The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Immunity

• Publication date

  2014-02-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.immuni.2014.01.003PMID 24508234PMCID PMC3964146
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IL‐22, not simply a Th17 cytokine

  2013cited by this paper
• IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

  2013cited by this paper
• Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut

  2013cited by this paper
• Bacterial load and inflammation in fetal tissues is not dependent on IL-17a or IL-22 in 10-14 day pregnant mice infected with Listeria monocytogenes.

  2013cited by this paper
• Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

  2013cited by this paper
• IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection

  2012cited by this paper
• Contrasting Roles of IL-22 and IL-17 in Murine Genital Tract Infection by Neisseria gonorrhoeae

  2012cited by this paper
• Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

  2012cited by this paper
• Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut.

  2012influential reference
• High-affinity manganese coordination by human calprotectin is calcium-dependent and requires the histidine-rich site formed at the dimer interface.

  2012cited by this paper
• Homeostatic Regulation of Salmonella-Induced Mucosal Inflammation and Injury by IL-23

  2012cited by this paper
• IL-22 Production Is Regulated by IL-23 During Listeria monocytogenes Infection but Is Not Required for Bacterial Clearance or Tissue Protection

  2011cited by this paper
• Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity

  2011cited by this paper
• Salmonella-Induced Mucosal Lectin RegIIIβ Kills Competing Gut Microbiota

  2011cited by this paper
• The Intestinal Microbiota Plays a Role in Salmonella-Induced Colitis Independent of Pathogen Colonization

  2011cited by this paper
• Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

  2011cited by this paper
• Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.

  2010influential reference
• Gut inflammation provides a respiratory electron acceptor for Salmonella

  2010influential reference
• This information is current as Infections Mycobacterial , Protozoan , and Helminth Redundant and Pathogenic Roles for IL-22 in

  2010cited by this paper
• Th17 Cytokines and the Gut Mucosal Barrier

  2010cited by this paper
• IL-17 in protective immunity to intracellular pathogens

  2010cited by this paper
• Nutritional immunity beyond iron: a role for manganese and zinc.

  2010cited by this paper
• IL-23 and IL-17A, but Not IL-12 and IL-22, Are Required for Optimal Skin Host Defense against Candida albicans

  2010cited by this paper
• Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.

  2009influential reference
• Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

  2009cited by this paper
• Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host.

  2009cited by this paper
• Induction of intestinal Th17 cells by segmented filamentous bacteria.

  2009cited by this paper
• The aryl hydrocarbon receptor in immunity.

  2009cited by this paper
• Th17 cytokines and host-pathogen interactions at the mucosa: dichotomies of help and harm.

  2009cited by this paper
• Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

  2008cited by this paper
• T Cells Help To Amplify Inflammatory Responses Induced by Salmonella enterica Serotype Typhimurium in the Intestinal Mucosa

  2008influential reference
• Biosynthesis and IroC‐dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium

  2008cited by this paper
• Oxidative innate immune defenses by Nox/Duox family NADPH oxidases.

  2008cited by this paper
• IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

  2008cited by this paper
• Interleukin-23 Orchestrates Mucosal Responses to Salmonella enterica Serotype Typhimurium in the Intestine

  2008cited by this paper
• Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

  2008cited by this paper
• Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut

  2008influential reference
• Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae.

  2007cited by this paper
• Host Transmission of Salmonella enterica Serovar Typhimurium Is Controlled by Virulence Factors and Indigenous Intestinal Microbiota

  2007cited by this paper
• Chemically induced mouse models of intestinal inflammation

  2007cited by this paper
• Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

  2007cited by this paper
• Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota

  2007cited by this paper
• Enteric Salmonellosis Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract

  2007cited by this paper
• Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

  2006cited by this paper
• The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2

  2006cited by this paper
• Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.

  2006cited by this paper
• Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

  2004influential reference
• Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN

  2003cited by this paper
• Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

  2003cited by this paper
• Nontyphoidal salmonellosis.

  2001cited by this paper
• IroN, a Novel Outer Membrane Siderophore Receptor Characteristic of Salmonella enterica

  1998cited by this paper
• Ethanolamine utilization in Salmonella typhimurium: nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster

  1995cited by this paper
• Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice.

  1993cited by this paper
• Calcium-dependent complex assembly of the myeloic differentiation proteins MRP-8 and MRP-14.

