Gingipains in the culture supernatant of Porphyromonas gingivalis cleave CD4 and CD8 on human T cells.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Periodontal Research

• Publication date

  2002-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1034/J.1600-0765.2002.01364.XPMID 12472841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1988cited by this paper
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  1988cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1985cited by this paper
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  1984cited by this paper
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  1951cited by this paper

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