Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Metabolic Engineering

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1096-7176(02)00011-3PMID 12749840
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic flux analysis of cultured hepatocytes exposed to plasma

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• [Fulminant hepatic failure].

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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1976cited by this paper
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