Beta A4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Neurobiology of Aging

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 8487921
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuropathological stageing of Alzheimer-related changes

  2004cited by this paper
• Laminar distribution of neocortical senile plaques in senile dementia of the alzheimer type

  2004cited by this paper
• Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type

  2004cited by this paper
• Subtypes and differential laminar distributions of βA4 deposits in Alzheimer's disease: relationship with the intellectual status of 26 cases

  2004cited by this paper
• Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease

  2004cited by this paper
• Identification of normal and pathological aging in prospectively studied nondemented elderly humans.

  1992cited by this paper
• Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

  1991cited by this paper
• Amyloid Precursor Protein (APP) and ΒZA4 Amyloid in the Etiology of Alzheimer's Disease: Precursor‐Product Relationships in the Derangement of Neuronal Function

  1991cited by this paper
• Processing of the Alzheimer's disease beta A4 amyloid protein precursor (APP).

  1991cited by this paper
• Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

  1991cited by this paper
• Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

  1991cited by this paper
• beta A4 amyloid protein deposition in brain after head trauma.

  1991cited by this paper
• A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities.

  1991cited by this paper
• Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories. A European multicenter study under the auspices of EURAGE.

  1990cited by this paper
• Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques.

  1989cited by this paper
• Neuronal loss and neuronal atrophy. Computer simulation in connection with Alzheimer's disease.

  1989cited by this paper
• Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

  1989cited by this paper
• Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.

  1988cited by this paper
• Aging and cerebral amyloid: early detection of amyloid in the human brain using biochemical extraction and immunostain.

  1988cited by this paper
• Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease.

  1988cited by this paper
• Clinico‐pathologic studies in dementia

  1988cited by this paper
• A4 amyloid protein deposition and the diagnosis of Alzheimer's disease

  1988cited by this paper
• Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.

  1987cited by this paper
• Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

  1987cited by this paper
• Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease.

  1987cited by this paper
• Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.

  1987cited by this paper
• The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease.

  1987cited by this paper
• Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome.

  1987cited by this paper
• [Neuropathological study of 12 centenarians: the incidence of Alzheimer type senile dementia is not particularly increased in this group of very old patients].

  1986cited by this paper
• Alzheimer's disease in Down's syndrome

  1985cited by this paper
• Diagnosis of Alzheimer's disease.

  1985cited by this paper
• Observations on the brains of non-demented old people.

  1968cited by this paper

• Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer’s disease

  2025cites this paper
• Machine learning in the positron emission tomography imaging of Alzheimer's disease.

  2023cites this paper
• Probiotic supplement as a promising strategy in early tau pathology prevention: Focusing on GSK-3β?

  2023cites this paper
• Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer’s Disease and Associated Amyloid-Disease Brain Tissue

  2023cites this paper
• A History of Senile Plaques: From Alzheimer to Amyloid Imaging.

  2022cites this paper
• APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?

  2022cites this paper
• Interaction Mechanism Between the HSV-1 Glycoprotein B and the Antimicrobial Peptide Amyloid-β

  2022cites this paper
• AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer’s and Parkinson’s Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery

  2022cites this paper
• Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease a systematic review.

  2021cites this paper
• What causes neurodegenerative disease?

  2020cites this paper
• The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease

  2020cites this paper
• APP accumulates around dense-core amyloid plaques with presynaptic proteins in Alzheimer’s disease brain

  2020cites this paper
• A walk through tau therapeutic strategies

  2019cites this paper
• Clinico-Neuropathological Findings in the Oldest Old from the Georgia Centenarian Study

  2019cites this paper
• Both hyper‐ and hypo‐activation to cognitive challenge are associated with increased beta‐amyloid deposition in healthy aging: A nonlinear effect

  2018cites this paper
• Amyloid-β Plaques in Clinical Alzheimer’s Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity

  2018cites this paper
• Dementia in the Oldest Old

  2018cites this paper
• Biomarkers for Early Diagnosis of Alzheimer’s Disease in the Oldest Old: Yes or No?

