Sarcopenia in the elderly: Basic and clinical issues

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Geriatrics & Gerontology International

• Publication date

  2012-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1447-0594.2012.00851.xPMID 22530761
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiopathological mechanism of sarcopenia.

  2011cited by this paper
• Physical activity and sarcopenia.

  2011cited by this paper
• The neurology of old age.

  2011cited by this paper
• Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.

  2011cited by this paper
• The epidemiology of sarcopenia.

  2011cited by this paper
• Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men.

  2010cited by this paper
• Sarcopenia: European consensus on definition and diagnosis

  2010cited by this paper
• Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men.

  2010cited by this paper
• Adverse events associated with testosterone administration.

  2010cited by this paper
• Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure

  2010cited by this paper
• Oxidative Stress, Molecular Inflammation and Sarcopenia

  2010cited by this paper
• European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people

  2010cited by this paper
• A mechanistic approach to blood flow occlusion.

  2010cited by this paper
• Adverse events associated with testosterone administration.

  2010cited by this paper
• Nutritional recommendations for the management of sarcopenia.

  2010cited by this paper
• Advances in understanding and treating cardiac cachexia: highlights from the 5th Cachexia Conference.

  2010cited by this paper
• Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men

  2009cited by this paper
• mTOR function in skeletal muscle: a focal point for overnutrition and exercise.

  2009cited by this paper
• Vitamin d deficiency/insufficiency practice patterns in a veterans health administration long-term care population: a retrospective analysis.

  2009cited by this paper
• Disproportionate changes in skeletal muscle strength and size with resistance training and ageing.

  2009cited by this paper
• Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men.

  2009cited by this paper
• Aerobic exercise training improves whole muscle and single myofiber size and function in older women.

  2009cited by this paper
• Bioimpedance vector analysis as a measure of muscle function.

  2009cited by this paper
• Impact of short‐term aerobic interval training on maximal exercise in sedentary aged subjects

  2009cited by this paper
• Muscle mitochondrial changes with aging and exercise.

  2009cited by this paper
• Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging

  2009cited by this paper
• Simultaneously significant hepatic and mild splenic uptake of Tc-99m MDP resulting from Waldenstrom macroglobulinemia.

  2009cited by this paper
• Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia

  2009cited by this paper
• Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

  2009cited by this paper
• HIGHLIGHTED TOPIC Regulation of Protein Metabolism in Exercise and Recovery Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men

  2009cited by this paper
• Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscle

  2009cited by this paper
• Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease

  2009cited by this paper
• Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events.

  2009cited by this paper
• Sarcopenia =/= dynapenia.

  2008cited by this paper
• The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action.

  2008cited by this paper
• The Functional Effects of Physical Exercise Training in Frail Older People

  2008cited by this paper
• Resistance training induces qualitative changes in muscle morphology, muscle architecture, and muscle function in elderly postoperative patients.

  2008cited by this paper
• Functional outcomes for clinical trials in frail older persons: time to be moving.

  2008cited by this paper
• The trend toward geriatric nephrology.

  2008cited by this paper
• Exercise is medicine and physicians need to prescribe it!

  2008cited by this paper
• Sarcopenia: Diagnosis and treatment

  2008cited by this paper
• Decreased muscle mass and increased central adiposity are independently related to mortality in older men.

  2007cited by this paper
• Alternative Definitions of Sarcopenia, Lower Extremity Performance, and Functional Impairment with Aging in Older Men and Women

  2007cited by this paper
• [Anthropometric measurements as a predictor of mortality of community-dwelling Japanese elderly: the Nagoya Longitudinal Study of Frail Elderly (NLS-FE)].

  2007cited by this paper
• Deterioration of contractile properties of muscle fibres in elderly subjects is modulated by the level of physical activity

  2007cited by this paper
• Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function.

  2007cited by this paper
• 訪問看護サービス利用者の身体計測指標と生命予後について―the Nagoya Longitudinal Study of Frail Elderly（NLS-FE）より

  2007cited by this paper
• Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers.

  2007cited by this paper
• Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association.

  2007cited by this paper
• Postmenopausal HRT and tibolone in relation to muscle strength and body composition.

