IL-33 promotes airway remodeling and is a marker of asthma disease severity

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Asthma

• Publication date

  2014-05-06

• Fields of study

  Medicine

• Identifiers
  DOI 10.3109/02770903.2014.921196PMID 24796648
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
• IL‐33 is a mediator rather than a trigger of the acute allergic response in humans

  2014cited by this paper
• Blockade of IL-33/ST2 ameliorates airway inflammation in a murine model of allergic asthma

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• IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.

  2013cited by this paper
• IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma.

  2013influential reference
• Induced sputum levels of IL-33 and soluble ST2 in young asthmatic children

  2013cited by this paper
• Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity.

  2012cited by this paper
• Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.

  2012cited by this paper
• IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation

  2010cited by this paper
• Increased IL-33 expression by epithelial cells in bronchial asthma.

  2010cited by this paper
• Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells1

  2009cited by this paper
• Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction.

  2009cited by this paper
• Immunologic and inflammatory mechanisms that drive asthma progression to remodeling.

  2008cited by this paper
• The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

  2008cited by this paper
• ST2 GENE INDUCED BY TYPE 2 HELPER T CELL (TH2) AND PROINFLAMMATORY CYTOKINE STIMULI MAY MODULATE LUNG INJURY AND FIBROSIS

  2007cited by this paper
• Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma.

  2006cited by this paper
• IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.

  2005cited by this paper
• Airway remodeling contributes to the progressive loss of lung function in asthma: an overview.

  2005cited by this paper
• Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma.

  2003cited by this paper
• Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules.

  2003cited by this paper
• Early thickening of the reticular basement membrane in children with difficult asthma.

  2003cited by this paper
• Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma

  2002cited by this paper
• Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation.

  2001cited by this paper
• Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group.

  1999cited by this paper
• Enhanced proteoglycan deposition in the airway wall of atopic asthmatics.

  1999cited by this paper
• Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid.

  1997cited by this paper
• The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway

  1997cited by this paper
• Airways remodeling is a distinctive feature of asthma and is related to severity of disease.

  1997cited by this paper
• Use of induced sputum cell counts to investigate airway inflammation in asthma.

  1992cited by this paper
• Myofibroblasts and subepithelial fibrosis in bronchial asthma.

  1990cited by this paper
• Subepithelial fibrosis in the bronchi of asthmatics.

  1989cited by this paper
• Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.

  1989cited by this paper
• HL-A 27 AND ANKYLOSING SPONDYLITIS

  1975cited by this paper

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  2026cites this paper
• Airway epithelial cells as drivers of severe asthma pathogenesis.

  2025cites this paper
• Targeting alarmins in asthma- From the bench to the clinic.

  2025cites this paper
• Traditional biomarkers and clinical hallmarks in the frame of epithelial driven airways inflammation.

  2025cites this paper
• Interleukin-33 in Comorbidity of Bronchial Asthma and Arterial Hypertension

  2025cites this paper
• Selective production of IL-33-neutralizing autoantibody ameliorates asthma responses and severity.

  2024cites this paper
• Airway remodelling in asthma and the epithelium: on the edge of a new era

  2024cites this paper
• Airway hyperresponsiveness in asthma: the role of the epithelium.

  2024cites this paper
• Pathogenetic Aspects of Bronchial Asthma Phenotyping

  2024cites this paper
• The epithelial era of asthma research: knowledge gaps and future direction for patient care

  2024cites this paper
• Biologics and airway remodeling in asthma: early, late, and potential preventive effects

  2024cites this paper
• Unraveling heterogeneity and treatment of asthma through integrating multi-omics data

  2024cites this paper
• Interleukin‐33 links asthma to alopecia areata: Mendelian randomization and mediation analysis

  2024cites this paper
• Rhinovirus induces airway remodeling: what are the physiological consequences?

  2023cites this paper
• Epithelial alarmins: a new target to treat chronic respiratory diseases

  2023cites this paper
• Serum interleukin-33 combined with FEF75% z-score and FeNO improves the diagnostic accuracy of asthma in children

  2023influential citation
• Elevated levels of interleukin‐33 are associated with asthma: A meta‐analysis

  2023influential citation
• Staphylococcus aureus Enterotoxin-Specific IgE Sensitization in Severe Eosinophilic Asthma Phenotype

  2023cites this paper
• Pediatric Obesity and severe asthma: targeting pathways driving inflammation.

