Neuroprotective effects of astaxanthin in a rat model of spinal cord injury

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Behavioural Brain Research

• Publication date

  2017-06-30

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.bbr.2017.04.026PMID 28442361
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2016influential reference
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  2015influential reference
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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• Intrathecal administration of naringenin improves motor dysfunction and neuropathic pain following compression spinal cord injury in rats: relevance to its antioxidant and anti-inflammatory activities

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• Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020influential citation
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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