Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Phytomedicine

• Publication date

  2008-06-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.phymed.2008.04.004PMID 18467083
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Eradication of Helicobacter pylori for non-ulcer dyspepsia.

  2011influential reference
• Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I ( kappa ) B kinase-dependent NF-kappaB activation

  2010cited by this paper
• Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report

  2006cited by this paper
• Astaxanthin, a carotenoid with potential in human health and nutrition.

  2006cited by this paper
• Helicobacter pylori extract induces nuclear factorkappa b, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells

  2006cited by this paper
• Helicobacter pylori and Non‐malignant Diseases

  2005cited by this paper
• Effects of astaxanthin and vitamin C on the prevention of gastric ulcerations in stressed rats.

  2005cited by this paper
• Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats.

  2005cited by this paper
• Suppressive Effect of Astaxanthin Isolated from the Xanthophyllomyces dendrorhous Mutant on Ethanol-Induced Gastric Mucosal Injury in Rats

  2005cited by this paper
• Treatment of Functional Dyspepsia with a Herbal Preparation

  2004cited by this paper
• Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.

  2003cited by this paper
• Effects of rutin and harmaline on rat reflux oesophagitis.

  2002cited by this paper
• Current concepts in the management of Helicobacter pylori infection—The Maastricht 2‐2000 Consensus Report

  2002cited by this paper
• Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress.

  2002cited by this paper
• Re: Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy.

  2001cited by this paper
• Double‐blind placebo‐controlled multicentre studies of rebamipide, a gastroprotective drug, in the treatment of functional dyspepsia with or without Helicobacter pylori infection

  2001cited by this paper
• Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats

  2001cited by this paper
• Helicobacter pylori : basic mechanisms to clinical cure 2000 : the proceedings of a symposium organised by Axcan Pharma, held in Bermuda, March 26-29, 2000

  2000cited by this paper
• Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes.

  2000cited by this paper
• Astaxanthin-Rich Algal Meal and Vitamin C InhibitHelicobacter pylori Infection in BALB/cA Mice

  2000cited by this paper
• Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy.

  2000cited by this paper
• Review article: the role of inflammation in the pathogenesis of gastric cancer

  1999cited by this paper
• Non-ulcer dyspepsia

  1999cited by this paper
• Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up

  1999cited by this paper
• Functional gastroduodenal disorders

  1999cited by this paper
• Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group.

  1999cited by this paper
• Prevalence of Helicobacter pylori in a representative Anglo‐Celtic population of urban Melbourne

  1998cited by this paper
• Guidelines for the management of Helicobacter pylori infection

  1998cited by this paper
• Efficacy of omeprazole in functional dyspepsia: double‐blind, randomized, placebo‐controlled trials (the Bond and Opera studies)

  1998cited by this paper
• Serum ferritin, hemoglobin, and Helicobacter pylori infection: a seroepidemiologic survey comprising 2794 Danish adults.

  1998cited by this paper
• A community‐based study of the epidemiology of Helicobacter pylori infection and associated asymptomatic gastroduodenal pathology

  1998cited by this paper
• Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia.

  1998cited by this paper
• [Prevalence of Helicobacter pylori infection in the Czech Republic--the South Moravia Region].

  1998cited by this paper
• Validation of seven graded diary cards for severity of dyspeptic symptoms in patients with non ulcer dyspepsia.

  1998cited by this paper
• Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia.

  1998cited by this paper
• Lack of correlation between self‐reported symptoms of dyspepsia and infection with Helicobacter pylori, in a general population sample

  1998cited by this paper
• Cisapride in functional dyspepsia in general practice. A placebo‐controlled, randomized, double‐blind study

  1997cited by this paper
• Challenges in managing dyspepsia in general practice

  1997cited by this paper
• Effect of cisapride on functional dyspepsia in patients with and without histological gastritis: A double‐blind placebo‐controlled trial

  1997cited by this paper
• Cisapride in functional dyspepsia in general practice. A placebo-controlled, randomized, double-blind study.

  1997cited by this paper
• Helicobacter-specific cell-mediated immune responses display a predominant Th1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice.

  1996cited by this paper
• Eradication ofHelicobacter pylori and long-term outcome of functional dyspepsia

  1996cited by this paper
• Relevance of norm values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease.

  1996cited by this paper
• Reflux esophagitis in humans is mediated by oxygen-derived free radicals.

  1995cited by this paper
• Helicobacter pylori in 205 consecutive endoscopy patients.

  1993cited by this paper
• Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations.

  1993cited by this paper
• Controlled clinical trial with sucralfate in the treatment of macroscopic gastritis.

  1989cited by this paper
• Drug Treatment of Functional Dyspepsia: A Meta‐Analysis of Randomized Controlled Clinical Trials

  1989cited by this paper
• Endoscopic findings and diagnoses in unselected dyspeptic patients at a primary health care center.

  1989cited by this paper
• Non-ulcer dyspepsia.

  1984cited by this paper

• Integrated network pharmacology and cellular assay revealed an anti-type 2 diabetes effect of Astaxanthin from Haematococcus pluvialis

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  2025cites this paper
• Promising effects of astaxanthin on pain-related behaviors and morphine tolerance in a mouse model of neuropathic pain: Possible involvement of Nrf2 and the NMDA receptor subunit NR2B

  2025cites this paper
• Astaxanthin: Unveiling biochemical mysteries, expanding horizons, and therapeutic opportunities in health science and biomedical research

  2025cites this paper
• Astaxanthin: A promising nutraceutical for cardiovascular health

  2025cites this paper
• Comparative Pharmacokinetic Study of Standard Astaxanthin and its Micellar Formulation in Healthy Male Volunteers

  2024cites this paper
• Tapping into Nature’s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention

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• Anticancer Activity of Astaxanthin-Incorporated Chitosan Nanoparticles

  2024cites this paper
• Natural anti-adhesive components against pathogenic bacterial adhesion and infection in gastrointestinal tract: case studies of Helicobacter pylori, Salmonella enterica, Clostridium difficile, and diarrheagenic Escherichia coli

  2024cites this paper
• The effectiveness and safety of natural food and food-derived extract supplements for treating functional gastrointestinal disorders-current perspectives.

  2024cites this paper
• Dietary Astaxanthin: A Promising Antioxidant and Anti-Inflammatory Agent for Brain Aging and Adult Neurogenesis

  2023cites this paper
• Astaxanthin: Past, Present, and Future

  2023cites this paper
• Oral suspension of thaliporphine alter the functional dyspepsia in gastroduodenal lesions rats via gastrointestinal hormones and brain-gut peptides

  2023cites this paper
• Recent progress in practical applications of a potential carotenoid astaxanthin in aquaculture industry: a review

  2023cites this paper
• Non-Chinese herbal medicines for functional dyspepsia.

  2023cites this paper
• Protective Effect of Astaxanthin Against Oxidative Stress-Induced Apoptosis and Inflammatory Increase in C6 Cells Induced by Hydrogen Peroxide

  2023cites this paper
• Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review

  2022cites this paper
• Astaxanthin

  2022cites this paper
• Chemical Features and Biological Effects of Astaxanthin Extracted from Haematococcus pluvialis Flotow: Focus on Gastrointestinal System

  2022cites this paper
• An overview of various algal biomolecules and its applications

  2022cites this paper
• Immunity boosting roles of biofunctional compounds available in aquafoods: A review

  2022cites this paper
• Antiaging agents: safe interventions to slow aging and healthy life span extension

  2022cites this paper
• Probiotics and Phytochemicals: Role on Gut Microbiota and Efficacy on Irritable Bowel Syndrome, Functional Dyspepsia, and Functional Constipation

  2022cites this paper
• Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent

  2021cites this paper
• Astaxanthin: An algae-based natural compound with a potential role in human health-promoting effect: An updated comprehensive review

  2021cites this paper
• Comprehensive integrated overview of the experimental and clinical neuroprotective effect of astaxanthin

  2021cites this paper
• Crustacea (Carotenoids Namely Astaxanthins) Against Cancer

  2021cites this paper
• What Do We Know about Antimicrobial Activity of Astaxanthin and Fucoxanthin?

  2021cites this paper
• Astaxanthin: health benefits and toxicity

  2021cites this paper
• Natural antioxidants in diabetes treatment and management: prospects of astaxanthin

  2021cites this paper
• Astaxanthin provides neuroprotection in an experimental model of traumatic brain injury via the Nrf2/HO-1 pathway.

  2021cites this paper
• Efficacy and Safety of a Novel Herbal Medicine in the Treatment of Irritable Bowel Syndrome: A Randomized Double-Blinded Clinical Trial

  2020cites this paper
• Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications

  2020cites this paper
• Comparison of a Novel Herbal Medicine and Omeprazole in the Treatment of Functional Dyspepsia: A Randomized Double-Blinded Clinical Trial

  2020cites this paper
• Novel Insights into the Biotechnological Production of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its Industrial Use as Novel Food Ingredient

  2020cites this paper
• A Review on the Historical Development of Phytoplankton in the Philippines and their Biological Importance throughout the Years

  2020cites this paper
• Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans

  2019cites this paper
• Astaxanthin: How much is too much? A safety review

  2019cites this paper
• Safety and efficacy of astaxanthin‐dimethyldisuccinate (Carophyll® Stay‐Pink 10%‐CWS) for salmonids, crustaceans and other fish

  2019cites this paper
• The efficacy of astaxanthin supplementation on indices of exercise recovery, metabolism and performance in humans

  2019cites this paper
• Astaxanthin Production by Microalgae Haematococcus pluvialis Through Wastewater Treatment: Waste to Resource

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data

  2019cites this paper
• Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review

  2018cites this paper
• Role of NRF2 in protection of the gastrointestinal tract against oxidative stress

  2018cites this paper
• Bioaccessibility of Marine Carotenoids

  2018cites this paper
• and AstaREAL L10) as novel food ingredients

  2018influential citation
• Astaxanthin as feed supplement in aquatic animals

  2018cites this paper
• Astaxanthin in Exercise Metabolism, Performance and Recovery: A Review

  2018cites this paper
• The effects of natural astaxanthin‐modified silica on properties of natural rubber

  2018cites this paper
• MOLECULAR DOCKING OF ASTAXANTHIN TO β-GLUCURONIDASE

  2018cites this paper
• Neuroprotective effects of astaxanthin in a rat model of spinal cord injury

  2017cites this paper
• EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the safety of astaxanthin-rich ingredients (AstaREAL A1010 and AstaREAL L10) as novel food ingredients

  2017influential citation
• CURCUMIN IN COMBINATION WITH TRIPLE THERAPY REGIMES AMELIORATES OXIDATIVE STRESS AND HISTOPATHOLOGIC CHANGES IN CHRONIC GASTRITIS-ASSOCIATED HELICOBACTER PYLORI INFECTION.

  2017cites this paper
• Cystoseira algae (Fucaceae): update on their chemical entities and biological activities

  2017cites this paper
• Astaxanthin-Producing Green Microalga Haematococcus pluvialis: From Single Cell to High Value Commercial Products

  2016cites this paper
• Review of genotoxicity and rat carcinogenicity investigations with astaxanthin.

  2016cites this paper
• Advances in Microalgae Biology and Sustainable Applications

  2016cites this paper
• Photoprotective and Cosmeceutical Prospects from Marine Origin

  2016cites this paper
• Astaxanthin: Health Benefits and Toxicity

  2016cites this paper
• Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer

  2015cites this paper
• Antioxidant, Biomolecule Oxidation Protective Activities of Nardostachys jatamansi DC and Its Phytochemical Analysis by RP-HPLC and GC-MS

  2015cites this paper
• UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CIÊNCIAS DA SAÚDE PROGRAMA DE PÓS-GRADUAÇÃO EM

  2014cites this paper
• Astaxanthin Structure , Metabolism , and Health Benefits

  2014cites this paper
• Chlorella zofingiensis as an Alternative Microalgal Producer of Astaxanthin: Biology and Industrial Potential

  2014cites this paper
• An overview: biomolecules from microalgae for animal feed and aquaculture

  2014cites this paper
• Antacids: Heart Burn OTC Drugs

  2014cites this paper
• Review article: adherence to Rome criteria in therapeutic trials in functional dyspepsia

  2014cites this paper
• Microalgal compounds modulate carcinogenesis in the gastrointestinal tract.

  2013cites this paper
• The Effects of Banha-sasim-tang on Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial

  2013cites this paper
• Effect of ethanolic extract of seeds of Linum usitatissimum (Linn.) in hyperglycaemia associated ROS production in PBMNCs and pancreatic tissue of alloxan induced diabetic rats

  2012cites this paper
• Therapeutic effect of H. pylori nosode, a homeopathic preparation in healing of chronic H. pylori infected ulcers in laboratory animals

  2012cites this paper
• Antiarrhythmic effect of flax lignan concentrate alone and concomitantly with omega 3 fatty acid mediated through inhibition of cardiomyocyte apoptosis in digoxin induced ventricular arrhythmia and lethality in rats

  2012cites this paper
• Shrimp waste extract and astaxanthin: rat alveolar macrophage, oxidative stress and inflammation.

  2012cites this paper
• Review article: current treatment options and management of functional dyspepsia

  2012cites this paper
• Combined astaxanthin and fish oil supplementation improves glutathione-based redox balance in rat plasma and neutrophils.

  2012cites this paper
• Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae.

  2011cites this paper
• Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.

  2011cites this paper
• Marine Carotenoids: Biological Functions and Commercial Applications

  2011cites this paper
• Protective Effects of Haematococcus Astaxanthin on Oxidative Stress in Healthy Smokers

  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper