Encarnação et al. show that Rab3a, together with its newly identified effector NMHC IIA, mediates the positioning of peripheral lysosomes in nonsecretory cells, thereby promoting lysosome exocytosis and plasma membrane repair.
A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair
Marisa Encarnação,Lília Espada,Cristina Escrevente,D. Mateus,J. Ramalho,X. Michelet,Inês B. Santarino,V. Hsu,M. Brenner,Duarte C. Barral,O. Vieira
Published 2016 in Journal of Cell Biology
ABSTRACT
PUBLICATION RECORD
- Publication year
2016
- Venue
Journal of Cell Biology
- Publication date
2016-06-20
- Fields of study
Biology, Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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