  2023cites this paper
• The Risk of Genetic Polymorphisms in the Immune Genes on the Developed of Respiratory Allergic Diseases

  2022cites this paper
• Sounding the alarmins—The role of alarmin cytokines in asthma

  2022cites this paper
• Serum Interleukin-33 and Soluble Suppression of Tumorigenicity 2 in Bronchial Asthma

  2022cites this paper
• Current Limitations and Recent Advances in the Management of Asthma.

  2022cites this paper
• IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis

  2022cites this paper
• Research advances in airway remodeling in asthma: a narrative review

  2022cites this paper
• Biologics and airway remodeling in severe asthma

  2022cites this paper
• BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens

  2022cites this paper
• Are blood cytokines reliable biomarkers of allergic disease diagnosis and treatment responses?

  2022cites this paper
• Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation.

  2021cites this paper
• Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation

  2021cites this paper
• Circulating IL-32 and IL-33 levels in patients with asthma and COPD: a retrospective cross-sectional study

  2021cites this paper
• Qufeng Xuanbi Formula Ameliorates Airway Remodeling in Asthmatic Mice by Suppressing Airway Smooth Muscle Cell Proliferation through MEK/ERK Signaling Pathway

  2021cites this paper
• Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment

  2021cites this paper
• Monoclonal Antibodies Targeting Alarmins: A New Perspective for Biological Therapies of Severe Asthma

  2021cites this paper
• Immunobiology of Steroid-Unresponsive Severe Asthma

  2021cites this paper
• Mechanisms and biomarkers of airway epithelial cell damage in asthma: A review

  2021cites this paper
• Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation

  2021cites this paper
• Regulation of Eosinophilia in Asthma—New Therapeutic Approaches for Asthma Treatment

  2021cites this paper
• The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention.

  2021cites this paper
• Narrative Review: Cytokine Levels and Polymorphisms in Childhood Asthma Among the Iranian Population

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
• Establishment of a fluorescent PCR melting curve method for detecting asthma susceptibility using gene SNP typing

  2020cites this paper
• The Prostaglandin D2 Receptor CRTH2 Promotes IL-33–Induced ILC2 Accumulation in the Lung

  2020cites this paper
• Comparation between serum levels of interleukin-33 in children with allergic asthma before and after inhalatory corticosteroid treatment

  2020cites this paper
• Recent advances in mast cell activation and regulation

  2020cites this paper
• Epithelial-macrophage-dendritic cell interactions impact alarmins expression in asthma and COPD.

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Characterization of immune responses and the lung transcriptome in a murine model of IL-33 challenge.

  2020cites this paper
• Airway epithelial cell damage in asthma: mechanisms and biomarkers

  2020cites this paper
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  2020cites this paper
• Interleukin-33 gene polymorphisms and chronic obstructive pulmonary disease in the Chinese Han population

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• IL-33 Mediated Inflammation in Chronic Respiratory Diseases—Understanding the Role of the Member of IL-1 Superfamily

  2019cites this paper
• Elevated levels of interleukin‐33 are associated with allergic and eosinophilic asthma

  2019cites this paper
• Mutual regulation between miR-21 and the TGFβ/Smad signaling pathway in human bronchial fibroblasts promotes airway remodeling

  2019cites this paper
• IL-33/IL-31 Axis in Immune-Mediated and Allergic Diseases

  2019cites this paper
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  2018cites this paper
• Relation of Serum Interleukin-33 level to Disease Severity in Asthmatic Patients

  2018cites this paper
• Immune markers and proteasomal gene polymorphisms specific for asthma phenotypes

  2018cites this paper
• Different effects of allergic rhinitis on nasal mucosa remodeling in chronic rhinosinusitis with and without nasal polyps

  2018cites this paper
• MiR-216a inhibits proliferation and promotes apoptosis of human airway smooth muscle cells by targeting JAK2

  2018cites this paper
• Fibroblast-to-myofibroblast transition in bronchial asthma

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Characteristics of severe asthma with fungal sensitization.

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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper