The first holocomplex structure of ribonucleotide reductase gives new insight into its mechanism of action.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Molecular Biology

• Publication date

  2006-06-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.JMB.2006.03.035PMID 16631785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors.

  2003cited by this paper
• Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes.

  2002cited by this paper
• The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer

  2002cited by this paper
• Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer

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• Pushing the boundaries of molecular replacement with maximum likelihood.

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• Kinetics in the pre-steady state of the formation of cystines in ribonucleoside diphosphate reductase: evidence for an asymmetric complex.

  2001cited by this paper
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  2001cited by this paper
• Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.

  2000cited by this paper
• Formation of the cystine between cysteine 225 and cysteine 462 from ribonucleoside diphosphate reductase is kinetically competent.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Evidence by Mutagenesis that Tyr370 of the Mouse Ribonucleotide Reductase R2 Protein Is the Connecting Link in the Intersubunit Radical Transfer Pathway*

  1999cited by this paper
• Glycyl radical enzymes: a conservative structural basis for radicals.

  1999cited by this paper
• A glycyl radical site in the crystal structure of a class III ribonucleotide reductase.

  1999cited by this paper
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  1998cited by this paper
• Preserved Catalytic Activity in an Engineered Ribonucleotide Reductase R2 Protein with a Nonphysiological Radical Transfer Pathway

  1998cited by this paper
• Databases in protein crystallography.

  1998cited by this paper
• Kinetic Evidence That a Radical Transfer Pathway in Protein R2 of Mouse Ribonucleotide Reductase Is Involved in Generation of the Tyrosyl Free Radical*

  1998cited by this paper
• Ribonucleotide reductases.

  1998cited by this paper
• Hydrogen Atom Transfer in Ribonucleotide Reductase (RNR)

  1998cited by this paper
• Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.

  1997cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
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  1997cited by this paper
• The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2.

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• Thiyl Radicals in Ribonucleotide Reductases

  1996cited by this paper
• The Bacillus subtilis genes for ribonucleotide reductase are similar to the genes for the second class I NrdE/NrdF enzymes of Enterobacteriaceae.

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• Iron ligand mutants in protein R2 of Escherichia coli ribonucleotide reductase

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• Two Conserved Tyrosine Residues in Protein R1 Participate in an Intermolecular Electron Transfer in Ribonucleotide Reductase*

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  1995cited by this paper
• Evidence by site-directed mutagenesis supports long-range electron transfer in mouse ribonucleotide reductase.

  1995cited by this paper
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  1994cited by this paper
• Structure of ribonucleotide reductase protein R1

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Isolation of ribonucleotide reductase from Mycobacterium tuberculosis and cloning, expression, and purification of the large subunit

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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1986cited by this paper
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  1980cited by this paper
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  1979cited by this paper
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