  2017cites this paper
• Multiregional Age-Associated Reduction of Brain Neuronal Reserve Without Association With Neurofibrillary Degeneration or &bgr;-Amyloidosis

  2017cites this paper
• Of Energy and Entropy: The Ineluctable Impact of Aging in Old Age Dementia

  2017cites this paper
• Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

  2016cites this paper
• Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition

  2016cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1182 Altered proteins in the aging brain

  2016cites this paper
• PART is part of Alzheimer disease

  2015cites this paper
• La Drosophile comme modèle pour l'étude de la maladie d'Alzheimer : rôle de la protéine précurseur Amyloïde dans la mémoire olfactive

  2014cites this paper
• Implication du récepteur LSR (lipolysis stimulated lipoprotein receptor) dans le contrôle de l’homéostasie du cholestérol cérébral et les capacités cognitives au cours du vieillissement

  2014cites this paper
• Longevity with Dignity

  2014cites this paper
• The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.

  2014cites this paper
• What causes alzheimer's disease?

  2013cites this paper
• Stable Size Distribution of Amyloid Plaques Over the Course of Alzheimer Disease

  2012cites this paper
• Imaging the default mode network in aging and dementia.

  2012cites this paper
• Butyrylcholinesterase Is Associated With &bgr;-Amyloid Plaques in the Transgenic APPSWE/PSEN1dE9 Mouse Model of Alzheimer Disease

  2012cites this paper
• β-amyloid (Aβ) deposition in cognitively normal brain, dementia with Lewy bodies, and Alzheimer's disease: a study using principal components analysis.

  2012cites this paper
• On the 'classification' of neurodegenerative disorders: discrete entities, overlap or continuum?

  2012cites this paper
• PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimer's disease

  2011cites this paper
• Behavioural and cellular effects of exogenous amyloid-β peptides in rodents.

  2011cites this paper
• Centenarian Studies: Important Contributors to Our Understanding of the Aging Process and Longevity

  2011cites this paper
• Density and spatial pattern of β-amyloid (Aβ) deposits in corticobasal degeneration.

  2011cites this paper
• Asymptomatic Alzheimer's disease: a prodrome or a state of resilience?

  2011cites this paper
• Brain aging, Alzheimer's disease, and mitochondria.

  2011cites this paper
• Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old

  2010cites this paper
• Rôle des ADAM dans le processus physiopathologique de la maladie d'Alzheimer

  2010cites this paper
• Brain Aging in the Oldest-Old

  2010cites this paper
• Neuropsychiatric Aspects of Vascular Cognitive Impairment

  2010cites this paper
• Prevalence of dementia disorders in the oldest-old: an autopsy study

  2010cites this paper
• Prevalence and Pathology of Vascular Dementia in the Oldest-Old

  2010cites this paper
• The neuropathological changes associated with normal brain aging

  2010cites this paper
• Die Alzheimer‐Demenz: von der Pathologie zu therapeutischen Ansätzen

  2009cites this paper
• Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp?

  2009cites this paper
• Amyloid-targeted therapeutics in Alzheimer's disease: use of human albumin in plasma exchange as a novel approach for Abeta mobilization.

  2009cites this paper
• Alzheimer's disease: from pathology to therapeutic approaches.

  2009cites this paper
• Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

  2009cites this paper
• LOOKING AHEAD AMYLOID-TARGETED THERAPEUTICS IN ALZHEIMER ' S DISEASE : USE OF HUMAN ALBUMIN IN PLASMA EXCHANGE AS A NOVEL APPROACH FOR A β MOBILIZATION

  2009cites this paper
• Is there a neuropathology difference between mild cognitive impairment and dementia?

  2009cites this paper
• Les lésions de la maladie d’Alzheimer. Perspectives thérapeutiques ?

  2008cites this paper
• Cortical Cholinergic Lesion Causes Aβ Deposition: Cholinergic-Amyloid Fusion Hypothesis

  2008cites this paper
• [The lesions of Alzheimer's disease: which therapeutic perspectives?].

  2008cites this paper
• Physiologic Origins of Age-Related β-Amyloid Deposition

  2008cites this paper
• Methodological Considerations in Studying Centenarians: Lessons Learned From the Georgia Centenarian Studies

  2007cites this paper
• Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm?

  2007cites this paper
• Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

  2007cites this paper
• Alzheimer disease models and human neuropathology: similarities and differences

  2007cites this paper
• Clinicopathologic correlates in the oldest-old: Commentary on "No disease in the brain of a 115-year-old woman".

  2007cites this paper
• Advances on the Understanding of the Origins of Synaptic Pathology in AD

  2007cites this paper
• Étude des mécanismes moléculaires impliqués dans la mort neuronale induite par le peptide de ß-amyloïde soluble : recherche et validation fonctionnelle de cibles cellulaires

  2006cites this paper
• Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience

  2006cites this paper
• Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly

  2006cites this paper
• Critères diagnostiques de la démence vasculaire : une étude de validité dans une population de nonagénaires et centenaires

  2005cites this paper
• Cortical Cholinergic Deafferentation Induces Aβ Deposition

  2005cites this paper
• Neurodegenerative Diseases: The role of ß-amyloid in Alzheimer's disease

  2005cites this paper
• Overlap between neurodegenerative disorders

  2005cites this paper
• Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging.

  2005cites this paper
• Detecting bioactive amyloid β peptide species in Alzheimer's disease

  2004cites this paper
• Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects

  2004cites this paper
• Detecting bioactive amyloid beta peptide species in Alzheimer's disease.

  2004cites this paper
• Cerebral β amyloid deposition in patients with malignant neoplasms: its prevalence with aging and effects of radiation therapy on vascular amyloid

  2004cites this paper
• Hormonal and non-hormonal factors associated with cognition in post-menopausal women

  2004cites this paper
• Age-related decreases in gonadal hormones in long-evans rats

  2004cites this paper
• Coexistence of reactive plasticity and neurodegeneration in Alzheimer diseased brains.

  2004cites this paper
• Quantifying the pathology of neurodegenerative disorders: quantitative measurements, sampling strategies and data analysis

  2003cites this paper
• A grading system of Alzheimer disease lesions in neocortical areas.

  2003cites this paper
• Prospect of therapeutic approaches to tauopathies

  2003cites this paper
• Hypertension and Related Factors in the Etiology of Alzheimer's Disease

  2002cites this paper
• Molecular basis for anti-amyloid therapy in the prevention and treatment of Alzheimer's disease.

  2002cites this paper
• [Neuropathology of the cerebral vessels of centenarians].

  2002cites this paper
• Neurohormonal Signalling Pathways and the Regulation of Alzheimer β-Amyloid Metabolism Integrating Basic and Clinical Observations for Developing Successful Strategies to Delay, Retard or Prevent Cerebral Amyloidosis in Alzheimer’s Disease

  2002cites this paper
• Zur ätiologischen und pathogenetischen Heterogenität der Alzheimer-Krankheit

  2002cites this paper
• [Etiologic and pathogenetic heterogeneity of Alzheimer disease].

  2002cites this paper
• The Aetiology of Alzheimer’s Disease: Diverse Routes into a Common Tau Pathway

  2001cites this paper
• Longevity and Brain Aging: The Paradigm of Centenarians

  2001cites this paper
• Mild Amyloid Pathology in the Primary Visual System of Nonagenarians and Centenarians

  2001cites this paper
• Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage alzheimer’s disease

  2001cites this paper
• Cerebral aging: neuropsychological, neuroradiological, and neurometabolic correlates.

  2001cites this paper
• Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice.

  2001cites this paper
• Brain Ageing in the New Millennium

  2001cites this paper
• [Neuropathology of Alzheimer's disease].

  2000cites this paper
• Centenarians and the genetics of longevity.

  2000cites this paper
• The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old

  2000cites this paper
• The cause of neuronal degeneration in Alzheimer's disease.

  2000cites this paper
• Low amyloid (Aβ) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer’s disease

  1999cites this paper