SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Cellular Physiology

• Publication date

  2007-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcp.20831PMID 16998810
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
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  2005cited by this paper
• Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

  2004cited by this paper
• p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

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  2003cited by this paper
• Chemosensitivity linked to p73 function.

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  2002cited by this paper
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  2002cited by this paper
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• Negative Control of p53 by Sir2 Promotes Cell Survival under Stress

  2001cited by this paper
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  2001cited by this paper
• SIR2 and aging--the exception that proves the rule.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Role of NAD(+) in the deacetylase activity of the SIR2-like proteins.

  2000cited by this paper
• Sir2 links chromatin silencing, metabolism, and aging.

  2000cited by this paper
• The Sir2 protein family: A novel deacetylase for gene silencing and more.

  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.

  1997cited by this paper
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  1997cited by this paper
• p73 is a simian [correction of human] p53-related protein that can induce apoptosis.

  1997cited by this paper
• p53 in growth control and neoplasia.

  1996cited by this paper
• p53: puzzle and paradigm.

  1996cited by this paper
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  1995cited by this paper
• Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites.

  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper

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