Oxygen consumption characteristics of porcine hepatocytes.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Metabolic Engineering

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1006/MBEN.1998.0105PMID 10935754
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  1997cited by this paper
• Use of Bioartificial and Artificial Liver Support Devices

  1996cited by this paper
• Isolation and culture of porcine hepatocytes for artificial liver support.

  1996cited by this paper
• Extracorporeal plasma perfusion of cultured hepatocytes: effect of intermittent perfusion on hepatocyte function and morphology.

  1996cited by this paper
• Measurement of PO2 in liver using EPR oximetry.

  1996cited by this paper
• Use of mammalian liver cells for artificial liver support.

  1996cited by this paper
• Development of a Hybrid Liver Support System: A Review

  1996cited by this paper
• Large-Scale Preparation and Function of Porcine Hepatocyte Spheroids

  1996cited by this paper
• Studies in Advanced Mathematics

  1996cited by this paper
• Reconstruction of liver tissue in vitro: geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver.

  1995cited by this paper
• Review of support systems used in the management of fulminant hepatic failure.

  1995cited by this paper
• Numerical Recipes in C: The Art of Scientific Computing.

  1994cited by this paper
• Development of a bioartificial liver using isolated hepatocytes.

  1994cited by this paper
• Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver.

  1994cited by this paper
• Bioreactor for a larger scale hepatocyte in vitro perfusion.

  1994cited by this paper
• A Device to Measure the Oxygen Uptake Rate of Attached Cells: Importance in Bioartificial Organ Design

  1994influential reference
• Rapid fluorescence quantitation of plasmid miniprep DNA.

  1993cited by this paper
• Evaluation of a hepatocyte‐entrapment hollow fiber bioreactor: A potential bioartificial liver

  1993cited by this paper
• Rapid fluorescence quantitation of plasmid miniprep DNA.

  1993cited by this paper
• Hepatocyte culture systems for artificial liver support

  1992cited by this paper
• Oxygen uptake rates in cultured rat hepatocytes.

  1992cited by this paper
• Hepatocyte function in a hollow fiber bioreactor: a potential bioartificial liver.

  1992cited by this paper
• Numerical recipes in C (2nd ed.): the art of scientific computing

  1992cited by this paper
• Hepatocyte culture systems for artificial liver support: Implications for critical care medicine (bioartificial liver support)

  1992cited by this paper
• Hepatic Tissue Engineering: Development of Critical Technologies

  1992cited by this paper
• Oxygen in mammalian tissue: methods of measurement and affinities of various reactions.

  1991cited by this paper
• Long‐Term in Vitro Function of Adult Hepatocytes in a Collagen Sandwich Configuration

  1991influential reference
• Fast Fourier Transforms

  1991cited by this paper
• Gas supply across membranes in bioreactors for hepatocyte culture.

  1990cited by this paper
• Numerical Recipes in C: The Art of Scientific Computing

  1989cited by this paper
• Measurement of p

  1985cited by this paper
• EFFECT OF TISSUE ABSORPTION AND MICROSCOPE OPTICAL PARAMETERS ON THE DEPTH OF PENETRATION FOR FLUORESCENCE AND REFLECTANCE MEASUREMENTS OF TISSUE SAMPLES

  1984cited by this paper
• Intracellular oxygen measurements of mouse liver cells using quantitative fluorescence video microscopy.

  1980cited by this paper
• [Methodical studies on the polarographic measurement of respiration and "critical oxygen pressure" in mitochondria and isolated cells with membrane-covered platinum electrodes].

  1972cited by this paper
• Intracellular measurement of oxygen by quenching of fluorescence of pyrenebutyric acid.

  1972cited by this paper
• COLLAGEN SUBSTRATA FOR STUDIES ON CELL BEHAVIOR

  1972cited by this paper

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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2015cites this paper
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