Impaired microRNA processing enhances cellular transformation and tumorigenesis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature Genetics

• Publication date

  2007-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ng2003PMID 17401365
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Extensive post-transcriptional regulation of microRNAs and its implications for cancer.

  2006cited by this paper
• High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras.

  2006cited by this paper
• A microRNA expression signature of human solid tumors defines cancer gene targets

  2006cited by this paper
• Reduced expression of Dicer associated with poor prognosis in lung cancer patients

  2005cited by this paper
• MicroRNA biogenesis and cancer.

  2005cited by this paper
• The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.

  2005cited by this paper
• A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.

  2005cited by this paper
• Characterization of Dicer-deficient murine embryonic stem cells.

  2005cited by this paper
• MicroRNA expression profiles classify human cancers

  2005cited by this paper
• c-Myc-regulated microRNAs modulate E2F1 expression

  2005cited by this paper
• A microRNA polycistron as a potential human oncogene

  2005cited by this paper
• An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

  2005cited by this paper
• The profile of repeat‐associated histone lysine methylation states in the mouse epigenome

  2005cited by this paper
• Transcriptional regulation and transformation by Myc proteins

  2005cited by this paper
• The differential effects of mutant p53 alleles on advanced murine lung cancer.

  2005cited by this paper
• Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing.

  2005cited by this paper
• RAS is regulated by the let-7 microRNA family.

  2005cited by this paper
• Sequence-Specific Inhibition of Small RNA Function

  2004cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• Human MicroRNA Targets

  2004cited by this paper
• Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.

  2004cited by this paper
• Cre-lox-regulated conditional RNA interference from transgenes.

  2004cited by this paper
• Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

  2004cited by this paper
• Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.

  2004cited by this paper
• siRNAs can function as miRNAs

  2003cited by this paper
• siRNAs can function as miRNAs.

  2003cited by this paper
• A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

  2002cited by this paper
• Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

  2001cited by this paper
• Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.

  2001cited by this paper
• Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.

  2000cited by this paper

• MicroRNAs in oncology: a translational perspective in the era of AI.

  2026cites this paper
• Deciphering RNA and protein expression discordance identifies TOP2A as a prognostic biomarker and potential therapeutic target in lung adenocarcinoma

  2026cites this paper
• NIR-switched DNA tweezer enables reversible miRNA recognition with erasable signal for in vivo continuous imaging

  2026cites this paper
• Functionally integrated palindromic hairpin-enabled signal efficient amplification and continuous transduction for one-pot miRNA sensing.

  2026cites this paper
• DICER1 Syndrome: What Do We Know of the Pathogenetic Mechanisms?

  2025cites this paper
• METTL14-mediated miR-122-5p maturation stimulated tumor progression by targeting KAT2A in hepatocellular carcinoma

  2025cites this paper
• Cancer therapeutics hope: microRNA clinical practice and perspectives

  2025cites this paper
• An Anticancer Bioactive Peptide Combined with Oxaliplatin Inhibited Gastric Cancer Cells In Vitro and In Vivo.

  2025cites this paper
• MiR-196a2 rs11614913 C Allele is Associated with Increased Wilms Tumor Susceptibility in Chinese Children

  2025cites this paper
• MicroRNAs in HPV-induced Cervical Cancer Carcinogenesis and Potential Biomarkers

  2025cites this paper
• Advances in microneedle-based transdermal fluorescent sensors.

  2025cites this paper
• Three Circulating miRNAs Related to Non-Small-Cell Lung Cancer Progression: An Integrative Analysis of Their Biological Roles

  2025cites this paper
• Pyrococcus furiosus Argonaute-Based Fluorometric Biosensor for One-Tube Detection of Cancer-Associated Single Nucleotide Polymorphisms in MicroRNAs.

  2025cites this paper
• MicroRNAs Expression Profile in MN1-Altered Astroblastoma

  2025cites this paper
• miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers

  2025cites this paper
• Palindrome-Mediated Isothermal Cascade DNA Amplification and Effortless Nanosignal Transduction for One-Pot and Ultrasensitive miRNA Sensing.