  2007cited by this paper
• Factors contributing to neuromuscular impairment and sarcopenia during aging.

  2007cited by this paper
• The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study.

  2006cited by this paper
• Effect of Inflammation on the Aging Microcirculation: Impact on Skeletal Muscle Blood Flow Control

  2006cited by this paper
• Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells.

  2005cited by this paper
• Effects of Resistance Training on Older Adults

  2004cited by this paper
• Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women

  2004cited by this paper
• Interventions for sarcopenia and muscle weakness in older people.

  2004cited by this paper
• Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women.

  2004cited by this paper
• Minireview: A hypothalamic role in energy balance with special emphasis on leptin.

  2004cited by this paper
• Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans

  2004cited by this paper
• Low Skeletal Muscle Mass Is Associated With Poor Structural Parameters of Bone and Impaired Balance in Elderly Men—The MINOS Study

  2004cited by this paper
• In vivo human muscle structure and function: adaptations to resistance training in old age

  2004cited by this paper
• Sarcopenia: Alternative Definitions and Associations with Lower Extremity Function

  2003cited by this paper
• Trends in aging--United States and worldwide.

  2003cited by this paper
• The role of cytokines in regulating protein metabolism and muscle function.

  2002cited by this paper
• TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation.

  2002cited by this paper
• Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability

  2002cited by this paper
• Corrected Arm Muscle Area: An Independent Predictor of Long‐Term Mortality in Community‐Dwelling Older Adults?

  2002cited by this paper
• TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation

  2002cited by this paper
• Chronic Administration of Ghrelin Improves Left Ventricular Dysfunction and Attenuates Development of Cardiac Cachexia in Rats With Heart Failure

  2001cited by this paper
• A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency.

  2001cited by this paper
• The effect of tibolone on fat mass, fat-free mass, and total body water in postmenopausal women.

  2001cited by this paper
• The effect of age on protein metabolism

  2000cited by this paper
• Short-term effects of leptin on skeletal muscle protein metabolism in the rat.

  2000cited by this paper
• Testosterone and leptin in older African-American men: relationship to age, strength, function, and season.

  2000cited by this paper
• Strength Training in the Elderly

  2000cited by this paper
• Reexamining the Sarcopenia Hypothesis: Muscle Mass versus Muscle Strength

  2000cited by this paper
• Mortality associated with body fat, fat-free mass and body mass index among 60-year-old Swedish men—a 22-year follow-up. The study of men born in 1913

  2000cited by this paper
• Age-related changes in muscle.

  2000cited by this paper
• Strength Training in the Elderly Effects on Risk Factors for Age-Related Diseases

  2000cited by this paper
• Once‐Weekly Resistance Exercise Improves Muscle Strength and Neuromuscular Performance in Older Adults

  1999cited by this paper
• Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women.

  1998cited by this paper
• Epidemiology of sarcopenia among the elderly in New Mexico.

  1998cited by this paper
• Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women's Health and Aging Study.

  1997cited by this paper
• Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability

  1996cited by this paper
• The application of blood flow measurements to the study of aging muscle.

  1995cited by this paper
• Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle.

  1995cited by this paper
• Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.

  1994cited by this paper
• Changes in Skeletal Muscle with Aging: Effects of Exercise Training

  1993cited by this paper
• Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds.

  1990cited by this paper
• What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men.

  1988cited by this paper
• The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals.

  1985cited by this paper
• Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections

  1983cited by this paper
• Impaired growth hormone secretion in the adult population: relation to age and adiposity.

  1981cited by this paper
• Compartmental body composition based on total-body nitrogen, potassium, and calcium.

  1980cited by this paper
• Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.

  1967cited by this paper

• Association Between Preoperative Sarcopenia and Postoperative Complications Following Hepatopancreatobiliary Cancer Surgery at a Tertiary Care Center in Eastern India.

