cited by this paper
• The language of flowers

  2016cited by this paper
• Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

  2016cited by this paper
• Nuclear envelope rupture and repair during cancer cell migration

  2016cited by this paper
• Precision glycocalyx editing as a strategy for cancer immunotherapy

  2016cited by this paper
• Analysis of nanoparticle delivery to tumours

  2016cited by this paper
• Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

  2016cited by this paper
• The biology and function of fibroblasts in cancer

  2016cited by this paper
• Tumor associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

  2016cited by this paper
• PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery

  2016cited by this paper
• Solid stress and elastic energy as measures of tumour mechanopathology

  2016cited by this paper
• Obesity and Cancer: An Angiogenic and Inflammatory Link

  2016cited by this paper
• Matrix stiffening promotes a tumor vasculature phenotype

  2016cited by this paper
• ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

  2016cited by this paper
• TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer.

  2016cited by this paper
• Cancer cell motility: lessons from migration in confined spaces

  2016cited by this paper
• Affinity Versus Label-Free Isolation of Circulating Tumor Cells: Who Wins?

  2016cited by this paper
• Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

  2016cited by this paper
• Third harmonic generation microscopy of cells and tissue organization

  2016cited by this paper
• Imaging approaches to optimize molecular therapies

  2016cited by this paper
• Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular-fibrosis and tumor progression

  2016cited by this paper
• Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm.

  2016cited by this paper
• A collective route to metastasis: Seeding by tumor cell clusters

  2016cited by this paper
• Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

  2016cited by this paper
• Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

  2016cited by this paper
• Abstract LB-346: Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

  2016cited by this paper
• Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.

  2015cited by this paper
• Exosome isolation: a microfluidic road-map.

  2015cited by this paper
• An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors

  2015cited by this paper
• Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients

  2015cited by this paper
• Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment

  2015cited by this paper
• Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

  2015cited by this paper
• Clinical experiences with systemically administered siRNA-based therapeutics in cancer

  2015cited by this paper
• A microfluidic device for label-free, physical capture of circulating tumor cell-clusters

  2015cited by this paper
• Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network

  2015cited by this paper
• Leukocytes as carriers for targeted cancer drug delivery

  2015cited by this paper
• A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: Preclinical activity and safety in nonhuman primates

  2015cited by this paper
• Advancing biomedical imaging

  2015cited by this paper
• A technology platform to assess multiple cancer agents simultaneously within a patient’s tumor

  2015cited by this paper
• Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells

  2015cited by this paper
• Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma.

  2015cited by this paper
• Organs-on-chips at the frontiers of drug discovery

  2015cited by this paper
• Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

  2015cited by this paper
• Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks.

  2015cited by this paper
• Biomaterials and emerging anticancer therapeutics: engineering the microenvironment

  2015cited by this paper
• Glycosylation in cancer: mechanisms and clinical implications

  2015cited by this paper
• Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

  2015cited by this paper
• Tumour exosome integrins determine organotropic metastasis

  2015cited by this paper
• Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer

  2015cited by this paper
• Drug testing in the patient: Toward personalized cancer treatment

  2015cited by this paper
• Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging

  2015cited by this paper
• Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

  2015cited by this paper
• Design considerations for nanotherapeutics in oncology.

  2015cited by this paper
• The cancer glycocalyx mechanically primes integrin-mediated growth and survival

  2014cited by this paper
• Small RNA combination therapy for lung cancer

  2014cited by this paper
• Light in and sound out: emerging translational strategies for photoacoustic imaging.

  2014cited by this paper
• Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.

  2014cited by this paper
• Multiplexed ion beam imaging of human breast tumors

  2014cited by this paper
• Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin

  2014cited by this paper
• Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice

  2014cited by this paper
• Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

  2014cited by this paper
• TRAIL-coated leukocytes that kill cancer cells in the circulation

  2014cited by this paper
• Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology.

  2014cited by this paper
• Water permeation drives tumor cell migration in confined microenvironments.

  2014cited by this paper
• In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

  2014cited by this paper
• Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

  2014cited by this paper
• Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

  2014cited by this paper
• Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations

  2014cited by this paper
• A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone.

  2014cited by this paper
• In vivo imaging of specific drug–target binding at subcellular resolution

  2014cited by this paper
• Cancer: Sugar-coated cell signalling

  2014cited by this paper
• An indirect way to tame cancer.