  1991cited by this paper

• Atlas of innate immune responses to experimental cholera and IL22 treatment demonstrates protection by mucus-secreting cells

  2025cites this paper
• Inhibition of IL-22-producing cells by Sutterella sp. bacteria

  2025cites this paper
• Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection

  2025influential citation
• Commensal yeast promotes Salmonella Typhimurium virulence

  2025cites this paper
• Inducible, but not constitutive, pancreatic REG/Reg isoforms are regulated by intestinal microbiota and pancreatic diseases

  2025cites this paper
• Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition

  2025cites this paper
• Enhanced porcine gut barrier functioning and reduced inflammation from a combination of seaweed bioactives

  2025cites this paper
• By dawn or dusk-how circadian timing rewrites bacterial infection outcomes.

  2025cites this paper
• The Biological Functions and Mode of Action of Transcription Factor ELF4: A Promising Target for Treating Intestinal Homeostasis Disorder-Related Diseases

  2025cites this paper
• Cecal Metabolome Profiles of Turkey Poults in Response to Salmonella Heidelberg Challenge with or Without Turkey-Derived Lactobacillus Probiotic and Trans-Cinnamaldehyde

  2025cites this paper
• Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits Salmonella.

  2025cites this paper
• Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens.

  2025cites this paper
• Mucosal immune response in biology, disease prevention and treatment

  2025cites this paper
• IL-22-dependent responses and their role during Citrobacter rodentium infection

  2024cites this paper
• Beyond Inflammation: Role of Pyroptosis Pathway Activation by Gram-Negative Bacteria and Their Outer Membrane Vesicles (OMVs) in the Interaction with the Host Cell

  2024cites this paper
• Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection

  2024cites this paper
• LGG promotes activation of intestinal ILC3 through TLR2 receptor and inhibits salmonella typhimurium infection in mice

  2024cites this paper
• Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model

  2024cites this paper
• Non-classical roles of bacterial siderophores in pathogenesis

  2024cites this paper
• Inflammasome activation links enteric Salmonella Typhimurium infection to a rapid, cytokine-dependent increase in intestinal mucin release

  2024cites this paper
• TH17 cell: a double-edged sword in the development of inflammatory bowel disease

  2024cites this paper
• Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease

  2024cites this paper
• Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β

  2024cites this paper
• Identification of ferroptosis-related genes in ulcerative colitis: a diagnostic model with machine learning

  2023cites this paper
• Bile acids as modulators of gut microbiota composition and function

  2023cites this paper
• Advances in the Relationship between Interleukin-22 and Colonic Diseases

  2023cites this paper
• Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β

  2023cites this paper
• Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection.

  2023cites this paper
• Pyroptosis modulation by bacterial effector proteins.

  2023cites this paper
• Biological markers of disease activity in inflammatory bowel diseases

  2023cites this paper
• Identifying Common Immune-Related Genes in Crohn’s Disease and Ulcerative Colitis

  2023cites this paper
• Unravelling the gut-lung axis: insights into microbiome interactions and Traditional Indian Medicine's perspective on optimal health

  2023cites this paper
• Tick bite-induced Alpha-Gal Syndrome and Immunologic Responses in an Alpha-Gal Deficient Murine Model

  2023cites this paper
• Modulation of innate lymphoid cells by enteric bacterial pathogens

  2023cites this paper
• Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection

  2023cites this paper
• Gut Microbiota Resilience Mechanisms Against Pathogen Infection and its Role in Inflammatory Bowel Disease

  2023cites this paper
• Microbiota-derived short-chain fatty acids and modulation of host-derived peptides formation: Focused on host defense peptides.

  2023cites this paper
• Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis

  2023cites this paper
• The Microbial Tryptophan Metabolite Contributes to the Remission of Salmonella typhimurium Infection in Mice.

  2023cites this paper
• Effects of intestinal microbes on rheumatic diseases: A bibliometric analysis

  2023cites this paper
• (Not) Home alone: Antigen presenting cell – T Cell communication in barrier tissues

  2022cites this paper
• Role of IL-22 in intestinal microenvironment and potential targeted therapy through diet

  2022cites this paper
• Effects of dietary tryptophan supplementation on body temperature, hormone, and cytokine levels in broilers exposed to acute heat stress

  2022cites this paper
• Mycobiota and diet-derived fungal xenosiderophores promote Salmonella gastrointestinal colonization

  2022cites this paper
• Manganese Utilization in Salmonella Pathogenesis: Beyond the Canonical Antioxidant Response

  2022cites this paper
• Effective Barriers: The Role of NKT Cells and Innate Lymphoid Cells in the Gut

  2022cites this paper
• Innate lymphoid cells: More than just immune cells

  2022cites this paper
• Bacterial Involvement in Progression and Metastasis of Colorectal Neoplasia

  2022cites this paper
• Practical Recommendation of the Scientific Сommunity for Human Microbiome Research (CHMR) and the Russian Gastroenterological Association (RGA) on Small Intestinal Bacterial Overgrowth in Adults