  2026cites this paper
• Examining the Relationship Between Sarcopenia and Rotator Cuff Tears: A Retrospective Comparative Study

  2025cites this paper
• Mediating role of possible sarcopenia in the association between diabetes and stroke: finding from the China health and retirement longitudinal study

  2025cites this paper
• Muscle Fat Infiltration in Patients with Multiple Myeloma: A Case–Control Study

  2025cites this paper
• Quality and Reliability of YouTube Videos as a Source of Information Regarding Exercises to Prevent Sarcopenia

  2025cites this paper
• Feasibility and efficacy of square dancing and elastic band training for sarcopenia in nursing home residents

  2025cites this paper
• Long-term burden of body mass index since childhood and impaired physical performance in midlife

  2025cites this paper
• Predictive Value of Gluteal Muscle Index for Diagnosing Sarcopenia in Community-Dwelling Adults

  2025cites this paper
• Electroacupuncture Plus Exercise for Sarcopenia in Older Adults: Protocol for a Randomized, Controlled, Assessor-Blinded Trial

  2025cites this paper
• Association between Fat Mass, Total Energy Metabolism, and Sarcopenia in Older Zhuang Adults from Southwest China: A Cross-Sectional Study

  2025cites this paper
• Sarcopenia defined by serum creatinine and cystatin C predicts poor survival outcomes in patients with cancers

  2025cites this paper
• Sarcopenia in systemic sclerosis: prevalence and impact—a systematic review and meta-analysis

  2024cites this paper
• Muscle Mass Is Associated with Depression in Adolescents and Young Adults

  2024cites this paper
• Proposal for New Diagnostic Criteria for Sarcopenia Based on CT Imaging in Saudi Population: A Novel Method in Oncology Research

  2024cites this paper
• Korean Nationwide Exploration of Sarcopenia Prevalence and Risk Factors in Late Middle-Aged Women

  2024cites this paper
• Association between metabolic phenotypes and incident pre-sarcopenia: 3 years follow-up of Tehran Lipid and Glucose Study

  2024cites this paper
• CT-defined muscle density as a prognostic factor in multiple myeloma undergoing autologous stem cell therapy: a retrospective single center study

  2024influential citation
• Nationwide Cross-sectional Analysis of Determinant Agents for Sarcopenia in Men in Their Forties: Based on the EWGSOP Criteria

  2024cites this paper
• Factors determinant of quality of life after total knee arthroplasty in knee osteoarthritis: A systematic review.

  2024cites this paper
• Prevalence and Factors Associated with Sarcopenia among a Sample Aged 60 Years and Older in Iraq

  2024cites this paper
• Evaluation of clinical manifestations of sarcopenia in elderly people in the Tyumen region

  2024cites this paper
• Commentaries on “Associations of Lower Extremity Muscle Strength, Area, and Specific Force With Lower Urinary Tract Symptoms in Older Men: The Baltimore Longitudinal Study of Aging”

  2024cites this paper
• Effects of Paraspinal Intramuscular Injection of Atelocollagen in Patients with Chronic Low Back Pain: A Retrospective Observational Study

  2024cites this paper
• Pharmacokinetics and effect of maslinic acid with physical exercise on grip strength and trunk muscle mass in healthy Japanese individuals

  2023cites this paper
• Analyzing Proportion and Susceptibility Markers of Sarcopenia In Korean Younger Female

  2023cites this paper
• Reference for normal measurements of psoas muscle among the adult population in Saudi Arabia

  2023cites this paper
• A Korean Nationwide Cross-Sectional Study Investigating Risk Factors, Prevalence, and Characteristics of Sarcopenia in Men in Early Old Age

  2023cites this paper
• Correlation of FIRE-MADE (Frailty Index in Rural Elderly - Mental Status, Activities of Daily Living, Depression, and Events) With Sarcopenia in Elderly Population of Central Rural India

  2023cites this paper
• Impact of body composition and physical strength changes during chemoradiotherapy on complications and survival after oesophagectomy.

  2023cites this paper
• Physical Activity, Sedentary Behavior, Fruit and Vegetable Consumption, and Sarcopenia in Older Chinese Adults: A Cross-Sectional Study

  2023cites this paper
• Prevalence, Anthropometric Risk Factors, and Clinical Risk Factors in Sarcopenic Women in Their 40s

  2023cites this paper
• An Assessment Article on the Cure of Sarcopenia and its Association with type 2 Diabetes in the Elderly

  2023cites this paper
• Sarcopenic obesity in children

  2023cites this paper
• Body composition and risk of liver cancer: a population-based prospective cohort study on gender difference

  2023cites this paper
• Air pollution exacerbates mild obstructive sleep apnea by disrupting nocturnal changes in lower-limb body composition: A cross-sectional study conducted in urban northern Taiwan.

  2023cites this paper
• CT-defined pectoralis muscle mass and muscle density are associated with mortality in acute pulmonary embolism. A multicenter analysis.

  2023cites this paper
• Association between the sarcopenia index and the risk of stroke in elderly patients with hypertension: a cohort study

  2023cites this paper
• CT-defined body composition as a prognostic factor in multiple myeloma

  2023influential citation
• Evaluation of Nutritional Status in an Acute Geriatric Unit: Retrospective Study and Analysis of Frailty Syndrome

  2023cites this paper
• Effects of additive interactions among obesity, visceral adiposity, and sarcopenia on nonalcoholic fatty liver disease

  2023cites this paper
• Elderly Patients and Management in Intensive Care Units (ICU): Clinical Challenges

  2023cites this paper
• Prognostic Role of Low-Skeletal Muscle Mass on Staging Computed Tomography in Metastasized Colorectal Cancer: A Systematic Review and Meta-Analysis.

  2022cites this paper
• Prevalence of sarcopenia in patients with solid tumors A meta analysis based on 81 814 patients.

  2022cites this paper
• Oral, enteral and parenteral nutritional therapies in scleroderma: A systematic review.

  2022cites this paper
• Association between grip strength and non-alcoholic fatty liver disease: A systematic review and meta-analysis

  2022cites this paper
• Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis

  2022cites this paper
• Computed tomography‐defined body composition as prognostic markers for unfavourable outcomes and in‐hospital mortality in coronavirus disease 2019

  2022cites this paper
• Sarcopenia Is Associated with Metabolic Syndrome in Korean Adults Aged over 50 Years: A Cross-Sectional Study

  2022cites this paper
• The frequency of sarcopenia and factors affecting appendicular muscle mass in patients with systemic sclerosis

  2022cites this paper
• Low skeletal muscle mass defined by thoracic CT as a prognostic marker in acute pulmonary embolism.

  2022cites this paper
• Longitudinal Associations Between Household Solid Fuel Use and Handgrip Strength in Middle-Aged and Older Chinese Individuals: The China Health and Retirement Longitudinal Study

  2022cites this paper
• Gender-Specific Risk Factors and Prevalence for Sarcopenia among Community-Dwelling Young-Old Adults

  2022cites this paper
• Clinical utility of computed tomography-based evaluation of trunk muscles in primary sclerosing cholangitis

  2022cites this paper
• Sarcopenia as a Prognostic Marker for Survival in Gastric Cancer Patients Undergoing Palliative Chemotherapy. A Systematic Review and Meta Analysis

  2022influential citation
• Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis

  2022cites this paper
• CT-defined low-skeletal muscle mass as a prognostic marker for survival in prostate cancer: A systematic review and meta-analysis.

  2021cites this paper
• Evaluation of Nutrients Intake for a Group of Jordanian Older Adults with Sarcopenia Syndrome in Amman: An Explorative and Pilot Study

  2021influential citation
• Physical Strength as a Heuristic Cue of Political Conservatism

  2021cites this paper
• Effect of a Training Program on Hepatic Fat Content and Cardiometabolic Risk in Postmenopausal Women: The Randomized Controlled Trial

  2021cites this paper
• Comparison of Sarcopenia with Modified Frailty Index as a Predictor of Adverse Outcomes in Critically Ill Elderly Patients

  2021cites this paper
• Health concerns regarding malnutrition among the older populations: considerations from a Slovenian perspective.

  2021cites this paper
• Computed tomography-defined low skeletal muscle mass as a prognostic marker for short-term mortality in critically ill patients: A systematic review and meta-analysis.