  2014cited by this paper
• Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma.

  2014cited by this paper
• Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

  2014cited by this paper
• Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia.

  2014cited by this paper
• Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

  2014cited by this paper
• Microfluidic organs-on-chips

  2014cited by this paper
• Non-viral vectors for gene-based therapy

  2014cited by this paper
• Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

  2014cited by this paper
• Structure-based programming of lymph-node targeting in molecular vaccines

  2014cited by this paper
• Comparison of strain and shear wave elastography for the differentiation of benign from malignant breast lesions, combined with B-mode ultrasonography: qualitative and quantitative assessments.

  2014cited by this paper
• Platinum Compounds for High‐Resolution In Vivo Cancer Imaging

  2014cited by this paper
• Tumor signatures in the blood

  2014cited by this paper
• The role of mechanical forces in tumor growth and therapy.

  2014cited by this paper
• Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response.

  2014cited by this paper
• Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells

  2013cited by this paper
• Multifunctional nanoparticles for drug delivery and molecular imaging.

  2013cited by this paper
• Strategies for advancing cancer nanomedicine.

  2013cited by this paper
• Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and siRNA for potential triple-negative breast cancer treatment.

  2013cited by this paper
• Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D.

  2013cited by this paper

• Axolotl as a Bio-Inspired Therapeutic Model: Role of Mucus in Disease Management and Advances in Preclinical Research

  2026cites this paper
• Holistic and Multivalent Engineering of In Vivo Nanomedicine Reactions for Enhanced Multistage Tumor Delivery.

  2026cites this paper
• Integrative transcriptomic and machine learning analysis identifies CDH17 and HOXC13 as robust candidate prognostic biomarkers in uveal melanoma.

  2026cites this paper
• Redox-Programmed Activation of a Dual-Modal Probe for High-Fidelity Tumor Delineation and Image-Guided Surgery.

  2026cites this paper
• Quantitative oncogene-mapping within malignant tumors through Multi-parameter MRI based on RNA-triggered nanoprobes.

  2026cites this paper
• Machine learning in cancer prognostic and diagnostic biomarkers: A promising approach for early cancer detection

  2025cites this paper
• Hypoxic-Core (HyCo) Spheroids Recapitulate Hallmarks of Clinical Hypoxia: A Simple Chip-Based Method for Translational Oncology

  2025cites this paper
• Nanoparticle-Based Delivery Strategies for Combating Drug Resistance in Cancer Therapeutics

  2025cites this paper
• Ferroptosis: The dawn of reversing drug resistance in digestive cancers

  2025cites this paper
• Integrated bioinformatics and deep learning (MLP) approach reveals a novel five miRNA prognostic signature in uveal melanoma

  2025cites this paper
• A data-efficient strategy for building high-performing medical foundation models

  2025influential citation
• Losartan as a mechanotherapeutic adjuvant: Remodeling the breast tumor microenvironment to improve treatment efficacy

  2025cites this paper
• Zwitterionic Polymers: Structure Design and Emerging Applications

  2025cites this paper
• Endogenous macrophages as "Trojan horses" for targeted oral delivery of mRNA-encoded cytokines in tumor microenvironment immunotherapy.

  2025cites this paper
• Targeting phosphatidylserine in tumor cell membranes with a zinc-containing molecule to efficiently combat tumor metastasis

  2025cites this paper
• Neutrophil-targeted nanomedicine delivery systems: therapeutic applications and future perspectives in sepsis management.

  2025cites this paper
• Triphenylphosphine-Based Mitochondrial Targeting Nanocarriers: Advancing Cancer Therapy

  2025cites this paper
• Engineering and biofabrication of early cancer models

  2025cites this paper
• Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer

  2025cites this paper
• A new way to modulate tumor therapy: artificial intelligence predicts nanoshape efficacy.

  2025cites this paper
• Design and simulation of a novel THz patch antenna for early detection of malignant neoplasms

  2024cites this paper
• Inherent Tumor Microenvironment‐Reversing Hydrogels: Potentiating Molecular Therapy Efficacy Against Drug‐Resistant Tumors

  2024cites this paper
• NIR-II light in clinical oncology: opportunities and challenges

  2024cites this paper
• Engineering cancer's end: An interdisciplinary approach to confront the complexities of cancer.

  2024cites this paper
• Physiochemically and Genetically Engineered Bacteria: Instructive Design Principles and Diverse Applications

  2024cites this paper
• Copper Sulfide-based Hollow Nanoarchitectonics for Augmented Photothermal, Chemodynamic, and Chemotherapeutic Modalities

  2024cites this paper
• Mechano-mediated M2 macrophage polarization and immune suppression in stiffened tumor microenvironment

  2024cites this paper
• A photo-controlled charge regulator improves cancer theranostics

  2024cites this paper
• Fabrication of heterocellular spheroids with controllable core-shell structure using inertial focusing effect for scaffold-free 3D cell culture models

  2024cites this paper
• Artificial intelligence in cytopathological applications for cancer: a review of accuracy and analytic validity

  2024cites this paper
• Side-view optical microscopy-assisted atomic force microscopy for thickness-dependent nanobiomechanics

  2024cites this paper
• Harnessing Gene Editing Technology for Tumor Microenvironment Modulation: An Emerging Anticancer Strategy.

  2024cites this paper
• Brachytherapy on-a-chip: a clinically-relevant approach for radiotherapy testing in 3d biology.

  2024cites this paper
• Near-Infrared Chemiluminophore Switches Photodynamic Processes via Protein Complexation for Biomarker-Activatable Cancer Therapy.

  2024cites this paper
• Novel candidate theranostic radiopharmaceutical based on strontium hexaferrite nanoparticles conjugated with azacrown ligand.

  2023cites this paper
• Multicomponent metal-organic framework nanocomposites for tumor-responsive synergistic therapy.

  2023cites this paper
• Human Intestinal Organoids and Microphysiological Systems for Modeling Radiotoxicity and Assessing Radioprotective Agents

  2023cites this paper
• Light-responsive nanomedicine for cancer immunotherapy

  2023cites this paper
• Microfluidics for nano-drug delivery systems: From fundamentals to industrialization

  2023cites this paper
• The Three-Dimensional In Vitro Cell Culture Models in the Study of Oral Cancer Immune Microenvironment

  2023cites this paper
• Controlling the biodistribution and clearance of nanomedicines

  2023cites this paper
• Mathematical modeling of tumor based on in vitro and in vivo data, and in vitro to in vivo extrapolation and its challenges: a literature review

  2023cites this paper
• Harnessing atomic force microscopy‐based single‐cell analysis to advance physical oncology

  2023cites this paper
• Multistage Self-Assembled Nanomaterials for Cancer Immunotherapy

  2023cites this paper
• Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy.

  2023cites this paper
• Artificial intelligence in cancer diagnosis and therapy: Current status and future perspective

  2023cites this paper
• Advances in AI‐based cancer cytopathology

  2023cites this paper
• Modulating tumor mechanics with nanomedicine for cancer therapy.

  2023cites this paper
• AI-Aided Disease Prediction in Visualized Medicine.

  2023cites this paper
• Dual-targeting nanotheranostics for MRI-guided enhanced chemodynamic therapy of hepatoma via regulating the tumor microenvironment.

  2023cites this paper
• Targeting glutamine metabolism with photodynamic immunotherapy for metastatic tumor eradication.

  2023cites this paper
• Artificial Intelligence: An Emerging Intellectual Sword for Battling Carcinomas.

  2023cites this paper
• Preparation of the Protein/Polyphenylboronic Acid Nanospheres for Drug Loading and Unloading

  2023cites this paper
• Interstitial flow potentiates TGF-β/Smad-signaling activity in lung cancer spheroids in a 3D-microfluidic chip

  2023cites this paper
• Functional biomaterials for biomimetic 3D in vitro tumor microenvironment modeling

  2023cites this paper
• Image-Based Modeling of Drug Delivery during Intraperitoneal Chemotherapy in a Heterogeneous Tumor Nodule

  2023cites this paper
• Near-Infrared Photodynamic Chemiluminescent Probes for Cancer Therapy and Metastasis Detection.

  2023cites this paper
• High‐Throughput Electromechanical Coupling Chip Systems for Real‐Time 3D Invasion/Migration Assay of Cells

  2023cites this paper
• TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems

  2022cites this paper
• Emerging pharmacologic interventions for pre-eclampsia treatment

  2022cites this paper
• Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti‐Tumor Immunity in Murine Glioblastoma

  2022cites this paper
• Magnetic resonance elastography of malignant tumors

  2022cites this paper
• Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy.

  2022cites this paper
• Biophysical determinants of cancer organotropism.

  2022cites this paper
• Inducible endothelial leakiness in nanotherapeutic applications.

  2022cites this paper
• Nonviral vector system for cancer immunogene therapy

  2022cites this paper
• A novel and easy to prepare azo-based bioreductive linker and its application in hypoxia-sensitive cationic liposomal doxorubicin: synthesis, characterization, in vitro and in vivo studies in mice bearing C26 tumor.

  2022cites this paper
• Cherenkov Luminescence in Tumor Diagnosis and Treatment: A Review

  2022cites this paper
• New progress in the mechanism of microenvironment-driven chemoradiotherapy resistance in digestive system tumors

  2022cites this paper
• On-Demand Triggered Chemodynamic Therapy by NIR-II Light on Oxidation-Prevented Bismuth Nanodots.

  2022cites this paper
• Microfluidics meets 3D cancer cell migration.

  2022cites this paper
• Dose Finding in Oncology: What is Impeding Coming of Age?

  2022cites this paper
• Dual-responsive polypeptide nanoparticles attenuate tumor-associated stromal desmoplasia and anticancer through programmable dissociation.

  2022cites this paper
• Radiotherapy on-chip: microfluidics for translational radiation oncology.

  2022cites this paper
• The Patient-Derived Cancer Organoids: Promises and Challenges as Platforms for Cancer Discovery

  2022cites this paper
• Numerical Investigation on the Anti-Angiogenic Therapy-Induced Normalization in Solid Tumors

  2022cites this paper
• Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI: Promises and Challenges

  2022cites this paper
• TARGETING INFLAMMATORY MONOCYTES BY IMMUNE-MODIFYING NANOPARTICLES PREVENTS ACUTE KIDNEY ALLOGRAFT REJECTION.

  2022cites this paper
• Polymeric Hydrogels for In Vitro 3D Ovarian Cancer Modeling

  2022cites this paper
• Biomaterials and Its Advances for Delivering Anticancer Drugs

  2021cites this paper
• Injectable Microfluidic Hydrogel Microspheres for Cell and Drug Delivery

  2021cites this paper
• Mitochondria-targeted nanoparticles (mitoNANO): An emerging therapeutic shortcut for cancer

  2021cites this paper
• A Multi-Learning Training Approach for Distinguishing Low and High Risk Cancer Patients

  2021cites this paper
• 3D Collagen-Nanocellulose Matrices Model the Tumour Microenvironment of Pancreatic Cancer

  2021cites this paper
• Drug transport kinetics of intravascular triggered drug delivery systems

  2021cites this paper
• Hierarchical Micro-/Nanotopography for Tuning Structures and Mechanics of Cells Probed by Atomic Force Microscopy

  2021cites this paper
• Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices

  2021cites this paper
• FluidFM for single-cell biophysics

  2021cites this paper
• Neutrally charged self-assembling peptide hydrogel recapitulates in vitro mechanisms of breast cancer progression.

  2021cites this paper
• A Physical Perspective on Oncology Research: The Critically Emerging Role of Physical Science in the Fight Against Brain Cancer

  2021cites this paper
• Delivery technologies to engineer natural killer cells for cancer immunotherapy

  2021cites this paper
• Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs

  2021cites this paper
• Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy

  2021cites this paper
• Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

  2021cites this paper
• Microfluidic formulation of nanoparticles for biomedical applications.

  2021cites this paper
• Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy.

  2021cites this paper
• Externally triggered smart drug delivery system encapsulating idarubicin shows superior kinetics and enhances tumoral drug uptake and response

  2021cites this paper
• 3D Tumor Spheroid Models for In Vitro Therapeutic Screening of Nanoparticles.

  2021cites this paper
• Silica Nanoparticles Decorated with Gadolinium Oxide Nanoparticles for Magnetic Resonance and Optical Imaging of Tumors

  2021cites this paper
• RGD-expressed bacterial membrane-derived nanovesicles enhance cancer therapy via multiple tumorous targeting

  2021cites this paper