Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biochemistry

• Publication date

  2003-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI034887YPMID 14622011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis and characterization of Tyr(Bzl)9,11,13,15 and Tyr9,11,13,15 gramicidin A.

  2009cited by this paper
• Effects of the Flavonoids Biochanin A, Morin, Phloretin, and Silymarin on P-Glycoprotein-Mediated Transport

  2003cited by this paper
• Hydrophobic Coupling of Lipid Bilayer Energetics to Channel Function

  2003cited by this paper
• Structure of gramicidin a in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data.

  2003cited by this paper
• X-ray structure of a voltage-dependent K+ channel

  2003cited by this paper
• The principle of gating charge movement in a voltage-dependent K+ channel

  2003cited by this paper
• Gating the Selectivity Filter in ClC Chloride Channels

  2003cited by this paper
• EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.

  2003cited by this paper
• The open pore conformation of potassium channels

  2002cited by this paper
• Open channel structure of MscL and the gating mechanism of mechanosensitive channels

  2002cited by this paper
• Structural changes in the calcium pump accompanying the dissociation of calcium

  2002cited by this paper
• Agents that increase tyrosine phosphorylation activate a non‐selective cation current in single rabbit portal vein smooth muscle cells

  2001cited by this paper
• Comparison of spontaneous and noradrenaline‐evoked non‐selective cation channels in rabbit portal vein myocytes

  2001cited by this paper
• Mechanism of Inhibition of Cyclic Nucleotide–Gated Channel by Protein Tyrosine Kinase Probed with Genistein

  2001cited by this paper
• Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles.

  2001cited by this paper
• A common mechanism for cystic fibrosis transmembrane conductance regulator protein activation by genistein and benzimidazolone analogs.

  2001cited by this paper
• Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

  2000cited by this paper
• Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes

  2000cited by this paper
• Cloning and functional expression of rKCNQ2 K(+) channel from rat brain.

  2000cited by this paper
• Direct inhibition of glycine receptors by genistein, a tyrosine kinase inhibitor.

  2000cited by this paper
• Effect of chain length and unsaturation on elasticity of lipid bilayers.

  2000cited by this paper
• Modulation of a cloned human A-type voltage-gated potassium channel (hKv1.4) by the protein tyrosine kinase inhibitor genistein

  2000cited by this paper
• Protein tyrosine kinase regulates the number of renal secretory K channels.

  2000cited by this paper
• Inclusion-induced bilayer deformations: effects of monolayer equilibrium curvature.

  2000cited by this paper
• On the mechanism of genistein-induced activation of protein kinase A-dependent Cl– conductance in cardiac myocytes

  1999cited by this paper
• Protein tyrosine kinase is required for the induction of long‐term potentiation in the rat hippocampus

  1999cited by this paper
• Tyrosine kinases modulate K+ channel gating in mouse Schwann cells

  1999cited by this paper
• Inhibition by genistein of the hyperpolarization‐activated cation current in porcine sino‐atrial node cells

  1999cited by this paper
• Stimulation of maxi-K channels in trabecular meshwork by tyrosine kinase inhibitors.

  1999cited by this paper
• Spring constants for channel-induced lipid bilayer deformations. Estimates using gramicidin channels.

  1999cited by this paper
• Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel.

  1998cited by this paper
• Actions of Genistein on Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating

  1998cited by this paper
• Regulation of a swelling‐activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins

  1998cited by this paper
• Energetics of inclusion-induced bilayer deformations.

  1998cited by this paper
• The structure of the potassium channel: molecular basis of K+ conduction and selectivity.

  1998cited by this paper
• Effect of lipid characteristics on the structure of transmembrane proteins.

  1998cited by this paper
• Antioxidant activities of isoflavones and their biological metabolites in a liposomal system.

  1998cited by this paper
• Tyrosine kinase inhibitors suppress N-type and T-type Ca2+ channel currents in NG108–15 cells

  1998cited by this paper
• High-resolution polypeptide structure in a lamellar phase lipid environment from solid state NMR derived orientational constraints.

  1997cited by this paper
• Contrasting membrane localization and behavior of halogenated cyclobutanes that follow or violate the Meyer-Overton hypothesis of general anesthetic potency.

  1997cited by this paper
• Genistein directly induces cardiac CFTR chloride current by a tyrosine kinase-independent and protein kinase A-independent pathway in guinea pig ventricular myocytes.

  1997cited by this paper
• Inhibitory effects of genistein on ATP‐sensitive K+ channels in rabbit portal vein smooth muscle

  1997cited by this paper
• Direct block of voltage-sensitive sodium channels by genistein, a tyrosine kinase inhibitor.

  1997cited by this paper
• Synergistic activation of guinea‐pig cardiac cystic fibrosis transmembrane conductance regulator by the tyrosine kinase inhibitor genistein and cAMP

  1997cited by this paper
• Mechanism of alamethicin insertion into lipid bilayers.

  1996cited by this paper
• Attenuation of endothelin-1-induced calcium response by tyrosine kinase inhibitors in vascular smooth muscle cells.

  1996cited by this paper
• Membrane stiffness and channel function.

  1996cited by this paper
• Genistein directly inhibits L-type calcium currents but potentiates cAMP-dependent chloride currents in cardiomyocytes.

  1996cited by this paper
• Tyrosine phosphorylation is a novel pathway for regulation of chloride secretion in shark rectal gland.

  1995cited by this paper
• cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein.

  1995cited by this paper
• Multiple effects of tyrosine kinase inhibitors on vascular smooth muscle contraction.

  1995cited by this paper
• Experimental tests for protrusion and undulation pressures in phospholipid bilayers.

  1995cited by this paper
• Regulation of NMDA receptors by tyrosine kinases and phosphatases

  1994cited by this paper
• Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers

  1994cited by this paper
• Energetics of heterodimer formation among gramicidin analogues with an NH2-terminal addition or deletion. Consequences of missing a residue at the join in the channel.

  1993cited by this paper
• Lipids and their effects on membrane proteins: evidence against a role for fluidity.

  1991cited by this paper
• Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

  1991cited by this paper
• Gramicidin single-channel properties show no solvent-history dependence.

  1990cited by this paper
• Kinetics of gramicidin channel formation in lipid bilayers: transmembrane monomer association.

  1990cited by this paper
• Energetics of gramicidin hybrid channel formation as a test for structural equivalence. Side-chain substitutions in the native sequence.

  1990cited by this paper
• Calculation of deformation energies and conformations in lipid membranes containing gramicidin channels.

  1990cited by this paper
• Platelet-activating factor is a general membrane perturbant.

  1989cited by this paper
• Induction of conductance heterogeneity in gramicidin channels.

  1989cited by this paper
• Genistein, a specific inhibitor of tyrosine-specific protein kinases.

  1987cited by this paper
• Deformation free energy of bilayer membrane and its effect on gramicidin channel lifetime.

  1986cited by this paper
• Single-channel studies on linear gramicidins with altered amino acid side chains. Effects of altering the polarity of the side chain at position 1 in gramicidin A.

  1986cited by this paper
• Single-channel studies on linear gramicidins with altered amino acid sequences. A comparison of phenylalanine, tryptophane, and tyrosine substitutions at positions 1 and 11.

  1984cited by this paper
• Ion movement through gramicidin A channels. Single-channel measurements at very high potentials.

  1983cited by this paper
• The effects of bilayer thickness and tension on gramicidin single-channel lifetime.

  1983cited by this paper
• Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles.

  1983cited by this paper
• Influence of membrane thickness and ion concentration on the properties of the gramicidin a channel. Autocorrelation, spectral power density, relaxation and single-channel studies.

  1977cited by this paper
• Effect of phloretin on the permeability of thin lipid membranes

  1976cited by this paper
• Electrical capacity of black lipid films and of lipid bilayers made from monolayers.

  1975cited by this paper
• Elastic Properties of Lipid Bilayers: Theory and Possible Experiments

  1973cited by this paper
• Ion transfer across lipid membranes in the presence of gramicidin A. I. Studies of the unit conductance channel.

  1972cited by this paper
• The fluid mosaic model of the structure of cell membranes.

  1972cited by this paper
• Physical properties of bilayer membranes formed from a synthetic saturated phospholipid in n-decane.

  1971cited by this paper
• The role of diffusion in enzyme kinetics.

  1970cited by this paper
• The effects of the macrotetralide actin antibiotics on the electrical properties of phospholipid bilayer membranes

  1969cited by this paper

• Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers

  2024cites this paper
• Membrane Dipole Potential: Modification Methods and Consequences for Ion Channels Incorporation in the Membrane

  2024cites this paper
• A platform to deliver single and bi-specific Cas9/guide RNA to perturb genes in vitro and in vivo

  2024cites this paper
• Recommended Tool Compounds for Modifying the Cystic Fibrosis Transmembrane Conductance Regulator Channel Variants.

  2024cites this paper
• Comparative efficacy, toxicity, and insulin-suppressive effects of simvastatin and pravastatin in fatty acid-challenged mouse insulinoma MIN6 β-cell model

  2024cites this paper
• Differential Effects of Soy Isoflavones on the Biophysical Properties of Model Membranes

  2024cites this paper
• Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function

  2023cites this paper
• Modulation of the Dipole Potential of Model Lipid Membranes with Phytochemicals: Molecular Mechanisms, Structure–Activity Relationships, and Implications in Reconstituted Ion Channels

  2023cites this paper
• ATP modulation of osmotically activated anionic current in the membrane of Phycomyces blakesleeanus sporangiophore

  2023cites this paper
• Chromone-Containing Allylmorpholines Influence Ion Channels in Lipid Membranes via Dipole Potential and Packing Stress

  2022cites this paper
• Regulation of Gramicidin Channel Function Solely by Changes in Lipid Intrinsic Curvature

  2022cites this paper
• Hyperosmolarity stimulates transporter-mediated insertion of estrone sulfate into the plasma membrane, but inhibits the uptake by SLC10A1 (NTCP).

  2021cites this paper
• Sesamol protects MIN6 pancreatic beta cells against simvastatin-induced toxicity by restoring mitochondrial membrane potentials

  2020cites this paper
• Anionic nanoparticle-induced perturbation to phospholipid membranes affects ion channel function

  2020cites this paper
• Mechanisms of Regulation of Amyloid-Induced Permeability of Model Lipid Membranes by Polyphenols

  2019cites this paper
• Antidepressants are modifiers of lipid bilayer properties

  2019cites this paper
• Simvastatin Inhibits L-Type Ca2+-Channel Activity Through Impairment of Mitochondrial Function.

  2019cites this paper
• Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels.

  2018cites this paper
• General Introduction and Nanoscale View of the Cell

  2018cites this paper
• Mechanical Transduction and the Dark Energy of Biology.

  2018cites this paper
• Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics

  2018cites this paper
• Real, Joana and Miranda, Caroline and Olofsson, Charlotta S. and Smith, Paul A. (2018) Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins

  2018cites this paper
• Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta‐cell KATP channels and stimulate insulin secretion; statins as a test case

  2018cites this paper
• Coupling between Inclusions and Membranes at the Nanoscale.

  2018cites this paper
• Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties

  2017cites this paper
• Divergent effects of anesthetics on lipid bilayer properties and sodium channel function

  2017cites this paper
• The dipole-modifying effect of styrylpyridinium dyes and flavonoids on model membranes of different lipid compositions

  2017cites this paper
• Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism

  2017cites this paper
• kinasesventricle by Src and EGFR protein tyrosine current - Antagonistic regulation of swelling-activated Cl

  2016cites this paper
• Profound regulation of Na/K pump activity by transient elevations of cytoplasmic calcium in murine cardiac myocytes

  2016cites this paper
• Membrane dipole modifiers modulate single-length nystatin channels via reducing elastic stress in the vicinity of the lipid mouth of a pore.

  2015cites this paper
• Effects of dipole modifiers on channel-forming activity of amyloid and amyloid-like peptides in lipid bilayers

  2015cites this paper
• Insulin Resistance in Cystic Fibrosis: Management

  2015cites this paper
• TRPV2 Protein Expressing Distinct Combinations of TRPV1 and Heat Sensitization in Skin and Muscle Nociceptors

  2015cites this paper
• Two types of syringomycin E channels in sphingomyelin-containing bilayers

  2015cites this paper
• Studies on the hydrogen bond acidity, and other descriptors and properties for hydroxyflavones and hydroxyisoflavones

  2015cites this paper
• Modifiers of the Dipole Potential of Lipid Bilayers

  2015cites this paper
• Modifiers of membrane dipole potentials as tools for investigating ion channel formation and functioning.

  2015cites this paper
• Bilayer Effects of Antimalarial Compounds

  2015cites this paper
• A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics

  2015cites this paper
• Mechanical transduction by ion channels: A cautionary tale

  2015cites this paper
• Cellular approaches to the interaction between cannabinoid receptor ligands and nicotinic acetylcholine receptors.

  2014cites this paper
• Regulation of channel function due to physical energetic coupling with a lipid bilayer.

  2014cites this paper
• Investigation of Channel-Forming Activity of Polyene Macrolide Antibiotics in Planar Lipid Bilayers in the Presence of Dipole Modifiers

  2014cites this paper
• Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

  2014cites this paper
• The interaction of dipole modifiers with amphotericin-ergosterol complexes. Effects of phospholipid and sphingolipid membrane composition

  2014cites this paper
• X-ray structure, thermodynamics, elastic properties and MD simulations of cardiolipin/dimyristoylphosphatidylcholine mixed membranes.

  2014cites this paper
• Study and ch aracterization of the antioxidant activity of the inclusion complex of apigenin with β-cyclodextrin and 2-hydroxylpropyl-β-cyclodextrin in solution

  2014cites this paper
• The Influence of Halogen Derivatives of Thyronine and Fluorescein on the Dipole Potential of Phospholipid Membranes

  2014cites this paper
• Bilayer perturbation is a distinct parameter for regulating the experimental use of biological probes and the development of antimalarials

  2014cites this paper
• Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic 1 mitochondrial toxicity 2 3

  2013cites this paper
• Changes of dipole potential of phospholipid membranes resulted from flavonoid adsorption

  2013cites this paper
• FTIR, (1)H NMR and EPR spectroscopy studies on the interaction of flavone apigenin with dipalmitoylphosphatidylcholine liposomes.

  2013cites this paper
• Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.

  2013cites this paper
• Summation Solute Hydrogen Bonding Acidity Values for Hydroxyl Substituted Flavones Determined by NMR Spectroscopy

  2013cites this paper
• Effect of curcumin on the diffusion kinetics of a hemicyanine dye, LDS-698, across a lipid bilayer probed by second harmonic spectroscopy.

  2013cites this paper
• Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications.

  2013cites this paper
• Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation.

  2013cites this paper
• Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity.

  2013cites this paper
• Small-molecule photostabilizing agents are modifiers of lipid bilayer properties.

  2013cites this paper
• Ion Pore Formation in Membranes due to Complex Interactions between Lipids and Antimicrobial Peptides or Biomolecules

  2012cites this paper
• 9.12 Interactions of the Cell Membrane with Integral Proteins

  2012cites this paper
• Effect of dipole modifiers on the magnitude of the dipole potential of sterol-containing bilayers.

  2012cites this paper
• Molecular force transduction by ion channels – diversity and unifying principles

  2012cites this paper
• Ion pore formation in lipid bilayers and related energetic considerations.

  2012cites this paper
• Structure and elasticity of lipid membranes with genistein and daidzein bioflavinoids using X-ray scattering and MD simulations.

  2012cites this paper
• Lipid Bilayer-Membrane Protein Coupling

  2012cites this paper
• Bilayer Elasticity at the Nanoscale: The Need for New Terms

  2012cites this paper
• The Interaction of Dipole Modifiers with Polyene-Sterol Complexes

  2012cites this paper
• Statistics and dynamics of complex membranes

  2012cites this paper
• Inhibition of Kv4.3 by genistein via a tyrosine phosphorylation-independent mechanism.

  2011cites this paper
• Curcumin and genistein additively potentiate G551D-CFTR.

  2011cites this paper
• Regulation of Protein Function by Membrane Elastic Properties

  2011cites this paper
• Nanoscale patterning controls inorganic-membrane interface structure.

  2011cites this paper
• Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery

  2011cites this paper
• 5- and 4'-Hydroxylated flavonoids affect voltage gating of single alpha-hemolysin pore.

  2011cites this paper
• Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling

  2011cites this paper
• Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties

  2011cites this paper
• A One-Dimensional Continuum Elastic Model for Membrane-Embedded Gramicidin Dimer Dissociation

  2011cites this paper
• Amphiphile regulation of ion channel function by changes in the bilayer spring constant

  2010cites this paper
• Structure and water permeability of fully hydrated diphytanoylPC.

  2010cites this paper
• Surfactin activity depends on the membrane dipole potential.

  2010cites this paper
• Screening for Small Molecules' Bilayer-Modifying Potential Using a Gramicidin-Based Fluorescence Assay

  2010cites this paper
• Stretch-activated ion channels: what are they?

  2010cites this paper
• Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

  2010cites this paper
• Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases

  2010cites this paper
• Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.

  2009cites this paper
• Phytochemicals as Modulators of Neoplastic Phenotypes

  2009cites this paper
• Chemistry and Physics of Lipids

  2009cites this paper
• Molecular basis for genistein-induced inhibition of Kir2.3 currents

  2008influential citation
• The effect of dipole potential of lipid bilayers on the properties of ion channels formed by cyclic lipodepsipeptide syringomycin E

  2008cites this paper
• Genistein derivatives decrease liposome membrane integrity--calcein release and molecular modeling study.

  2008cites this paper
• Experimental Methods of Studying Mechanosensitive Channels and Possible Errors in Data Interpretation

  2008cites this paper
• Meyer and Overton revisited.

  2008cites this paper
• Rutaecarpine Induces Chloride Secretion across Rat Isolated Distal Colon

  2008cites this paper
• Membrane-thinning effect of curcumin.

  2008cites this paper
• Restoration of cystic fibrosis transmembrane conductance regulator function to CF mutants by enhancing protein processing and channel activity

  2008influential citation
• Altering the activity of syringomycin E via the membrane dipole potential.

  2008cites this paper
• Potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl− currents by the chemical solvent tetrahydrofuran

  2008cites this paper
• The bound states of amphipathic drugs in lipid bilayers: study of curcumin.

  2008influential citation