  2021cites this paper
• Correlation of Sarcopenia With Modified Frailty Index as a Predictor of Outcome in Critically Ill Elderly Patients: A Cross-Sectional Study

  2021cites this paper
• Effects of anti-diabetic drugs on sarcopenia: Best treatment options for elderly patients with type 2 diabetes mellitus and sarcopenia

  2021cites this paper
• Sarcopenic Obesity Is Significantly Associated With Coronary Artery Calcification

  2021cites this paper
• Association between Health Indicators and Health-Related Quality of Life according to Physical Activity of Older Women

  2020cites this paper
• Effects of low skeletal muscle mass and sarcopenic obesity on albuminuria: a 7-year longitudinal study

  2020cites this paper
• The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study

  2020cites this paper
• Passport to Successful ICU Discharge

  2020cites this paper
• Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

  2020cites this paper
• Sociodemographic Prevalence of Sarcopenic Obesity Among Gender in African American Population

  2020cites this paper
• Risk Factors for Sarcopenia in the Elderly with Type 2 Diabetes Mellitus and the Effect of Metformin

  2020cites this paper
• A Study on the Analysis of Physical Function in Adults with Sarcopenia

  2020cites this paper
• Nutrition: Calories Count

  2020cites this paper
• Advanced microvascular damage associated with occurence of sarcopenia in systemic sclerosis patients: results from a retrospective cohort study.

  2020cites this paper
• Harnessing Muscle–Liver Crosstalk to Treat Nonalcoholic Steatohepatitis

  2020cites this paper
• Effect of Pu’er tea extract on C2C12 myoblast differentiation

  2020cites this paper
• Association between sarcopenia and rheumatological diseases

  2019cites this paper
• Association between sarcopenia and depressive mood in urban‐dwelling older adults: A cross‐sectional study

  2019cites this paper
• Noncontrast Chest Computed Tomographic Imaging of Obesity and the Metabolic Syndrome: Part II Noncardiovascular Findings

  2019cites this paper
• University of Birmingham Interventions for the management and prevention of sarcopenia in the critically ill: a systematic review

  2019cites this paper
• Early Mobility in the Intensive Care Unit: Evidence, Barriers, and Future Directions.

  2019cites this paper
• Sarcopenia assessed using bioimpedance analysis is associated independently with significant liver fibrosis in patients with chronic liver diseases.

  2019cites this paper
• Sarcopenia Is Significantly Associated with Presence and Severity of Nonalcoholic Fatty Liver Disease

  2019cites this paper
• Effects of PM2.5 on Skeletal Muscle Mass and Body Fat Mass of the Elderly in Taipei, Taiwan

  2019cites this paper
• Automatic Classification of Sarcopenia Level in Older Adults: A Case Study at Tijuana General Hospital

  2019cites this paper
• Resilience among older cardiovascular disease patients with probable sarcopenia.

  2019cites this paper
• Prevalence of sarcopenia in patients with geriatric depression diagnosis

  2019cites this paper
• Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women

  2019cites this paper
• Association of Sarcopenia with Metabolic Syndrome in Korean Population Using 2009–2010 Korea National Health and Nutrition Examination Survey

  2019cites this paper
• Interventions for the management and prevention of sarcopenia in the critically ill: A systematic review

  2019cites this paper
• Femoral bone mineral density and rectus femoris phenotype as sarcopenia indicators after a pulmonary rehabilitation protocol in patients with chronic respiratory disease

  2019cites this paper
• Evaluation of the association between decreased skeletal muscle mass and extubation failure after long-term mechanical ventilation.

  2019cites this paper
• Low paravertebral muscle mass in patients with bone metastases from lung cancer is associated with poor prognosis

  2019cites this paper
• Sarcopenia Updates in Concept, Diagnosis, and Treatment: Could Medium Chain Triglycerides Be a Treatment Candidate for Sarcopenia?

  2018cites this paper
• Effects of an exercise model based on functional circuits in an older population with different levels of social participation

  2018cites this paper
• Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson’s disease

  2018cites this paper
• Low relative muscle mass and left ventricular diastolic dysfunction in middle-aged adults.

  2018cites this paper
• Prevalence of sarcopenia in systemic sclerosis: assessing body composition and functional disability in patients with systemic sclerosis.

  2018cites this paper
• Risk of malnutrition is associated with poor physical function in patients undergoing cardiac rehabilitation following heart failure

  2018cites this paper