  2025cites this paper
• Split activator ligation assay: A CRISPR/Cas12a-enabled biosensor for the genotyping of cancer-associated miRNA single-nucleotide polymorphisms

  2025cites this paper
• The Life of MicroRNAs: Biogenesis, Function and Decay in Cancer

  2025cites this paper
• DICER1 syndrome with hepatoblastoma and pleuropulmonary blastoma

  2024cites this paper
• The coexistence of a BRCA2 germline and a DICER1 somatic variant in two first-degree cousins suggests their potential synergic effect

  2024cites this paper
• The miR-9-5p/KLF5/IL-1β Axis Regulates Airway Smooth Muscle Cell Proliferation and Apoptosis to Aggravate Airway Remodeling and Inflammation in Asthma

  2024cites this paper
• Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma

  2024cites this paper
• Evolving Landscape of Detection and Targeting miRNA/Epigenetics for Therapeutic Strategies in Ovarian Cancer.

  2024cites this paper
• NF2: An underestimated player in cancer metabolic reprogramming and tumor immunity

  2024cites this paper
• The evolution of preclinical models for myelodysplastic neoplasms

  2024cites this paper
• Unlocking the epigenetic code: new insights into triple-negative breast cancer

  2024cites this paper
• Differential microRNAs Expression during Cancer Development, and Chemoprevention by Natural Compounds: A Comprehensive Review.

  2024cites this paper
• Tumor Microenvironment Modulation by Cancer-Derived Extracellular Vesicles

  2024cites this paper
• Genetic Alchemy unveiled: MicroRNA-mediated gene therapy as the Artisan craft in the battlefront against hepatocellular carcinoma—a comprehensive chronicle of strategies and innovations

  2024cites this paper
• Targeted Cancer Stem Cell Therapeutics: An Update.

  2024cites this paper
• USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression

  2023cites this paper
• DICER ribonuclease removes harmful R-loops.

  2023cites this paper
• Hallmark discoveries in the biology of Wilms tumour

  2023cites this paper
• Lung cancer associated with combustion particles and fine particulate matter (PM2.5) - The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR)

  2023cites this paper
• DICER1 Syndrome in Twins With Ovarian Sertoli-Leydig Cell Tumor and Papillary Thyroid Carcinoma

  2023cites this paper
• The Role of MicroRNAs in Breast Cancer and the Challenges of Their Clinical Application

  2023cites this paper
• MicroRNA Biogenesis in Cell Senescence Induced by Chronic Endoplasmic Reticulum Stress

  2023cites this paper
• Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas

  2023cites this paper
• miR‐100 rs1834306 a > G polymorphism decreases neuroblastoma risk in Chinese children

  2023cites this paper
• MicroRNAs as clinical tools for diagnosis, prognosis, and therapy in prostate cancer

  2023cites this paper
• FOXO-mediated repression of Dicer1 regulates metabolism, stress resistance, and longevity in Drosophila

  2023cites this paper
• 2,4-DICHLOROPHENOXYACETIC ACID (2,4-D) EXPOSURE DURING POSTNATAL DEVELOPMENT ALTERS THE EFFECTS OF WESTERN DIET ON MOUSE PROSTATE.

  2023cites this paper
• The 3’ UTR polymorphisms rs3742330 in DICER1 and rs10719 in DROSHA genes are not associated with primary open-angle and angle-closure glaucoma: As case-control study

  2023cites this paper
• Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management

  2023cites this paper
• DISE, an ancient anti-cancer mechanism that senses mutational load in cancerous cells?

  2023cites this paper
• miRNA-Based Technologies in Cancer Therapy

  2023cites this paper
• MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D Expression

  2023cites this paper
• microRNA Biogenesis during Cellular Senesence Induced by Chronic Stress of the Endoplasmic Reticulum

  2023cites this paper
• Chaperone‐mediated autophagy degrade Dicer to promote breast cancer metastasis

  2023cites this paper
• Downregulation of DROSHA: Could It Affect miRNA Biogenesis in Endometriotic Menstrual Blood Mesenchymal Stem Cells?

  2023cites this paper
• Functional Axis of PDE5/cGMP Mediates Timosaponin-AIII-Elicited Growth Suppression of Glioblastoma U87MG Cells

  2023cites this paper
• MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells

  2023cites this paper
• Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan

  2023cites this paper
• Oncogenic MORC2 in cancer development and beyond

  2023cites this paper
• Exosome-derived lncRNA HOXA-AS3 promotes castration resistance and progression of prostate cancer via the miR-29b-3p/Mcl-1/STAT3 axis

  2022cites this paper
• MiR-101: An Important Regulator of Gene Expression and Tumor Ecosystem

  2022cites this paper
• miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

  2022cites this paper
• A Sample and Detection Microneedle Patch for Psoriasis MicroRNA Biomarker Analysis in Interstitial Fluid.

  2022cites this paper
• Non-coding RNA in rhabdomyosarcoma progression and metastasis

  2022cites this paper
• Role of microRNAs in type 2 diseases and allergen-specific immunotherapy

  2022cites this paper
• The clinical utility of dysregulated microRNA expression in paediatric solid tumours.

  2022cites this paper
• Targeting Novel microRNAs in Developing Novel Alzheimer's Disease Treatments

  2022cites this paper
• Regulation of Embryonic Stem Cell Self-Renewal

  2022cites this paper
• miRNAs as Biomarkers and Possible Therapeutic Strategies in Synovial Sarcoma

  2022cites this paper
• APE1 controls DICER1 expression in NSCLC through miR-33a and miR-130b

  2022cites this paper
• Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer

  2022cites this paper
• Histone citrullination represses miRNA expression resulting in Histone citrullination represses miRNA expression resulting in increased oncogene mRNAs in somatolactotrope cells. increased oncogene mRNAs in somatolactotrope cells.

  2022cites this paper
• Non-coding RNAs as potential biomarkers of gallbladder cancer

  2022cites this paper
• Regulation of ROCK1/2 by long non-coding RNAs and circular RNAs in different cancer types

  2022cites this paper
• ERK-dependent DICER1 phosphorylation promotes open chromatin state and lineage plasticity to mediate tumor progression

  2022cites this paper
• Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis

  2022cites this paper
• Etoposide-induced MicroRNA-205-5p Suppresses Proliferation and Migration by Targeting ERBB4 in MCF-7 Cells

  2022cites this paper
• Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

  2022cites this paper
• Epidemiological evidence for associations between variants in microRNA and cancer risk.

  2022cites this paper
• Effects of nutrient restriction during early or mid-gestation in bovine on placental development and miRNA expression in the cotyledon.

  2022cites this paper
• MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2

  2022cites this paper
• Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers

  2022cites this paper
• Interplay between K-RAS and miRNAs.

  2022cites this paper
• Exosomes in breast cancer management: Where do we stand? A literature review

  2022cites this paper
• MicroRNAs and Drug Resistance in Non-Small Cell Lung Cancer: Where Are We Now and Where Are We Going

  2022cites this paper
• Targeting Castration-Resistant Prostate Cancer Using Mesenchymal Stem Cell Exosomes for Therapeutic MicroRNA-let-7c Delivery.

  2022cites this paper
• Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

  2021cites this paper
• Merkel cell polyomavirus T-antigens regulate DICER1 mRNA stability and translation through HSC70

  2021cites this paper
• A comprehensive review on oncogenic miRNAs in breast cancer

  2021cites this paper
• A shape-shifting nuclease unravels structured RNA

  2021cites this paper
• Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy

  2021cites this paper
• The Roles of the Let-7 Family of MicroRNAs in the Regulation of Cancer Stemness

  2021cites this paper
• Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications

  2021influential citation
• Long noncoding RNA DATOC-1 that associate with DICER promotes development in epithelial ovarian cancer by upregulating miR-7 expression

  2021influential citation
• RNA-binding proteins of COSMIC importance in cancer.

  2021cites this paper
• MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer

  2021cites this paper
• Adipose Tissue-Derived Extracellular Vesicles and the Tumor Microenvironment: Revisiting the Hallmarks of Cancer

  2021cites this paper
• The Role of microRNA Let-7d in Female Malignancies and Diseases of the Female Reproductive Tract

  2021influential citation
• IL-1α and colorectal cancer pathogenesis: Enthralling candidate for anti-cancer therapy.

  2021cites this paper
• Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8

  2021cites this paper
• Identification by MicroRNA Analysis of Environmental Risk Factors Bearing Pathogenic Relevance in Non-Smoker Lung Cancer

  2021cites this paper
• Tumor Suppressive Effects of miR-124 and Its Function in Neuronal Development

  2021cites this paper
• MicroRNA and Hemophilia-A Disease: Bioinformatics Prediction and Experimental Analysis

  2021cites this paper
• Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

  2021cites this paper
• Classical and noncanonical functions of miRNAs in cancers.

  2021cites this paper