  2022cites this paper
• ILC3 pyroptosis limits Salmonella infection

  2022cites this paper
• Mechanisms for the Invasion and Dissemination of Salmonella

  2022influential citation
• Group 3 innate lymphoid cell pyroptosis represents a host defence mechanism against Salmonella infection

  2022cites this paper
• Cross-Talk Between the Intestinal Epithelium and Salmonella Typhimurium

  2022cites this paper
• Distal Consequences of Mucosal Infections in Intestinal and Lung Inflammation

  2022cites this paper
• Bacterial and Viral Co-Infection in the Intestine: Competition Scenario and Their Effect on Host Immunity

  2022cites this paper
• Fungal xenosiderophores from mycobiota and diet promote Salmonella colonization of the inflamed gut

  2022cites this paper
• Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

  2022cites this paper
• A microbiologist can't let their sourdough die

  2022cites this paper
• Microbiota-mediated colonization resistance: mechanisms and regulation

  2022cites this paper
• Gut microbial response to host metabolic phenotypes

  2022cites this paper
• Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.

  2022cites this paper
• Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella

  2021cites this paper
• Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

  2021cites this paper
• Cooperative defenses during enteropathogenic infection.

  2021cites this paper
• Innate Lymphoid Cells and Natural Killer Cells in Bacterial Infections: Function, Dysregulation, and Therapeutic Targets

  2021cites this paper
• Salmonella enterica serovar Typhimurium chitinases modulate the intestinal glycome and promote small intestinal invasion

  2021influential citation
• Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

  2021cites this paper
• Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

  2021cites this paper
• The Interleukins Orchestrate Mucosal Immune Responses to Salmonella Infection in the Intestine

  2021cites this paper
• Act Locally, Act Globally—Microbiota, Barriers, and Cytokines in Atherosclerosis

  2021cites this paper
• Endoscopic Injection Treatment of Vesicoureteral Reflux in Children: Meeting with the Factors Involved in the Success Rate.

  2021cites this paper
• Colonizing Microbes, IL-10 and IL-22: Keeping the Peace at the Mucosal Surface

  2021cites this paper
• Goeckerman Regimen Reduces Alarmin Levels and PASI Score in Paediatric Patients with Psoriasis.

  2021cites this paper
• Human induced pluripotent stem cells for modeling of Salmonella infection

  2021cites this paper
• Salmonella Typhimurium ST313 isolated in Brazil revealed to be more invasive and inflammatory in murine colon compared to ST19 strains

  2021cites this paper
• The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock.

  2021influential citation
• Calprotectin (S100A8/A9) Is an Innate Immune Effector in Experimental Periodontitis

  2021cites this paper
• The Intestinal Microbiota: Impacts of Antibiotics Therapy, Colonization Resistance, and Diseases

  2021cites this paper
• Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate

  2021cites this paper
• Gut-microbiota derived bioactive metabolites and their functions in host physiology

  2021cites this paper
• Effects of oral administration of Spirulina platensis and probiotics on serum immunity indexes, colonic immune factors, fecal odor, and fecal flora in mice.

  2021cites this paper
• Cytosolic replication in epithelial cells fuels intestinal expansion and chronic fecal shedding of Salmonella Typhimurium.

  2021cites this paper
• Immune cell control of nutrient absorption

  2021cites this paper
• Conjugation to Enterobactin and Salmochelin S4 Enhances the Antimicrobial Activity and Selectivity of β-Lactam Antibiotics against Nontyphoidal Salmonella.

  2021cites this paper
• T-helper 22 cells develop as a distinct lineage from Th17 cells during bacterial infection and phenotypic stability is regulated by T-bet

  2021cites this paper
• Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy

  2021cites this paper
• The microbiome(s) and cancer: know thy neighbor(s)

  2021cites this paper
• Proteus mirabilis Employs a Contact-Dependent Killing System against Competing Enterobacteriaceae

  2021cites this paper
• Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions

  2021cites this paper
• Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

  2021cites this paper
• Loss of Interleukin-10 (IL-10) Signaling Promotes IL-22-Dependent Host Defenses against Acute Clostridioides difficile Infection

  2021cites this paper
• Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection.

  2021cites this paper
• IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

  2021cites this paper
• Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93.

  2021cites this paper
• Yersiniabactin contributes to overcoming zinc restriction during Yersinia pestis infection of mammalian and insect hosts

  2021cites this paper
• Research Note: Expression of T cell-related cytokines in chicken cecal and spleen tissues following Eimeria tenella infection in vivo

  2021cites this paper
• Interplay between gut microbiota and antimicrobial peptides

  2020cites this paper
• Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute Clostridioides difficile infection

  2020cites this paper
• From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System

  2020cites this paper
• Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense

  2020cites this paper